Abstract:
:A newly found human retrovirus, adult T-cell leukemia virus (ATLV) was shown by means of membrane immunofluorescence to bind to various hematopoietic cells including T-, B- and non-T, non-B-cell lines. Partially purified viral gp46 from culture fluids of ATL virus producer lines also bound efficiently to an ATLV-negative T-cell line, CCRF-CEM cells. When the viruses were pre-incubated with anti-ATLV-positive human sera, ATLV binding to the cells was clearly inhibited but not by pre-incubation with anti-ATLV-negative sera. These data suggest that: (1) ATLV binds not only to T-cells but also to multiple types of cells of hematopoietic origin; (2) anti-ATLV antibody-positive human sera have the blocking antibody for the binding of ATLV to lymphoid cells.
journal_name
Cancer Lettjournal_title
Cancer lettersauthors
Yamamoto N,Chosa T,Koyanagi Y,Tochikura T,Schneider J,Hinuma Ydoi
10.1016/0304-3835(84)90004-1subject
Has Abstractpub_date
1984-01-01 00:00:00pages
261-8issue
3eissn
0304-3835issn
1872-7980pii
0304-3835(84)90004-1journal_volume
21pub_type
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