Rotenone, an anticarcinogen, inhibits cellular proliferation but not peroxisome proliferation in mouse liver.

Abstract:

:In previous National Toxicology Program (NTP) studies, rotenone reduced the background incidence of hepatocellular carcinoma in male B6C3F1 mice. In the present studies, rotenone reduced the basal hepatic labeling index of male B6C3F1 mice in a dose-dependent fashion and inhibited hepatocellular proliferation, but not peroxisome proliferation, induced by the peroxisome proliferator Wy-14,643. These results indicate that reduction of hepatic tumors by rotenone may have been due to decreased liver cell replication, that peroxisome proliferation can be induced in the absence of hepatocellular proliferation and suggest rotenone as a potential tool in studies of relationships of cell proliferation, peroxisomal proliferation and hepatocarcinogenesis.

journal_name

Cancer Lett

journal_title

Cancer letters

authors

Cunningham ML,Soliman MS,Badr MZ,Matthews HB

doi

10.1016/0304-3835(95)03869-x

subject

Has Abstract

pub_date

1995-08-16 00:00:00

pages

93-7

issue

1-2

eissn

0304-3835

issn

1872-7980

pii

0304-3835(95)03869-X

journal_volume

95

pub_type

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