Abstract：
:Retinoic acid alone has no effect on the human breast cancer cell line BT-20 but can amplify the antiproliferative action of interferon-gamma (IFN-gamma). In our system ornithine decarboxylase (ODC) activity correlates well with growth rate; it was investigated whether the antiproliferative effects of IFN-gamma and IFN-gamma plus retinoic acid could be attributed to suppression of ODC activity. The ODC inhibitor difluoromethylornithine (DFMO), which is active as a single agent did not enhance growth inhibition induced by the biological response modifiers. The substitution of the BT-20 cells with putrescine, the product of the enzymatic reaction mediated by ODC, reversed DFMO induced antiproliferative action. On the other hand putrescine did not affect the proliferation of BT-20 cells treated with interferon alone or in combination with retinoic acid.
journal_name
Cancer Lettjournal_title
Cancer lettersauthors
Marth C,Kirchebner P,Daxenbichler Gdoi
10.1016/0304-3835(89)90108-0subject
Has Abstractpub_date
1989-01-01 00:00:00pages
55-9issue
1eissn
0304-3835issn
1872-7980pii
0304-3835(89)90108-0journal_volume
44pub_type
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