Abstract：
:Glycyrrhetic acid is an anti-inflammatory agent isolated from licorice root that inhibits 12-O-tetradecanoylphorbol-13-acetate (TPA)-mediated tumor promotion in mouse skin. Although it has been established that glycyrrhetic acid inhibits a number of events induced by the phorbol ester tumor promoter TPA in cultured cells, its mechanisms of action has remained obscure. In this report, we demonstrate that glycyrrhetic acid inhibits the Ca2+-and phospholipid-dependent phosphotransferase activity of protein kinase C (PKC), the phorbol ester tumor promoter receptor. Therefore, inhibition of PKC may play a role in the anti-promoting activity of glycyrrhetic acid.
journal_name
Cancer Lettjournal_title
Cancer lettersauthors
O'Brian CA,Ward NE,Vogel VGdoi
10.1016/0304-3835(90)90132-hsubject
Has Abstractpub_date
1990-01-01 00:00:00pages
9-12issue
1eissn
0304-3835issn
1872-7980pii
0304-3835(90)90132-Hjournal_volume
49pub_type
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