Abstract:
:Serum beta-glucuronidase activity is shown to differ quantitatively in the following strains of mice, listed in order of increasing activity: C3H, C57BL/6 less than BALB/c, DBA/2, ICR less than SENCAR, A/He. The level of the enzyme in the murine strains is shown to correlate with the urinary excretion of 17-ketosteroids, which in turn reflects the endogenous level of androgens. Dietary calcium D-glucarate, an in vivo beta-glucuronidase inhibitor, reduced the steady state level of both beta-glucuronidase and 17-ketosteroid excretion in the highly susceptible A/He and SENCAR strains to that of strains known to be resistant to chemical carcinogenesis. Sensitivity of the A/He strain is significantly reduced by dietary calcium glucarate, which is shown to inhibit DNA binding and the induction of pulmonary adenomas by benzo[a]pyrene.
journal_name
Cancer Lettjournal_title
Cancer lettersauthors
Walaszek Z,Hanausek-Walaszek M,Webb TEdoi
10.1016/0304-3835(86)90098-4subject
Has Abstractpub_date
1986-10-01 00:00:00pages
25-32issue
1eissn
0304-3835issn
1872-7980pii
0304-3835(86)90098-4journal_volume
33pub_type
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