当前位置： SCI文献检索 > CANCER LETTERS期刊下所有文献 > Translational control: a target for cancer therapy.

Translational control: a target for cancer therapy.

Abstract：

:Cap-mediated translation is the default mechanism for the synthesis of proteins in eukaryotic cells. Increasingly, malignant cells have been found to have deregulation of this process. Return of normal translational control is associated with loss of tumorigenic potential in pre-clinical models. Currently, a variety of novel therapeutics are in development targeting this mechanism as a treatment for cancer.

journal_name

Cancer Lett

journal_title

Cancer letters

authors

Thumma SC,Kratzke RA

doi

10.1016/j.canlet.2007.08.022

subject

Has Abstract

pub_date

2007-12-08 00:00:00

pages

1-8

issue

1

eissn

0304-3835

issn

1872-7980

pii

S0304-3835(07)00408-9

journal_volume

258

pub_type

杂志文章,评审

相关文献

CANCER LETTERS文献大全
  • Metformin inhibits castration-induced EMT in prostate cancer by repressing COX2/PGE2/STAT3 axis.

    abstract：:Castration is the standard therapeutic treatment for advanced prostate cancer but with limited benefit due to the profound relapse and metastasis. Activation of inflammatory signaling pathway and initiation of epithelial-mesenchymal transition (EMT) are closely related to drug resistance, tumor relapseas well as metas...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/j.canlet.2016.12.031

    authors： Tong D,Liu Q,Liu G,Xu J,Lan W,Jiang Y,Xiao H,Zhang D,Jiang J

    更新日期：2017-03-28 00:00:00

  • Qualitative and quantitative separation of a series of phorbol-ester tumor promoters by high-pressure liquid chromatography.

    abstract：:A high-pressure liquid chromatographic (HPLC) method using a micro-particulate silica column and gradient elution was developed that separated 12-O-tetradecanoylphorbol-13-acetate (TPA) from 20-oxo-TPA; 12-O-tetradecanoylphorbol (TP); 13-O-acetylphorbol (PA), and from the diterpene alcohol, phorbol (P). A series of ot...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/s0304-3835(77)94943-6

    authors： Berry DL,Lieber MR,Fischer SM,Slaga TJ

    更新日期：1977-09-01 00:00:00

  • Genetic and epigenetic analysis of the TIMP-3 gene in ovarian cancer.

    abstract：:Chromosome 22q shows a high frequency of loss of heterozygosity (LOH) in ovarian cancers suggesting the existence of one or more important tumor suppressor genes (TSGs). The tissue inhibitor of metalloproteinase-3 (TIMP-3) is a plausible TSG candidate since it is often encompassed within these regions of LOH. TIMP-3 h...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/j.canlet.2006.03.024

    authors： Liu MC,Choong DY,Hooi CS,Williams LH,Campbell IG

    更新日期：2007-03-08 00:00:00

  • The tumor suppressor CDX2 opposes pro-metastatic biomechanical modifications of colon cancer cells through organization of the actin cytoskeleton.

    abstract：:The vast majority of cancer deaths are caused by the formation of metastases rather than the primary tumor itself. Despite this clinical importance, the molecular and cellular events that support the dissemination of cancer cells are not yet fully unraveled. We have previously shown that CDX2, a homeotic transcription...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/j.canlet.2016.10.040

    authors： Platet N,Hinkel I,Richert L,Murdamoothoo D,Moufok-Sadoun A,Vanier M,Lavalle P,Gaiddon C,Vautier D,Freund JN,Gross I

    更新日期：2017-02-01 00:00:00

  • The timing of insulin/c-Ras signal is critical for its effect upon the differentiation of C3H10T1/2-derived preadipocytes.

    abstract：:The effect of the peptide hormone insulin upon the differentiation of a 10T1/2-derived preadipocytic line was found to display a potent time-dependence. Insulin addition before cell confluence strongly enhanced differentiation, while addition after confluence had no effect. In keeping with the role of c-Ras as a downs...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/s0304-3835(97)04724-1

    authors： Preston T,Brownell H,Raptis L

    更新日期：1997-05-19 00:00:00

  • MEAF6/PHF1 is a recurrent gene fusion in endometrial stromal sarcoma.

    abstract：:The chimeric transcripts described in endometrial stromal sarcomas (ESS) are JAZF1/SUZ12, YWHAE/FAM22, ZC3H7/BCOR, MBTD1/CXorf67, and recombinations of PHF1 with JAZF1, EPC1, and MEAF6. The MEAF6/PHF1 fusion had hitherto been identified in only one tumor. We present two more ESS with MEAF6/PHF1 detected by transcripto...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/j.canlet.2014.01.030

    authors： Micci F,Gorunova L,Gatius S,Matias-Guiu X,Davidson B,Heim S,Panagopoulos I

    更新日期：2014-05-28 00:00:00

  • Epstein-Barr virus-activating principle in the ether extracts of soils collected from under plants which contain active diterpene esters.

    abstract：:Soil samples were collected from the ground under the plants of Euphorbiaceae and Thymelaeaceae known to possess Epstein-Barr virus-activating diterpene esters. In a test system, the ether extracts of such soil samples at a concentration of 20 micrograms/ml induced Epstein-Barr virus early antigen in approximately 5-2...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/0304-3835(83)90144-1

    authors： Ito Y,Ohigashi H,Koshimizu K,Yi Z

    更新日期：1983-06-01 00:00:00

  • Radiomics model of magnetic resonance imaging for predicting pathological grading and lymph node metastases of extrahepatic cholangiocarcinoma.

    abstract：:The aim of this study was to evaluate diagnostic performance of radiomics models of MRI in the detection of differentiation degree (DD) and lymph node metastases (LNM) of extrahepatic cholangiocarcinoma (ECC). We retrospectively enrolled 100 patients with ECC confirmed by pathology from January 2011 to December 2018. ...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/j.canlet.2019.11.036

    authors： Yang C,Huang M,Li S,Chen J,Yang Y,Qin N,Huang D,Shu J

    更新日期：2020-02-01 00:00:00

  • Promoting effect of intestinal Pseudomonas aeruginosa on gastric tumorigenesis in rats with N-methyl-N'-nitro-N-nitrosoguanidine.

    abstract：:The effect of Pseudomonas aeruginosa colonizing in the gut on the development of gastrointestinal tumors was studied in rats treated orally with N-methyl-N'-nitro-N-nitrosoguanidine (MNNG). The animals were inoculated with or accidentally colonized by P. aeruginosa after MNNG treatment. In 3 serial experiments, P. aer...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/0304-3835(83)90174-x

    authors： Morishita Y,Shimizu T

    更新日期：1983-01-01 00:00:00

  • Hsp90 inhibition by AUY922 as an effective treatment strategy against myxoid liposarcoma.

    abstract：:Liposarcoma is one of the most common soft tissue sarcomas in adults. Recognized histological subtypes include well differentiated/dedifferentiated liposarcoma (WD/DDLS), myxoid liposarcoma (MLS) and pleomorphic liposarcoma. Currently, there are no proper subtype-specific treatments due to the genetic, histological an...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/j.canlet.2015.07.025

    authors： Steinmann S,Gali-Muhtasib H,Huebner K,Al-Halabi R,Abou Merhi R,Aman P,Agaimy A,Haller F,Schneider-Stock R

    更新日期：2015-10-28 00:00:00

  • Mutations in the VHL gene from potassium bromate-induced rat clear cell renal tumors.

    abstract：:Potassium bromate (KBrO(3)) is a rat renal carcinogen and a major drinking water disinfection by-product in water disinfected with ozone. Clear cell renal tumors, the most common form of human renal epithelial neoplasm, are rare in animals but are inducible by KBrO(3) in F344 rats. Detection of cytoplasmic periodic ac...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/s0304-3835(02)00407-x

    authors： Shiao YH,Kamata SI,Li LM,Hooth MJ,DeAngelo AB,Anderson LM,Wolf DC

    更新日期：2002-12-10 00:00:00

  • Inhibition of the skin tumorigenicity of (+/-)-7 beta,8 alpha-dihydroxy-9 alpha,10 alpha-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene by tannic acid, green tea polyphenols and quercetin in Sencar mice.

    abstract：:The effect of pretreatment of skin of Sencar mice with topically applied tannic acid, quercetin and green tea polyphenols (GTP) on the skin tumor initiating activity of (+/-)-7 beta,8 alpha-dihydroxy-9 alpha,10 alpha-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene (BPDE-2) has been evaluated. The animals were pretreated with ...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/0304-3835(88)90232-7

    authors： Khan WA,Wang ZY,Athar M,Bickers DR,Mukhtar H

    更新日期：1988-09-01 00:00:00

  • Post-initiation effects of a super critical extract of propolis in a rat two-stage carcinogenesis model in female F344 rats.

    abstract：:Post-initiation modifying effects of dietary administration of a super critical extract of propolis on major organs were examined using a two-stage carcinogenesis model. Groups of 21 or 22 F344 female rats were treated sequentially with 2,2'-dihydroxy-di-n-propylnitrosamine (DHPN, i.g.), 7,12-dimethylbenz[a]anthracene...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/s0304-3835(99)00305-5

    authors： Kimoto N,Hirose M,Kawabe M,Satoh T,Miyataka H,Shirai T

    更新日期：1999-12-01 00:00:00

  • Staurosporine inhibits the proliferation, alters the cell cycle distribution and induces apoptosis in HT-29 human colon adenocarcinoma cells.

    abstract：:Staurosporine (ST), a potent inhibitor of protein kinase C (PKC), was evaluated for its effect on the proliferation of HT-29 colon adenocarcinoma cells; PKC is associated with increased colon cell proliferation. ST inhibited cell proliferation in a time- and concentration-dependent manner by up to 90%. It also blocked...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/0304-3835(96)04346-7

    authors： Qiao L,Koutsos M,Tsai LL,Kozoni V,Guzman J,Shiff SJ,Rigas B

    更新日期：1996-10-01 00:00:00

  • Stabilization and quantitative analysis of fecapentaenes in human feces, using synthetic fecapentaene-12.

    abstract：:Naturally occurring fecal mutagens, called fecapentaenes, are hypothesized to contribute to large bowel carcinogenesis. To understand health risks it is necessary to relate fecal mutagen concentrations to intestinal pathologies, i.e. colon cancer. However, fast and reliable methods for analysis of stool for fecapentae...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/0304-3835(89)90104-3

    authors： Kleinjans JC,Pluijmen MH,Hageman GJ,Verhagen H

    更新日期：1989-01-01 00:00:00

  • Effects of tyrosinase activity on the cytotoxicity of 4-S-cysteaminylphenol and N-acetyl-4-S-cysteaminylphenol in melanoma cells.

    abstract：:The rationale for melanoma specific antitumor agents containing phenolic amines is based in part upon the ability of the enzyme tyrosinase to oxidize these prodrugs to toxic intermediates. Two phenolic amine compounds, N-acetyl-4-S-cysteaminylphenol (N-Ac-4-S-CAP) and 4-S-cysteaminylphenol (4-S-CAP), demonstrated grow...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/0304-3835(92)90092-a

    authors： Prezioso JA,Epperly MW,Wang N,Bloomer WD

    更新日期：1992-03-31 00:00:00

  • Differential nuclear matrix-intermediate filament expression in human prostate cancer in respect to benign prostatic hyperplasia.

    abstract：:We have characterized the changes in composition of the nuclear matrix-intermediate filament complex (NM-IF) isolated from prostate cancer (PCa), compared with benign prostatic hyperplasia (BPH). We prepared the NM-IF from ten patients undergoing radical retropubic prostectomy; the benign hyperplastic tissue was obtai...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/s0304-3835(96)04444-8

    authors： Alberti I,Parodi S,Barboro P,Sanna P,Nicolò G,Allera C,Patrone E,Galli S,Balbi C

    更新日期：1996-12-03 00:00:00

  • Fetal microchimerism and cancer.

    abstract：:The acquisition and persistence of fetal microchimerism, small numbers of genetically disparate cells from the fetus in the mother, is now a well-recognized consequence of normal pregnancy. Fetal microchimerism has been associated with several classical autoimmune diseases, but its role in normal health remains undefi...

    journal_title：Cancer letters

    pub_type： 杂志文章,评审

    doi：10.1016/j.canlet.2008.07.025

    authors： Gadi VK

    更新日期：2009-04-08 00:00:00

  • High-LET radiation combined with oxaliplatin induce autophagy in U-87 glioblastoma cells.

    abstract：:Modern protocols of concomitant chemo/radiotherapy provide a very effective strategy to treat certain types of tumors. High-linear energy transfer (LET) radiations, on the other hand, have an increased efficacy against cancer with low radiosensibility and critical localization. We previously reported that oxaliplatin,...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/j.canlet.2008.01.023

    authors： Benzina S,Altmeyer A,Malek F,Dufour P,Denis JM,Gueulette J,Bischoff P

    更新日期：2008-06-08 00:00:00

  • Azelaic acid as a competitive inhibitor of thioredoxin reductase in human melanoma cells.

    abstract：:Azelaic acid has been shown to inhibit thioredoxin reductase (TR) at the surface of guinea pig and human skin, on cultures of human keratinocytes, melanocytes, melanoma cells, murine melanoma cells (Cloudman S91), and on purified enzymes from Escherichia coli, rat liver, and human melanoma. Human melanoma cells are mo...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/0304-3835(87)90023-1

    authors： Schallreuter KU,Wood JM

    更新日期：1987-09-01 00:00:00

  • Antisense lncRNA FOXC2-AS1 promotes doxorubicin resistance in osteosarcoma by increasing the expression of FOXC2.

    abstract：:Recent efforts have revealed that numerous natural antisense lncRNAs play a crucial role in the regulation of cancer biology. Here, based on our previous study, we further identified that the lncRNA FOXC2-AS1 and its antisense transcript FOXC2 are positively up-regulated in doxorubicin-resistant osteosarcoma cell line...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/j.canlet.2017.03.018

    authors： Zhang CL,Zhu KP,Ma XL

    更新日期：2017-06-28 00:00:00

  • Rotenone, an anticarcinogen, inhibits cellular proliferation but not peroxisome proliferation in mouse liver.

    abstract：:In previous National Toxicology Program (NTP) studies, rotenone reduced the background incidence of hepatocellular carcinoma in male B6C3F1 mice. In the present studies, rotenone reduced the basal hepatic labeling index of male B6C3F1 mice in a dose-dependent fashion and inhibited hepatocellular proliferation, but not...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/0304-3835(95)03869-x

    authors： Cunningham ML,Soliman MS,Badr MZ,Matthews HB

    更新日期：1995-08-16 00:00:00

  • Ki-67 and CEA expression as prognostic markers in Dukes' C colorectal cancer.

    abstract：:This study investigated the relationship between clinicopathological or immunohistochemical factors and postoperative prognosis for Dukes' C colorectal cancer. Short-term survivors died from cancer within 2 years of surgery, whereas long-term survivors were disease-free for over 10 years. The groups differed in Ki-67 ...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/j.canlet.2003.10.032

    authors： Ishida H,Miwa H,Tatsuta M,Masutani S,Imamura H,Shimizu J,Ezumi K,Kato H,Kawasaki T,Furukawa H,Kawakami H

    更新日期：2004-04-15 00:00:00

  • Heat shock (hsp70) and resistance proteins in non-small cell lung carcinomas.

    abstract：:The aim of the study was to prove whether or not an association exists between the heat shock protein 70 (hsp70) and drug resistance. Tumor samples of 90 patients with previously untreated non-small lung carcinomas were investigated immunohistochemically for expression of resistance related proteins. Additionally, res...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/0304-3835(95)03893-2

    authors： Volm M,Koomägi R,Mattern J,Stammler G

    更新日期：1995-08-16 00:00:00

  • Cells of origin and tumor-initiating cells for nonmelanoma skin cancers.

    abstract：:The epidermis of the skin is a multilayered stratified epithelium whose primary function is to provide a barrier against our external environment. As a result, cells in the epidermis are subject to constant assault from environmental pathogens, many of which can cause deleterious mutations. However, most of these muta...

    journal_title：Cancer letters

    pub_type： 杂志文章,评审

    doi：10.1016/j.canlet.2012.05.008

    authors： Thieu K,Ruiz ME,Owens DM

    更新日期：2013-09-10 00:00:00

  • Effects of naturally occurring antioxidants on combined 1,2-dimethylhydrazine- and 1-methyl-1-nitrosourea-initiated carcinogenesis in F344 male rats.

    abstract：:The effects of treatment with naturally occurring antioxidants, selenium, beta-carotene, ferulic acid, esculin and eugenol during the promotional phase of tumor development were investigated in male F344 rats pre-treated with 1,2-dimethylhydrazine (DMH) and 1-methyl-1-nitrosourea (MNU). Animals were given 3 subcutaneo...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/0304-3835(90)90065-6

    authors： Imaida K,Hirose M,Yamaguchi S,Takahashi S,Ito N

    更新日期：1990-11-19 00:00:00

  • Sulforaphane enhances the anticancer activity of taxanes against triple negative breast cancer by killing cancer stem cells.

    abstract：:Triple negative breast cancer (TNBC) typically exhibits rapid progression, high mortality and faster relapse rates relative to other breast cancer subtypes. In this report we examine the combination of taxanes (paclitaxel or docetaxel) with a breast cancer stem cell (CSC)-targeting agent sulforaphane for use against T...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/j.canlet.2017.02.023

    authors： Burnett JP,Lim G,Li Y,Shah RB,Lim R,Paholak HJ,McDermott SP,Sun L,Tsume Y,Bai S,Wicha MS,Sun D,Zhang T

    更新日期：2017-05-28 00:00:00

  • Volatile isoprenoid constituents of fruits, vegetables and herbs cumulatively suppress the proliferation of murine B16 melanoma and human HL-60 leukemia cells.

    abstract：:Substantial evidence from epidemiological studies supports the inverse association between the intake of fruits, vegetables and other plant products and cancer incidence. Cancer-preventive constituents of fruits and vegetables may inhibit carcinogen activation, enhance carcinogen detoxification, prevent carcinogens fr...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/s0304-3835(01)00723-6

    authors： Tatman D,Mo H

    更新日期：2002-01-25 00:00:00

  • Recombinant arginine deiminase as a potential anti-angiogenic agent.

    abstract：:Arginine deiminase (ADI), isolated from Mycoplasma cell extracts, has been suggested to inhibit endothelial cell growth in vitro. However, anti-angiogenic activity by ADI has not yet been demonstrated. In this study, we investigated the in vitro effect of recombinant ADI (rADI) on the growth, migration, and tube forma...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/s0304-3835(01)00793-5

    authors： Beloussow K,Wang L,Wu J,Ann D,Shen WC

    更新日期：2002-09-26 00:00:00

  • Lobatin B inhibits NPM/ALK and NF-κB attenuating anaplastic-large-cell-lymphomagenesis and lymphendothelial tumour intravasation.

    abstract：:An apolar extract of the traditional medicinal plant Neurolaena lobata inhibited the expression of the NPM/ALK chimera, which is causal for the majority of anaplastic large cell lymphomas (ALCLs). Therefore, an active principle of the extract, the furanoheliangolide sesquiterpene lactone lobatin B, was isolated and te...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/j.canlet.2014.11.019

    authors： Kiss I,Unger C,Huu CN,Atanasov AG,Kramer N,Chatruphonprasert W,Brenner S,McKinnon R,Peschel A,Vasas A,Lajter I,Kain R,Saiko P,Szekeres T,Kenner L,Hassler MR,Diaz R,Frisch R,Dirsch VM,Jäger W,de Martin R,Bochkov

    更新日期：2015-01-28 00:00:00