Abstract：
:The expression of DNA-topoisomerase II was analysed at the protein level in newly diagnosed cases of acute lymphoblastic leukemia (ALL) in children. Blast cells obtained from 81 children with untreated ALL were determined by means of immunocytochemistry. Of the ALL, 49 (60%) were positive for topoisomerase II and 32 (40%) negative. No significant correlation was found between the expression of topoisomerase II and the relapse rate or relapse-free intervals. These results were substantiated by determining the topoisomerase II mRNA expression in a collective of 21 patients by semiquantitative PCR. The PCR-assay and immunocytochemistry corresponded in 13 of 21 cases (62%).
journal_name
Cancer Lettjournal_title
Cancer lettersauthors
Stammler G,Sauerbrey A,Volm Mdoi
10.1016/0304-3835(94)90368-9subject
Has Abstractpub_date
1994-09-15 00:00:00pages
141-7issue
2eissn
0304-3835issn
1872-7980pii
0304-3835(94)90368-9journal_volume
84pub_type
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