Abstract:
:Women who have breast cysts with intracystic Na+/K+ < 3 may have a higher risk of developing breast cancer than women who have breast cysts with intracystic Na+/K+ > 3. In this study wide-ranging intracystic concentrations of cathepsin D and pS2 (oestrogen inducible proteins/polypeptides) as well as oestradiol were found. The concentrations of cathepsin D and oestradiol were significantly higher in the low electrolyte ratio cyst group than in the high electrolyte ratio cyst group. No significant difference was found between pS2 concentrations in the two groups. The significantly higher intracystic concentrations of cathepsin D, a mitogenic lysosomal endopeptidase and oestradiol in the low electrolyte ratio group may partly provide an explanation for the higher risk of breast cancer which has been observed in this group of women.
journal_name
Cancer Lettjournal_title
Cancer lettersauthors
Lai LC,Cornell C,Lennard TWdoi
10.1016/0304-3835(93)90027-7subject
Has Abstractpub_date
1993-04-15 00:00:00pages
21-5issue
1eissn
0304-3835issn
1872-7980pii
0304-3835(93)90027-7journal_volume
69pub_type
杂志文章相关文献
CANCER LETTERS文献大全abstract::Effect of CF(3)-STLC, a potent kinesin spindle protein (KSP) inhibitor, on K562 human CML cell line was investigated. Treatment with CF(3)-STLC induced mitotic arrest of the cell cycle with the appearance of characteristic monoastral spindles, subsequent apoptotic cell death and cleavage of PARP-1, caspase-3, and 4E-B...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2010.06.007
更新日期:2010-12-01 00:00:00
abstract::Virtually all cervical cancer morbidities are associated with genital skin or mucosa cell infection with human papillomavirus (HPV). The HPV oncogenic proteins E6 and E7 are able to inactivate p53 and Rb proteins, which results in malignant transformation. Employing quantitative real-time PCR and Western blot analysis...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2008.06.030
更新日期:2008-12-08 00:00:00
abstract::The expression of the WAF1/CIP1 gene product, p21, in enzyme-altered foci (EAF) induced by diethylnitrosamine (DEN) and phenobarbital (PB) was examined. p21 expression in the nucleus of hepatocytes in EAF was decreased compared to surrounding tissue. Fifty-eight percent of all GST-P-positive EAF induced by DEN and 79%...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(96)04218-8
更新日期:1996-06-24 00:00:00
abstract::Aquaporin 3 (AQP3) and c-Met are both overexpressed in human gastric carcinoma and highly associated with its metastasis and invasion. However, it still remains unknown whether c-Met and AQP3 correlate with each other. Herein, we demonstrated that c-Met expression in gastric cancer tissues significantly correlated wit...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2011.12.040
更新日期:2012-06-01 00:00:00
abstract::The anti-carcinogenic activity of dietary fruit and vegetables observed in several epidemiological and experimental animal studies is likely to be an effect of the combined exposure to a large number of substances acting together. This is plausible, as these compounds are present simultaneously in a diet containing ve...
journal_title:Cancer letters
pub_type: 杂志文章,评审
doi:10.1016/s0304-3835(97)04681-8
更新日期:1997-03-19 00:00:00
abstract::We previously demonstrated that female Sprague-Dawley rats fed AIN-93G diets containing soy protein isolate (SPI+) had lower DMBA-induced mammary tumor incidence than those fed diets containing casein (CAS), due partly to altered Phase I metabolism with soy. Here, we evaluated the tumor protective effects of these sam...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2004.11.009
更新日期:2005-06-16 00:00:00
abstract::The present study was conducted to clarify the mechanism responsible for enhancement of the anti-melanoma activity of levodopa methylester by supplemental ascorbate in vivo. 5-Hydroxydopa, a known cytotoxic agent and the major metabolite formed from levodopa in the presence of ascorbate and mushroom tyrosinase in vitr...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(85)90154-5
更新日期:1985-11-01 00:00:00
abstract::The progression of hepatocellular carcinoma (HCC) is known to be strongly related to overexpression of hepatitis Bx (HBx) protein and dysfunction of p53. While the inhibition of p53 by HBx is well known, the effect of p53 on HBx function has not been well studied. In this report, we found that p53 affects the stabilit...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2009.03.019
更新日期:2009-09-18 00:00:00
abstract::Triple-negative breast cancer (TNBC) treatment offers only limited benefits, and it is very relevant given the significant number of deaths that it causes. DNA repair pathways can enable tumor cells to survive DNA damage that is induced by chemotherapeutic or radiation treatments. Histone deacetylase inhibitors (HDACi...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2017.04.023
更新日期:2017-08-01 00:00:00
abstract::The present study evaluates the postnatal efficacy of Momordica charantia peel, pulp, seed and whole fruit extract via assessing the modulation in the biotransformation system enzymes of suckling neonates and lactating mice. The peel, seed or whole fruit extract of Momordica (100 microl/animal/day) independently induc...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/s0304-3835(97)00381-9
更新日期:1998-01-09 00:00:00
abstract::Two-month-old outbred female LIO rats were exposed weekly to 15 (experiment I, groups 1, 2 and 3) or to 5 (experiment II, groups 4, 5 and 6) subcutaneous injections of 1,2-dimethylhydrazine (DMH) at a single dose of 21 mg/kg of body weight. From the day of the first injection of the carcinogen, the rats from groups 2,...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/s0304-3835(98)00362-0
更新日期:1999-04-26 00:00:00
abstract::The mixed lineage kinase domain-like protein (MLKL) has emerged as a critical mediator of necroptosis, which results in the release of cellular damage-associated molecular patterns (DAMPs). However, its physiological role in regulating inflammation is not fully understood. We herein showed that Mlkl-/- mice were highl...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2019.05.034
更新日期:2019-09-10 00:00:00
abstract::cIAP-1, an apoptosis inhibiting protein, has been suggested to play important roles in the development of cervical and esophageal squamous cell carcinomas (SCCs). In order to clarify the subcellular localization of cIAP-1 and to investigate its clinicopathological significance in head and neck SCCs (HNSCCs), we examin...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2004.11.049
更新日期:2005-06-16 00:00:00
abstract::Highly invasive and rapidly fatal, small-cell lung cancer (SCLC) has been an insurmountable gulf since discovery. Innate immunity plays a vital role in anti-tumor response, among which macrophages contribute to an indispensable character. Here, we found that macrophage infiltration in SCLC reduced significantly in a s...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2020.11.034
更新日期:2021-02-28 00:00:00
abstract::Chronic elevated free fatty (FFA) levels are linked to metabolic disorders and tumorigenesis. However, the molecular mechanism by which FFAs induce cancer remains poorly understood. Here, we show that the tumor suppressor PTEN protein levels were decreased in high fat diet (HFD) fed mice. As palmitic acid (PA, C16:0) ...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2020.10.007
更新日期:2021-01-01 00:00:00
abstract::Inclusion of 10% ethanol with 6.8 ppm N-nitrosodiethylamine in the drinking water of strain A male mice resulted in a 4-fold enhancement of multiplicity of lung tumors and a 16-fold increase in incidence of fore-stomach tumors, compared with carcinogen alone. Given with 40 ppm N-nitrosopyrrolidine, ethanol caused a 5....
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(93)90220-4
更新日期:1993-01-15 00:00:00
abstract::Both PTEN (encoding phosphate and tensin homologue) and p53 are known as cancer suppressor genes, and they are assumed that their gene mutations and loss of heterozygosity (LOH) occur frequently in various types of carcinoma. In the present study, we investigated both the p53 mutation and LOH of PTEN in 113 gastric ca...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2004.12.006
更新日期:2005-09-08 00:00:00
abstract::Anthocyanins belong to the flavonoid family and are ubiquitous in plants, especially in flower petals and fruit peels. We established that anthocyanins isolated from fruits of Aronia melanocarpa markedly inhibited the mutagenic activity of benzo(a)pyrene and 2-amino fluorene in the Ames test. In the Sister Chromatid E...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/s0304-3835(97)00248-6
更新日期:1997-10-28 00:00:00
abstract::Internal tandem duplication (ITD) of the juxtamembrane region of FMS-like tyrosine kinase-3 (FLT3) receptor is a common type of mutation in adult acute myeloid leukemia (AML), and patient response to FLT3 inhibitors appears to be transient due to the emergence of drug resistance. We established two sorafenib-resistant...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2016.04.040
更新日期:2016-07-28 00:00:00
abstract::The ability to induce changes in cell membrane properties is nowadays considered an additional mechanism to explain the pharmacological effects of non-steroidal anti-inflammatory drugs (NSAIDs). We previously demonstrated that the NSAID Licofelone, a dual cyclooxygenase/5-lipoxygenase inhibitor, triggers apoptosis in ...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2012.02.003
更新日期:2012-08-28 00:00:00
abstract::Epigenetic disruption of tumor suppressor genes (TSGs), particularly DNA methylation, plays a key role in hepatocellular carcinoma (HCC) pathogenesis. Through methylome study, we identified BCLB as a methylated gene in HCC. BCLB was methylated in all tumor cell lines with silenced or reduced expression. BCLB was furth...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2017.02.030
更新日期:2017-06-01 00:00:00
abstract::The limitations of current chemotherapies have motivated research in developing new treatments. Growing evidence shows that interaction between tumors and their microenvironment, but not tumor cells per se, is the key factor in tumor progression and therefore of obvious scientific interest and therapeutic value. Exoso...
journal_title:Cancer letters
pub_type: 杂志文章,评审
doi:10.1016/j.canlet.2015.07.014
更新日期:2015-10-10 00:00:00
abstract::Serum beta-glucuronidase activity is shown to differ quantitatively in the following strains of mice, listed in order of increasing activity: C3H, C57BL/6 less than BALB/c, DBA/2, ICR less than SENCAR, A/He. The level of the enzyme in the murine strains is shown to correlate with the urinary excretion of 17-ketosteroi...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(86)90098-4
更新日期:1986-10-01 00:00:00
abstract::The phthalocyanines are a new class of photosensitizers with promising properties for use in photodynamic therapy of cancer [E. Ben-Hur and I. Rosenthal (1985) Int. J. Radiat. Biol., 47, 145--147]. The ability of aluminum phthalocyanine tetrasulfonate (AlPCS) to cause membrane damage upon light exposure was tested usi...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(86)90057-1
更新日期:1986-03-01 00:00:00
abstract::The plant species Ephedra is commonly used in both folk medicine and for the preparation of health teas. Nitrosation of a tea made from Ephedra altissima yielded N-nitrosoephedrine (NEP), N-nitrosopseudoephedrine (NPEP), N-nitrosoproline (NPRO), N-nitrosomethylbenzylamine (NMBA), trace quantities of 2 unidentified non...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(87)90045-0
更新日期:1987-05-01 00:00:00
abstract::Various dose levels of benzo[a]pyrene (BP) were tested on short-term cultured foetal hamster lung cells for transforming effects in vitro in 6 similar experiments. The statistical evaluation of the results indicated a weak reproducibility (P = 0.09). Factors which inherently influence such reproducibility were conside...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(79)90023-5
更新日期:1979-11-01 00:00:00
abstract::The implementation of novel therapeutic interventions has improved the survival rates of melanoma patients with metastatic disease. Nonetheless, only 33% of treated cases exhibit long term responses. Circulating tumor cell (CTC) measurements are currently of clinical value in breast, prostate and colorectal cancers. H...
journal_title:Cancer letters
pub_type: 杂志文章,评审
doi:10.1016/j.canlet.2018.03.013
更新日期:2018-06-28 00:00:00
abstract::The p53 signaling pathway plays critical roles in determining the radio-sensitivity of normal tissues but is frequently inactivated in cancer. In various cancer cells, p53 has different effects on radio-sensitivity through complex mechanisms. Acetylation of p53 is an important means of post-translational modifications...
journal_title:Cancer letters
pub_type: 杂志文章,评审
doi:10.1016/j.canlet.2015.04.015
更新日期:2015-07-28 00:00:00
abstract::The mouse monoclonal anti-BAL antibody induced apoptosis in a pre-B acute lymphocytic leukemia cell line within 2 days of incubation, after being crosslinked by a secondary antibody. The antibody specifically recognized a 37 kDa membrane protein that was expressed on a wide spectrum of normal and malignant cells, but ...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(93)90194-e
更新日期:1993-12-10 00:00:00
abstract::Oral treatment with reduced glutathione for 10 weeks has no effect on the development of tumours from aflatoxin B1-induced gamma-glutamyl transpeptidase-positive pre-neoplastic focal lesions. ...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(83)90086-1
更新日期:1983-11-01 00:00:00