Histone deacetylase inhibitors as a new weapon in the arsenal of differentiation therapies of cancer.

abstract：:Calcium channel blockers of 3 chemical classes and calmodulin antagonists have recently been shown to enhance the cytotoxicity of conventional cancer chemotherapeutic agents. We tested the ability of nifedipine, a dihydropyridine class calcium channel blocker, to enhance the cytotoxicity of cisplatin, the current chem...

journal_title：Cancer letters

authors： Onoda JM,Jacobs JR,Taylor JD,Sloane BF,Honn KV

更新日期：1986-02-01 00:00:00

abstract：:Malignant tumor cells of different origin seem to have preferential sites for metastasis. Breast cancer, prostate cancer and certain melanomas have bone as one of their preferential targets for metastasis. Bone is continuously being remodelled, a process largely controlled by local growth factors. A possible explanati...

journal_title：Cancer letters

authors： Giunciuglio D,Cai T,Filanti C,Manduca P,Albini A

更新日期：1995-10-20 00:00:00

abstract：:Cancer metabolism has been extensively investigated by various tools, and the fact of diverse metabolic reprogramming in cancer cells has been gradually unveiled. In this review, we discuss some contributions in cancer metabolism by general proteomic analysis and post-translational modification analysis using mass spe...

journal_title：Cancer letters

authors： Zhou W,Liotta LA,Petricoin EF

更新日期：2015-01-28 00:00:00

abstract：:Degradation of DNA produces deoxycytidine. Metabolism of deoxycytidine to dCTP inhibits phosphorylation of cytosine arabinoside (araC), fludarabine (FaraA) and 2-chlorodeoxyadenosine (CdA) by deoxycytidine kinase. This study measured plasma deoxycytidine in healthy adults and two leukemia patients and then determined ...

journal_title：Cancer letters

authors： Cohen JD,Strock DJ,Teik JE,Katz TB,Marcel PD

更新日期：1997-06-24 00:00:00

abstract：:A RNA-dependent DNA polymerase (RTase) was purified from human osteosarcoma tissue by successive column chromatography of the microsomal fraction on DEAE-cellulose (DE-23 and DE-52) and phosphocellulose. The purified enzyme has a molecular weight of about 68,000, a pH optimum of 8.1, a Mg2+ optimum of 0.8 mM, Mn2+ opt...

journal_title：Cancer letters

authors： Ebener U,Welte K,Chandra P

更新日期：1979-08-01 00:00:00

abstract：:Immunohistochemically detected expression of sialyl Lewis(x) (Le(x)) antigen was analyzed in 101 stage 0-II gastric cancers to clarify its prognostic value after curative gastrectomy. Patients with a high-expression of sialyl Le(x) antigen within their tumors had shorter disease-specific intervals than those with nega...

journal_title：Cancer letters

authors： Nakagoe T,Fukushima K,Sawai T,Tsuji T,Jibiki Ma,Nanashima A,Tanaka K,Yamaguchi H,Yasutake T,Ayabe H,Arisawa K,Ishikawa H

更新日期：2002-01-25 00:00:00

abstract：:We carried out a mutational analysis of BRCA1 and BRCA2 genes in 103 individuals from a population in Western Central Spain and we identified nine new variants: two truncating mutations in BRCA2 [2604C>A (Y792X), 8873del4], three missense mutations in BRCA2 [677A>G (H150R), 958G>A (D224N) and 3398A>G (K1057R], and fou...

journal_title：Cancer letters

authors： Salazar R,Cruz-Hernandez JJ,Sanchez-Valdivieso E,Rodriguez CA,Gomez-Bernal A,Barco E,Fonseca E,Portugal T,Gonzalez-Sarmiento R

更新日期：2006-02-20 00:00:00

abstract：:The promoting potential of oxymetholone (OXM) administration on development of liver cell foci was investigated in male F344 rats previously treated with N-diethylnitrosamine (DEN). One week after a single injection of DEN (100 mg/kg, i.p.), rats were given OXM at a dietary level of 0.2% for the first 4 weeks and then...

journal_title：Cancer letters

authors： Shimoji N,Imaida K,Hasegawa R,Matsuoka C,Uneyama CT,Takahashi M,Hayashi Y

更新日期：1990-02-01 00:00:00

abstract：:Acute myeloid leukemia (AML) cells in vivo are constantly exposed to lymphangiogenic cytokines such as VEGF-C. However, it is poorly understood how the VEGF-C signaling modulates the immune functions in the tumor microenvironment. We have previously reported that natural killer (NK) cells in AML patients strongly upre...

journal_title：Cancer letters

authors： Lee JY,Park S,Min WS,Kim HJ

更新日期：2014-11-28 00:00:00

abstract：:We investigated effects of sex steroids and analogs (estradiol, DES, norgestrel, progesterone, medroxyprogesterone, and testosterone) on the proliferation and survival of 10 human leukemia/lymphoma cell lines (HL-60, K562, U937, CEM, KG-1, Jurkat, U266, H929, PA and SUNHL). Micromolar concentrations of sex steroids ex...

journal_title：Cancer letters

authors： Blagosklonny MV,Neckers LM

更新日期：1994-01-30 00:00:00

abstract：:Increasing evidence points to a fundamental role for cancer stem cells (CSC) in the initiation and propagation of many tumors. As such, in the context of glioblastoma multiforme (GBM), the development of treatment strategies specifically targeted towards CSC-like populations may hold significant therapeutic promise. T...

journal_title：Cancer letters

authors： Ehtesham M,Mapara KY,Stevenson CB,Thompson RC

更新日期：2009-02-18 00:00:00

abstract：:Of the erythropoietin-producing human hepatocellular receptors (Ephs), EphB4 has recently emerged as a potential target in several cancers due to its roles in modified cell migration and invasion. As little is known about the roles of EphB4 in glioma, we sought to investigate its function in glioma by in vitro cell mi...

journal_title：Cancer letters

authors： Kawahara Y,Furuta T,Sabit H,Tamai S,Dong Y,Jiapaer S,Zhang J,Zhang G,Oishi M,Miyashita K,Hayashi Y,Nakada M

更新日期：2019-05-01 00:00:00

abstract：:Dibenzo[a,e]fluoranthene ( DBF ), a non- alternant carcinogenic polycyclic aromatic hydrocarbon (PAH), binds covalently to DNA. The main adducts were characterized as covalent additions of its bay-region and pseudo-bay-region diol-epoxides. The structure of these 2 adducts was analyzed by mass spectrometry using their...

journal_title：Cancer letters

authors： Perin-Roussel O,Croisy A,Ekert B,Zajdela F

更新日期：1984-04-01 00:00:00

abstract：:The selectivity of photodynamic therapy (PDT) derived from the tailored accumulation of photosensitizing drug (photosensitizer; PS) in the tumor microenvironment (TME), and from local irradiation, turns it into a "magic bullet" for the treatment of resistant tumors without sparing the healthy tissue and possible adver...

journal_title：Cancer letters

authors： Pucelik B,Sułek A,Barzowska A,Dąbrowski JM

更新日期：2020-11-01 00:00:00

abstract：:Ibrutinib, an inhibitor of Bruton tyrosine kinase (BTK), has shown promising pharmacologic effects in acute myeloid leukemia (AML). In this study, we report that abivertinib or AC0010, a novel BTK inhibitor, inhibits cell proliferation, reduces colony-forming capacity, and induces apoptosis and cell cycle arrest in AM...

journal_title：Cancer letters

authors： Huang S,Pan J,Jin J,Li C,Li X,Huang J,Huang X,Yan X,Li F,Yu M,Hu C,Jin J,Xu Y,Ling Q,Ye W,Wang Y,Jin J

更新日期：2019-10-01 00:00:00

abstract：:Liposome encapsulation of anticancer agents results in reduced side effects of the entrapped drug and improved therapeutic efficacy. The external surface of the lipidic envelope can be coupled with antibodies directed against tumor-associated antigens. The resulting immunoliposomes allow to increase the therapeutic in...

journal_title：Cancer letters

authors： Brignole C,Marimpietri D,Pagnan G,Di Paolo D,Zancolli M,Pistoia V,Ponzoni M,Pastorino F

更新日期：2005-10-18 00:00:00

abstract：:We investigated the effect of HMGB2 on the stability of p53 protein in HeLa cells. Overexpression of HMGB2 led to accumulation of the p53 protein, whereas HMGB2 knockdown with siRNA resulted in a substantial decrease in the p53 protein level. The HMGB2-dependent increase of p53 stability was specific for HPV-positive ...

journal_title：Cancer letters

authors： Lee D,Kwon JH,Kim EH,Kim ES,Choi KY

更新日期：2010-06-01 00:00:00

abstract：:Hepatocytes were isolated from B6C3F1 male mouse neoplastic livers (containing hepatocellular adenomas and carcinomas) or two-thirds partially hepatectomized livers and tested in primary culture for their cytotoxic response to hepatotoxins. Partially hepatectomized mouse hepatocytes were less sensitive to lindane, met...

journal_title：Cancer letters

authors： Ruch RJ,Klaunig JE,Pereira MA

更新日期：1985-04-01 00:00:00

abstract：:Inhibition of angiogenesis provides a potential anti-cancer therapy. Here we describe a novel recombinant peptide composed of active fragments of two distinct angiogenesis inhibitors, platelet factor-4 (C-13 fragment) and vasostatin (N-terminal amino acids 135-164) with a nonpolar peptide bridge of Gly-Pro-Gly. This f...

journal_title：Cancer letters

authors： Li X,Jiang L,Wang Y,Xiao Y,Huang Y,Yao Q,Yang Y,Wu X

更新日期：2007-10-18 00:00:00

abstract：:Hypoxia-inducible factor 1 (HIF-1) is a heterodimeric transcription factor composed of alpha and beta subunits, which plays an essential role in cancer cell hypoxia adaptation, glycolysis, and angiogenesis. Normally, HIF-1alpha protein, the dominant subunit of HIF-1, is accumulated in nuclei when cells are exposed to ...

journal_title：Cancer letters

authors： Zhong H,Mabjeesh N,Willard M,Simons J

更新日期：2002-07-26 00:00:00

abstract：:We have examined the expression of nitrotyrosine, a marker of peroxynitrite formation, in 55 esophageal cancers by immunohistochemistry. Nitrotyrosine was detected in 21 of 55 (38.2%) esophageal cancers. Comparison of nitrotyrosine expression and the pathological findings showed that there was a significant associatio...

journal_title：Cancer letters

authors： Kato H,Miyazaki T,Yoshikawa M,Nakajima M,Fukai Y,Tajima K,Masuda N,Tsutsumi S,Tsukada K,Nakajima T,Kuwano H

更新日期：2000-05-29 00:00:00

abstract：:The mdm2 oncogene is amplified and overexpressed in a variety of human tumours and the oncogenic potential of MDM2 is partly due to its ability to inactivate tumour suppressor p53 function. In the present communication we describe the cloning, sequence analysis and expression of the complete wildtype canine and equine...

journal_title：Cancer letters

authors： Nasir L,Burr PD,McFarlane ST,Gault E,Thompson H,Argyle DJ

更新日期：2000-04-28 00:00:00

abstract：:cIAP-1, an apoptosis inhibiting protein, has been suggested to play important roles in the development of cervical and esophageal squamous cell carcinomas (SCCs). In order to clarify the subcellular localization of cIAP-1 and to investigate its clinicopathological significance in head and neck SCCs (HNSCCs), we examin...

journal_title：Cancer letters

authors： Tanimoto T,Tsuda H,Imazeki N,Ohno Y,Imoto I,Inazawa J,Matsubara O

更新日期：2005-06-16 00:00:00

abstract：:cDNA libraries were generated from the prostate gland tissue obtained from a normal donor and from a patient with prostate cancer. Subtractive cDNA cloning was used to identify phenotype-specific cDNA sequences from both normal and cancerous prostate tissue. One clone, pN44, isolated from normal prostate tissue, codes...

journal_title：Cancer letters

authors： Liu AY,Bradner RC,Vessella RL

更新日期：1993-10-15 00:00:00

abstract：:MLL-rearranged leukemia is an aggressive malignancy associated with poor outcome, which is refractory to conventional treatment. Melatonin has been proven to exert anti-tumor activity, but the effect of melatonin on MLL-r leukemia and the underlying mechanism remain poorly understood. In this study, melatonin inhibite...

journal_title：Cancer letters

authors： Tang YL,Sun X,Huang LB,Liu XJ,Qin G,Wang LN,Zhang XL,Ke ZY,Luo JS,Liang C,Peng CJ,Tang WY,Li Y,Huang W,Luo XQ,Deng W

更新日期：2019-02-28 00:00:00

abstract：:Changes in hepatic membrane binding capacity for epidermal growth factor (EGF) were assessed during 2-acetylaminofluorine (2-AAF)-induced hepatocarcinogenesis. An overall decrease in membrane EGF binding levels was observed throughout the period of 2-AAF administration. Immunochemical studies indicated the decreases i...

journal_title：Cancer letters

authors： DeCicco LA,Kong J,Ringer DP

更新日期：1997-01-01 00:00:00

abstract：:Human epidermal growth factor receptor 2 (HER2) is an attractive target for cancer vaccine. However, autoimmune tolerance prevents vaccines based on HER2 protein from inducing long-lasting, highly effective anti-tumor immunity. In this study, we proved that the introduction of p-nitrophenylalanine in the universal T c...

journal_title：Cancer letters

authors： Tian H,He Y,Song X,Jiang L,Luo J,Xu Y,Zhang W,Gao X,Yao W

更新日期：2018-08-28 00:00:00

abstract：:We previously showed that BARD1 is a shuttling protein with pro-apoptotic activity in MCF-7 breast cancer cells. BARD1 is expressed as splice variant isoforms in breast cancer. Here we characterized YFP-tagged BARD1 splice variants (beta, omega, phi, ΔRIN, epsilon) for subcellular localization and apoptotic efficacy. ...

journal_title：Cancer letters

authors： Marzec KA,Martino-Echarri E,Irminger-Finger I,Henderson BR

更新日期：2016-10-10 00:00:00

abstract：:The aim of this study was to investigate the interaction of tamoxifen (TAM) with the so-called Type II estrogen binding sites (Type II EBS) in both the cytosolic and the nuclear fraction of the ER-negative A 2780 human ovarian cancer cell line and in an ER-negative ovarian cancer tissue. Although cytosolic and nuclear...

journal_title：Cancer letters

authors： Ferrandina G,Ranelletti FO,Scambia G,Benedetti Panici P,D'Agostino G,Piantelli M,Isola G,Mancuso S

更新日期：1995-09-04 00:00:00

abstract：:The growth of primary subcutaneous fibrosarcomas and their pulmonary metastases was studied in normal and athymic Swiss mice. The metastases tended to develop more rapidly than did the primary tumors. However, when growth rates of tumors of small volumes (up to 1 cm3) were compared, the tumor and metastases exhibited ...

journal_title：Cancer letters

authors： Plesnicar S,Kuszynski C,Patil KD

更新日期：1982-03-01 00:00:00