Abstract：
:The ability to recognize and respond to universal molecular patterns on invading microorganisms allows our immune system to stay on high alert, sensing danger to our self-integrity. Our own damaged cells and tissues in pathological situations activate similar warning systems as microbes. In this way, the body is able to mount a response that is appropriate to the danger. Toll-like receptors are at the heart of this pattern recognition system that initiates innate pro-oxidant, pro-inflammatory signaling cascades and ultimately bridges recognition of danger to adaptive immunity. The acute inflammatory lesions that are formed segue into resolution of inflammation, repair and healing or, more dysfunctionally, into chronic inflammation, autoimmunity, excessive tissue damage and carcinogenesis. Redox is at the nexus of this decision making process and is the point at which ionizing radiation initially intercepts to trigger similar responses to self-damage. In this review we discuss our current understanding of how radiation-damaged cells interact with Toll-like receptors and how the immune systems interprets these radiation-induced danger signals in the context of whole-body exposures and during local tumor irradiation.
journal_name
Cancer Lettjournal_title
Cancer lettersauthors
Ratikan JA,Micewicz ED,Xie MW,Schaue Ddoi
10.1016/j.canlet.2015.03.031subject
Has Abstractpub_date
2015-11-28 00:00:00pages
238-45issue
2eissn
0304-3835issn
1872-7980pii
S0304-3835(15)00223-2journal_volume
368pub_type
杂志文章,评审相关文献
CANCER LETTERS文献大全abstract：:Neuroendocrine (carcinoid) tumours of the thymus are rare neoplasms characterized by a highly malignant clinical behavior. Some of these tumors are associated with MEN1. In this study we evaluated 10 cases of sporadic thymic neuroendocrine tumours using immunohistochemistry and comparative genomic hybridization (CGH)....
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2004.10.027
更新日期：2005-06-01 00:00:00
abstract：:We investigated whether the level of bone marrow-derived progenitor cells and mature endothelial cells could be used as predictors of clinical outcome in patients receiving taxotere-based chemotherapy for advanced gastric cancer. Peripheral blood mononuclear cells were obtained from 49 gastric cancer patients who rece...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2008.05.011
更新日期：2008-11-08 00:00:00
abstract：:Azelaic acid has been shown to inhibit thioredoxin reductase (TR) at the surface of guinea pig and human skin, on cultures of human keratinocytes, melanocytes, melanoma cells, murine melanoma cells (Cloudman S91), and on purified enzymes from Escherichia coli, rat liver, and human melanoma. Human melanoma cells are mo...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/0304-3835(87)90023-1
更新日期：1987-09-01 00:00:00
abstract：:The porphyrin content of cells labelled with hematoporhyrin derivative (Hpd) and tumours of mice injected with Hpd was analysed by means of high pressure liquid chromatography (HPLC). The components of Hpd may be classified in 3 groups: (A) Components with a high fluorescence quantum yield and with sharp peaks in the ...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/0304-3835(83)90204-5
更新日期：1983-12-01 00:00:00
abstract：:We describe an optimized systematic screen of known kinases using osteosarcoma cell lines (KHOS and U-2OS) and a lentiviral-based short hairpin RNA (shRNA) human kinase library. CellTiter 96(R)AQueous One Solution Cell Proliferation Assay was used to measure cell growth and survival. We identified several kinases, inc...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2010.01.014
更新日期：2010-07-28 00:00:00
abstract：:Current limitation in cancer genomic studies is a lack of the integration of various omics data generated through next generation sequencing technologies, as well as a lack of the sounding and comprehensive epigenomic and genomic information about a particular cancer cell type. In this review, we will discuss main asp...
journal_title：Cancer letters
pub_type： 杂志文章,评审
doi：10.1016/j.canlet.2012.11.033
更新日期：2013-11-01 00:00:00
abstract：:Four glycoglycerolipid analogues, 1-O-hexanoyl-2-O-beta-D-glucopyranosyl-sn-glycerol (1), 1-O-hexanoyl-2-O-beta-D-galactopyranosyl-sn-glycerol (2), 2-O-(6-O-hexanoyl-beta-D-galactopyranosyl)-sn-glycerol (3) and 2-O-(6-O-hexanoyl-alpha-D-galactopyranosyl)-sn-glycerol (4), potent in vitro inhibitors of 12-O-tetradecanoy...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/s0304-3835(00)00610-8
更新日期：2000-12-20 00:00:00
abstract：:The effects of different sources of dietary protein, fat and carbohydrate on tumor development and on tests relating to cell-mediated immunity were investigated in male BALB/c mice after subcutaneous injection of 8 X 10(4) 1,2-dimethylhydrazine (DMH)-induced colon tumor (no. 51) cells. Results indicated that mice fed ...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/0304-3835(83)90117-9
更新日期：1983-02-01 00:00:00
abstract：:2-Amino-1-methyl-6-phenylimidazo[4,5-b]-pyridine (PhIP) is known to induce colon tumors in male Fischer-344 rats. Using 32P-postlabeling assays, we have examined PhIP-DNA adduct formation in various organs and white blood cells (WBCs) of the male Fischer-344 rat 24 h after a single oral dose of 0, 0.5, 5 or 50 mg PhIP...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/0304-3835(92)90134-h
更新日期：1992-12-24 00:00:00
abstract：:For biochemical modulation, components of green tea have been shown to be useful modulators in combination with doxorubicin (DOX). We have confirmed that theanine enhances the antitumor activity of DOX due to inhibition of DOX efflux from tumor cells. Because theanine is a glutamate analogue, we found that it is assoc...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/s0304-3835(02)00012-5
更新日期：2002-05-28 00:00:00
abstract：:Rituximab is the first anti-cancer antibody approved by the FDA for the treatment of B-cell lymphoma. However, its efficacy remains variable and often modest. Some patients are initially unresponsive to rituximab or later develop resistance to it, and require alternative therapies. Rituximab activity has been thought ...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2010.01.023
更新日期：2010-08-01 00:00:00
abstract：:Aristolochic acid (AA), a naturally occurring nephrotoxin and carcinogen, has been associated with the development of urothelial cancer in humans. Using the 32P-postlabeling assay we showed that AAI is activated by human recombinant cytochrome P450 (CYP) 1A1, CYP1A2 and NADPH:CYP reductase to species generating DNA ad...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2005.06.038
更新日期：2005-11-18 00:00:00
abstract：:Loss of radioactivity from nude mice was determined after inoculation of human tumor cells prelabeled with [111In]indium oxine (111InOx). Elimination of 111In was increased somewhat by treating the mice with diphtheria toxin (DT), which is toxic selectively for human cells compared to mice. Calcium disodium edetate (C...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/0304-3835(84)90134-4
更新日期：1984-09-01 00:00:00
abstract：:Amplification and overexpression of PPM1D (protein phosphatase magnesium-dependent 1 delta) has been observed in various cancer cell lines and primary tumors and has also been associated with cancers of poor prognosis. In addition to the negative feedback regulation of p38-p53 signaling, PPM1D inhibits other tumor sup...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2007.09.019
更新日期：2008-01-18 00:00:00
abstract：:AGR2 has evolutionarily conserved roles in development and tissue regeneration and is linked with several human cancers. The exact functions and regulation of AGR2 are poorly understood, but current data identify AGR2 as a clinically relevant factor that modulates the behavior and response of hormone-dependent cancers...
journal_title：Cancer letters
pub_type： 杂志文章,评审
doi：10.1016/j.canlet.2010.12.023
更新日期：2011-05-01 00:00:00
abstract：:Chlorophyllin (CHL), a water-soluble derivative of chlorophyll, has been used for the treatment of several abnormal human conditions without apparent toxicity. Recent studies have revealed that CHL has the excellent chemopreventive potential. In the present investigation, we have found the inhibitory activities of CHL...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/s0304-3835(99)00229-3
更新日期：1999-10-18 00:00:00
abstract：:Twenty-seven patients with malignant teratoma, 19 of which received radiation, are presented and the radiation response analyzed. Radiotherapy seems most effective in the palliation of undifferentiated (embryonal) teratoma of the gonads and sacrococcygeal region in early childhood. It is less effective, yet useful, in...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/s0304-3835(75)95697-9
更新日期：1975-11-01 00:00:00
abstract：:In this report we demonstrated that [3H]suramin enters polarized human colon adenocarcinoma cells when added to the apical side of the monolayer. Using light microscopic quantitative autoradiography, we showed that suramin was accumulated in the apical cytoplasm and in the nucleus. In contrast, a weak labeling was not...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/0304-3835(93)90057-g
更新日期：1993-12-20 00:00:00
abstract：:Current in vivo investigations of tumor angiogenesis mainly rely on the results obtained from engrafted models in mice. In the present study, we attempt to assess the potential of human tumor endothelium to form neovasculature in different engrafted tumor models. The tumor endothelial cells were isolated from human es...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2006.12.015
更新日期：2007-07-08 00:00:00
abstract：:Medulloblastoma (MB) is the most frequent malignant brain tumour in children with a poor outcome. Divided into four molecular subgroups, MB of the Sonic hedgehog (SHH) subgroup accounts for approximately 25% of the cases and is driven by mutations within components of the SHH pathway, such as its receptors PTCH1 or SM...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2020.02.028
更新日期：2020-05-01 00:00:00
abstract：:Antibodies directed against the L1 cell adhesion protein inhibit growth of SKOV3ip human ovarian cancer cells in vitro and in vivo. Responses of SKOV3ip cells in vitro to anti-L1 mAb chCE7 and Genistein were investigated. Genistein potentiated the anti-proliferative and pro-apoptotic effects of chCE7 in SKOV3ip cells....
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2007.11.012
更新日期：2008-03-18 00:00:00
abstract：:Toxicity reduction of cisplatin is necessary for improved treatment of cancer. Here we have demonstrated the synergistic growth-inhibitory effect of cisplatin on cervical cancer cells in-combination with a nontoxic herbal carbazole alkaloid, mahanine. Mahanine enhanced cisplatin-induced apoptosis and reduced its effec...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2014.05.005
更新日期：2014-08-28 00:00:00
abstract：:Breast fluid which bathes the mammary ductal epithelium may contain tumorogenic components. In view of the number of tobacco components inhaled during smoking, it was of interest whether nicotine and its metabolites were present in this fluid. Fluid was obtained from the nipple from menstruating women who were smokers...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/s0304-3835(79)80042-7
更新日期：1979-04-01 00:00:00
abstract：:Pancreatic ductal adenocarcinoma (PDAC) is highly aggressive disease and current treatment regimens fail to effectively cure PDAC. Development of resistance to current therapy is one of the key reasons for this outcome. Nimbolide (NL), a triterpenoid obtained from Azadirachta indica, exhibits anticancer properties in ...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2017.10.029
更新日期：2018-01-28 00:00:00
abstract：:Standard chemotherapy for pancreatic ductal adenocarcinoma (PDAC), nab-paclitaxel (NPT) plus gemcitabine (Gem), has led to an average survival of 8.5 months. Presently, no therapeutics exist that effectively target the KRAS oncogene, activated in 95% of PDACs, but alternative strategies focus on inhibition of downstre...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2019.05.037
更新日期：2019-09-10 00:00:00
abstract：:Endothelin-1 (ET-1) is a potent vasoconstrictor that has been shown to significantly impact many benign and malignant tissues by signaling through its two cognate receptors: ET(A) and ET(B). As ET-1 has a role in both normal and diseased kidney, we initiated studies to investigate endothelin axis expression and functi...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2006.02.007
更新日期：2007-02-08 00:00:00
abstract：:We present the data of 105 serum samples from 20 patients suffering from cervical cancer. Mean serum levels of basic fibroblast growth factor (bFGF) in patients with or without tumor present were 31.3 +/- 32.1 (minimum 0, maximum 156.7) pg/ml and 4.8 +/- 6.8 (minimum 0, maximum 29.6) pg/ml, respectively (P = 0.0001). ...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/0304-3835(95)03853-o
更新日期：1995-08-01 00:00:00
abstract：:The effect of ligation of the left ureter on the development of lesions in the urinary bladder were investigated in male F344 rats treated with 0.05% N-butyl-N-(4-hydroxybutyl)-nitrosamine (BBN) for 2 weeks followed by 0.002% N-ethyl-N-(4-hydroxybutyl)nitrosamine (EHBN) for 10 or 22 weeks. The lesions of the urinary b...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/0304-3835(84)90093-4
更新日期：1984-07-01 00:00:00
abstract：:The hypoxic microenvironment is well-characterized in hepatocellular carcinoma (HCC). Delineation of hypoxia-responsive events is an integral part to understand the pathogenesis of HCC. We studied the functional role and clinical relevance of Stanniocalcin 1 (STC1), a hypoxia-induced molecular target, in HCC. In our c...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2017.06.034
更新日期：2017-09-10 00:00:00
abstract：:Although overall mortality rate of prostate cancer (PCa) declines in recent years, castration-resistant prostate cancer (CRPC) remains incurable. Clinical evidence indicates that CRPC recurred from hormonal therapy exhibits neuroendocrine differentiated (NED) phenotypes, which could contribute to therapeutic resistanc...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2017.01.018
更新日期：2017-04-10 00:00:00
