Cytostatic and cytotoxic activity of sex steroids against human leukemia cell lines.

abstract：:We investigated the relationship between ErbB-2 and HLA in order to clarify the clinical and genetic factors related to Japanese patients with lung cancer. Thirty-nine of the 73 lung cancer patients (53.4%) had elevated levels of ErbB-2. Only seven of 23 (30. 4%) patients with small cell carcinoma had elevated ErbB-2 ...

journal_title：Cancer letters

authors： Yoshimura C,Nomura S,Yamaoka M,Ohtani T,Matsuzakiz T,Yamaguchi K,Fukuharal S

更新日期：2000-04-28 00:00:00

abstract：:Immunogenic, methylcholanthrene-induced sarcomas failed to elicit the production of rapidly cytolytic T lymphocytes in syngeneic mice, although they did elicit the production of more slowly cytotoxic cells. They were, however, susceptible to attack by cytolytic T cells from allo-immune mice and, if infected with ectro...

journal_title：Cancer letters

authors： Nelson DS,Hopper KE,Blanden RV,Gardner ID,Kearney R

更新日期：1978-08-01 00:00:00

abstract：:The formation of nitroso compounds and mutagens from 5 nitrogen-containing drugs (cinnarizine, ethambutol, piromidic acid, pyridinol carbamate and tiaramide) by drug/nitrite interaction was examined. On the reaction of 50 micrometers drug and 500 micrometers nitrite at pH 3.0--3.4 and 37 degrees C for 4 h, the conside...

journal_title：Cancer letters

authors： Takeda Y,Kanaya H

更新日期：1982-01-01 00:00:00

abstract：:uPA system plays an important role in cancer invasion and metastasis. The binding of uPA to its receptor, uPAR, is necessary for the activation of uPA system. We studied by immunohistochemistry the distribution pattern of uPAR on 173 paraffin-embedded samples of invasive breast carcinomas in relation to clinicopatholo...

journal_title：Cancer letters

authors： Giannopoulou I,Mylona E,Kapranou A,Mavrommatis J,Markaki S,Zoumbouli Ch,Keramopoulos A,Nakopoulou L

更新日期：2007-02-08 00:00:00

abstract：:The preparation of chlorophyllin copper complex (CCC), shown to be a tumor promoter in an animal model (Nelson, R.L. (1992) Chlorophyllin, an antimutagen, acts as a tumor promoter in the rat-dimethylhydrazine colon carcinogenesis model. Anticancer Res., 12, 737-740), also inhibits the activities of direct- and indirec...

journal_title：Cancer letters

authors： Chernomorsky S,Rancourt R,Virdi K,Segelman A,Poretz RD

更新日期：1997-12-09 00:00:00

abstract：:A physiologically relevant glioma tumor model is important to the study of disease progression and screening drug candidates. However, current preclinical glioma models lack the brain microenvironment, and the established tumor cell lines do not represent glioma biology and cannot be used to evaluate the therapeutic e...

journal_title：Cancer letters

authors： Zhang L,Liu F,Weygant N,Zhang J,Hu P,Qin Z,Yang J,Cheng Q,Fan F,Zeng Y,Tang Y,Li Y,Tang A,He F,Peng J,Liao W,Hu Z,Li M,Liu Z

更新日期：2021-03-01 00:00:00

abstract：:A single tumorigenic dose of methylazoxymethanol acetate increased adenylate cyclase activity in total liver homogenates 70-100% by the seventh day after treatment. The increased activity occurred in the plasma membranes rather than in the nuclei and was accompanied by a significant increase in 5'-nucleotidase activit...

journal_title：Cancer letters

authors： Zedeck MS,Swislocki NI

更新日期：1975-11-01 00:00:00

abstract：:Human RecQ helicases that share homology with E. coli RecQ helicase play critical roles in diverse biological activities such as DNA replication, transcription, recombination and repair. Mutations in three of the five human RecQ helicases (RecQ1, WRN, BLM, RecQL4 and RecQ5) result in autosomal recessive syndromes char...

journal_title：Cancer letters

authors： Mo D,Zhao Y,Balajee AS

更新日期：2018-01-28 00:00:00

abstract：:Calcium channel blockers of 3 chemical classes and calmodulin antagonists have recently been shown to enhance the cytotoxicity of conventional cancer chemotherapeutic agents. We tested the ability of nifedipine, a dihydropyridine class calcium channel blocker, to enhance the cytotoxicity of cisplatin, the current chem...

journal_title：Cancer letters

authors： Onoda JM,Jacobs JR,Taylor JD,Sloane BF,Honn KV

更新日期：1986-02-01 00:00:00

abstract：:Trypsin inhibitors have been shown to promote pancreatic growth as well as the development of pancreatic tumours in rats. The present study was carried out to examine the effects of the synthetic trypsin inhibitor camostate on the growth of the pancreas and on the development of pancreatic preneoplastic and neoplastic...

journal_title：Cancer letters

authors： Meijers M,van Garderen-Hoetmer A,Lamers CB,Rovati LC,Jansen JB,Woutersen RA

更新日期：1991-12-01 00:00:00

abstract：:Glucosinolates constitute a well-defined group of secondary plant metabolites in cruciferous plants. They occur especially in brassica vegetables, which represent a major part of the human diet. Glucosinolates undergo hydrolysis, catalysed by an endogenous plant enzyme, known as myrosinase, into a range of biological ...

journal_title：Cancer letters

authors： Verkerk R,van der Gaag MS,Dekker M,Jongen WM

更新日期：1997-03-19 00:00:00

abstract：:Genomic instability is characteristic of malignant cells, and a strong correlation exists between abnormal karyotype and tumorigenicity. Increased expression of the homologous recombination and DNA repair protein Rad51 has been reported in immortalized cell lines and multiple primary tumor cell types which could alter...

journal_title：Cancer letters

authors： Richardson C

更新日期：2005-02-10 00:00:00

abstract：:Specific [3H]fucose-labeled glycoproteins were found in the serum of rats bearing Zajdela hepatoma, which possess different isoelectric points in comparison with serum glycoproteins from normal rats. The electrophoretic profile of the serum glycoproteins is significantly altered. There is approximately a 2.5 times inc...

journal_title：Cancer letters

authors： Ivanov D,Antonova M,Stoilov J,Zacharieva S,Gavazova E,Ivanov S

更新日期：1998-03-13 00:00:00

abstract：:To investigate whether particular patterns of food consumption are related to the occurrence of breast and colon cancer, two simultaneous case-control studies of French-Canadians with 616 cases (414 breast cancer, 202 colon cancer) and 429 population-based controls were carried out. Food consumption data were obtained...

journal_title：Cancer letters

authors： Nkondjock A,Ghadirian P

更新日期：2005-06-01 00:00:00

abstract：:Here we found that dual mTORC1/2 inhibitor AZD-2014 significantly inhibited RCC cell survival and growth, with higher efficiency than conventional mTORC1 inhibitors rapamycin and RAD001. RCC cell apoptosis was also induced by AZD-2014. AZD-2014 disrupted mTORC1/2 assembly and activation, while downregulating HIF-1α/2α...

journal_title：Cancer letters

authors： Zheng B,Mao JH,Qian L,Zhu H,Gu DH,Pan XD,Yi F,Ji DM

更新日期：2015-02-28 00:00:00

abstract：:Cancer cells often exhibit altered epigenetic signatures that can misregulate genes involved in processes such as transcription, proliferation, apoptosis and DNA repair. As regulation of chromatin structure is crucial for DNA repair processes, and both DNA repair and epigenetic controls are deregulated in many cancers...

journal_title：Cancer letters

authors： Agarwal P,Jackson SP

更新日期：2016-10-01 00:00:00

abstract：:The cell transforming ability of asbestos dust was investigated using C3H10T 1/2 murine fibroblasts. In a series of experiments both crocidolite and amosite caused no increase in the number of transformed foci over that seen in cultures from untreated cells. The dusts, were, however, capable of augmenting the oncogeni...

journal_title：Cancer letters

authors： Brown RC,Poole A,Fleming GT

更新日期：1983-03-01 00:00:00

abstract：:Cyclooxygenase-2 (COX-2) is a transcriptional target and downstream effector of the ErbB-1 (EGFR) and ErbB-2 signaling pathways. We found that anti-EGFR and anti-ErbB-2 antibodies inhibited ERK phosphorylation and downregulated COX-2 protein expression in HCA-7 human colon carcinoma cells. Both antibodies also augment...

journal_title：Cancer letters

authors： Half E,Sun Y,Sinicrope FA

更新日期：2007-06-28 00:00:00

abstract：:Telomeres constitute the ends of the linear eukaryotic chromosomes and are essential for the maintenance of chromosome stability and genome integrity. One of the consequences of an altered telomere structure is the formation of telomeric fusions (TFs), that is aberrant chromosomes in which two elements are fused at th...

journal_title：Cancer letters

authors： Rebuzzini P,Lisa A,Giulotto E,Mondello C

更新日期：2004-01-08 00:00:00

abstract：:A direct relationship exists between aging and increasing incidences of chronic diseases. In fact, with most age-associated diseases individuals manifest an underlying chronic inflammatory state as evidenced by local infiltration of inflammatory cells, such as macrophages, and higher circulatory levels of pro-inflamma...

journal_title：Cancer letters

authors： Sarkar D,Fisher PB

更新日期：2006-05-08 00:00:00

abstract：:Three sections of brain tissue from 2,657 female C57BL/6 mice were stained with hematoxylin and eosin and evaluated microscopically for proliferative lesions. Mice had been treated with either split-dose ionizing radiation (0, 3.0, 4.0 and 5.1 Gy), chronic lifetime 60 Hz circularly polarized magnetic field exposure (a...

journal_title：Cancer letters

authors： Kharazi AI,Babbitt JT,Hahn TJ

更新日期：1999-12-01 00:00:00

abstract：:Triple-negative breast cancer (TNBC) and colon cancer (CC) are two stigmatic examples of poorly treatable tumors, whose progression critically depends upon hyperactivation of the Wnt signaling. Development of specific anti-Wnt inhibitors is required to develop drugs against these and other Wnt-dependent cancers. Natur...

journal_title：Cancer letters

authors： Koval A,Pieme CA,Queiroz EF,Ragusa S,Ahmed K,Blagodatski A,Wolfender JL,Petrova TV,Katanaev VL

更新日期：2018-10-28 00:00:00

abstract：:Overall survival and quality of life of patients with metastatic colorectal cancer (mCRC) have improved due to the development of standard systemic treatment. However, many patients are still suffering from the eventual progression of cancer, treatment-related toxicities, and the economic burden of new drugs. Salvage ...

journal_title：Cancer letters

authors： Woo IS,Jung YH

更新日期：2017-08-01 00:00:00

abstract：:Toxicity reduction of cisplatin is necessary for improved treatment of cancer. Here we have demonstrated the synergistic growth-inhibitory effect of cisplatin on cervical cancer cells in-combination with a nontoxic herbal carbazole alkaloid, mahanine. Mahanine enhanced cisplatin-induced apoptosis and reduced its effec...

journal_title：Cancer letters

authors： Das R,Bhattacharya K,Samanta SK,Pal BC,Mandal C

更新日期：2014-08-28 00:00:00

abstract：:The environmental mutagens, 1-nitropyrene, 1,3-dinitropyrene, 1,6-dinitropyrene and 1,8-dinitropyrene were evaluated for their ability to initiate skin tumors in male and female SENCAR mice. 1-Nitropyrene (greater than 99.5% purity) did not induce papilloma formation over a dose range of 0-3.0 mg/mouse after 30 weeks ...

journal_title：Cancer letters

authors： Nesnow S,Triplett LL,Slaga TJ

更新日期：1984-05-01 00:00:00

abstract：:Samples of human endometrial carcinomas of ranging degree of histological differentiation, and normal endometrial tissues were screened for the presence of single site DNA mutations at codon 12 of the C-K-ras gene using oligonucleotide hybridisation of DNA amplified by the polymerase chain reaction (PCR). Two instance...

journal_title：Cancer letters

authors： Lester DR,Cauchi MN

更新日期：1990-05-15 00:00:00

abstract：:The thiol N-acetylcysteine (NAC), a precursor of intracellular glutathione (GSH), efficiently prevented the induction of lung tumors in Swiss albino mice, when supplemented to the diet (0.2%) both before and after an i.p. injection of the carcinogen urethan (ethyl carbamate). Irrespective of urethan administration, NA...

journal_title：Cancer letters

authors： De Flora S,Astengo M,Serra D,Bennicelli C

更新日期：1986-09-01 00:00:00

abstract：:MICAL2 is a tumor-promoting factor involved in cell migration, invasion, deformation, and proliferation not yet fully explored in lung adenocarcinoma (LUAD). This study demonstrated that MICAL2 was overexpressed and cytoplasm-enriched in LUAD tissues. Moreover, high cytoplasmic MICAL2 and/or total MICAL2 expression le...

journal_title：Cancer letters

authors： Zhou W,Liu Y,Gao Y,Cheng Y,Chang R,Li X,Zhou Y,Wang S,Liang L,Duan C,Zhang C

更新日期：2020-07-28 00:00:00

abstract：:Ellagic acid (EA) and 13-cis-retinoic acid (CRA), both alone and in combination, were tested for their ability to inhibit N-nitrosobenzylmethylamine-induced tumors in the rat esophagus. Groups of male rats were fed AIN-76A diet containing EA (4 g/kg), CRA (240 mg/kg), or a combination of EA and CRA (4 g/kg and 240 mg/...

journal_title：Cancer letters

authors： Daniel EM,Stoner GD

更新日期：1991-02-01 00:00:00

abstract：:Angiotensin II (Ang II) has been implicated in muscle protein loss in cachexia. To determine whether the Ang I/II system directly inhibits protein synthesis in muscle their effect has been monitored in vitro using murine myotubes as a surrogate model system. Ang I inhibited protein synthesis by 40-50% over the concent...

journal_title：Cancer letters

authors： Russell ST,Sanders PM,Tisdale MJ

更新日期：2006-01-18 00:00:00