Abstract：
:Benzo[a]pyrene (B[a]P) metabolism and macromolecular binding have been studied in explants from 4 tissues, bladder, skin, bronchus and esophagus from 8 donors sampled within 4 h after death. Explants were incubated with [3H]benzo[a]pyrene for 24 h, then the metabolites extracted and analyzed by high-pressure liquid chromatography. Fibroblasts were grown from explants from 2 patients and also incubated with B[a]P. Metabolite profiles were qualitatively the same for explants and fibroblasts with similar product ratios, although fibroblasts were less active in B[a]P metabolism. DNA binding studies showed a broad variance between patients and tissues with the relative distribution being widest in bladder, followed by skin, bronchus and esophagus, respectively.
journal_name
Cancer Lettjournal_title
Cancer lettersauthors
Selkirk JK,Nikbakht A,Stoner GDdoi
10.1016/0304-3835(83)90112-xsubject
Has Abstractpub_date
1983-02-01 00:00:00pages
11-9issue
1eissn
0304-3835issn
1872-7980pii
0304-3835(83)90112-Xjournal_volume
18pub_type
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