Abstract：
:Comparison of LCC2, the E(2)-independent, tamoxifen-resistant subline of the MCF-7 human breast cancer cell line with its parent line, disclosed that it is more resistant to growth inhibition and apoptosis induction by a variety of agents acting by diverse mechanisms. Thus, LCC2 cells can serve as a useful in-vitro model for the study of the molecular mechanisms of this resistance. It was found that bcl-2 protein and mRNA were elevated and that bax protein and mRNA were reduced in LCC2 compared with MCF-7 cells. Incubation of both lines in the presence of bcl-2 antisense caused growth inhibition and reduced bcl-2 protein levels only in MCF-7 cells, suggesting the involvement of bcl-2 in the regulation of normal growth of breast cancer cells. Increased bcl-2 expression in breast cancer cells may correlate with their resistance to growth inhibitory agents. Bcl-2 is a useful target for enhancing the effects of growth inhibitory agents.
journal_name
Cancer Lettjournal_title
Cancer lettersauthors
Lilling G,Hacohen H,Nordenberg J,Livnat T,Rotter V,Sidi Ydoi
10.1016/s0304-3835(00)00579-6keywords:
subject
Has Abstractpub_date
2000-12-08 00:00:00pages
27-34issue
1eissn
0304-3835issn
1872-7980pii
S0304-3835(00)00579-6journal_volume
161pub_type
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