Abstract:
:Treatment of mouse lymphoma L5178Y cells with spermine in Fischer's medium containing bovine serum lead to formation of chromatid aberrations. The cause of this effect seems to be that bovine serum contains spermine oxidase which catalyzes oxidation of spermine to unstable aldehyde derivatives (oxidized spermine) and hydrogen peroxide. Fraction of chromatid aberrations induced by oxidized spermine was estimated in experiments in which the cells were treated with spermine or a stoichiometric amount of hydrogen peroxide in the presence and in the absence of catalase. Cytotoxicity of oxidized spermine was evaluated by clonogenic assay.
journal_name
Cancer Lettjournal_title
Cancer lettersauthors
Bouzyk E,Rosiek Odoi
10.1016/0304-3835(88)90044-4subject
Has Abstractpub_date
1988-02-01 00:00:00pages
93-9issue
1eissn
0304-3835issn
1872-7980pii
0304-3835(88)90044-4journal_volume
39pub_type
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