Abstract:
:We previously reported that β6 integrin played an important role in the progression of colon cancer. In this study, we demonstrated that β6 integrin induced the expression of MMP-3/MMP-9 and the invasion of colon cancer cells. Moreover, that function was abolished by the inhibition of ERK/MAPK pathways or knockdown of ETS1, an important transcription factor of MMP genes. Here, we showed that β6 induced phosphorylation of ETS1 via the ERK/MAPK pathways, through which the MMP-3/MMP-9 promoters were stimulated, thereby leading to the up-regulation of MMP-3/MMP-9, and subsequent the invasion of colon cancer cells.
journal_name
Cancer Lettjournal_title
Cancer lettersauthors
Gao H,Peng C,Liang B,Shahbaz M,Liu S,Wang B,Sun Q,Niu Z,Niu W,Liu E,Wang J,Lin P,Wang J,Niu Jdoi
10.1016/j.canlet.2014.08.017subject
Has Abstractpub_date
2014-11-28 00:00:00pages
427-37issue
2eissn
0304-3835issn
1872-7980pii
S0304-3835(14)00447-9journal_volume
354pub_type
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