Genetic and epigenetic analysis of the TIMP-3 gene in ovarian cancer.

abstract：:Malignant tumors remain a major health burden throughout the world, and effective therapeutic strategies are urgently needed. Combining gene therapy with chemotherapeutics in a single delivery system is more effective than co-treatment of cancer with individual delivery systems carrying either gene or drug. In this st...

journal_title：Cancer letters

authors： Dong D,Gao W,Liu Y,Qi XR

更新日期：2015-04-10 00:00:00

abstract：:The aim of the study was to prove whether or not an association exists between the heat shock protein 70 (hsp70) and drug resistance. Tumor samples of 90 patients with previously untreated non-small lung carcinomas were investigated immunohistochemically for expression of resistance related proteins. Additionally, res...

journal_title：Cancer letters

authors： Volm M,Koomägi R,Mattern J,Stammler G

更新日期：1995-08-16 00:00:00

abstract：BACKGROUND AND AIMS:Understanding the molecular pathogenesis of hepatocellular carcinoma (HCC) is essential to identify therapeutic targets. A hepatitis B virus (HBV) related double transgenic murine model was developed. METHODS:Liver specific expression of HBV X protein (HBx) and insulin receptor substrate 1 (IRS1) w...

journal_title：Cancer letters

authors： Chung W,Kim M,de la Monte S,Longato L,Carlson R,Slagle BL,Dong X,Wands JR

更新日期：2016-01-01 00:00:00

abstract：:The etiology of prostatic adenocarcinoma remains unclear. Prostate cancer cells of varying metastatic potential and apoptotic resistance show altered expression of plasma membrane ion channels and unbalanced Ca2+ homeostasis. Ca(2+)-activated Cl(-) channels (CaCCs) are robustly expressed in epithelial cells and functi...

journal_title：Cancer letters

authors： Liu W,Lu M,Liu B,Huang Y,Wang K

更新日期：2012-12-29 00:00:00

abstract：:NF-kappaB is activated in many types of cancer. Phosphorylation of p65 at serine 276 is required for the expression of a subset of NF-kappaB regulated genes, including vascular cell adhesion molecule-1 (VCAM-1) and interleukin-8 (IL-8). Thus, inhibition of serine 276 phosphorylation may prevent metastasis and angiogen...

journal_title：Cancer letters

authors： Law M,Corsino P,Parker NT,Law BK

更新日期：2010-05-28 00:00:00

abstract：:Electron microscopic studies were made on an in vitro cultured cell line obtained from the FCB transplantable murine bladder tumour. The cells exhibited a loss of differentiation compared with solid tumour and the presence of C-type virus particles, many in the process of budding. The possible relation of this virus t...

journal_title：Cancer letters

authors： Flaks A

更新日期：1977-07-01 00:00:00

abstract：:The human multidrug resistance ABC transporters provide a protective function in our body against a large number of toxic compounds. These proteins, residing in the plasma membrane, perform an active, ATP-dependent extrusion of such xenobiotics. However, the same proteins are also used by the tumor cells to fight vari...

journal_title：Cancer letters

authors： Cervenak J,Andrikovics H,Ozvegy-Laczka C,Tordai A,Német K,Váradi A,Sarkadi B

更新日期：2006-03-08 00:00:00

abstract：:The heat shock protein 40kDa (HSP40/DNAJ) co-chaperones constitute the largest and most diverse sub-group of the heat shock protein (HSP) family. DNAJ are widely accepted as regulators of HSP70 function, but also have roles as co-chaperones for the HSP90 chaperone machine, and a growing number of biological functions ...

journal_title：Cancer letters

authors： Sterrenberg JN,Blatch GL,Edkins AL

更新日期：2011-12-22 00:00:00

abstract：:Antimutagenic activity of copper chlorophyllin against various carcinogenic mutagens was assayed with Drosophila genotoxicity tests, i.e., the wing spot test for detecting somatic cell mutations and the DNA repair test for detecting DNA damage. In these tests, Drosophila larvae were fed carcinogens together with chlor...

journal_title：Cancer letters

authors： Negishi T,Nakano H,Kitamura A,Itome C,Shiotani T,Hayatsu H

更新日期：1994-08-15 00:00:00

abstract：:Glutathione S-transferases (GST) alpha and pi, glutathione (GSH) and aldehyde dehydrogenase (ADH) were determined in colorectal cancer tissue specimens and in the adjacent normal colon tissue. The median contents in normal and cancer tissue were 8.1 (2.3-30.3) (5-95% quantiles) and 15.1 (5.3-50.3) microg/mg protein fo...

journal_title：Cancer letters

authors： Hengstler JG,Böttger T,Tanner B,Dietrich B,Henrich M,Knapstein PG,Junginger T,Oesch F

更新日期：1998-06-05 00:00:00

abstract：:A direct relationship exists between aging and increasing incidences of chronic diseases. In fact, with most age-associated diseases individuals manifest an underlying chronic inflammatory state as evidenced by local infiltration of inflammatory cells, such as macrophages, and higher circulatory levels of pro-inflamma...

journal_title：Cancer letters

authors： Sarkar D,Fisher PB

更新日期：2006-05-08 00:00:00

abstract：:Glycyrrhetic acid is an anti-inflammatory agent isolated from licorice root that inhibits 12-O-tetradecanoylphorbol-13-acetate (TPA)-mediated tumor promotion in mouse skin. Although it has been established that glycyrrhetic acid inhibits a number of events induced by the phorbol ester tumor promoter TPA in cultured ce...

journal_title：Cancer letters

authors： O'Brian CA,Ward NE,Vogel VG

更新日期：1990-01-01 00:00:00

abstract：:Epidemiological reports suggest that Asians consuming a diet high in soy have a low incidence of clinically manifested prostate cancer. We have tested the hypothesis that life-time exposure to genistein, the primary isoflavone component of soy, is responsible for this protective effect. Lobund-Wistar rats were exposed...

journal_title：Cancer letters

authors： Wang J,Eltoum IE,Lamartiniere CA

更新日期：2002-12-01 00:00:00

abstract：:Fibronectin (FN), a heterodimeric glycoprotein overexpressed in several types of tumors, has been implicated in cancer progression via the activation of integrin-mediated pro-oncogenic pathways. The FN level in human bile fluid is dramatically increased in malignant biliary diseases; however, FN expression and its bio...

journal_title：Cancer letters

authors： Cao Y,Liu X,Lu W,Chen Y,Wu X,Li M,Wang XA,Zhang F,Jiang L,Zhang Y,Hu Y,Xiang S,Shu Y,Bao R,Li H,Wu W,Weng H,Yen Y,Liu Y

更新日期：2015-05-01 00:00:00

abstract：:The insulin-like growth factor (IGF) family of ligands, binding proteins and receptors is an important growth factor system involved in both the development of the organism and the maintenance of normal function of many cells of the body. The system also has powerful anti-apoptotic effects. More recently, evidence has...

journal_title：Cancer letters

authors： LeRoith D,Roberts CT Jr

更新日期：2003-06-10 00:00:00

abstract：:The tumor promoter, phorbol-12-myristate-13-acetate (PMA), elicited a significant increase in lysosomal membrane permeability, as measured by release of free beta-glucurnidase, in guinea pig and hamster isolated hepatic lysosomes in vitro. This response was antagonized by zinc sulfate; zinc compounds having previously...

journal_title：Cancer letters

authors： Pfeiffer CJ,Cho CH

更新日期：1980-07-01 00:00:00

abstract：:We constructed an SV40-derived expression vector containing a mutated albumin minigene of Nagase analbuminemic rats (NAR), and introduced it into cultured cells. Transient expression of the minigene mRNA was determined by RT-PCR. Three kinds of aberrant mRNAs were expressed by the non-hepatic cells COS-1, and the undi...

journal_title：Cancer letters

authors： Sugiyama K,Hitomi Y,Adachi H,Esumi H

更新日期：1994-08-15 00:00:00

abstract：:Recently developed quantitative and high-throughput technologies that allow automated and rapid screening of the whole genome, transcriptome and proteome have revolutionized the field of cancer genetics. At the same time, new challenges are met, e.g. the need for improved data analysis and standardization of tumor sam...

journal_title：Cancer letters

authors： De Preter K,Vandesompele J,Heimann P,Kockx MM,Van Gele M,Hoebeeck J,De Smet E,Demarche M,Laureys G,Van Roy N,De Paepe A,Speleman F

更新日期：2003-07-18 00:00:00

abstract：:Receptors for all classes of steroid hormones were identified in cytosols of adenocarcinoma of the lung. In contrast, the incidence of receptor in squamous cell carcinoma was limited and small cell carcinomas appeared devoid of receptor. Receptor binding was of high affinity, saturable and localized to the 8, 6-7 and ...

journal_title：Cancer letters

authors： Chaudhuri PK,Thomas PA,Walker MJ,Briele HA,Das Gupta TK,Beattie CW

更新日期：1982-09-01 00:00:00

abstract：:The human c-myb gene which encodes a DNA binding protein and which is rarely amplified in neoplastic cells was found to be altered in four human glioblastoma cell lines. It exists in multiple copies in 2 out of 4 cases studied. The degree of amplification as determined by densitometry was about 10-fold, a rearrangemen...

journal_title：Cancer letters

authors： Welter C,Henn W,Theisinger B,Fischer H,Zang KD,Blin N

更新日期：1990-06-30 00:00:00

abstract：:Well differentiated thyroid carcinomas provide a unique model of human, epithelial cell carcinogenesis. Their molecular characterization has allowed to associate specific genetic alterations to the two papillary and follicular histotypes which, despite their common origin, display different biological and clinical beh...

journal_title：Cancer letters

authors： Pierotti MA

更新日期：2001-05-10 00:00:00

abstract：:We have previously shown that transforming growth factor (TGF)-beta up-regulates matrix metalloproteinase (MMP)-2 leading to the induction of oncogenic signaling in preneoplastic MCF10A human breast epithelial cells. The present study investigated the mechanism of transcriptional regulation of MMP-2 by TGF-beta in MCF...

journal_title：Cancer letters

authors： Kim ES,Sohn YW,Moon A

更新日期：2007-07-08 00:00:00

abstract：:The over-expression of N-myc down-regulated gene 1 (NDRG1) in hepatocellular carcinoma (HCC) was previously reported to correlate with vascular invasion and patient survival. Our current study aims to elucidate its functions in HCC. We found that it lacked the tumorigenic ability to promote soft agar colony formation ...

journal_title：Cancer letters

authors： Yan X,Chua MS,Sun H,So S

更新日期：2008-04-08 00:00:00

abstract：:Our earlier studies have shown that simultaneous inhibition of glycolysis and pentose phosphate pathway using 2-deoxy-d-glucose (2-DG, an inhibitor of glycolysis) and 6-aminonicotinamide (6-AN, an inhibitor of pentose phosphate pathway) lead to metabolic oxidative stress (MOS), resulting in radiosensitization in malig...

journal_title：Cancer letters

authors： Sharma PK,Bhardwaj R,Dwarakanath BS,Varshney R

更新日期：2010-09-28 00:00:00

abstract：:Resistance to anoikis is a hallmark of human malignancies. Our results showed that hepatoma cells resisted anoikis by non-proliferation, non-apoptosis and cell cycle arrest which were termed synoikis-like. These synoikis-like cells are more resistant to extracellular stimuli and could spontaneously attach and prolifer...

journal_title：Cancer letters

authors： Zhang Z,Cao L,Li J,Liang X,Liu Y,Liu H,Du J,Qu Z,Cui M,Liu S,Gao L,Ma C,Zhang L,Han L,Sun W

更新日期：2008-08-18 00:00:00

abstract：:Estrogens are important for the development and growth of estrogen receptor (ER)-positive breast cancer, for which anti-estrogen therapy is one of the most effective treatments. However, its efficacy can be limited by either de novo or acquired resistance. Aromatase is a key enzyme for the biosynthesis of estrogens, a...

journal_title：Cancer letters

authors： Phuong NT,Lim SC,Kim YM,Kang KW

更新日期：2014-08-28 00:00:00

abstract：:Isothiocyanates are found in cruciferous vegetables such as broccoli, Brussels sprouts, cauliflower, and cabbage. Epidemiologic studies suggest that cruciferous vegetable intake may lower overall cancer risk, including colon and prostate cancer. Sulforaphane (SFN) is an isothiocyanate found in cruciferous vegetables a...

journal_title：Cancer letters

authors： Clarke JD,Dashwood RH,Ho E

更新日期：2008-10-08 00:00:00

abstract：:The T-cell lymphoma cell line YACUT was fused with the Mls-1a antigen-responsive non-tumorigenic T-cell line G4 to construct growth-arrested hybrids which could be induced to proliferate in the presence of Mls-1a antigen. Prolonged growth of the hybrids by repeated antigenic stimulation resulted in the emergence of ce...

journal_title：Cancer letters

authors： Kubota K,Tamauchi H,Nakazato K

更新日期：1996-03-29 00:00:00

abstract：:The expression of the WAF1/CIP1 gene product, p21, in enzyme-altered foci (EAF) induced by diethylnitrosamine (DEN) and phenobarbital (PB) was examined. p21 expression in the nucleus of hepatocytes in EAF was decreased compared to surrounding tissue. Fifty-eight percent of all GST-P-positive EAF induced by DEN and 79%...

journal_title：Cancer letters

authors： Martens U,Lennartsson P,Högberg J,Stenius U

更新日期：1996-06-24 00:00:00

abstract：:DNA methylation of the CpG-rich 5' region of the deoxycytidine kinase (dCK) gene is potentially involved in the suppression of the gene and the resistance of tumour cells to arabinosylcytosine (ara-C). 2-Chlorodeoxyadenosine (cladribine, CdA) and 2-chloro-2'-arabino-fluoro-2'-deoxyadenosine (CAFdA) are purine nucleosi...

journal_title：Cancer letters

authors： Leegwater PA,De Abreu RA,Albertioni F

更新日期：1998-08-14 00:00:00