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Genomic instability and increased expression of BUB1B and MAD2L1 genes in ductal breast carcinoma.

Abstract：

:In a series of invasive ductal breast carcinoma, we investigated the status of chromosomal and intrachromosomal instability by fluorescence in situ hybridisation and determined the level of mRNA expression for two genes involved in the mitotic spindle checkpoint pathway, BUB1B and MAD2L1. All breast cancers demonstrated higher chromosomal instability rates in tumor samples (average: 56.86%, range: 36.24-76.78%) than in controls (average: 11.54%, range: 9.91-14.84%) (P<0.0001). As well as intrachromosomal instability rates were elevated in tumor (average: 18.45% range: 8.34-35.8%) as compared with controls (average: 4.18% range: 3.47-4.81%) (P<0.0001). An increase in BUB1B and MAD2L1 transcripts was demonstrated in the majority of the tumor tested. BUB1B mRNA levels but not MAD2L1 levels correlated with intrachromosomal instability (r=0.722, P=0.018).

journal_name

Cancer Lett

journal_title

Cancer letters

authors

Scintu M,Vitale R,Prencipe M,Gallo AP,Bonghi L,Valori VM,Maiello E,Rinaldi M,Signori E,Rabitti C,Carella M,Dallapiccola B,Altomare V,Fazio VM,Parrella P

doi

10.1016/j.canlet.2007.03.021

subject

Has Abstract

pub_date

2007-09-08 00:00:00

pages

298-307

issue

2

eissn

0304-3835

issn

1872-7980

pii

S0304-3835(07)00152-8

journal_volume

254

pub_type

杂志文章

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