Targeting autophagy by small molecule inhibitors of vacuolar protein sorting 34 (Vps34) improves the sensitivity of breast cancer cells to Sunitinib.

abstract：:Dioxane, perchloroethylene, and trichloroethylene were investigated as rat liver altered foci promoters in an initiation/promotion protocol. Animals were initiated with diethylnitrosamine, 30 mg/kg, injected i.p. 24 h after 2/3 partial hepatectomy. The chemical under study was administered by gavage once a day, 5 time...

journal_title：Cancer letters

authors： Lundberg I,Högberg J,Kronevi T,Holmberg B

更新日期：1987-07-01 00:00:00

abstract：:Vinblastine inhibited the growth of cultured KB cells 3 days after drug treatment by 55% and 67% at 2.7 ng/ml and 3.5 ng/ml of the medium, respectively. Lysolecithin and phosphatidylinositol showed only a marginal inhibitory effect on the growth of KB cells at respective concentrations of 35-125 microgram/ml and 50-15...

journal_title：Cancer letters

authors： Tsuruo T,Iida H,Tsukagoshi S,Sakurai Y

更新日期：1981-07-01 00:00:00

abstract：:The emerging roles of integrin β3 in the epithelial-mesenchymal transition (EMT) and drug resistance underline its significance in cancer metastasis and recurrence. However, the molecular mechanism underlying the distinctive expression of integrin β3 is less understood. In the present report, we demonstrated that repe...

journal_title：Cancer letters

authors： Hong SK,Park JR,Kwon OS,Kim KT,Bae GY,Cha HJ

更新日期：2016-07-01 00:00:00

abstract：:Artemisinin, a compound isolated from the sweet wormwood Artemisia annua L., has previously been shown to have selective toxicity towards cancer cells in vitro. In the present experiment, we studied the potential of artemisinin to prevent breast cancer development in rats treated with a single oral dose (50mg/kg) of 7...

journal_title：Cancer letters

authors： Lai H,Singh NP

更新日期：2006-01-08 00:00:00

abstract：:Pancreatic cancer is a highly lethal disease for which limited therapeutic options are available. Pancreatic cancer exhibits a pronounced collagen-rich stromal reaction, which induces chemoresistance by inhibiting drug diffusion into the tumor. Complementary treatment with oncolytic virus such as an oncolytic adenovir...

journal_title：Cancer letters

authors： Jung KH,Choi IK,Lee HS,Yan HH,Son MK,Ahn HM,Hong J,Yun CO,Hong SS

更新日期：2017-06-28 00:00:00

abstract：:Macrophage migration inhibitory factor (MIF) is up-regulated in diverse solid tumors and acts as the critical link between immune response and tumorigenesis. In this study, we demonstrated that MIF overexpression promoted migration of breast cancer cells by elevating TLR4 expression. Further investigation evidenced th...

journal_title：Cancer letters

authors： Lv W,Chen N,Lin Y,Ma H,Ruan Y,Li Z,Li X,Pan X,Tian X

更新日期：2016-06-01 00:00:00

abstract：:Intravenous methotrexate (MTX) therapy is widely used for treatment of various neoplastic diseases in children. The optimization of the MTX dose and/or the subsequent leucovorin rescue is based on pharmacokinetic data calculated from plasma concentrations collected after cessation of the MTX administration. The influe...

journal_title：Cancer letters

authors： Eksborg S,Albertioni F,Rask C,Beck O,Palm C,Schroeder H,Peterson C

更新日期：1996-11-29 00:00:00

abstract：:Because of the abnormal vasculature, most growing solid tumors contain regions that experience either acute or chronic hypoxia. However, tumor cells can maintain a high glycolytic rate even when there is enough oxygen supply. Hypoxia-inducible factors (HIFs) play crucial role in the response of tumor cells to this dis...

journal_title：Cancer letters

authors： Zeng W,Liu P,Pan W,Singh SR,Wei Y

更新日期：2015-01-28 00:00:00

abstract：:One of the most promising strategies to increase the efficacy of standard chemotherapy drugs is by combining them with low doses of histone deacetylases inhibitors (HDACis). Regarded as chemosensitizers, the addition of well-tolerated doses of HDACis to platinum-based chemotherapeutics has been proven in vitro and in ...

journal_title：Cancer letters

authors： Diyabalanage HV,Granda ML,Hooker JM

更新日期：2013-02-01 00:00:00

abstract：:Glutathione S-transferases (GST) alpha and pi, glutathione (GSH) and aldehyde dehydrogenase (ADH) were determined in colorectal cancer tissue specimens and in the adjacent normal colon tissue. The median contents in normal and cancer tissue were 8.1 (2.3-30.3) (5-95% quantiles) and 15.1 (5.3-50.3) microg/mg protein fo...

journal_title：Cancer letters

authors： Hengstler JG,Böttger T,Tanner B,Dietrich B,Henrich M,Knapstein PG,Junginger T,Oesch F

更新日期：1998-06-05 00:00:00

abstract：:Endothelin-1 (ET-1) is a potent vasoconstrictor that has been shown to significantly impact many benign and malignant tissues by signaling through its two cognate receptors: ET(A) and ET(B). As ET-1 has a role in both normal and diseased kidney, we initiated studies to investigate endothelin axis expression and functi...

journal_title：Cancer letters

authors： Pflug BR,Zheng H,Udan MS,D'Antonio JM,Marshall FF,Brooks JD,Nelson JB

更新日期：2007-02-08 00:00:00

abstract：:Nitrosatability of dried Nigerian vegetables and spices was investigated under simulated gastric conditions. N-Nitroso-dimethylamine (NDMA) was the only volatile nitrosamine found above the preformed level except in ugwu where N-nitroso-piperidine (2.3 ppb) was also detected. The lowest NDMA value of 0.4 ppb was found...

journal_title：Cancer letters

authors： Atawodi SE,Maduagwu EN,Preussmann R,Spiegelhalder B

更新日期：1991-05-24 00:00:00

abstract：:Increased fatty acids (FAs) regulate pancreatic cancer progression, however, the detailed mechanism is not clear, and different forms of FAs may play diversified roles in pancreatic cancer. To elucidate the underlying mechanism, we compared the effects of four major types of FAs on pancreatic cancer growth both in cel...

journal_title：Cancer letters

authors： Yu M,Liu H,Duan Y,Zhang D,Li S,Wang F

更新日期：2015-05-01 00:00:00

abstract：:Third generation bisphosphonates (BPs), including YM175 and YM529, are known to inhibit bone resorption. The aim of this study was to evaluate the anti-tumor effects of these drugs on murine osteosarcoma cell lines, in terms of proliferation and apoptosis. We found that both YM175 and YM529 strongly inhibited the in v...

journal_title：Cancer letters

authors： Horie N,Murata H,Nishigaki Y,Matsui T,Segawa H,Nogawa M,Yuasa T,Kimura S,Maekawa T,Fushiki S,Kubo T

更新日期：2006-07-08 00:00:00

abstract：:To identify non-tumor biomarkers for prediction of tumor HPV status and prognosis of patients with squamous cell carcinoma of the oropharynx (SCCOP), we evaluated the association of single nucleotide polymorphisms (SNPs) in pre-miRNAs with HPV16 status and survival for SCCOP patients. We analyzed HPV16 status in tumor...

journal_title：Cancer letters

authors： Guan X,Sturgis EM,Song X,Liu Z,El-Naggar AK,Wei Q,Li G

更新日期：2013-04-28 00:00:00

abstract：:The faithful inheritance of chromosomes is essential for the propagation of organisms. In eukaryotes, central to this process is the mitotic spindle. Recently, we have identified TRIM8 as a gene aberrantly expressed in gliomas whose expression reduces the clonogenic potential in the patients' glioma cells. TRIM8 encod...

journal_title：Cancer letters

authors： Venuto S,Monteonofrio L,Cozzolino F,Monti M,Appolloni I,Mazza T,Canetti D,Giambra V,Panelli P,Fusco C,Squeo GM,Croce AI,Pucci P,Malatesta P,Soddu S,Merla G,Micale L

更新日期：2020-03-31 00:00:00

abstract：:Gastroesophageal reflux disease (GERD) is the main risk factor for Barrett's tumorigenesis. In this study, we investigated the role of NRF2 in response to exposure to acidic bile salts (ABS), in conditions that mimic GERD, using Barrett's esophagus cell models. We detected an increase in NRF2 protein levels, following...

journal_title：Cancer letters

authors： Peng D,Lu H,Zhu S,Zhou Z,Hu T,Chen Z,Zaika A,El-Rifai W

更新日期：2019-08-28 00:00:00

abstract：:The limitations of current chemotherapies have motivated research in developing new treatments. Growing evidence shows that interaction between tumors and their microenvironment, but not tumor cells per se, is the key factor in tumor progression and therefore of obvious scientific interest and therapeutic value. Exoso...

journal_title：Cancer letters

authors： Tang MK,Wong AS

更新日期：2015-10-10 00:00:00

abstract：:Although it is well known that ovarian endometriosis occasionally gives rise to ovarian cancers with specific histology such as endometrioid and clear cell carcinomas, its etiology is not fully understood. We have shown that a stressful microenvironment within the endometriotic cyst may lead to cancer development by i...

journal_title：Cancer letters

authors： Mandai M,Matsumura N,Baba T,Yamaguchi K,Hamanishi J,Konishi I

更新日期：2011-11-28 00:00:00

abstract：:Highly invasive and rapidly fatal, small-cell lung cancer (SCLC) has been an insurmountable gulf since discovery. Innate immunity plays a vital role in anti-tumor response, among which macrophages contribute to an indispensable character. Here, we found that macrophage infiltration in SCLC reduced significantly in a s...

journal_title：Cancer letters

authors： Zheng Y,Wang Z,Wei S,Liu Z,Chen G

更新日期：2021-02-28 00:00:00

abstract：:Non-steroidal anti-inflammatory drugs (NSAIDs) are used extensively for analgesic and antipyretic treatments. In addition, NSAIDs reduce the risk and mortality to several cancers. Their mechanisms in anti-tumorigenesis are not fully understood, but both cyclooxygenase (COX)-dependent and -independent pathways play a r...

journal_title：Cancer letters

authors： Liggett JL,Zhang X,Eling TE,Baek SJ

更新日期：2014-05-01 00:00:00

abstract：:Several enzymes metabolize the toxic aldehydes produced during lipid peroxidation, such as 4-hydroxynonenal. During carcinogenesis induced by diethylnitrosamine in rat liver, an increase in aldehyde dehydrogenase, in comparison with normal liver, has already been shown. This paper demonstrates that, although to a less...

journal_title：Cancer letters

authors： Canuto RA,Muzio G,Maggiora M,Biocca ME,Dianzani MU

更新日期：1993-02-01 00:00:00

abstract：:Despite the significance of tumor angiogenesis and the extensive knowledge on the molecular basis of blood vessel formation in carcinoma of colorectum, no data exist in hyperplastic polyp. This prompted us to examine angiogenesis in hyperplastic polyp. Eleven small hyperplastic polyps, 13 large hyperplastic polyps and...

journal_title：Cancer letters

authors： Sano Y,Maeda N,Kanzaki A,Fujii T,Ochiai A,Takenoshita S,Takebayashi Y

更新日期：2005-02-10 00:00:00

abstract：:Colorectal cancer (CRC) is a commonly diagnosed malignancy with unsatisfactory survival outcomes. Recent studies indicate that noncoding RNAs (ncRNAs) can be selectively packaged into exosomes, the extracellular vesicles composed of a lipid bilayer, and delivered from donor to recipient cells, thus regulating the beha...

journal_title：Cancer letters

authors： Wu Q,Liu W,Wang J,Zhu L,Wang Z,Peng Y

更新日期：2020-11-28 00:00:00

abstract：:Several natural phenolic compounds were tested in vitro for their effect on the activity of protein kinase C isolated from liver cytosol, particulate and nuclear fractions of normal and aflatoxin B1 treated rats. Quercetin and kaempferol inhibited the enzyme activity of all these fractions at very low dose levels. The...

journal_title：Cancer letters

authors： Mistry KJ,Krishna M,Bhattacharya RK

更新日期：1997-12-16 00:00:00

abstract：:Obesity is one of the major modifiable risk factors in breast cancer, with obese adipose tissue showing a pathological role in breast cancer development and malignancy via the release of secretory factors, such as proinflammatory cytokines and adipocytokines. The current article focuses on visfatin and resistin, two s...

journal_title：Cancer letters

authors： Wang YY,Hung AC,Lo S,Yuan SF

更新日期：2021-02-01 00:00:00

abstract：:The candidate prostate cancer gene ELAC2 encodes tRNA 3' processing endoribonuclease (tRNase ZL). We produced recombinant human tRNase ZL's, which contain one to three amino-acid substitutions from three missense mutations (Ser217Leu, Ala541Thr, and Arg781His) that are associated with the occurrence of prostate cancer...

journal_title：Cancer letters

authors： Minagawa A,Takaku H,Takagi M,Nashimoto M

更新日期：2005-05-26 00:00:00

abstract：:Patients with inadequate anti-cancer T cell responses experience limited benefit from immune checkpoint inhibitors and other immunotherapies that require T cells. Therefore, treatments that induce de novo anti-cancer T cell immunity are needed. One strategy - referred to as in situ vaccination - is to deliver chemothe...

journal_title：Cancer letters

authors： Lynn GM,Laga R,Jewell CM

更新日期：2019-09-10 00:00:00

abstract：:While the vast majority of cancers are believed to occur sporadically, most forms of cancer, both adult and paediatric, have a hereditary equivalent. In the case of adult malignancies, these include hereditary breast and ovarian cancer and syndromes such as the multiple endocrine neoplasias types 1 and 2 characterised...

journal_title：Cancer letters

authors： Marsh D,Zori R

更新日期：2002-07-26 00:00:00

abstract：:The influence of 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone, a mutagen in chlorinated water, on cell proliferation and lipid peroxidation in the glandular stomach mucosa was investigated in male 4-week-old Wistar rats. Animals were given 50 p.p.m., 25 p.p.m., 12.5 p.p.m., 6.25 p.p.m. or 0 p.p.m. of MX soluti...

journal_title：Cancer letters

authors： Nishikawa A,Kinae N,Furukawa F,Mitsui M,Enami T,Hasegawa T,Takahashi M

更新日期：1994-10-14 00:00:00