Effect of the length of alkyl chain on the cytochrome P450 dependent metabolism of N-diakylnitrosamines.


:Liver microsomes from control and treated rats (P4501A, 2B, 2E1-induced) metabolize at variable metabolic rates eight N-nitroso-di-n-alkylamines, including five symmetrical (N-nitroso-dimethyl, -diethyl, -dipropyl, -dibutyl and -diamyl-amines) and four asymmetrical (N-nitrosomethylethyl, methylpropyl, methylbutyl, and methylamyl-amines), into aldehydes. Thus, the longer the alkyl chain of symmetrical N-nitrosamines, the smaller was the metabolic rate of the corresponding aldehyde formation. The chain length of the alkyl group of N-nitroso-methylalkylamines modified the oxidation of the alkyl moiety: the oxidation by CYP2E1 decreased as the n-alkyl chain length increased and conversely for the oxidation by CYP1A and CYP2B. Finally, the longer the n-alkyl chain length of asymmetrical N-nitrosamines, the greater was the oxidation of methyl groups.


Cancer Lett


Cancer letters


Bellec G,Goasduff T,Dreano Y,Menez JF,Berthou F




Has Abstract


1996-02-27 00:00:00














  • Anti-angiogenic activity of ursodeoxycholic acid and its derivatives.

    abstract::Ursodeoxycholic acid (UDCA) and its derivatives were examined for anti-angiogenic activities by using the chick embryo chorioallantoic membrane (CAM) assay. The presence of UDCA or its derivatives inhibited angiogenesis in a dose-dependent manner; the dose required for half-maximal inhibition (ID50) was 4 microg per C...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Suh H,Jung EJ,Kim TH,Lee HY,Park YH,Kim KW

    更新日期:1997-02-26 00:00:00

  • Secretory Stanniocalcin 1 promotes metastasis of hepatocellular carcinoma through activation of JNK signaling pathway.

    abstract::The hypoxic microenvironment is well-characterized in hepatocellular carcinoma (HCC). Delineation of hypoxia-responsive events is an integral part to understand the pathogenesis of HCC. We studied the functional role and clinical relevance of Stanniocalcin 1 (STC1), a hypoxia-induced molecular target, in HCC. In our c...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Chan KK,Leung CO,Wong CC,Ho DW,Chok KS,Lai CL,Ng IO,Lo RC

    更新日期:2017-09-10 00:00:00

  • Isorhamnetin augments the anti-tumor effect of capecitabine through the negative regulation of NF-κB signaling cascade in gastric cancer.

    abstract::Development of drug resistance to standard chemotherapy is a common phenomenon that leads to poor prognosis in patients. Thus, novel agents that can attenuate chemoresistance are urgently needed. Therefore, we analyzed whether isorhamnetin (IH), a 3'-O-methylated metabolite of quercetin, can enhance the potential effi...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Manu KA,Shanmugam MK,Ramachandran L,Li F,Siveen KS,Chinnathambi A,Zayed ME,Alharbi SA,Arfuso F,Kumar AP,Ahn KS,Sethi G

    更新日期:2015-07-10 00:00:00

  • Costunolide, a sesquiterpene lactone from Saussurea lappa, inhibits the VEGFR KDR/Flk-1 signaling pathway.

    abstract::Costunolide (CT), a sesquiterpene lactone constituent isolated from Saussurea lappa (Compositae), exerted an antiangiogenic effect. CT selectively inhibited the endothelial cell proliferation induced by vascular endothelial growth factor (VEGF). Further, CT was also found to inhibit the VEGF-induced chemotaxis of huma...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Jeong SJ,Itokawa T,Shibuya M,Kuwano M,Ono M,Higuchi R,Miyamoto T

    更新日期:2002-12-10 00:00:00

  • Alterations in repair of alkylating agent-induced DNA damage in polyamine-depleted human cells.

    abstract::Treatment of HeLa cells with the polyamine biosynthesis inhibitors difluoromethylornithine (DFMO) and/or methylglyoxal bis(guanylhydrazone) (MGBG) results in marked depression in levels of the cellular polyamines putrescine, spermidine and spermine. Cells in this polyamine-depleted state exhibited increased sensitivit...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Snyder RD,Bhatt S

    更新日期:1993-08-16 00:00:00

  • Cancer chemopreventive activity of flavanones on Epstein-Barr virus activation and two-stage mouse skin carcinogenesis.

    abstract::To search for possible cancer chemopreventive agents from natural sources, we performed primary screening of ten flavanones isolated from plants belonging to Rutaceae and Leguminosae by examining their possible inhibitory effects on Epstein-Barr virus (EBV) early antigen activation induced by 12-O-tetradecanoylphorbol...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Itoigawa M,Ito C,Ju-ichi M,Nobukuni T,Ichiishi E,Tokuda H,Nishino H,Furukawa H

    更新日期:2002-02-08 00:00:00

  • Cdk1 and Cdk2 complexes (cyclin dependent kinases) in apoptosis: a role beyond the cell cycle.

    abstract::The family of cyclin-dependent kinase complexes (Cdks) are well known for their role in the cell division cycle. What is less well known, however, is that Cdks also participate in a subset of apoptosis programs. Evidence for the role of Cdks in apoptosis comes from a variety of experimental approaches, including studi...

    journal_title:Cancer letters

    pub_type: 杂志文章,评审


    authors: Golsteyn RM

    更新日期:2005-01-20 00:00:00

  • Artesunate reduces chicken chorioallantoic membrane neovascularisation and exhibits antiangiogenic and apoptotic activity on human microvascular dermal endothelial cell.

    abstract::Artesunate (ART), a semi-synthetic derivative of artemisinin extracted from the Chinese herb Artemisia annua, is a safe and effective antimalarial drug. ART has now been analyzed for its anti-angiogenic activity in vivo and in vitro. The anti-angiogenic effect in vivo was evaluated on chicken chorioallantoic membrane ...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Huan-huan C,Li-Li Y,Shang-Bin L

    更新日期:2004-08-10 00:00:00

  • Hyaluronan grafted lipid-based nanoparticles as RNAi carriers for cancer cells.

    abstract::RNA interference (RNAi), a natural cellular mechanism for RNA-guided regulation of gene expression could in fact become new therapeutic modality if an appropriate efficient delivery strategy that is also reproducible and safe will be developed. Numerous efforts have been made for the past eight years to address this c...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Landesman-Milo D,Goldsmith M,Leviatan Ben-Arye S,Witenberg B,Brown E,Leibovitch S,Azriel S,Tabak S,Morad V,Peer D

    更新日期:2013-07-01 00:00:00

  • Effects of methotrexate on folates in Krebs ascites and L1210 murine leukemia cells.

    abstract::Changes in reduced folates upon exposure of Krebs ascites cells and L1210 murine leukemia cells to methotrexate (MTX) have been measured by stoichiometric entrapment of tissue methylenetetrahydrofolate into a stable ternary complex with thymidylate synthase and tritiated 5-fluoro-2'-deoxy-uridine-5'-monophosphate. Tet...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Kesavan V,Sur P,Doig MT,Scanlon KJ,Priest DG

    更新日期:1986-01-01 00:00:00

  • Accumulation of cytoplasmic CDC25A in cutaneous squamous cell carcinoma leads to a dependency on CDC25A for cancer cell survival and tumor growth.

    abstract::Despite its documented role in cell cycle regulation, over-expression of the cyclin-dependent kinase activator CDC25A does not consistently correlate with worse cancer patient outcomes or predict successful clinical response to CDC25A inhibition. The current study was undertaken to investigate CDC25A in skin cancer an...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Al-Matouq J,Holmes T,Hammiller B,Tran N,Holmes M,Freeman SC,Hansen LA

    更新日期:2017-12-01 00:00:00

  • Decreased plasma levels of cholecystokinin in healthy males after chronic ingestion of a heat-treated soya product.

    abstract::Administration of raw soya containing a trypsin inhibitor stimulated excessive release of cholecystokinin (CCK) which led to pancreatic hypertrophy, hyperplasia and cancer in the rats (Booth et al. (1964) Proc. Soc. Exp. Biol. Med., 116, 1067). More postprandial CCK release in healthy humans was observed after ingesti...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Lu LJ,Anderson KE,Gomez G,Nealon WH

    更新日期:1995-04-14 00:00:00

  • Overexpression of c-Jun induced by quercetin and resverol inhibits the expression and function of the androgen receptor in human prostate cancer cells.

    abstract::Previously, we reported that quercetin and resveratrol inhibit the function of androgen receptor (AR). Further studies showed that these two polyphenols caused an increase in expression of c-Jun as well as its phosphorylated form in a dose-dependent manner in prostatic cell lines. Gel shift assay showed that induced c...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Yuan H,Pan Y,Young CY

    更新日期:2004-09-30 00:00:00

  • Deoxycytidine in human plasma: potential for protecting leukemic cells during chemotherapy.

    abstract::Degradation of DNA produces deoxycytidine. Metabolism of deoxycytidine to dCTP inhibits phosphorylation of cytosine arabinoside (araC), fludarabine (FaraA) and 2-chlorodeoxyadenosine (CdA) by deoxycytidine kinase. This study measured plasma deoxycytidine in healthy adults and two leukemia patients and then determined ...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Cohen JD,Strock DJ,Teik JE,Katz TB,Marcel PD

    更新日期:1997-06-24 00:00:00

  • Prevailing over T cell exhaustion: New developments in the immunotherapy of pancreatic cancer.

    abstract::Pancreatic cancer is one of the most aggressive malignancies and has been considered poorly immunogenic for decades. However, this characterization might be over-simplistic. A more sophisticated approach is needed in order to develop new treatment strategies. In this review, we will focus on T cell exhaustion as a phe...

    journal_title:Cancer letters

    pub_type: 杂志文章,评审


    authors: Bauer C,Kühnemuth B,Duewell P,Ormanns S,Gress T,Schnurr M

    更新日期:2016-10-10 00:00:00

  • Autoradiographic localization of tritiated suramin in polarized human colon adenocarcinoma cells.

    abstract::In this report we demonstrated that [3H]suramin enters polarized human colon adenocarcinoma cells when added to the apical side of the monolayer. Using light microscopic quantitative autoradiography, we showed that suramin was accumulated in the apical cytoplasm and in the nucleus. In contrast, a weak labeling was not...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Baghdiguian S,Boudier JA,Boudier JL,Fantini J

    更新日期:1993-12-20 00:00:00

  • Quercetin exerts a preferential cytotoxic effect on active dividing colon carcinoma HT29 and Caco-2 cells.

    abstract::The effect of the naturally occurring flavonol, quercetin, was investigated on cell growth and metabolism of two human carcinoma cell lines, HT29 and Caco-2 cells, both during the exponentially growing phase and after confluence. Our results show clearly that, after a 48-h period of treatment, quercetin (in the range ...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Agullo G,Gamet L,Besson C,Demigné C,Rémésy C

    更新日期:1994-11-25 00:00:00

  • Differences in inducibility of morphological differentiation of parental cells, selected variant cells and cells from spontaneous metastases of mouse neuroblastoma cells.

    abstract::The in vitro sensitivities to differentiating agents of a murine neuroblastoma cell line (N18) and a selected variant cell line (N18-LM5) were examined. In addition, the sensitivities to differentiating agents of cells from spontaneous metastases produced by N18 cells were examined. When N18 cells (1 X 10(5) cells/mou...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Takenaga K

    更新日期:1983-05-01 00:00:00

  • Fascin over-expression is associated with aggressiveness of oral squamous cell carcinoma.

    abstract::Oral squamous cell carcinoma (OSCC) is associated with a high potential of tumor recurrence and metastasis, leading to poor prognosis. Cell motility is an important factor in the progression and metastasis of cancers. Recently, Fascin has been linked to tumor progression by induction of cell motility. However, the pre...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Lee TK,Poon RT,Man K,Guan XY,Ma S,Liu XB,Myers JN,Yuen AP

    更新日期:2007-09-08 00:00:00

  • MUC16 C terminal-induced secretion of tumor-derived IL-6 contributes to tumor-associated Treg enrichment in pancreatic cancer.

    abstract::Pancreatic cancer is the most lethal tumor. CA125 (gene symbol MUC16) is an important serum marker for pancreatic cancer diagnosis and treatment. High serum CA125 is related to metabolic tumor burden and poor prognosis. The circulating Treg subset is another independent prognostic factor for pancreatic cancer. Our unp...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Fan K,Yang C,Fan Z,Huang Q,Zhang Y,Cheng H,Jin K,Lu Y,Wang Z,Luo G,Yu X,Liu C

    更新日期:2018-04-01 00:00:00

  • Promoting effects of unilateral ureteric ligation on two-stage urinary bladder carcinogenesis in rats.

    abstract::The effect of ligation of the left ureter on the development of lesions in the urinary bladder were investigated in male F344 rats treated with 0.05% N-butyl-N-(4-hydroxybutyl)-nitrosamine (BBN) for 2 weeks followed by 0.002% N-ethyl-N-(4-hydroxybutyl)nitrosamine (EHBN) for 10 or 22 weeks. The lesions of the urinary b...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Miyata Y,Fukushima S,Imaida K,Ito N

    更新日期:1984-07-01 00:00:00

  • Lack of initiating and promoting activity of thiourea in rat liver foci bioassay.

    abstract::Thiourea (TU) fails to enhance the incidence of foci deficient in adenosine-5'-triphosphatase (ATPase) either by initiation or by promotion in a rat liver foci bioassay. To weanling female Sprague-Dawley rats, 3 x 200 or 3 x 500 mg/kg body wt of TU, respectively, were applied for initiation. One week later Clophen A 5...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Oesterle D,Deml E

    更新日期:1988-08-30 00:00:00

  • Tea and health: a historical perspective.

    abstract::In many parts of the world, green tea and black tea are produced from the plant Camellia sinensis. Tea is one of the most widely consumed beverages, second only to water. It is one of the safest beverages since it is made with boiling, sterile water and has been popular for over 4000 years. Dogma has it that people kn...

    journal_title:Cancer letters

    pub_type: 历史文章,杂志文章


    authors: Weisburger JH

    更新日期:1997-03-19 00:00:00

  • Growth suppression and immunogenicity enhancement of Hep-2 or primary laryngeal cancer cells by adenovirus-mediated co-transfer of human wild-type p53, granulocyte-macrophage colony-stimulating factor and B7-1 genes.

    abstract::Co-transfer of immunomodulatory and antiproliferative genes may be the basis for new strategies to potentiate tumor regression. In this study, we evaluated the in vitro effect of the introduction of human wild-type p53, granulocyte-macrophage colony-stimulating factor (GM-CSF), and B7-1 genes via recombinant adenoviru...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Qiu ZH,Wu CT,Lao MF,Pan LZ,Li YM

    更新日期:2002-08-28 00:00:00

  • S/RV Cri-ba, a hairless mouse strain sensitive to skin tumorigenesis by suboptimal doses of 7,12-dimethylbenz[a]anthracene, initiation-promotion and two stage promotion protocols.

    abstract::Susceptibility of hairless inbred S/RV Cri-ba or Bare mice to skin tumor development with suboptimal doses of 7,12-dimethylbenz[a]anthracene (DMBA), DMBA-TPA two stage protocol and two stage promotion using 12-O-tetradecanoylphorbol-13-acetate (TPA) as sub-stage 1 promoter and mezerein (MEZ) or phorbol retinoate aceta...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Bhisey RA,Veturkar PL

    更新日期:1990-06-30 00:00:00

  • Mechanisms regulating glioma invasion.

    abstract::Glioblastoma (GBM) is the most aggressive, deadliest, and most common brain malignancy in adults. Despite the advances made in surgical techniques, radiotherapy and chemotherapy, the median survival for GBM patients has remained at a mere 14 months. GBM poses several unique challenges to currently available treatments...

    journal_title:Cancer letters

    pub_type: 杂志文章,评审


    authors: Paw I,Carpenter RC,Watabe K,Debinski W,Lo HW

    更新日期:2015-06-28 00:00:00

  • The PHGDH enigma: Do cancer cells only need serine or also a redox modulator?

    abstract::Upregulation of serine biosynthesis pathway activity is an increasingly apparent feature of many cancers. Most notably, the first rate-limiting enzyme of the pathway, phosphoglycerate dehydrogenase (PHGDH), is genomically amplified in some melanomas and breast cancers and can be transcriptionally regulated by various ...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Li AM,Ye J

    更新日期:2020-04-28 00:00:00

  • Expression analysis of endogenous retroviral elements belonging to the HERV-F family from human tissues and cancer cells.

    abstract::Based on the primer binding site for Phe-tRNA, human endogenous retroviruses (HERVs) have been classified as HERV-F family members, HERV-F, HERV-FXA, HERV-Fb, and HERV-Fc. The HERV-F family was expressed in human placenta preferentially. We investigated pol fragments of HERV-F family in various human tissues and cance...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Yi JM,Kim HS

    更新日期:2004-07-28 00:00:00

  • Regulation of the intestinal mucin MUC2 gene expression in vivo: evidence for the role of promoter methylation.

    abstract::In the present work we investigated the in vivo regulation of the mucin gene MUC2, which is overexpressed in all mucinous colorectal carcinomas. The inhibition of methylation by 5-azadeoxycytidine induces de novo expression of MUC2 in the colon carcinoma cell line COLO 205. The expression is retained in xenograft tiss...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Gratchev A,Siedow A,Bumke-Vogt C,Hummel M,Foss HD,Hanski ML,Kobalz U,Mann B,Lammert H,Mansmann U,Stein H,Riecken EO,Hanski C

    更新日期:2001-07-10 00:00:00

  • The Bmi-1 oncoprotein is overexpressed in human colorectal cancer and correlates with the reduced p16INK4a/p14ARF proteins.

    abstract::To clarify the roles of Bmi-1 in colorectal carcinoma, we examined the expression of Bmi-1 in 41 samples out of 46 colorectal carcinomas by reverse transcription-PCR, whereas all 46 were analyzed by immunostaining. In addition, we analyzed the expression patterns of Bmi-1 in association with p16INK4a and p14ARF (in mo...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Kim JH,Yoon SY,Kim CN,Joo JH,Moon SK,Choe IS,Choe YK,Kim JW

    更新日期:2004-01-20 00:00:00