Anti-tumor-promoting effects of glycoglycerolipid analogues on two-stage mouse skin carcinogenesis.

abstract：:The etiology of prostatic adenocarcinoma remains unclear. Prostate cancer cells of varying metastatic potential and apoptotic resistance show altered expression of plasma membrane ion channels and unbalanced Ca2+ homeostasis. Ca(2+)-activated Cl(-) channels (CaCCs) are robustly expressed in epithelial cells and functi...

journal_title：Cancer letters

authors： Liu W,Lu M,Liu B,Huang Y,Wang K

更新日期：2012-12-29 00:00:00

abstract：:To investigate whether particular patterns of food consumption are related to the occurrence of breast and colon cancer, two simultaneous case-control studies of French-Canadians with 616 cases (414 breast cancer, 202 colon cancer) and 429 population-based controls were carried out. Food consumption data were obtained...

journal_title：Cancer letters

authors： Nkondjock A,Ghadirian P

更新日期：2005-06-01 00:00:00

abstract：:The regulation of MYC-regulated long non-coding RNAs has been reported to contribute to certain types of cancers. However, the role of MYC-induced long non-coding RNA (MINCR) in the tumorigenesis of gallbladder cancer (GBC) is still largely unknown. In this study, we discovered that MINCR was markedly upregulated in G...

journal_title：Cancer letters

authors： Wang SH,Yang Y,Wu XC,Zhang MD,Weng MZ,Zhou D,Wang JD,Quan ZW

更新日期：2016-09-28 00:00:00

abstract：:Cancer cells often exhibit altered epigenetic signatures that can misregulate genes involved in processes such as transcription, proliferation, apoptosis and DNA repair. As regulation of chromatin structure is crucial for DNA repair processes, and both DNA repair and epigenetic controls are deregulated in many cancers...

journal_title：Cancer letters

authors： Agarwal P,Jackson SP

更新日期：2016-10-01 00:00:00

abstract：:Metastasis remains a formidable problem in malignant tumors. In this study, MTT assay revealed that 4-methyl-3-nitro-benzoic acid (MNBA) had no effect on cell viability and did not interfere with cell cycle in any breast cancer cell lines tested. However, treatment with MNBA on breast cancer cells can inhibit EGF-indu...

journal_title：Cancer letters

authors： Guo H,Li M,Chen P,Blake DJ,Kong X,Hao X,Niu R,Zhang N

更新日期：2011-06-01 00:00:00

abstract：:Activation of the cytoplasmic (Ras-Raf-MEK-ERK) signaling cascade was shown to be both, necessary and sufficient for transformation in vitro as well as in vivo. However, over the last years the involvement of stress-activated protein kinases (SAPKs)/Jun N-terminal kinases (JNKs), and their substrate c-Jun in the proce...

journal_title：Cancer letters

authors： Rennefahrt U,Illert B,Greiner A,Rapp UR,Troppmair J

更新日期：2004-11-08 00:00:00

abstract：:Mouse mammary tumor viruses (MMTV) replicate in the mammary gland, appear as infectious particles in mother's milk and invade the sucking pups from the intestinal tract. The immune system is essential for MMTV in the gut to reach the mammary gland. These properties make the life cycle of MMTV unique. We review the onc...

journal_title：Cancer letters

authors： Matsuzawa A,Nakano H,Yoshimoto T,Sayama K

更新日期：1995-03-23 00:00:00

abstract：:Lysophosphatidic acid (LPA) receptors including LPA(1), LPA(2), and LPA(3) mediate lysophosphatidic acid signals. We analyzed the expression of LPA receptors, vascular endothelial growth factor (VEGF), and interleukin-8 in 97 patients from normal ovary to ovarian cancer, using reverse transcription polymerase chain re...

journal_title：Cancer letters

authors： Fujita T,Miyamoto S,Onoyama I,Sonoda K,Mekada E,Nakano H

更新日期：2003-03-31 00:00:00

abstract：:Well-differentiated liposarcomas (WDLPS) and dedifferentiated liposarcomas are cytogenetically characterized by the presence of supernumerary ring or giant chromosomes containing amplified material from the 12q14-15 region. These chromosomes contain neocentromeres, which are able to bind the kinetochore proteins and t...

journal_title：Cancer letters

authors： Italiano A,Maire G,Sirvent N,Nuin PA,Keslair F,Foa C,Louis C,Aurias A,Pedeutour F

更新日期：2009-01-18 00:00:00

abstract：:Experiments were conducted to determine whether gamma-ray-induced genetic damage in parental rats can lead to the development of cancer in their offspring rats using glutathione S-transferase-positive (GST-P+) hepatic foci with or without the addition of diethylnitrosamine (DEN), a carcinogen. A single 1 Gy whole-body...

journal_title：Cancer letters

authors： Lee YS,Lee MJ,Lee MS,Lee JH,Kim TH,Jang JJ

更新日期：1998-10-23 00:00:00

abstract：:In order to search for the direct evidence of cellular response to low-dose radiation, we investigated wild-type p53 protein accumulation in several organs of mice after exposure to low doses of X-rays. Significant p53 accumulation within 24 h was observed in the mouse adrenal glands and pancreas after X-ray irradiati...

journal_title：Cancer letters

authors： Wang X,Matsumoto H,Takahashi A,Nakano T,Okaichi K,Ihara M,Ohnishi T

更新日期：1996-06-24 00:00:00

abstract：:Modern protocols of concomitant chemo/radiotherapy provide a very effective strategy to treat certain types of tumors. High-linear energy transfer (LET) radiations, on the other hand, have an increased efficacy against cancer with low radiosensibility and critical localization. We previously reported that oxaliplatin,...

journal_title：Cancer letters

authors： Benzina S,Altmeyer A,Malek F,Dufour P,Denis JM,Gueulette J,Bischoff P

更新日期：2008-06-08 00:00:00

abstract：:This study investigated the role of miR-206 in estrogen receptor-α (ERα)-positive endometrial endometrioid adenocarcinoma (EEC). We profiled miR-206 expression in 30 EEC clinical samples using qRT-PCR, and explored its relationship with ERα and clinical parameters. A luciferase reporter assay assessed the ERα targetin...

journal_title：Cancer letters

authors： Chen X,Yan Q,Li S,Zhou L,Yang H,Yang Y,Liu X,Wan X

更新日期：2012-01-01 00:00:00

abstract：:The involvement of beta-catenin gene alterations in pancreatic duct carcinogenesis induced by N-nitrosobis(2-oxopropyl)amine (BOP) in hamsters was examined by polymerase chain reaction-single strand conformation polymorphism analysis and the expression of beta-catenin protein was examined by immunohistochemistry. No m...

journal_title：Cancer letters

authors： Kubozoe T,Tsujiuchi T,Murata N,Sasaki Y,Tsunoda T,Konishi Y,Tsutsumi M

更新日期：2001-07-10 00:00:00

abstract：:Serial determinations of urinary biopterin were performed in rats during the development of lung tumors induced by radon inhalation and 5,6-benzonaphtoflavone administration. A striking increase in biopterin levels was observed in animals which developed single or multiple epidermoid carcinoma of the lung and this inc...

journal_title：Cancer letters

authors： Mura P,Morlier JP,Barriere M,Bredon P,Papet Y,Chameaud J

更新日期：1990-10-08 00:00:00

abstract：:The treatment of HeLa cells with different concentrations of adriamycin (0, 5, 10, 25, 50 and 100 microg/ml) resulted in a significant and dose-dependent decline in the cell survival. Conversely, the frequency of micronuclei increased in a concentration-dependent manner. The micronuclei-induction and cell survival wer...

journal_title：Cancer letters

authors： Jagetia GC,Nayak V

更新日期：1996-12-20 00:00:00

abstract：:Green tea components exert many biological effects, including antitumor and cancer preventive activities. In the search for anticancer agents for prostate cancer the inhibitory effects of green tea components were tested on the prostate cancer cell lines LNCaP, PC-3 and DU145. (-)-Epigallocatechin-3-gallate (EGCG) pro...

journal_title：Cancer letters

authors： Paschka AG,Butler R,Young CY

更新日期：1998-08-14 00:00:00

abstract：:To date, dozens of melanoma-associated antigens (MAGE) have been identified. Based on the differences in tissue-specific gene expression and gene structure, the MAGE family has been divided into two big subfamilies: MAGE-I and MAGE-II. MAGE-I genes were identified as a group of highly attractive targets for cancer imm...

journal_title：Cancer letters

authors： Sang M,Wang L,Ding C,Zhou X,Wang B,Wang L,Lian Y,Shan B

更新日期：2011-03-28 00:00:00

abstract：:The family of cyclin-dependent kinase complexes (Cdks) are well known for their role in the cell division cycle. What is less well known, however, is that Cdks also participate in a subset of apoptosis programs. Evidence for the role of Cdks in apoptosis comes from a variety of experimental approaches, including studi...

journal_title：Cancer letters

authors： Golsteyn RM

更新日期：2005-01-20 00:00:00

abstract：:In experimental trials using the N-nitroso-N-methylurea (NMU)-induced rat mammary tumor model, a significant decrease in tumor incidence (to 5%) was observed in rats treated with melatonin and 9-cis-retinoic acid (9 cRA) compared to controls (55%). Although 9cRA alone decreased tumor incidence to 26%, this response di...

journal_title：Cancer letters

authors： Teplitzky SR,Kiefer TL,Cheng Q,Dwivedi PD,Moroz K,Myers L,Anderson MB,Collins A,Dai J,Yuan L,Spriggs LL,Blask DE,Hill SM

更新日期：2001-07-26 00:00:00

abstract：:Neural stem cells (NSCs) led to the development of a novel strategy for delivering therapeutic genes to tumors. NSCs expressing rabbit carboxyl esterase (F3.CE), which activates CPT-11, significantly inhibited the growth of MDA-MB-435 cells in the presence of CPT-11. F3.CE cells migrated selectively into the brain met...

journal_title：Cancer letters

authors： Seol HJ,Jin J,Seong DH,Joo KM,Kang W,Yang H,Kim J,Shin CS,Kim Y,Kim KH,Kong DS,Lee JI,Aboody KS,Lee HJ,Kim SU,Nam DH

更新日期：2011-12-08 00:00:00

abstract：:Caffeine may very well be the most frequently ingested neuroactive drug in the world. Mechanistically, caffeine has been reported to affect cell cycle function, induce programmed cell death or apoptosis and perturb key cell cycle regulatory proteins. Although the effects of caffeine have been heavily investigated, muc...

journal_title：Cancer letters

authors： Bode AM,Dong Z

更新日期：2007-03-08 00:00:00

abstract：:Epidermal growth factor receptor (EGFR) is highly expressed in many human tumors including hepatocellular carcinoma (HCC). Therefore, inhibition of EGF receptors could be a potential target for anticancer therapy. In this study, we investigated the effects of two EGFR tyrosine kinase inhibitors, PD153035 and its analo...

journal_title：Cancer letters

authors： Liu Y,Poon RT,Shao W,Sun X,Chen H,Kok TW,Fan ST

更新日期：2007-04-08 00:00:00

abstract：:In many parts of the world, green tea and black tea are produced from the plant Camellia sinensis. Tea is one of the most widely consumed beverages, second only to water. It is one of the safest beverages since it is made with boiling, sterile water and has been popular for over 4000 years. Dogma has it that people kn...

journal_title：Cancer letters

authors： Weisburger JH

更新日期：1997-03-19 00:00:00

abstract：:Overall survival and quality of life of patients with metastatic colorectal cancer (mCRC) have improved due to the development of standard systemic treatment. However, many patients are still suffering from the eventual progression of cancer, treatment-related toxicities, and the economic burden of new drugs. Salvage ...

journal_title：Cancer letters

authors： Woo IS,Jung YH

更新日期：2017-08-01 00:00:00

abstract：:FHIT is a tumour suppressor gene which is frequently inactivated in different types of cancer. Both genetic (mutations, deletions, chromosomal rearrangements) and epigenetic (aberrant methylation of the 5'CpG island) alterations of the FHIT gene have been reported in various malignancies. Yet little is known about the...

journal_title：Cancer letters

authors： Kvasha S,Gordiyuk V,Kondratov A,Ugryn D,Zgonnyk YM,Rynditch AV,Vozianov AF

更新日期：2008-07-08 00:00:00

abstract：:Studies have been demonstrating Pfaffia paniculata root (Brazilian ginseng) anticarcinogenic activities. We evaluated its chemopreventive effects on preneoplastic hepatic lesions. BALB/c aged-15 days received 10mug/g of diethylnitrosamine carcinogen, i.p. They were fed with the powdered root added to the diet: 0.5, 2 ...

journal_title：Cancer letters

authors： da Silva TC,Paula da Silva A,Akisue G,Luis Avanzo J,Kazumi Nagamine M,Fukumasu H,Matsuzaki P,César Raspantini P,Haraguchi M,Lima Górniak S,Dagli ML

更新日期：2005-08-26 00:00:00

abstract：:The vast majority of cancer deaths are caused by the formation of metastases rather than the primary tumor itself. Despite this clinical importance, the molecular and cellular events that support the dissemination of cancer cells are not yet fully unraveled. We have previously shown that CDX2, a homeotic transcription...

journal_title：Cancer letters

authors： Platet N,Hinkel I,Richert L,Murdamoothoo D,Moufok-Sadoun A,Vanier M,Lavalle P,Gaiddon C,Vautier D,Freund JN,Gross I

更新日期：2017-02-01 00:00:00

abstract：:Previously, we have shown that dietary retinoic acid (RA) at pharmacological doses (30 micrograms/g of diet) inhibited the malignant conversion of skin papillomas to carcinomas induced by a two-stage carcinogenesis protocol with 7,12-dimethylbenz[a]anthracene as initiator and 12-O-tetradecanoylphorbol-13-acetate (TPA)...

journal_title：Cancer letters

authors： Chen LC,Kirchhoff S,De Luca LM

更新日期：1994-04-01 00:00:00

abstract：:Absent or altered differentiation is one of the major features of cancer cells. Histone deacetylases (HDACs) play a central role in the epigenetic regulation of gene expression. Aberrant activity of HDACs has been documented in several types of cancers, leading to the development of HDAC inhibitors (HDACi) as anti-tum...

journal_title：Cancer letters

authors： Botrugno OA,Santoro F,Minucci S

更新日期：2009-08-08 00:00:00