Combined effects of 13-cis-retinoic acid, tamoxifen and interferon on the growth of human breast cancer cells.


:We studied the effect of 13-cis-retinoic acid (13-cRA) alone and in combination with interferons (IFNs) and tamoxifen (TAM) in two established human breast cancer cell lines: the estrogen-sensitive CG-5 and the estrogen-insensitive MDA-MB-453 cells. 13-cRA (10(-9)-10(-5) M) significantly reduced the growth of both cell lines in a dose-dependent fashion, after 3 and 6 days of treatment. When the retinoid (10(-9)-10(-5) M) was combined with natural beta-IFN (100-1000 IU/ml) for 6 days, we observed a growth inhibition more pronounced than that produced by each of the two single agents in both CG-5 and MDA-MB-453 cells. Only in the former model was the inhibitory effect synergistic at all the drug concentrations used. Association of 13-cRA (10(-9)-10(-5) M) and recombinant alpha2a-IFN (100-1000 IU/ml) or TAM (10(-7)-10(-6) M) did not determine an additive or synergistic effect on the growth of CG-5 cells.


Cancer Lett


Cancer letters


Lama G,Angelucci C,Recchia F,Sica G




Has Abstract


1996-02-27 00:00:00














  • Involvement of reactive oxygen species in 2-methoxyestradiol-induced apoptosis in human neuroblastoma cells.

    abstract::Neuroblastoma is the most common extra-cranial solid tumor in children. Despite advances in the treatment of childhood cancer, outcomes for children with advanced-stage neuroblastoma remain poor. Here we reported that 2-methoxyestradiol (2-ME) inhibited the proliferation and induced apoptosis in human neuroblastoma SK...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Zhang Q,Ma Y,Cheng YF,Li WJ,Zhang Z,Chen SY

    更新日期:2011-12-27 00:00:00

  • Cytokeratin 8 silencing in human nasopharyngeal carcinoma cells leads to cisplatin sensitization.

    abstract::By comparing protein profiles of nasopharyngeal carcinoma HONE1 cells to transformed nasopharyngeal epithelial NP 69 cells, several clusters of differentially expressed proteins were identified. The increased expression of cytokeratin 8 (CK8) and pyruvate kinase M2 was a common feature in four NPC cell lines compared ...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Wang Y,He QY,Tsao SW,Cheung YH,Wong A,Chiu JF

    更新日期:2008-07-08 00:00:00

  • Inhibitory activity of chlorophyllin on the genotoxicity of carcinogens in Drosophila.

    abstract::Antimutagenic activity of copper chlorophyllin against various carcinogenic mutagens was assayed with Drosophila genotoxicity tests, i.e., the wing spot test for detecting somatic cell mutations and the DNA repair test for detecting DNA damage. In these tests, Drosophila larvae were fed carcinogens together with chlor...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Negishi T,Nakano H,Kitamura A,Itome C,Shiotani T,Hayatsu H

    更新日期:1994-08-15 00:00:00

  • Anti-tumor and radiosensitization activities of the iron chelator HDp44mT are mediated by effects on intracellular redox status.

    abstract::A novel iron chelator, HDp44mT, has been reported to have potent anti-proliferative effects on cancer cells; however, the underlying mechanism of action is not well understood. In this study, we characterized the cytotoxic effect of HDp44mT in a chemo- and radio-resistant cell line (PC-3) of prostatic cancer origin. T...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Tian J,Peehl DM,Zheng W,Knox SJ

    更新日期:2010-12-08 00:00:00

  • EBV DNA polymerase inhibition of tannins from Eugenia uniflora.

    abstract::Nasopharyngeal carcinoma (NPC) is one of the high population malignant tumors among Chinese in southern China and southeast Asia. Epstein-Barr virus (EBV) is a human B lymphotropic herpes virus which is known to be closely associated with NPC. EBV DNA polymerase is a key enzyme during EBV replication and is measured b...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Lee MH,Chiou JF,Yen KY,Yang LL

    更新日期:2000-06-30 00:00:00

  • Effects of nicotine infusion on the metabolism of the tobacco carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in rats.

    abstract::The tobacco-specific nitrosamine, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) is a lung carcinogen in the rat and believed to be a causative agent for lung cancer in smokers. To exert its carcinogenic potential NNK is metabolically activated by cytochrome P450-catalyzed alpha-hydroxylation. Nicotine and NNK s...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Keyler D,Pentel PR,Kuehl G,Collins G,Murphy SE

    更新日期:2003-12-08 00:00:00

  • The comparison of the prognosis between Epstein-Barr virus (EBV)-positive gastric carcinomas and EBV-negative ones.

    abstract::The relationship between the degree of lymphocytic infiltration into the tumor and the prognosis has not been completely evaluated between Epstein-Barr virus (EBV)-positive and -negative gastric carcinoma (GC). Although the average numbers and the grades of the infiltrating CD8+T cells, natural killer cells, dendritic...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Kijima Y,Ishigami S,Hokita S,Koriyama C,Akiba S,Eizuru Y,Aikou T

    更新日期:2003-10-08 00:00:00

  • Long noncoding RNAs as potential biomarkers in gastric cancer: Opportunities and challenges.

    abstract::Gastric cancer (GC) is a major threat to human health, and its prognosis is poor due to the lack of appropriate biomarkers. LncRNAs are a group of non-protein-coding RNAs that regulate gene expression at the transcriptional or posttranscriptional level. LncRNAs play essential roles in GC initiation and development in ...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Yang Z,Guo X,Li G,Shi Y,Li L

    更新日期:2016-02-01 00:00:00

  • Immune modulation in advanced radiotherapies: Targeting out-of-field effects.

    abstract::By virtue of being a localized treatment modality, radiotherapy is unable to deliver a tumoricidal radiation dose to tissues outside of the irradiated field. Nevertheless, ionizing radiation may result in radiation damage mediated by a bystander like effect away from the irradiated field, but this response is likely t...

    journal_title:Cancer letters

    pub_type: 杂志文章,评审


    authors: Hanna GG,Coyle VM,Prise KM

    更新日期:2015-11-28 00:00:00

  • piR-823, a novel non-coding small RNA, demonstrates in vitro and in vivo tumor suppressive activity in human gastric cancer cells.

    abstract::Piwi-interacting RNAs (piRNAs), new non-coding small RNAs, are association with chromatin organization, messenger RNA stability and genome structure. However, the roles of piRNA in carcinogenesis are not clearly defined. By using real-time reverse transcription-polymerase chain reaction technology, we found that the e...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Cheng J,Deng H,Xiao B,Zhou H,Zhou F,Shen Z,Guo J

    更新日期:2012-02-01 00:00:00

  • Post-transplant lymphoproliferative disorders: from epidemiology to pathogenesis-driven treatment.

    abstract::Post-transplant lymphoproliferative disorders (PTLDs) represent the most severe complication of both solid organ and hematopoietic stem cell transplantation. The Epstein-Barr Virus (EBV) is the main driver of PTLD, particularly those occurring early after transplantation. EBV-driven malignancies are associated with se...

    journal_title:Cancer letters

    pub_type: 杂志文章,评审


    authors: Petrara MR,Giunco S,Serraino D,Dolcetti R,De Rossi A

    更新日期:2015-12-01 00:00:00

  • Polo-like kinase 1 contributes to the tumorigenicity of BEL-7402 hepatoma cells via regulation of Survivin expression.

    abstract::Polo-like kinase 1 (PLK1) is required for multiple stages of mitosis and has been found to be overexpressed in many human malignancies. Previous studies by our group have revealed PLK1 overexpression as an independent prognostic factor for hepatocellular carcinoma (HCC). However, the underlying mechanisms of the tumor...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: He Z,Wu J,Dang H,Lin H,Zheng H,Zhong D

    更新日期:2011-04-28 00:00:00

  • Garlic and associated allyl sulfur components inhibit N-methyl-N-nitrosourea induced rat mammary carcinogenesis.

    abstract::Our previous studies demonstrated that dietary garlic powder supplementation inhibits N-nitrosamine induced DNA alkylation in liver and mammary tissue. The present studies compared the impact of dietary supplementation with garlic powder or two garlic constituents, water-soluble S-allyl cysteine (SAC) and oil-soluble ...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Schaffer EM,Liu JZ,Green J,Dangler CA,Milner JA

    更新日期:1996-04-19 00:00:00

  • Feasibility of using lower doses of chemopreventive agents in a combination regimen for cancer protection.

    abstract::In experimental cancer chemoprevention studies, the doses of the agent used to produce an inhibitory response are generally very high, sometimes bordering on levels that will result in toxicity to the test animals. The present study was designed to test the hypothesis that low doses of two or more agents may be just a...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Ip C

    更新日期:1988-04-01 00:00:00

  • Nemo-like kinase (NLK) primes colorectal cancer progression by releasing the E2F1 complex from HDAC1.

    abstract::Control of E2F1 activity is restricted via its interactions with RB1 and HDAC1. However, the detailed regulatory mechanisms underlying the E2F1/HDAC1 complex remain elusive. Here, we report that Nemo-like kinase (NLK) boosts cell cycle progression, which facilitates tumor development by releasing the E2F1 protein from...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Li SZ,Zeng F,Li J,Shu QP,Zhang HH,Xu J,Ren JW,Zhang XD,Song XM,Du RL

    更新日期:2018-09-01 00:00:00

  • Activation of signal transduction pathways during hepatic oncogenesis.

    abstract:BACKGROUND AND AIMS:Understanding the molecular pathogenesis of hepatocellular carcinoma (HCC) is essential to identify therapeutic targets. A hepatitis B virus (HBV) related double transgenic murine model was developed. METHODS:Liver specific expression of HBV X protein (HBx) and insulin receptor substrate 1 (IRS1) w...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Chung W,Kim M,de la Monte S,Longato L,Carlson R,Slagle BL,Dong X,Wands JR

    更新日期:2016-01-01 00:00:00

  • Intraperitoneal injection of adenovirus expressing antisense K-ras RNA suppresses peritoneal dissemination of hamster syngeneic pancreatic cancer without systemic toxicity.

    abstract::We examined the antitumor effect and safety of the adenovirus-mediated expression of antisense K-ras RNA in two peritoneal dissemination models of pancreatic cancer. First, we found that the infection of an adenovirus vector expressing antisense human K-ras RNA (AxCA-AS) induced significant apoptosis in vitro in human...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Miura Y,Ohnami S,Yoshida K,Ohashi M,Nakano M,Ohnami S,Fukuhara M,Yanagi K,Matsushita A,Uchida E,Asaka M,Yoshida T,Aoki K

    更新日期:2005-01-31 00:00:00

  • Small molecule inhibitor agerafenib effectively suppresses neuroblastoma tumor growth in mouse models via inhibiting ERK MAPK signaling.

    abstract::Neuroblastoma (NB) is the most common extracranial solid tumor in early childhood. Despite intensive multimodal therapy, nearly half of children with high-risk disease will relapse with therapy-resistant tumors. Dysregulation of MAPK pathway has been implicated in the pathogenesis of relapsed and refractory NB patient...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Li H,Yu Y,Zhao Y,Wu D,Yu X,Lu J,Chen Z,Zhang H,Hu Y,Zhai Y,Su J,Aheman A,De Las Casas A,Jin J,Xu X,Shi Z,Woodfield SE,Vasudevan SA,Agarwal S,Yan Y,Yang J,Foster JH

    更新日期:2019-08-10 00:00:00

  • Novel treatments for hepatocellular cancer.

    abstract::Hepatocellular cancer (HCC) has always been considered a therapeutic challenge, given the cytoxic drug resistant nature of the cancer and associated disorder in liver function, reducing the safety of many conventional chemotherapy agents. The Multikinase inhibitor sorafenib has been found to prolong survival in patien...

    journal_title:Cancer letters

    pub_type: 杂志文章,评审


    authors: Kerr SH,Kerr DJ

    更新日期:2009-12-01 00:00:00

  • Distribution and activity of transglutaminase in rat brain carcinogenesis and in gliomas.

    abstract::Tissue transglutaminase is a calcium-dependent enzyme which may influence cell morphology, cytoskeletal processes and membrane functions. During rat brain carcinogenesis induced by transplacental administration of N-ethyl-N-nitrosourea to BD IX rats, cytosolic tissue transglutaminase activity was increased by about 14...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Tunici P,Sessa A,Rabellotti E,Calloni A,Perin A

    更新日期:1999-06-01 00:00:00

  • Preclinical comparison of regorafenib and sorafenib efficacy for hepatocellular carcinoma using multimodality molecular imaging.

    abstract::Sorafenib has been used as a clinical targeted therapy for hepatocellular carcinoma (HCC) for more than a decade. In 2017, regorafenib was approved for HCC treatment and has since been reported to prolong the survival of advanced HCC patients after treatment failure with sorafenib. However, there has been no direct sy...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Liu S,Du Y,Ma H,Liang Q,Zhu X,Tian J

    更新日期:2019-07-01 00:00:00

  • Prenylation of oncogenic human PTP(CAAX) protein tyrosine phosphatases.

    abstract::Many isoprenylated proteins are known to participate in signal transduction, but not all have been identified. Using an in vitro prenylation screen, two human cDNAs (PTP(CAAXI) and PTP(CAAX2)) homologous to the rat PRL-1 and human OV-1 protein tyrosine phosphatase genes were identified. PTP(CAAXI) and PTP(CAAX2) were ...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Cates CA,Michael RL,Stayrook KR,Harvey KA,Burke YD,Randall SK,Crowell PL,Crowell DN

    更新日期:1996-12-20 00:00:00

  • Histone deacetylase inhibition induces apoptosis and autophagy in human neuroblastoma cells.

    abstract::Neuroblastoma (NB) is the most common solid extracranial tumor in children. Here we showed that trichostatin A, a histone deacetylase inhibitor (HDACi), decreases cell viability in three NB cell lines of different phenotypes. The treatment leads to G2/M-phase arrest, apoptosis and autophagy. Autophagy induction accomp...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Francisco R,Pérez-Perarnau A,Cortés C,Gil J,Tauler A,Ambrosio S

    更新日期:2012-05-01 00:00:00

  • Fusion genes as biomarkers in pediatric cancers: A review of the current state and applicability in diagnostics and personalized therapy.

    abstract::The incidence of pediatric cancers is rising steadily across the world, along with the challenges in understanding the molecular mechanisms and devising effective therapeutic strategies. Pediatric cancers are presented with diverse molecular characteristics and more distinct subtypes when compared to adult cancers. Re...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Vellichirammal NN,Chaturvedi NK,Joshi SS,Coulter DW,Guda C

    更新日期:2021-02-28 00:00:00

  • Stress kinase signaling in cancer: fact or fiction?

    abstract::Cancer results from genetic alterations in intracellular signaling pathways, which normally orchestrate the execution of developmental programs and the organismic response to extrinsic factors. Mutations in upstream activators and components of the cytoplasmic (Ras-Raf MEK-ERK) cascade frequently occur in tumors. In v...

    journal_title:Cancer letters

    pub_type: 杂志文章,评审


    authors: Rennefahrt U,Janakiraman M,Ollinger R,Troppmair J

    更新日期:2005-01-10 00:00:00

  • Emerging next-generation sequencing-based discoveries for targeted osteosarcoma therapy.

    abstract::Osteosarcoma (OS) is the most common primary bone malignancy and is frequently lethal via metastasis to the lung. While surgical techniques and adjuvant chemotherapies have emerged to combat this deadly cancer, the 5-year survival rate has plateaued over the past four decades. Therapeutic progress has been notably poo...

    journal_title:Cancer letters

    pub_type: 杂志文章,评审


    authors: Zhao J,Dean DC,Hornicek FJ,Yu X,Duan Z

    更新日期:2020-04-01 00:00:00

  • Amine nitrosation by sodium nitroprusside.

    abstract::Nitrosamine formation from the reaction of nitroprusside with morpholine was found to be a light-dependent reaction. Maximum nitrosation occurred when the reactants were exposed to UV light (lambda = 275-300 nm). However, considerable nitrosation also occurred with light in the visible spectrum up to 500 nm. No signif...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Cooney RV,Ramseyer J,Ross PD

    更新日期:1988-06-15 00:00:00

  • Purified autoantibodies against glucose-regulated protein 78 (GRP78) promote apoptosis and decrease invasiveness of ovarian cancer cells.

    abstract::Circulating glucose-regulated protein 78 (GRP78) autoantibodies represent potential biomarker of epithelial ovarian cancer. However there is relatively limited identification of these antibodies in response to ovarian cancer. Here, we were interested in characterization of these antibodies and into their role in tumor...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Cohen M,Petignat P

    更新日期:2011-10-01 00:00:00

  • PET/CT imaging-guided dose painting in radiation therapy.

    abstract::Application of functional imaging to radiotherapy (RT) is a rapidly expanding field with the development of new modalities and techniques. Functional imaging of PET in conjunction with RT provides new avenues towards the clinical application of dose painting - a new RT strategy delivering optimized dose redistribution...

    journal_title:Cancer letters

    pub_type: 杂志文章,评审


    authors: Shi X,Meng X,Sun X,Xing L,Yu J

    更新日期:2014-12-28 00:00:00

  • A case study in misidentification of cancer cell lines: MCF-7/AdrR cells (re-designated NCI/ADR-RES) are derived from OVCAR-8 human ovarian carcinoma cells.

    abstract::Multidrug-resistant MCF-7 breast adenocarcinoma cells (originally named MCF-7/AdrR cells and later re-designated NCI/ADR-RES) have served as an important and widely used research tool during the last two decades. However, the real identity of these cells has been in doubt since 1998 and has since been debated. The ori...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Liscovitch M,Ravid D

    更新日期:2007-01-08 00:00:00