Abstract:
:Experimental data were provided to demonstrate the inhibitory effects of retinoids (retinal, retinoic acid, retinyl acetate and retinyl palmitate) and carotenoids (beta-carotene, lycopene and crocetin) on the growth and development of the C-6 glioma cells inoculated in rats. In the pretreatment experiments, most of these compounds could prolong the latency period of T50 (time for 50% tumor incidence). At week 7, the growth inhibition was 57-67% (P less than 0.02) with carotenoids and 40-55% (P less than 0.05) with retinoids. In the post-treatment experiments, the growth inhibition was 30-55% (P less than 0.05) with carotenoids and 21-42% (P less than 0.05) with retinoids. No significant hepatotoxic effect was observed in all treated groups as indicated by the constant levels of serum enzymes (e.g. aspartate amino-transferase, alanine amino-transferase and alkaline phosphatase) and bilirubin. The mechanisms of tumor inhibition through the enhancement of anti-tumor immunity by both carotenoids and retinoids were discussed.
journal_name
Cancer Lettjournal_title
Cancer lettersauthors
Wang CJ,Chou MY,Lin JKdoi
10.1016/0304-3835(89)90050-5subject
Has Abstractpub_date
1989-11-30 00:00:00pages
135-42issue
2eissn
0304-3835issn
1872-7980pii
0304-3835(89)90050-5journal_volume
48pub_type
杂志文章相关文献
CANCER LETTERS文献大全abstract::Benign mammary gross cystic disease is the most common breast lesion; women with apocrine changes of epithelium lining the cysts are at higher risk for developing breast cancer than the normal population. Total cholesterol, high- and low-density lipoproteins fractions, triglycerides and phospholipids, lipase activity ...
journal_title:Cancer letters
pub_type: 杂志文章
doi:
更新日期:1996-01-02 00:00:00
abstract::The heat shock protein 40kDa (HSP40/DNAJ) co-chaperones constitute the largest and most diverse sub-group of the heat shock protein (HSP) family. DNAJ are widely accepted as regulators of HSP70 function, but also have roles as co-chaperones for the HSP90 chaperone machine, and a growing number of biological functions ...
journal_title:Cancer letters
pub_type: 杂志文章,评审
doi:10.1016/j.canlet.2011.08.019
更新日期:2011-12-22 00:00:00
abstract::Epigenetic silencing of HOPX has been shown to be frequent and specific in human cancers. HOPX is thought as a tumor suppressor gene and its promoter methylation is the main mechanism of down-regulation. In non-hereditary breast cancer, since roles of epigenetic modifications are more critical than in other cancers, t...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2016.10.017
更新日期:2017-01-01 00:00:00
abstract::Treatment resistance in acute lymphoblastic leukemia (ALL) is often caused by defects in programmed cell death, e.g. by overexpression of Inhibitor of Apoptosis (IAP) proteins. Here, we report that small-molecule Smac mimetics (i.e. BV6, LCL161, birinapant) that neutralize x-linked IAP (XIAP), cellular IAP (cIAP)1 and...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2016.02.040
更新日期:2016-05-28 00:00:00
abstract::Recent work has demonstrated that oncogenes and tumor suppressor proteins regulate apoptotic cell death. Current efforts are therefore directed at determining how they exert their effects. It appears that oncogenes can control activation of the apoptosis endonuclease(s) either by regulating the signal(s) that trigger ...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(95)03835-k
更新日期:1995-07-20 00:00:00
abstract::In a development trial for an initiation bioassay system, cell proliferation kinetics after partial hepatectomy (PH) or CCl4 administration (1 ml/kg b.w., i.g.) and the effect of administration time after PH or CCl4 treatment on liver cell foci induction by the direct and indirect non-hepatocarcinogens, N-methyl-N'-ni...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/s0304-3835(97)00222-x
更新日期:1997-09-16 00:00:00
abstract::Medulloblastoma (MB) is the most frequent malignant brain tumour in children with a poor outcome. Divided into four molecular subgroups, MB of the Sonic hedgehog (SHH) subgroup accounts for approximately 25% of the cases and is driven by mutations within components of the SHH pathway, such as its receptors PTCH1 or SM...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2020.02.028
更新日期:2020-05-01 00:00:00
abstract::Human papillomavirus (HPV) infection is one of the most common sexually transmitted infections (STIs) in young women. They can occur in one or multiple areas of the female genitalia. Usually, the vulva is the initial site of implantation for HPV. The purpose of our study is to evaluate the epidemiological aspects, inc...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/s0304-3835(03)00218-0
更新日期:2003-07-10 00:00:00
abstract::Semi-permeable magnetic microcapsules containing polyethyleneimine (PEI) have been developed as retrievable carcinogen traps. In vitro, the soluble core PEI and membrane both bound reactive substances of limited aqueous stability, such as from [14C]N-methyl-N-nitrosourea ([14C]NMU), and aqueous stable dyes of molecula...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(87)90101-7
更新日期:1987-07-01 00:00:00
abstract::To better understand causative relations of smoking to lung adenocarcinomas, the frequency of loss of heterozygosity (LOH) of all autosomal chromosomes was compared among the three grades of histological differentiation with 119 pulmonary adenocarcinomas (AC) and 41 squamous cell carcinomas (SCC), using Southern blott...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/s0304-3835(02)00383-x
更新日期:2002-12-10 00:00:00
abstract::Gene methylation is an important molecular event in prostate carcinogenesis that may have diagnostic and prognostic significance. We evaluated the methylation status of eight genes implicated in prostate carcinogenesis. DNA was extracted from archived paraffin-embedded tumor blocks from 90 prostate cancer patients. Ge...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2003.11.027
更新日期:2004-03-18 00:00:00
abstract::High doses of folate and its quinazoline analogue with antitumour activity, N10-propargyl-5,8-dideazafolic acid (CB 3717), caused severe renal damage in mice, leading in the case of folate to death. The mouse kidneys increased in weight, which was accompanied by time- and dose-dependent induction of ornithine decarbox...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(91)90147-a
更新日期:1991-09-01 00:00:00
abstract::Retinoic acid alone has no effect on the human breast cancer cell line BT-20 but can amplify the antiproliferative action of interferon-gamma (IFN-gamma). In our system ornithine decarboxylase (ODC) activity correlates well with growth rate; it was investigated whether the antiproliferative effects of IFN-gamma and IF...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(89)90108-0
更新日期:1989-01-01 00:00:00
abstract::Chronic exposure to cadmium is known to be a risk factor for human prostate cancer. Despite over-whelming evidence of cadmium causing carcinogenicity in humans, the specific underlying molecular mechanisms that govern metal-induced cellular transformation remain unclear. Acute exposure (up to 72 h) to cadmium induces ...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2017.08.023
更新日期:2017-11-01 00:00:00
abstract::We have developed a simple system for rapid detection and measurement of glutathione S-transferase placental form (GSTP1) that detoxify polycyclic aromatic hydrocarbons using the cultured rat normal liver epithelial cell line, (RL34) cells. Survey of fruit extracts for GST inducing ability identified both papaya and a...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/s0304-3835(00)00487-0
更新日期:2000-09-01 00:00:00
abstract::A six-month bioassay in A/J mice was conducted to test the hypothesis that chronically inhaled mainstream cigarette smoke would either induce lung cancer or promote lung carcinogenicity induced by the tobacco-specific nitrosamine, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK). Groups of 20 female A/J mice were ...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(95)04059-5
更新日期:1996-02-06 00:00:00
abstract::The aim of the present study was to estimate the expression of mRNA, specific for thymidine kinase 1 (TK1), deoxycytidine kinase (dCK), and thymidine phosphorylase (dThdPase), i.e. enzymes involved in pyrimidine and purine metabolism in human papillary thyroid carcinoma (PTC) tissue. Additionally, the expression of dC...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2004.10.044
更新日期:2005-07-28 00:00:00
abstract::The South American opossum, Monodelphis domestica, has been used as a model system to study ultraviolet (UV)-induced genetic alterations that lead to the development of melanoma. Suckling young of Monodelphis exposed to multiple doses of UVB radiation can develop benign or malignant melanomas later as adults. Point mu...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/s0304-3835(01)00783-2
更新日期:2002-10-08 00:00:00
abstract::Doxorubicin (dox) is an anthracycline antibiotic which is broadly used in solid tumors. Long-term therapy with this drug is accompanied by potentially lethal, dose-dependent side effects. Several reports suggest that oxygen free radicals produced during the metabolic activation of dox may have toxic effects on heart m...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(95)04021-8
更新日期:1996-01-19 00:00:00
abstract::Oxidative stress is implicated in the etiology of cancer, hence compounds that alleviate oxidative stress by inducing enzymes that defend against free radical damage might be useful as cancer chemopreventives. Glutathione S-transferase (GST) has been suggested to be a candidate for a critical enzyme in protecting cell...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/s0304-3835(00)00368-2
更新日期:2000-08-11 00:00:00
abstract::Telomeres constitute the ends of the linear eukaryotic chromosomes and are essential for the maintenance of chromosome stability and genome integrity. One of the consequences of an altered telomere structure is the formation of telomeric fusions (TFs), that is aberrant chromosomes in which two elements are fused at th...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2003.08.028
更新日期:2004-01-08 00:00:00
abstract::Rafoxanide is used in veterinary medicine for the treatment of fascioliasis. We previously repositioned the drug as the inhibitor of B-Raf V600E, but its anti-tumor effect in human cancer has never been reported. In this study, we investigated the effects of rafoxanide in multiple myeloma (MM) in vitro and in vivo. We...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2018.12.014
更新日期:2019-03-01 00:00:00
abstract::Spontaneous testicular teratomas which develop at a high rate in 129/Sv-Sl/+ mice are thought to be derived from germ cells. The teratomas present initially as groups of atypical germ-like cells within seminiferous cords of the 15.5 days post coitum (dpc) embryonic testes. These pluripotent teratoma stem cells are cap...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(95)04068-4
更新日期:1996-02-27 00:00:00
abstract::Two hepatoma cell lines were incubated for 72 h with ATRA and its analog 13cisRA and according to MTT assay, Hep3B cells were highly susceptible whereas HepG2 cells were more resistant to the treatment. At the high concentration of 166 microM, retinoids were able to induce apoptosis in both cell lines and the highest ...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2005.06.047
更新日期:2005-11-18 00:00:00
abstract::Monitoring angiogenesis is potentially an effective strategy for the early detection of cancer. In this study, early detection was achieved by evaluating blood vessel density in the liver using a three-dimensional contrast-enhanced high-frequency ultrasound (CE-HFUS) system and Sonazoid microbubbles. Three-dimensional...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2013.06.006
更新日期:2013-10-10 00:00:00
abstract::MDM2 is a phosphoprotein that interacts with P53 and inhibits its activity. Recently, a T/G substitution (SNP309) in the promoter of MDM2 was identified and has been demonstrated to be associated with an increased MDM2 expression and a significantly earlier age of onset of several tumors, including breast cancer. To t...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2005.09.019
更新日期:2006-08-28 00:00:00
abstract::Exosomes are 30-100 nm small membrane vesicles of endocytic origin that are secreted by all types of cells, and can also be found in various body fluids. Increasing evidence implicates that exosomes confer stability and can deliver their cargos such as proteins and nucleic acids to specific cell types, which subsequen...
journal_title:Cancer letters
pub_type: 杂志文章,评审
doi:10.1016/j.canlet.2017.08.003
更新日期:2017-10-28 00:00:00
abstract::EGFR polymorphisms have not been thoroughly evaluated for association with head and neck squamous cell carcinoma (HNSCC) risk. We genotyped 578 HNSCC patients and 588 cancer-free controls for 60 EGFR single nucleotide polymorphisms (SNPs) and tested associations with HNSCC risk. EGFR intronic SNPs rs12535536, rs207511...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2014.12.008
更新日期:2015-02-28 00:00:00
abstract::Highly active antiretroviral therapy (HAART) changed the natural history of pediatric HIV infection. This review focuses on trends of HIV-associated cancers in childhood in the HAART era and analyses potential pathogenetic mechanisms. HAART reduced AIDS-defined-malignancies (ADM), but incidence of several non-ADM is i...
journal_title:Cancer letters
pub_type: 杂志文章,评审
doi:10.1016/j.canlet.2014.02.002
更新日期:2014-05-28 00:00:00
abstract::The mutagenic effects of chamuvaritin, dihydrobenzylchalcone isolated from Uvaria chamae, were investigated using Salmonella typhimurium tester strains TA92, TA94--98, TA100--1535, TA1537 and TA1538. The phytochemical was mutagenic in tester strains TA98 and TA100 and required activation by the hepatic S-9 microsomal ...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(79)90027-2
更新日期:1979-11-01 00:00:00