The carcinogenic effect of dimethylnitrosamine in laboratory bred European hamsters (Cricetus cricetus).

abstract：:Patients with pancreatic adenocarcinoma (PDAC) have a 5-year survival rate of 8%, the lowest of any cancer in the United States. Traditional chemotherapeutic regimens, such as gemcitabine- and fluorouracil-based regimens, often only prolong survival by months. Effective precision targeted therapy is therefore urgently...

journal_title：Cancer letters

authors： Liu SH,Yu J,Creeden JF,Sutton JM,Markowiak S,Sanchez R,Nemunaitis J,Kalinoski A,Zhang JT,Damoiseaux R,Erhardt P,Brunicardi FC

更新日期：2020-10-28 00:00:00

abstract：:By virtue of being a localized treatment modality, radiotherapy is unable to deliver a tumoricidal radiation dose to tissues outside of the irradiated field. Nevertheless, ionizing radiation may result in radiation damage mediated by a bystander like effect away from the irradiated field, but this response is likely t...

journal_title：Cancer letters

authors： Hanna GG,Coyle VM,Prise KM

更新日期：2015-11-28 00:00:00

abstract：:Receptors for all classes of steroid hormones were identified in cytosols of adenocarcinoma of the lung. In contrast, the incidence of receptor in squamous cell carcinoma was limited and small cell carcinomas appeared devoid of receptor. Receptor binding was of high affinity, saturable and localized to the 8, 6-7 and ...

journal_title：Cancer letters

authors： Chaudhuri PK,Thomas PA,Walker MJ,Briele HA,Das Gupta TK,Beattie CW

更新日期：1982-09-01 00:00:00

abstract：:Dihydroagarofuran sesquiterpenes, which were isolated from Tripterygium wilfordii Hook fil. var. regelii Makino and Euonymus sieboldianus Blume, showed inhibitory effects on Epstein-Barr virus early antigen (EBV-EA) activation induced by 12-O-tetradecanoylphorbol-13-acetate (TPA). Triptogelin A-1, one of the active di...

journal_title：Cancer letters

authors： Ujita K,Takaishi Y,Tokuda H,Nishino H,Iwashima A,Fujita T

更新日期：1993-02-01 00:00:00

abstract：:Pseudogenes are a subclass of long non-coding (lnc) RNAs that arose from protein-coding genes, but have lost the ability to produce proteins. Pseudogenes play an important role in the pathogenesis of various tumors; however, the role of pseudogenes in hepatocellular carcinoma (HCC) is poorly understood. In this study,...

journal_title：Cancer letters

authors： Kong Y,Zhang L,Huang Y,He T,Zhang L,Zhao X,Zhou X,Zhou D,Yan Y,Zhou J,Xie H,Zhou L,Zheng S,Wang W

更新日期：2017-10-28 00:00:00

abstract：:By comparing protein profiles of nasopharyngeal carcinoma HONE1 cells to transformed nasopharyngeal epithelial NP 69 cells, several clusters of differentially expressed proteins were identified. The increased expression of cytokeratin 8 (CK8) and pyruvate kinase M2 was a common feature in four NPC cell lines compared ...

journal_title：Cancer letters

authors： Wang Y,He QY,Tsao SW,Cheung YH,Wong A,Chiu JF

更新日期：2008-07-08 00:00:00

abstract：:Flue gas condensate from briquet-fired residential furnaces was separated into a polycyclic aromatic compound (PAC)-free and a PAC-containing part, followed by a subfractionation of the PAC-containing fraction into 3 parts: PAC consisting predominantly of (a) 2 and 3 rings, (b) 4 and 5 rings and (c) 6 and more rings. ...

journal_title：Cancer letters

authors： Grimmer G,Brune H,Deutsch-Wenzel R,Dettbarn G,Misfeld J,Abel U,Timm J

更新日期：1985-09-15 00:00:00

abstract：:Insertion of functional interleukin-2 (IL-2) gene into a plasmacytoma cell line X63-Ag8.653 substantially reduced tumorigenicity of the resulting cloned cells, designated as X63-m-IL-2. Peritumoral administration of the X63-m-IL-2 cells, producing constitutively large quantities of IL-2, resulted in regressions of est...

journal_title：Cancer letters

authors： Bubeník J,Lotzová E,Indrová M,Símová J,Jandlová T,Bubeníková D

更新日期：1992-03-15 00:00:00

abstract：:Dinitropyrenes are mutagenic environmental pollutants. Of these compounds, 1,6-dinitropyrene is a potent tumorigen while 1,3-dinitropyrene appears to be weakly or non-tumorigenic. Two-electron reduction of dinitropyrenes yields nitro-nitrosopyrenes, which have been shown previously to be the major aerobic metabolites ...

journal_title：Cancer letters

authors： Djuric Z

更新日期：1992-07-31 00:00:00

abstract：:Recent studies in several tumor models indicated that treatment with angiogenic inhibitors may trigger induction of metastasis to other organs. Here we investigated modes of resistance and invasion in several tumor cell lines including 4T1 (breast), H460 (lung) and Colo205 (colorectal) using sunitinib at doses compara...

journal_title：Cancer letters

authors： Shojaei F,Simmons BH,Lee JH,Lappin PB,Christensen JG

更新日期：2012-07-01 00:00:00

abstract：:Intussusception is an alternative to the sprouting mode of angiogenesis. The advantage of this mechanism of vascular growth is that blood vessels are generated more rapidly and the capillaries thereby formed are less leaky. This review article summarizes our current knowledge concerning the role played by intussuscept...

journal_title：Cancer letters

authors： Ribatti D,Djonov V

更新日期：2012-03-28 00:00:00

abstract：:Resistance to chemotherapy is a challenging problem for treatment of cancer patients and autophagy has been shown to mediate development of resistance. In this study we systematically screened a library of 306 known anti-cancer drugs for their ability to induce autophagy using a cell-based assay. 114 of the drugs were...

journal_title：Cancer letters

authors： Dyczynski M,Yu Y,Otrocka M,Parpal S,Braga T,Henley AB,Zazzi H,Lerner M,Wennerberg K,Viklund J,Martinsson J,Grandér D,De Milito A,Pokrovskaja Tamm K

更新日期：2018-10-28 00:00:00

abstract：:Potential interaction of Aurora-A amplification and BRCA2 mutation was examined in breast tumours from BRCA2 999del5 mutation carriers (n=20) and non-carriers (n=41). Aurora-A amplification studied by FISH was significantly more common in breast tumours from BRCA2 mutation carriers (p=0.0005). Extensive Aurora-A ampli...

journal_title：Cancer letters

authors： Bodvarsdottir SK,Hilmarsdottir H,Birgisdottir V,Steinarsdottir M,Jonasson JG,Eyfjord JE

更新日期：2007-04-08 00:00:00

abstract：:The effects of carotenoids--alpha-carotene, beta-carotene, lycopene, beta-cryptoxanthin, zeaxanthin, lutein, canthaxanthin, astaxanthin--on the invasion of rat ascites hepatoma AH109A cells were investigated by co-culturing the hepatoma cells with rat mesentery-derived mesothelial cells (M-cells). All the carotenoids ...

journal_title：Cancer letters

authors： Kozuki Y,Miura Y,Yagasaki K

更新日期：2000-04-03 00:00:00

abstract：:Dioxane, perchloroethylene, and trichloroethylene were investigated as rat liver altered foci promoters in an initiation/promotion protocol. Animals were initiated with diethylnitrosamine, 30 mg/kg, injected i.p. 24 h after 2/3 partial hepatectomy. The chemical under study was administered by gavage once a day, 5 time...

journal_title：Cancer letters

authors： Lundberg I,Högberg J,Kronevi T,Holmberg B

更新日期：1987-07-01 00:00:00

abstract：:Breast cancer stem cells (BCSCs) initiate and sustain breast cancers, and several putative markers have been proposed to prospectively isolate BCSC from the non-cancer stem cell population. The candidate BCSC marker Sca-1 is a GPI-linked membrane protein expressed on activated lymphocytes, hematopoietic stem cells and...

journal_title：Cancer letters

authors： Matilainen H,Yu XW,Tang CW,Berridge MV,McConnell MJ

更新日期：2012-10-01 00:00:00

abstract：:Human papillomavirus (HPV) DNA integrations may affect therapeutic responses in cancers through ATM network-related DNA damage response (DDR). We studied whether cisplatin-induced DDR was altered in human HK-2 renal tubular cells immortalized by HPV16 E6/E7 genes. Cytotoxicity assays utilized thiazolyl blue dye and DD...

journal_title：Cancer letters

authors： Dogra S,Bandi S,Viswanathan P,Gupta S

更新日期：2015-01-28 00:00:00

abstract：:p66(Shc), one of the SHC1 gene encoding proteins, promotes cell death and reports cell anchorage status, mediating anoikis in vitro and functioning as a metastasis suppressor in vivo. However, very little is known about p66(Shc) gene regulation in cancer cells. Here, we show that methylation of a specific CpG site in ...

journal_title：Cancer letters

authors： Du W,Jiang Y,Zheng Z,Zhang Z,Chen N,Ma Z,Yao Z,Terada L,Liu Z

更新日期：2013-08-28 00:00:00

abstract：:Epithelial-to-mesenchymal transition (EMT) is the fundamental process by which an epithelial cell loses its epithelial characteristics including cell polarity and acquires mesenchymal and stemness-related features. Therefore, we investigated whether malignant pleural mesothelioma (MPMs) histologies were associated wit...

journal_title：Cancer letters

authors： Casarsa C,Bassani N,Ambrogi F,Zabucchi G,Boracchi P,Biganzoli E,Coradini D

更新日期：2011-03-28 00:00:00

abstract：:The present study was conducted to clarify the mechanism responsible for enhancement of the anti-melanoma activity of levodopa methylester by supplemental ascorbate in vivo. 5-Hydroxydopa, a known cytotoxic agent and the major metabolite formed from levodopa in the presence of ascorbate and mushroom tyrosinase in vitr...

journal_title：Cancer letters

authors： Pierson HF,Meadows GG

更新日期：1985-11-01 00:00:00

abstract：:The immune repertoire (IR) refers to the sum of B cells and T cells with functional diversity in the circulatory system of one individual at any given time. Immune cells, which reside within microenvironments and are responsible for protecting the human body, include T cells, B cells, macrophages, and dendritic cells....

journal_title：Cancer letters

authors： Han Y,Li H,Guan Y,Huang J

更新日期：2016-09-01 00:00:00

abstract：:Bombesin-like peptides (BLP) and their receptors are widely distributed throughout the intestine and are potential mitogens for gastrointestinal cancers. In this study we characterized the proliferation induced by BLP in the human adenocarcinoma cell line HT-29. The number of HT-29 cells, partially serum deprived (1% ...

journal_title：Cancer letters

authors： Cassano G,Resta N,Gasparre G,Lippe C,Guanti G

更新日期：2001-10-30 00:00:00

abstract：:Multi-drug resistance (MDR) has become the largest obstacle to the success of cancer chemotherapies. The mechanisms of MDR and the approaches to test MDR have been discovered, yet not fully understood. This review covers the in vivo and in vitro approaches for the detection of MDR in the laboratory and the mechanisms ...

journal_title：Cancer letters

authors： Wu Q,Yang Z,Nie Y,Shi Y,Fan D

更新日期：2014-06-01 00:00:00

abstract：:Populations consuming soybeans have reduced rates of breast, colon and prostate cancer possibly due, in part, to the presence in soybeans of two estrogenic isoflavones, genistein and daidzein. This study investigated the genotoxicity of these soya isoflavones and their interactions with 7,12-dimethylbenz[a]anthracene ...

journal_title：Cancer letters

authors： Giri AK,Lu LJ

更新日期：1995-08-16 00:00:00

abstract：:Primary cultures of mouse embryo cells are more efficient in excising DNA-carcinogen adducts resulting from exposure to either 7-bromomethylbenz-[alpha]anthracene or the more carcinogen 7-bromomethyl-12-methylbenz[alpha]anthracene than are mouse L 929 cell suspension cultures. However, within each of these systems, th...

journal_title：Cancer letters

authors： Dipple A,Schultz E

更新日期：1979-07-01 00:00:00

abstract：:Microtubule targeting based therapies have revolutionized cancer treatment; however, resistance and side effects remain a major limitation. Therefore, novel strategies that can overcome these limitations are urgently needed. We made a novel discovery that fisetin, a hydroxyflavone, is a microtubule stabilizing agent. ...

journal_title：Cancer letters

authors： Mukhtar E,Adhami VM,Sechi M,Mukhtar H

更新日期：2015-10-28 00:00:00

abstract：:We describe here the establishment of a new synovial sarcoma cell line, SYO-1, derived from a biphasic synovial sarcoma that developed in the groin of a 19-year-old female. The cell line was maintained for more than 70 passages (more than 24 months) in vitro. The SYO-1 cells in monolayer culture exhibited a spindle sh...

journal_title：Cancer letters

authors： Kawai A,Naito N,Yoshida A,Morimoto Y,Ouchida M,Shimizu K,Beppu Y

更新日期：2004-02-10 00:00:00

abstract：:Adult T-cell leukemia (ATL) is a fatal malignancy caused by infection with human T lymphotropic virus type-1 (HTLV-1). To search for a new biomarker of ATL, we analyzed sera from ATL patients using ProteinChip arrays. The spectral comparison of ATL patients with HTLV-1 carriers and healthy volunteers showed that the i...

journal_title：Cancer letters

authors： Ishida Y,Yamashita K,Sasaki H,Takajou I,Kubuki Y,Morishita K,Tsubouchi H,Okayama A

更新日期：2008-11-18 00:00:00

abstract：:We examined the antitumor effect and safety of the adenovirus-mediated expression of antisense K-ras RNA in two peritoneal dissemination models of pancreatic cancer. First, we found that the infection of an adenovirus vector expressing antisense human K-ras RNA (AxCA-AS) induced significant apoptosis in vitro in human...

journal_title：Cancer letters

authors： Miura Y,Ohnami S,Yoshida K,Ohashi M,Nakano M,Ohnami S,Fukuhara M,Yanagi K,Matsushita A,Uchida E,Asaka M,Yoshida T,Aoki K

更新日期：2005-01-31 00:00:00

abstract：:Over the last decade the linkage between hyperthermia, heat shock proteins and fever with the body's immune system has been well investigated. The immunomodulatory function of hyperthermia has been found to be quite sensitively regulated by temperature, as different levels of heating can bring different modulatory eff...

journal_title：Cancer letters

authors： Zhang HG,Mehta K,Cohen P,Guha C

更新日期：2008-11-28 00:00:00