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Aurora-A amplification associated with BRCA2 mutation in breast tumours.

Abstract：

:Potential interaction of Aurora-A amplification and BRCA2 mutation was examined in breast tumours from BRCA2 999del5 mutation carriers (n=20) and non-carriers (n=41). Aurora-A amplification studied by FISH was significantly more common in breast tumours from BRCA2 mutation carriers (p=0.0005). Extensive Aurora-A amplification was also detected on metaphase chromosomes in three breast epithelial cell lines with the same BRCA2 mutation. In addition, significant association was found between Aurora-A amplification and TP53 mutations in non-BRCA2 mutation carrier tumours (p=0.007). These results suggest that breast tumours with mutations in BRCA2 or TP53 could be promising candidates for Aurora-A targeted treatment.

journal_name

Cancer Lett

journal_title

Cancer letters

authors

Bodvarsdottir SK,Hilmarsdottir H,Birgisdottir V,Steinarsdottir M,Jonasson JG,Eyfjord JE

doi

10.1016/j.canlet.2006.06.003

subject

Has Abstract

pub_date

2007-04-08 00:00:00

pages

96-102

issue

1

eissn

0304-3835

issn

1872-7980

pii

S0304-3835(06)00410-1

journal_volume

248

pub_type

杂志文章

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