Abstract:
:The preparation of chlorophyllin copper complex (CCC), shown to be a tumor promoter in an animal model (Nelson, R.L. (1992) Chlorophyllin, an antimutagen, acts as a tumor promoter in the rat-dimethylhydrazine colon carcinogenesis model. Anticancer Res., 12, 737-740), also inhibits the activities of direct- and indirect-acting mutagens in the Salmonella assay and exhibits cytostatic and cytocidal effects toward myeloma cells. Data from elemental analyses, spectrophotometry and reversed-phase high-performance liquid chromatography indicate that CCC preparations generally used in antimutagenic/anticarcinogenic experiments are variable, complex mixtures of structurally distinct porphyrins lacking copper in some instances. This variability of the composition may be a cause for the differences reported for the tumor promotion activity of CCC.
journal_name
Cancer Lettjournal_title
Cancer lettersauthors
Chernomorsky S,Rancourt R,Virdi K,Segelman A,Poretz RDdoi
10.1016/s0304-3835(97)00304-2subject
Has Abstractpub_date
1997-12-09 00:00:00pages
141-7issue
2eissn
0304-3835issn
1872-7980pii
S0304-3835(97)00304-2journal_volume
120pub_type
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