Mutation of Y925F in focal adhesion kinase (FAK) suppresses melanoma cell proliferation and metastasis.

abstract：:Patients with Her2-positive breast cancer exhibit de novo resistance or develop acquired resistance in less than one year after Her2 targeting treatment, but the mechanism is not fully elucidated. Compensatory pathways such as the IGF-1R/IRS-1 pathway, are activated, leading to aberrant enhanced PI3K/Akt/mTOR pathway ...

journal_title：Cancer letters

authors： Qiu N,He YF,Zhang SM,Zhan YT,Han GD,Jiang M,He WX,Zhou J,Liang HL,Ao X,Xia HM,Li J,Yang YY,He ZM,Zou ZZ,Li HS

更新日期：2019-11-01 00:00:00

abstract：:This review centers on recent findings with respect to modulating cancer multidrug resistance (MDR) with the well-known antidepressant fluoxetine (prozac). The MDR phenomena and mechanisms are discussed, including the roles of ABC transporters as MDR-pumps and the potential involvement of cancer stem cells. The three ...

journal_title：Cancer letters

authors： Peer D,Margalit R

更新日期：2006-06-18 00:00:00

abstract：:d-Alpha tocopheryl succinate (vitamin E succinate), which inhibited growth and survival, and induced differentiation in murine B-16 melanoma cells in culture, increased adenosine 3',5'cyclic monophosphate-(cAMP)-dependent protein kinase (PK) activity without increasing the cellular cAMP level. Prostaglandin (PG)A2, wh...

journal_title：Cancer letters

authors： Torelli S,Masoudi F,Prasad KN

更新日期：1988-03-01 00:00:00

abstract：:Experimental data were provided to demonstrate the inhibitory effects of retinoids (retinal, retinoic acid, retinyl acetate and retinyl palmitate) and carotenoids (beta-carotene, lycopene and crocetin) on the growth and development of the C-6 glioma cells inoculated in rats. In the pretreatment experiments, most of th...

journal_title：Cancer letters

authors： Wang CJ,Chou MY,Lin JK

更新日期：1989-11-30 00:00:00

abstract：:Thiourea (TU) fails to enhance the incidence of foci deficient in adenosine-5'-triphosphatase (ATPase) either by initiation or by promotion in a rat liver foci bioassay. To weanling female Sprague-Dawley rats, 3 x 200 or 3 x 500 mg/kg body wt of TU, respectively, were applied for initiation. One week later Clophen A 5...

journal_title：Cancer letters

authors： Oesterle D,Deml E

更新日期：1988-08-30 00:00:00

abstract：:Several classes of plant polyphenols namely, flavonoids, chalcones and coumarins exhibited varying degrees of inhibition on the cell proliferation of human colon adenocarcinoma cell line 220.1. At the highest concentration tested (100 microM), many of the chalcones showed > 100% growth inhibition and their order of po...

journal_title：Cancer letters

authors： Yit CC,Das NP

更新日期：1994-07-15 00:00:00

abstract：:Obesity is one of the major modifiable risk factors in breast cancer, with obese adipose tissue showing a pathological role in breast cancer development and malignancy via the release of secretory factors, such as proinflammatory cytokines and adipocytokines. The current article focuses on visfatin and resistin, two s...

journal_title：Cancer letters

authors： Wang YY,Hung AC,Lo S,Yuan SF

更新日期：2021-02-01 00:00:00

abstract：:Circular RNAs (circRNAs) are a class of non-coding RNAs that do not have 5' end caps or 3' end poly (A) tails. There are more than one hundred thousand genes that encode circRNAs. Clinical data show that there are differences in the expression of circRNAs in a variety of diseases, including cancer, suggesting that cir...

journal_title：Cancer letters

authors： Zhou R,Wu Y,Wang W,Su W,Liu Y,Wang Y,Fan C,Li X,Li G,Li Y,Xiong W,Zeng Z

更新日期：2018-07-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is one of the most common cancers worldwide, which ranks as the sixth of cancer-related death. Despite the emergence of targeted therapy, advanced-stage HCC remains largely incurable due to low response rate and therapeutic resistance. In this review, we mainly focused on the current pro...

journal_title：Cancer letters

authors： Chen S,Cao Q,Wen W,Wang H

更新日期：2019-09-28 00:00:00

abstract：:The modifying effects of nonylphenol and genistein on cancer induction were assessed in a multi-organ carcinogenesis model in male F344 rats initially treated with five different carcinogens. In experiment 1 rats received 250 or 25 ppm nonylphenol, or 250 or 25 ppm genistein in their diet for 28 weeks. The total incid...

journal_title：Cancer letters

authors： Seike N,Wanibuchi H,Morimura K,Wei M,Nishikawa T,Hirata K,Yoshikawa J,Fukushima S

更新日期：2003-03-20 00:00:00

abstract：:Ultrasound (US) has been shown to induce apoptosis and cell lysis in cancer cells. In this study, we report on the potential of using Sonazoid, a new echo-contrast agent, that is chemically more stable and US-resistant in combination with US in cancer therapy. The biological effects and their mechanisms in the presenc...

journal_title：Cancer letters

authors： Furusawa Y,Zhao QL,Hassan MA,Tabuchi Y,Takasaki I,Wada S,Kondo T

更新日期：2010-02-01 00:00:00

abstract：:Microsomes isolated from hyperplastic liver nodules and hepatomas, induced by DL-ethionine, exhibited a reduced cytochrome P-450 content and aminopyrine N-demethylase activity when compared to the organelles of control and surrounding non-nodular liver. Phenobarbital administration to rats caused an increase of micros...

journal_title：Cancer letters

authors： Feo F,Canuto RA,Garcea R,Brossa O,Caselli GC

更新日期：1978-07-01 00:00:00

abstract：:In the present study a methodological approach is taken which quantitates aberrant dysplastic crypts in the unsectioned murine colon. C57BL/6J or CF1 female mice (7-8 weeks old) were injected (i.p.) with azoxymethane (5 mg/kg body wt./week) for 4 weeks. Their colons were excised, cut open on the median axis and fixed ...

journal_title：Cancer letters

authors： Bird RP

更新日期：1987-10-30 00:00:00

abstract：:Inadequate immunity that occurs in a tumor environment is in part due to the presence of M2-type tumor-associated macrophages (TAMs). TGF-β has a multi-functional role in tumor development including modulating the biological activity of both the tumor and TAMs. In this study, using an in vitro TAM/tumor cell co-cultur...

journal_title：Cancer letters

authors： Peng J,Tsang JY,Li D,Niu N,Ho DH,Lau KF,Lui VC,Lamb JR,Chen Y,Tam PK

更新日期：2013-05-01 00:00:00

abstract：:BEC, a standard mixture of solasodine glycosides is effective in vivo against murine sarcoma 180 (S180), whereas the aglycone solasodine at equimolar concentrations is ineffective. The efficacy of BEC against S180 in vivo can be inhibited by rhamnose. Mice which are in their terminal stage with S180 can tolerate and b...

journal_title：Cancer letters

authors： Cham BE,Daunter B

更新日期：1990-12-17 00:00:00

abstract：:Curcumin, a major component of the Curcuma species, is known to have antioxidant, anti-inflammatory properties and induce apoptosis of cancer cells, however, the precise molecular mechanisms of apoptosis in vitro are unclear. In this study, we showed that curcumin, a plant product containing the phenolic phytochemical...

journal_title：Cancer letters

authors： Lin SS,Huang HP,Yang JS,Wu JY,Hsia TC,Lin CC,Lin CW,Kuo CL,Gibson Wood W,Chung JG

更新日期：2008-12-08 00:00:00

abstract：:A direct relationship exists between aging and increasing incidences of chronic diseases. In fact, with most age-associated diseases individuals manifest an underlying chronic inflammatory state as evidenced by local infiltration of inflammatory cells, such as macrophages, and higher circulatory levels of pro-inflamma...

journal_title：Cancer letters

authors： Sarkar D,Fisher PB

更新日期：2006-05-08 00:00:00

abstract：:Although docetaxel significantly improves survival in a variety of malignancies, its clinical utility is severely restricted by acquired chemoresistance and disease relapse. To uncover the mechanisms underlying these all too common occurrences, an abundance of research has focused on mutations and gene expression patt...

journal_title：Cancer letters

authors： Ogden A,Rida PC,Knudsen BS,Kucuk O,Aneja R

更新日期：2015-10-28 00:00:00

abstract：:The mutagenic effects of chamuvaritin, dihydrobenzylchalcone isolated from Uvaria chamae, were investigated using Salmonella typhimurium tester strains TA92, TA94--98, TA100--1535, TA1537 and TA1538. The phytochemical was mutagenic in tester strains TA98 and TA100 and required activation by the hepatic S-9 microsomal ...

journal_title：Cancer letters

authors： Uwaifo AO,Okorie DA,Bababunmi EA

更新日期：1979-11-01 00:00:00

abstract：:Hepatocellular Carcinoma (HCC) in high-incidence areas (sub-Saharan Africa, South-Eastern Asia) often contains a somatic mutation at codon 249 in TP53 (R249S). This mutation is rare in low-incidence areas of Europe and the United States. There is evidence that R249S occurs as the result of mutagenesis by aflatoxin in ...

journal_title：Cancer letters

authors： Gouas D,Shi H,Hainaut P

更新日期：2009-12-01 00:00:00

abstract：:Lumican is a small leucine-rich proteoglycan (SLRP) of the extracellular matrix (ECM) with anti-tumor activity. We recently demonstrated that lumican inhibits the migration of melanoma cells and identified beta1 integrin as mediator of this effect [M.F. D'Onofrio, S. Brézillon, T. Baranek, C. Perreau, P.J. Roughley, F...

journal_title：Cancer letters

authors： Brézillon S,Radwanska A,Zeltz C,Malkowski A,Ploton D,Bobichon H,Perreau C,Malicka-Blaszkiewicz M,Maquart FX,Wegrowski Y

更新日期：2009-09-28 00:00:00

abstract：:The effect of Pseudomonas aeruginosa colonizing in the gut on the development of gastrointestinal tumors was studied in rats treated orally with N-methyl-N'-nitro-N-nitrosoguanidine (MNNG). The animals were inoculated with or accidentally colonized by P. aeruginosa after MNNG treatment. In 3 serial experiments, P. aer...

journal_title：Cancer letters

authors： Morishita Y,Shimizu T

更新日期：1983-01-01 00:00:00

abstract：:Fibronectin concentration was determined in plasma from 97 patients with benign or malignant breast disease and from 62 controls. Median plasma fibronectin concentration (microgram FN/ml plasma) appeared to be significantly higher in patients with non-metastatic or metastatic breast cancer as compared to age-matched c...

journal_title：Cancer letters

authors： Boccardo F,Guarneri D,Zanardi S,Castellani P,Borsi L,Zardi L

更新日期：1986-12-01 00:00:00

abstract：:Patients with hormone-receptor-positive early breast cancer have a significant risk of recurrence despite the use of adjuvant tamoxifen. The third-generation aromatase inhibitors letrozole, anastrozole, and exemestane offer promise as alternative or additional therapy to tamoxifen. As extended adjuvant therapy followi...

journal_title：Cancer letters

authors： Spicer J,Ellis P

更新日期：2007-04-18 00:00:00

abstract：:We used selective biochemical markers of effect to evaluate some non-genotoxic cocarcinogenic properties of methyl thiophanate (MTH) associated with cytochrome P450 (CYP) changes. Several CYP-dependent reactions were monitored in the liver, kidney and lung microsomes of male and female Sprague-Dawley rats treated (i.p...

journal_title：Cancer letters

authors： Paolini M,Pozzetti L,Perocco P,Mazzullo M,Cantelli-Forti G

更新日期：1999-01-29 00:00:00

abstract：:Sorafenib has been used as a clinical targeted therapy for hepatocellular carcinoma (HCC) for more than a decade. In 2017, regorafenib was approved for HCC treatment and has since been reported to prolong the survival of advanced HCC patients after treatment failure with sorafenib. However, there has been no direct sy...

journal_title：Cancer letters

authors： Liu S,Du Y,Ma H,Liang Q,Zhu X,Tian J

更新日期：2019-07-01 00:00:00

abstract：:We studied the effect of staurosporine (SSP), a broad-spectrum protein kinase inhibitor, on the levels of protein kinase C (PKC) activity and proliferation in two murine neuroblastoma cell lines, Neuro2a and its clone NB41A3. The PKC activity was examined in whole cell lysate, cytosolic and particulate fractions. A di...

journal_title：Cancer letters

authors： Mohan DR,Nagarathna R,Krishna M,Jagtap JC,Shastry P

更新日期：1999-05-24 00:00:00

abstract：:Exposure of HeLa cells to 0, 5, 10, 25, 50 and 100 microg/ml of guduchi extracts (methanol, aqueous and methylene chloride) resulted in a dose-dependent but significant increase in cell killing, when compared to non-drug-treated controls. The effects of methanol and aqueous extracts were almost identical. However, met...

journal_title：Cancer letters

authors： Jagetia GC,Nayak V,Vidyasagar MS

更新日期：1998-05-15 00:00:00

abstract：:Immunometabolism, which has important implications in cancer biology, has emerged as a major regulator of different immune cell types. Various factors that integrate metabolic switches within immune cells with signal directed program that promote or inhibit their functions remain largely unidentified. Furthermore, sex...

journal_title：Cancer letters

authors： Zi Xu YX,Ande SR,Mishra S

更新日期：2018-02-28 00:00:00

abstract：:Thrombospondin-1 is one of most important natural angiogenic inhibitors. The three thrombospondin-1 type 1 repeats (3TSR), an anti-angiogenic domain of thrombospondin-1, is a promising novel agent for anti-angiogenic treatment. In the present study, we showed 3TSR was biologically stable at least for 7 days in mini-os...

journal_title：Cancer letters

authors： Zhang X,Connolly C,Duquette M,Lawler J,Parangi S

更新日期：2007-03-08 00:00:00