当前位置： SCI文献检索 > CANCER LETTERS期刊下所有文献 > Macrophage migration inhibitory factor promotes breast cancer metastasis via activation of HMGB1/TLR4/NF kappa B axis.

Macrophage migration inhibitory factor promotes breast cancer metastasis via activation of HMGB1/TLR4/NF kappa B axis.

Abstract：

:Macrophage migration inhibitory factor (MIF) is up-regulated in diverse solid tumors and acts as the critical link between immune response and tumorigenesis. In this study, we demonstrated that MIF overexpression promoted migration of breast cancer cells by elevating TLR4 expression. Further investigation evidenced that MIF induced ROS generation. MIF-induced ROS led to ERK phosphorylation, which facilitated HMGB1 release from the nucleus to the cytoplasm. MIF overexpression also induced caveolin-1 phosphorylation. Caveolin-1 phosphorylation contributed to HMGB1 secretion from the cytoplasm to the extracellular matrix. The extracellular HMGB1 activated TLR4 signaling including NF-κB phosphorylation, which was responsible for the transcription of Snail and Twist as well as MMP2 activation. Furthermore, MIF-induced caveolin-1-dependent HMGB1 secretion might control the recruitment of CD11b+ immune cells. Our data suggested that MIF affected the intrinsic properties of tumors and the host immune response in tumor microenvironment by regulating the TLR4/HMGB1 axis, leading to metastasis of breast cancer.

journal_name

Cancer Lett

journal_title

Cancer letters

authors

Lv W,Chen N,Lin Y,Ma H,Ruan Y,Li Z,Li X,Pan X,Tian X

doi

10.1016/j.canlet.2016.02.005

subject

Has Abstract

pub_date

2016-06-01 00:00:00

pages

245-255

issue

2

eissn

0304-3835

issn

1872-7980

pii

S0304-3835(16)30051-9

journal_volume

375

pub_type

杂志文章

相关文献

CANCER LETTERS文献大全
  • Enhanced IkappaB kinase activity is responsible for the augmented activity of NF-kappaB in human head and neck carcinoma cells.

    abstract：:The nuclear transcription factor kappaB (NF-kappaB) plays an important role in the development and progression of cancers. However, the mechanism by which cancer cells in the head and neck region acquire high NF-kappaB activity has not yet been clarified. In this study, we examined the NF-kappaB binding activity and t...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/s0304-3835(01)00611-5

    authors： Tamatani T,Azuma M,Aota K,Yamashita T,Bando T,Sato M

    更新日期：2001-10-10 00:00:00

  • Guggulsterone sensitizes glioblastoma cells to Sonic hedgehog inhibitor SANT-1 induced apoptosis in a Ras/NFκB dependent manner.

    abstract：:Since Shh pathway effector, Gli1, is overexpressed in gliomas, we investigated the effect of novel Shh inhibitor SANT-1 on glioma cell viability. Though SANT-1 failed to induce apoptosis, it reduced proliferation of glioma stem-like cells. Apart from canonical Shh cascade, Gli1 is also induced by non-canonical pathway...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/j.canlet.2013.03.025

    authors： Dixit D,Ghildiyal R,Anto NP,Ghosh S,Sharma V,Sen E

    更新日期：2013-08-19 00:00:00

  • Inhibition of MDR1 gene expression by H-87, a selective inhibitor of cAMP-dependent protein kinase.

    abstract：:N-[2-(p-bromocinnamylmethylamino) ethyl]-5-isoquinolinesulfonamide (H-87), a newly synthesized inhibitor of protein kinase A, significantly decreased the drug resistance of multidrug resistant human U937/M cells, mouse FM3A/M and P388/M cells. Northern blot analysis showed MDR1 gene expression was decreased in H-87-tr...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/0304-3835(93)90041-7

    authors： Kim SH,Park JI,Chung BS,Kang CD,Hidaka H

    更新日期：1993-10-15 00:00:00

  • Thymidylate synthase genotypes and tumour regression in stage II/III rectal cancer patients after neoadjuvant fluorouracil-based chemoradiation.

    abstract：PURPOSE:According to the CAO-/ARO-/AIO-94 trial of the German Rectal Cancer Study Group, pre-operative 5-fluorouracil (5-FU)-based long-term chemoradiotherapy (CT/RT) is recommended for patients with rectal cancer UICC stage II/III. However, despite the local benefit of neoadjuvant treatment, the overall prognostic val...

    journal_title：Cancer letters

    pub_type： 临床试验,杂志文章

    doi：10.1016/j.canlet.2008.07.008

    authors： Stoehlmacher J,Goekkurt E,Mogck U,Aust DE,Kramer M,Baretton GB,Liersch T,Ehninger G,Jakob C

    更新日期：2008-12-18 00:00:00

  • Binding of 1-nitro[14C]pyrene to DNA and protein in cultured lung macrophages and respiratory tissues.

    abstract：:Binding of 1-nitro[14C]pyrene (1-NP) or its metabolites to cellular DNA and protein in cultures of rabbit alveolar macrophages and lung and tracheal tissues was examined. DNA binding was highest in tracheal tissue (136.9 +/- 18.3 pmol 1-NP/mg DNA). DNA binding in macrophages and lung tissue was one-fifth of the level ...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/0304-3835(83)90091-5

    authors： King LC,Jackson M,Ball LM,Lewtas J

    更新日期：1983-07-01 00:00:00

  • Relationship between CD44 expression and differentiation of human prostate adenocarcinomas.

    abstract：:It is well documented that CD44 plays an important role in tumor metastasis. We investigated whether there is a correlation between the expression of its isoforms in prostate cancer cells and patient prognosis using 72 cases with biopsy specimens. Immunohistochemistry demonstrated expression of CD44H (68.1%), v6 (36.1...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/s0304-3835(98)00088-3

    authors： Takahashi S,Kimoto N,Orita S,Cui L,Sakakibara M,Shirai T

    更新日期：1998-07-03 00:00:00

  • Network-based cancer precision medicine: A new emerging paradigm.

    abstract：:The complex interactions in biological systems have been shown to affect the response to single-targeted therapies which were initially developed under the "reductionist paradigm" of cancer precision medicine. To address these fundamental challenges, great efforts have been dedicated from a network perspective to expl...

    journal_title：Cancer letters

    pub_type： 杂志文章,评审

    doi：10.1016/j.canlet.2019.05.015

    authors： Tan A,Huang H,Zhang P,Li S

    更新日期：2019-08-28 00:00:00

  • A novel fully-human cytolytic fusion protein based on granzyme B shows in vitro cytotoxicity and ex vivo binding to solid tumors overexpressing the epidermal growth factor receptor.

    abstract：:Human cytolytic fusion proteins (hCFPs) offer a promising immunotherapeutic approach for the treatment of solid tumors, avoiding the immunogenicity and undesirable side-effects caused by immunotoxins derived from plants or bacteria. The well-characterized human serine protease granzyme B has already been used as a the...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/j.canlet.2016.02.020

    authors： Niesen J,Hehmann-Titt G,Woitok M,Fendel R,Barth S,Fischer R,Stein C

    更新日期：2016-05-01 00:00:00

  • Nuclear expression of hypoxia-inducible factor 1alpha protein is heterogeneous in human malignant cells under normoxic conditions.

    abstract：:Hypoxia-inducible factor 1 (HIF-1) is a heterodimeric transcription factor composed of alpha and beta subunits, which plays an essential role in cancer cell hypoxia adaptation, glycolysis, and angiogenesis. Normally, HIF-1alpha protein, the dominant subunit of HIF-1, is accumulated in nuclei when cells are exposed to ...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/s0304-3835(02)00053-8

    authors： Zhong H,Mabjeesh N,Willard M,Simons J

    更新日期：2002-07-26 00:00:00

  • Activation of reactive oxygen species/AMP activated protein kinase signaling mediates fisetin-induced apoptosis in multiple myeloma U266 cells.

    abstract：:We investigated the molecular mechanisms responsible for fisetin-induced apoptosis in U266 cells. Fisetin elicited the cytotoxicity in U266 cells, manifested as an increased fraction of the cells with sub-G1 content or stained positively with TUNEL labeling. Fisetin enhanced caspase-3 activation, downregulation of Bcl...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/j.canlet.2012.01.008

    authors： Jang KY,Jeong SJ,Kim SH,Jung JH,Kim JH,Koh W,Chen CY,Kim SH

    更新日期：2012-06-28 00:00:00

  • Activation of fibronectin/PI-3K/Akt2 leads to chemoresistance to docetaxel by regulating survivin protein expression in ovarian and breast cancer cells.

    abstract：:The purpose of this study was to investigate the possible role of PI-3K/Akt2 pathway in docetaxel-induced apoptosis. Here we showed that transfection of full-length Akt2 into breast and ovarian cancer cells could provoke Akt phosphorylation and induce an enhanced resistance to docetaxel. FN adhesion promoted Akt phosp...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/j.canlet.2007.11.022

    authors： Xing H,Weng D,Chen G,Tao W,Zhu T,Yang X,Meng L,Wang S,Lu Y,Ma D

    更新日期：2008-03-08 00:00:00

  • Cells of origin and tumor-initiating cells for nonmelanoma skin cancers.

    abstract：:The epidermis of the skin is a multilayered stratified epithelium whose primary function is to provide a barrier against our external environment. As a result, cells in the epidermis are subject to constant assault from environmental pathogens, many of which can cause deleterious mutations. However, most of these muta...

    journal_title：Cancer letters

    pub_type： 杂志文章,评审

    doi：10.1016/j.canlet.2012.05.008

    authors： Thieu K,Ruiz ME,Owens DM

    更新日期：2013-09-10 00:00:00

  • Increased sensitivity to indomethacin of mice bearing the BCL1-leukemia.

    abstract：:Indomethacin is a non-steroidal anti-inflammatory agent that inhibits prostaglandin synthesis. Administration of indomethacin, in doses which were non-toxic to normal BALB/c mice, to mice bearing the BCL1 leukemia resulted in increased mortality of these animals. This effect was only observed if the indomethacin was a...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/0304-3835(84)90147-2

    authors： Hart DA

    更新日期：1984-06-01 00:00:00

  • The tumor suppressor CDX2 opposes pro-metastatic biomechanical modifications of colon cancer cells through organization of the actin cytoskeleton.

    abstract：:The vast majority of cancer deaths are caused by the formation of metastases rather than the primary tumor itself. Despite this clinical importance, the molecular and cellular events that support the dissemination of cancer cells are not yet fully unraveled. We have previously shown that CDX2, a homeotic transcription...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/j.canlet.2016.10.040

    authors： Platet N,Hinkel I,Richert L,Murdamoothoo D,Moufok-Sadoun A,Vanier M,Lavalle P,Gaiddon C,Vautier D,Freund JN,Gross I

    更新日期：2017-02-01 00:00:00

  • Targeting the p53-MDM2 pathway for neuroblastoma therapy: Rays of hope.

    abstract：:Despite being the subject of extensive research and clinical trials, neuroblastoma remains a major therapeutic challenge in pediatric oncology. The p53 protein is a central safeguard that protects cells against genome instability and malignant transformation. Mutated TP53 (the gene encoding p53) is implicated in many ...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/j.canlet.2020.09.023

    authors： Zafar A,Wang W,Liu G,Xian W,McKeon F,Zhou J,Zhang R

    更新日期：2021-01-01 00:00:00

  • Regulat-INGs in tumors and diseases: Focus on ncRNAs.

    abstract：:ING family genes (Inhibitor of Growth) are tumor suppressor genes that play a vital role in cell homeostasis. It has been shown that their expression is lost or diminished in many cancers and other diseases. The main mechanisms by which they are regulated in oncogenesis have not yet been fully elucidated. The involvem...

    journal_title：Cancer letters

    pub_type： 杂志文章,评审

    doi：10.1016/j.canlet.2019.01.006

    authors： Gournay M,Paineau M,Archambeau J,Pedeux R

    更新日期：2019-04-10 00:00:00

  • Effect of the length of alkyl chain on the cytochrome P450 dependent metabolism of N-diakylnitrosamines.

    abstract：:Liver microsomes from control and treated rats (P4501A, 2B, 2E1-induced) metabolize at variable metabolic rates eight N-nitroso-di-n-alkylamines, including five symmetrical (N-nitroso-dimethyl, -diethyl, -dipropyl, -dibutyl and -diamyl-amines) and four asymmetrical (N-nitrosomethylethyl, methylpropyl, methylbutyl, and...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/0304-3835(95)04078-1

    authors： Bellec G,Goasduff T,Dreano Y,Menez JF,Berthou F

    更新日期：1996-02-27 00:00:00

  • Ten recently identified associations between nsSNPs and colorectal cancer could not be replicated in German families.

    abstract：:Ten non-synonymous single nucleotide polymorphisms (nsSNPs), which were recently associated with colorectal cancer risk in a comprehensive, array based study (AKAP9 M463I, DKK3 G335R, AMPD1 Q12X, LIPC L356F, PSMB9 V32I, THBS1 N700S, CA6 S90G, ASCC3 C1995S, DHX36 S416C and CPA4 G303C) were re-evaluated in the present s...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/j.canlet.2008.05.043

    authors： Frank B,Burwinkel B,Bermejo JL,Försti A,Hemminki K,Houlston R,Mangold E,Rahner N,Friedl W,Friedrichs N,Buettner R,Engel C,Loeffler M,Holinski-Feder E,Morak M,Keller G,Schackert HK,Krüger S,Goecke T,Moeslein G,Kloo

    更新日期：2008-11-18 00:00:00

  • Comparative metabolism and macromolecular binding of benzo[a]pyrene in explant cultures of human bladder, skin, bronchus and esophagus from eight individuals.

    abstract：:Benzo[a]pyrene (B[a]P) metabolism and macromolecular binding have been studied in explants from 4 tissues, bladder, skin, bronchus and esophagus from 8 donors sampled within 4 h after death. Explants were incubated with [3H]benzo[a]pyrene for 24 h, then the metabolites extracted and analyzed by high-pressure liquid ch...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/0304-3835(83)90112-x

    authors： Selkirk JK,Nikbakht A,Stoner GD

    更新日期：1983-02-01 00:00:00

  • Activation of N-nitrosobis(2-oxopropyl)amine by liver and nasal mucosa tissue from intact and castrated male rats.

    abstract：:Methylation of liver and nasal mucosal DNA at the O6 position of guanine (O6-MeG) was measured in intact and castrated male rats after a dose of N-nitrosobis(2-oxopropyl)amine (BOP) (20 mg/kg; i.p.). There were no differences in O6-MeG persistence in liver DNA from either group. In the nasal mucosa more O6-MeG was det...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/0304-3835(90)90008-l

    authors： Lawson TA

    更新日期：1990-08-01 00:00:00

  • MUC16 C terminal-induced secretion of tumor-derived IL-6 contributes to tumor-associated Treg enrichment in pancreatic cancer.

    abstract：:Pancreatic cancer is the most lethal tumor. CA125 (gene symbol MUC16) is an important serum marker for pancreatic cancer diagnosis and treatment. High serum CA125 is related to metabolic tumor burden and poor prognosis. The circulating Treg subset is another independent prognostic factor for pancreatic cancer. Our unp...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/j.canlet.2018.01.017

    authors： Fan K,Yang C,Fan Z,Huang Q,Zhang Y,Cheng H,Jin K,Lu Y,Wang Z,Luo G,Yu X,Liu C

    更新日期：2018-04-01 00:00:00

  • Chemoprevention studies of heterocyclic amine-induced colon carcinogenesis.

    abstract：:The cooking of meat and fish produces heterocyclic amine mutagens, including 2-amino-1-methyl-6-phenylimidazo[4,5b]pyridine (PhIP) and 2-amino-3-methylimidazo[4,5-f]quinoline (IQ). Chronic administration of PhIP or IQ to the F344 rat induces tumors at several sites, including adenocarcinomas of the colon, and short-te...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/s0304-3835(99)00121-4

    authors： Xu M,Dashwood RH

    更新日期：1999-09-01 00:00:00

  • Caveolins in the development and diseases of musculoskeletal system.

    abstract：:Caveolins, essential scaffold proteins of caveolae, have emerged as versatile molecules that can influence numerous signaling pathways and disease processes. This brief review is focused on the role of caveolins in the physiology and pathology of musculoskeletal system and will discuss the key features of caveolins as...

    journal_title：Cancer letters

    pub_type： 杂志文章,评审

    doi：10.1016/j.canlet.2009.02.016

    authors： Serra M,Scotlandi K

    更新日期：2009-11-01 00:00:00

  • Induction of rat liver gamma-glutamyltranspeptidase-positive foci by oral administration of 1-nitropyrene.

    abstract：:In the present study, the question of whether the ubiquitous environmental pollutant, 1-nitropyrene (1-NP), can induce gamma-glutamyltranspeptidase (GGT)-positive foci, an early lesion occurring during hepatocarcinogenesis, when given orally to F344 rats was examined. Significant induction of GGT-positive foci was obs...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/0304-3835(89)90031-1

    authors： Denda A,Tsutsumi M,Tsujiuchi T,Eimoto H,Konishi Y,Sato S

    更新日期：1989-04-01 00:00:00

  • Molecular co-expression of the c-Met oncogene and hepatocyte growth factor in primary colon cancer predicts tumor stage and clinical outcome.

    abstract：INTRODUCTION/HYPOTHESIS:Over-expression of the c-Met receptor tyrosine kinase has been described in a variety of cancers and implicated in tumor progression. Unlike some solid tumors, current evidence indicates that c-Met activation in colon cancer is unrelated to gene mutation, is ligand dependent, and occurs via a pa...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/j.canlet.2006.07.007

    authors： Kammula US,Kuntz EJ,Francone TD,Zeng Z,Shia J,Landmann RG,Paty PB,Weiser MR

    更新日期：2007-04-18 00:00:00

  • Distinct mechanisms for opposite functions of homeoproteins Cdx2 and HoxB7 in double-strand break DNA repair in colon cancer cells.

    abstract：:Homeobox genes, involved in embryonic development and tissues homeostasis in adults, are often deregulated in cancer, but their relevance in pathology is far from being fully elucidated. In colon cancers, we report that the homeoproteins HoxB7 and Cdx2 exhibit different heterogeneous patterns, Cdx2 being localized in ...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/j.canlet.2016.02.026

    authors： Soret C,Martin E,Duluc I,Dantzer F,Vanier M,Gross I,Freund JN,Domon-Dell C

    更新日期：2016-05-01 00:00:00

  • Tumor initiating activities of 1-nitropyrene and its nitrated products in SENCAR mice.

    abstract：:The environmental mutagens, 1-nitropyrene, 1,3-dinitropyrene, 1,6-dinitropyrene and 1,8-dinitropyrene were evaluated for their ability to initiate skin tumors in male and female SENCAR mice. 1-Nitropyrene (greater than 99.5% purity) did not induce papilloma formation over a dose range of 0-3.0 mg/mouse after 30 weeks ...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/0304-3835(84)90055-7

    authors： Nesnow S,Triplett LL,Slaga TJ

    更新日期：1984-05-01 00:00:00

  • Adaptations of energy metabolism during cerebellar neurogenesis are co-opted in medulloblastoma.

    abstract：:Recent studies show that metabolic patterns typical of cancer cells, including aerobic glycolysis and increased lipogenesis, are not unique to malignancy, but rather originate in physiologic development. In the postnatal brain, where sufficient oxygen for energy metabolism is scrupulously maintained, neural progenitor...

    journal_title：Cancer letters

    pub_type： 杂志文章,评审

    doi：10.1016/j.canlet.2014.02.017

    authors： Tech K,Deshmukh M,Gershon TR

    更新日期：2015-01-28 00:00:00

  • Induction of apoptosis in human lymphocytes treated with Viscum album L. is mediated by the mistletoe lectins.

    abstract：:Viscum album L. (VAL) is a phytopreparation used in adjuvant cancer therapy with both immunostimulatory and DNA stabilizing properties at low drug concentrations and cytostatic/cytotoxic properties at higher concentrations. The present work examines the cytotoxic effects of VAL extracts produced from mistletoes grown ...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/0304-3835(95)04038-2

    authors： Büssing A,Suzart K,Bergmann J,Pfüller U,Schietzel M,Schweizer K

    更新日期：1996-01-19 00:00:00

  • Inhibition of NMU-induced mammary tumorigenesis by dietary soy.

    abstract：:We previously demonstrated that female Sprague-Dawley rats fed AIN-93G diets containing soy protein isolate (SPI+) had lower DMBA-induced mammary tumor incidence than those fed diets containing casein (CAS), due partly to altered Phase I metabolism with soy. Here, we evaluated the tumor protective effects of these sam...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/j.canlet.2004.11.009

    authors： Simmen RC,Eason RR,Till SR,Chatman L Jr,Velarde MC,Geng Y,Korourian S,Badger TM

    更新日期：2005-06-16 00:00:00