Aromatase induction in tamoxifen-resistant breast cancer: Role of phosphoinositide 3-kinase-dependent CREB activation.

abstract：:5-FU is commonly used for treatment of various solid tumors including colon carcinoma. We have previously demonstrated that Egr-1 induced by 5-FU enhanced TSP-1 expression in human colon cancer KM12C cells. In this study, a Genechip analysis of KM12C cells treated with 5-FU revealed down-regulation of 924 genes and up...

journal_title：Cancer letters

authors： Zhao HY,Ooyama A,Yamamoto M,Ikeda R,Haraguchi M,Tabata S,Furukawa T,Che XF,Iwashita K,Oka T,Fukushima M,Nakagawa M,Ono M,Kuwano M,Akiyama S

更新日期：2008-10-18 00:00:00

abstract：:Radiotherapy (RT) is one of the most important strategies in cancer treatment. Radioresistance is a major challenge to RT and results in locoregional recurrence and metastasis. Thus, there is a great interest in investigating biomarkers to distinguish radiosensitive from radioresistant (RR) cancer patients. The develo...

journal_title：Cancer letters

authors： Chang L,Graham P,Hao J,Bucci J,Malouf D,Gillatt D,Li Y

更新日期：2015-12-28 00:00:00

abstract：:The kinetics of total DNA adducts were compared in the liver, bladder epithelium and small intestinal epithelium of rats and mice following a single oral dose (100 mg/kg) of 3,3'-dichlorobenzidine [( 14C]DCB). Peak DNA binding (expressed as pmol DCB bound/mg DNA) in rat tissues was 153.5, 144.8 and 36.9 in the intesti...

journal_title：Cancer letters

authors： Ghosal A,Iba MM

更新日期：1990-09-01 00:00:00

abstract：:Gastrin, cholecystokinin2 receptor (CCK2R), and cyclooxygenase-2 (COX-2) have been implicated in the carcinogenesis and progression of gastric cancer. Our study demonstrated that antagonist or siRNA against CCK2R blocked amidated gastrin (G17)-induced activation of STAT3 and Akt in gastric cancer cell lines. G17-incre...

journal_title：Cancer letters

authors： Xu W,Chen GS,Shao Y,Li XL,Xu HC,Zhang H,Zhu GQ,Zhou YC,He XP,Sun WH

更新日期：2013-05-10 00:00:00

abstract：:The aim of this study was to investigate the interaction of tamoxifen (TAM) with the so-called Type II estrogen binding sites (Type II EBS) in both the cytosolic and the nuclear fraction of the ER-negative A 2780 human ovarian cancer cell line and in an ER-negative ovarian cancer tissue. Although cytosolic and nuclear...

journal_title：Cancer letters

authors： Ferrandina G,Ranelletti FO,Scambia G,Benedetti Panici P,D'Agostino G,Piantelli M,Isola G,Mancuso S

更新日期：1995-09-04 00:00:00

abstract：:Immunohistochemically detected expression of sialyl Lewis(x) (Le(x)) antigen was analyzed in 101 stage 0-II gastric cancers to clarify its prognostic value after curative gastrectomy. Patients with a high-expression of sialyl Le(x) antigen within their tumors had shorter disease-specific intervals than those with nega...

journal_title：Cancer letters

authors： Nakagoe T,Fukushima K,Sawai T,Tsuji T,Jibiki Ma,Nanashima A,Tanaka K,Yamaguchi H,Yasutake T,Ayabe H,Arisawa K,Ishikawa H

更新日期：2002-01-25 00:00:00

abstract：:In experimental trials using the N-nitroso-N-methylurea (NMU)-induced rat mammary tumor model, a significant decrease in tumor incidence (to 5%) was observed in rats treated with melatonin and 9-cis-retinoic acid (9 cRA) compared to controls (55%). Although 9cRA alone decreased tumor incidence to 26%, this response di...

journal_title：Cancer letters

authors： Teplitzky SR,Kiefer TL,Cheng Q,Dwivedi PD,Moroz K,Myers L,Anderson MB,Collins A,Dai J,Yuan L,Spriggs LL,Blask DE,Hill SM

更新日期：2001-07-26 00:00:00

abstract：:Groups of 50 male and 50 female B6C3F1 mice inhaled 10 or 40 ppm 1,2-dibromoethane 6 h/day, 5 days/week, for 103 (10 ppm) or 90 (40 ppm) weeks. Focal epithelial hyperplasia was found in 1 (low dose group) and 10 (high dose group) males and 3 (low dose group) and 11 (high dose group) females. Squamous papillomas or ade...

journal_title：Cancer letters

authors： Stinson SF,Reznik G,Ward JM

更新日期：1981-03-01 00:00:00

abstract：:Exosomes are 30-100 nm small membrane vesicles of endocytic origin that are secreted by all types of cells, and can also be found in various body fluids. Increasing evidence implicates that exosomes confer stability and can deliver their cargos such as proteins and nucleic acids to specific cell types, which subsequen...

journal_title：Cancer letters

authors： Zhou L,Lv T,Zhang Q,Zhu Q,Zhan P,Zhu S,Zhang J,Song Y

更新日期：2017-10-28 00:00:00

abstract：:Starvation-induced hypoglycaemia and streptozotocin-induced diabetes suppressed the growth of Ehrlich ascites tumor in mice. The suppression of tumor growth by diabetes was alleviated by administration of insulin. The number of glucose carriers on tumour cells was found to be reduced in diabetes and partial resumption...

journal_title：Cancer letters

authors： Fung KP,Chan TW,Choy YM

更新日期：1985-09-30 00:00:00

abstract：:Free hematoporphyrin administered intravenously to healthy rabbits (1-28 mg/kg body weight) is bound by the 3 major lipoprotein components of plasma (VLDL, LDL and HDL) with different efficiency. In vitro-prepared complexes of hematoporphyrin (Hp) with lipoprotein fractions isolated from mouse serum have been injected...

journal_title：Cancer letters

authors： Barel A,Jori G,Perin A,Romandini P,Pagnan A,Biffanti S

更新日期：1986-08-01 00:00:00

abstract：:Macrophage migration inhibitory factor (MIF) is up-regulated in diverse solid tumors and acts as the critical link between immune response and tumorigenesis. In this study, we demonstrated that MIF overexpression promoted migration of breast cancer cells by elevating TLR4 expression. Further investigation evidenced th...

journal_title：Cancer letters

authors： Lv W,Chen N,Lin Y,Ma H,Ruan Y,Li Z,Li X,Pan X,Tian X

更新日期：2016-06-01 00:00:00

abstract：:Crk is a signaling adaptor protein which is mostly composed of SH2 and SH3 domains, and has been shown to play a pivotal role in cell proliferation, differentiation, and migration. Because Crk was originally isolated as an avian sarcoma virus CT10 encoding oncoprotein v-Crk, we examined a potential role for c-Crk in t...

journal_title：Cancer letters

authors： Nishihara H,Tanaka S,Tsuda M,Oikawa S,Maeda M,Shimizu M,Shinomiya H,Tanigami A,Sawa H,Nagashima K

更新日期：2002-06-06 00:00:00

abstract：:The ability to induce changes in cell membrane properties is nowadays considered an additional mechanism to explain the pharmacological effects of non-steroidal anti-inflammatory drugs (NSAIDs). We previously demonstrated that the NSAID Licofelone, a dual cyclooxygenase/5-lipoxygenase inhibitor, triggers apoptosis in ...

journal_title：Cancer letters

authors： Tavolari S,Munarini A,Storci G,Laufer S,Chieco P,Guarnieri T

更新日期：2012-08-28 00:00:00

abstract：:Ellagic acid (EA) and 13-cis-retinoic acid (CRA), both alone and in combination, were tested for their ability to inhibit N-nitrosobenzylmethylamine-induced tumors in the rat esophagus. Groups of male rats were fed AIN-76A diet containing EA (4 g/kg), CRA (240 mg/kg), or a combination of EA and CRA (4 g/kg and 240 mg/...

journal_title：Cancer letters

authors： Daniel EM,Stoner GD

更新日期：1991-02-01 00:00:00

abstract：:We investigated the relative effectiveness of four differentiation-inducing chemicals to induce a more normal or benign phenotype in the human colon cancer cell lines Moser and HT29. The differentiation-inducing capability of all-trans retinoic acid (ATRA), difluoromethylornithine (DFMO), sodium butyrate (NaB) and sod...

journal_title：Cancer letters

authors： Reynolds S,Rajagopal S,Chakrabarty S

更新日期：1998-12-11 00:00:00

abstract：:Cancer cells are shed into the blood stream and are exposed to hemodynamic shear stress during metastasis. It has been shown that shear stress can destroy circulating tumor cells (CTCs) both in vitro and in vivo. However, it remains unclear whether shear stress can modulate the properties and functions of tumor cells ...

journal_title：Cancer letters

authors： Ma S,Fu A,Chiew GG,Luo KQ

更新日期：2017-03-01 00:00:00

abstract：:Serum alpha-N-acetylgalactosaminidase (NaGalase) is responsible for the deglycosylation of vitamin D(3)-binding protein (Gc protein). The deglycosylated Gc protein cannot be converted into major macrophage-activating factor (MAF), leading to immunosuppression. NaGalase is universally detected in a variety of cancer pa...

journal_title：Cancer letters

authors： Reddi AL,Sankaranarayanan K,Arulraj HS,Devaraj N,Devaraj H

更新日期：2000-09-29 00:00:00

abstract：:The Chinese Glioma Cooperative Group (CGCG) Guideline Panel for adult diffuse gliomas provided recommendations for diagnostic and therapeutic procedures. The Panel covered all fields of expertise in neuro-oncology, i.e. neurosurgeons, neurologists, neuropathologists, neuroradiologists, radiation and medical oncologist...

journal_title：Cancer letters

authors： Jiang T,Mao Y,Ma W,Mao Q,You Y,Yang X,Jiang C,Kang C,Li X,Chen L,Qiu X,Wang W,Li W,Yao Y,Li S,Li S,Wu A,Sai K,Bai H,Li G,Chen B,Yao K,Wei X,Liu X,Zhang Z,Dai Y,Lv S,Wang L,Lin Z,Dong J,Xu G,M

更新日期：2016-06-01 00:00:00

abstract：:The anti-carcinogenic activity of dietary fruit and vegetables observed in several epidemiological and experimental animal studies is likely to be an effect of the combined exposure to a large number of substances acting together. This is plausible, as these compounds are present simultaneously in a diet containing ve...

journal_title：Cancer letters

authors： Vang O,Rasmussen BF,Andersen O

更新日期：1997-03-19 00:00:00

abstract：:We generated mice expressing a COX-2 transgene in colon epithelium and found that they did not develop spontaneous colon tumors. But when treated with azoxymethane, a colon carcinogen, COX-2 mice had a higher tumor load compared to wild-type mice. There was no change in the number of pre-neoplastic lesions, indicating...

journal_title：Cancer letters

authors： Al-Salihi MA,Terrece Pearman A,Doan T,Reichert EC,Rosenberg DW,Prescott SM,Stafforini DM,Topham MK

更新日期：2009-01-18 00:00:00

abstract：:Extracts of leukemic lymphocytes and leukemic myelomonocytic cells bind significantly more cAMP/mg protein than do normal cells. The binding of cAMP in leukemic cells is non-specific since the binders are unable to effectively discriminate between cAMP and cGMP in contrast to normal cells. When normal lymphocytes are ...

journal_title：Cancer letters

authors： Weber TH,Linkola J

更新日期：1980-01-01 00:00:00

abstract：:A newly found human retrovirus, adult T-cell leukemia virus (ATLV) was shown by means of membrane immunofluorescence to bind to various hematopoietic cells including T-, B- and non-T, non-B-cell lines. Partially purified viral gp46 from culture fluids of ATL virus producer lines also bound efficiently to an ATLV-negat...

journal_title：Cancer letters

authors： Yamamoto N,Chosa T,Koyanagi Y,Tochikura T,Schneider J,Hinuma Y

更新日期：1984-01-01 00:00:00

abstract：:Although Apc(Min/+) mice are widely used for an animal model of human familial adenomatous polyposis (FAP), a majority of intestinal polyps locate in the small intestine. We recently reported that numerous beta-catenin-accumulated crypts (BCAC), which are reliable precursor lesions for colonic adenocarcinoma, develop ...

journal_title：Cancer letters

authors： Hata K,Tanaka T,Kohno H,Suzuki R,Qiang SH,Yamada Y,Oyama T,Kuno T,Hirose Y,Hara A,Mori H

更新日期：2006-07-28 00:00:00

abstract：:Matrix metalloproteinases (MMPs) are an homologous family of proteolytic enzymes capable of degrading components of the extracellular matrix (ECM) and thereby facilitating the invasion of tumour cells into normal tissues. The neural cell adhesion molecules (NCAMs) of neuronal and glial cells provide a Ca2+-independent...

journal_title：Cancer letters

authors： Maidment SL,Rucklidge GJ,Rooprai HK,Pilkington GJ

更新日期：1997-06-03 00:00:00

abstract：:YM529, a new third generation bisphosphonate, induced apoptosis of a human breast cancer cell line, MX-1. Cytotoxic activity of YM529 was more potent than that of incadronate. YM529 activated caspase-9, but not caspase-8, and induced the release of cytochrome c into cytosol. YM529 increased Bax expression and decrease...

journal_title：Cancer letters

authors： Nakajima H,Magae J,Tsuruga M,Sakaguchi K,Fujiwara I,Mizuta M,Sawai K,Yamagishi H,Mizuta N

更新日期：2007-08-08 00:00:00

abstract：:We constructed an SV40-derived expression vector containing a mutated albumin minigene of Nagase analbuminemic rats (NAR), and introduced it into cultured cells. Transient expression of the minigene mRNA was determined by RT-PCR. Three kinds of aberrant mRNAs were expressed by the non-hepatic cells COS-1, and the undi...

journal_title：Cancer letters

authors： Sugiyama K,Hitomi Y,Adachi H,Esumi H

更新日期：1994-08-15 00:00:00

abstract：:Therapeutic biomacromolecules are confronted with in vivo challenges of low bio-stability and poor tumor tissue-penetration. Herein, we report for the first time, our development and characterization of a hybrid nanocomposite for delivering a Bcl-2-converting peptide (NuBCP9, N9 hereafter) and testing its efficacy alo...

journal_title：Cancer letters

authors： Xie J,Xu W,Wu Y,Niu B,Zhang X

更新日期：2020-01-28 00:00:00

abstract：:N-ethyl-N-nitrosourea-induced rat gliomas showed a stimulation of cytosolic spermidine N-acetyltransferase activity compared with normal brain, with an increased formation of N1 and N8-acetylspermidine, suggesting the activation of two enzymes acetylating the polyamine in N1 and N8 position, respectively. The enhancem...

journal_title：Cancer letters

authors： Sessa A,Broglia E,Terreni MR,Perin A

更新日期：1994-01-30 00:00:00

abstract：:Of the erythropoietin-producing human hepatocellular receptors (Ephs), EphB4 has recently emerged as a potential target in several cancers due to its roles in modified cell migration and invasion. As little is known about the roles of EphB4 in glioma, we sought to investigate its function in glioma by in vitro cell mi...

journal_title：Cancer letters

authors： Kawahara Y,Furuta T,Sabit H,Tamai S,Dong Y,Jiapaer S,Zhang J,Zhang G,Oishi M,Miyashita K,Hayashi Y,Nakada M

更新日期：2019-05-01 00:00:00