Abstract：
:Selenium-dependent (Se-GSH-Px), selenium-independent (non-Se-GSH-Px) glutathione peroxidase and glutathione reductase (GSSG-Rx) activities have been determined in cancerous and non-cancerous human adult kidney. Large inter-individual variation in the activities of all enzymes tested were found in both tumour and non-tumour specimens. In general a significant decrease in the activities of the three enzymes was found in tumours. When a comparison was made between cancerous and non-cancerous tissues of the same individual, Se-GSH-Px activity was found to be lower in tumour in 17 cases out of 29, and the non-Se-GSH-Px activity in 20. In 20 cases out of 29 GSSG-Rx was found to be lower in tumour. It was concluded that changes in the factors involved in the anti-oxidative protection actually occur in human kidney tumour.
journal_name
Cancer Lettjournal_title
Cancer lettersauthors
Di Ilio C,Sacchetta P,Angelucci S,Zezza A,Tenaglia R,Aceto Adoi
10.1016/0304-3835(95)03710-esubject
Has Abstractpub_date
1995-05-04 00:00:00pages
19-23issue
1eissn
0304-3835issn
1872-7980pii
030438359503710Ejournal_volume
91pub_type
杂志文章相关文献
CANCER LETTERS文献大全abstract：:Cancer cells often exhibit altered epigenetic signatures that can misregulate genes involved in processes such as transcription, proliferation, apoptosis and DNA repair. As regulation of chromatin structure is crucial for DNA repair processes, and both DNA repair and epigenetic controls are deregulated in many cancers...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2016.07.009
更新日期：2016-10-01 00:00:00
abstract：:In this study, we investigated the antitumor effects of deguelin in several human breast cancer cells in vitro and in vivo. Deguelin inhibited cell viability and the anchorage-dependent and anchorage-independent colony formation of triple-negative (MDA-MB-231 and MDA-MB-468) and triple-positive (MCF-7) breast cancer c...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2013.01.022
更新日期：2013-05-10 00:00:00
abstract：:Chronic elevated free fatty (FFA) levels are linked to metabolic disorders and tumorigenesis. However, the molecular mechanism by which FFAs induce cancer remains poorly understood. Here, we show that the tumor suppressor PTEN protein levels were decreased in high fat diet (HFD) fed mice. As palmitic acid (PA, C16:0) ...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2020.10.007
更新日期：2021-01-01 00:00:00
abstract：:Lymphatic metastasis is the main route of breast cancer metastasis. It is known that lymphangiogenesis facilitates lymphatic metastasis through vascular endothelial growth factor-C (VEGF-C)/VEGF receptor 3 (VEGFR3) pathway-linked interactions between the tumor and its microenvironment. Here, we report a novel mechanis...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2018.01.069
更新日期：2018-04-28 00:00:00
abstract：:Background is presented to suggest that a great many biologic processes are chaotic. It is well known that chaotic processes can be accurately characterized by non-linear technologies. Evidence is presented that an artificial neural network, which is a known method for the application of non-linear statistics, is able...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/0304-3835(94)90090-6
更新日期：1994-03-15 00:00:00
abstract：:Nuclear factor-kappa B (NF-kappaB) activation by tumor necrosis factor-alpha (TNF-alpha) attenuates the TNF-alpha-induced apoptosis pathway. Thus, blockage of NF-kappaB activity may improve the anti-cancer activity of TNF-alpha. HA14-1 induces apoptosis in various human cancer cells, and the molecular mechanisms of th...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2009.11.014
更新日期：2010-06-01 00:00:00
abstract：:Hepatocytes were isolated from B6C3F1 male mouse neoplastic livers (containing hepatocellular adenomas and carcinomas) or two-thirds partially hepatectomized livers and tested in primary culture for their cytotoxic response to hepatotoxins. Partially hepatectomized mouse hepatocytes were less sensitive to lindane, met...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/0304-3835(85)90053-9
更新日期：1985-04-01 00:00:00
abstract：:Incubation of mouse epidermal cells (HEL-37) with phospholipase C (Clostridium perfringens) caused about a 50% decrease in the specific binding of [20-3H]phorbol-12,13-dibutyrate. Phospholipase C caused a decrease in the apparent number of binding sites from 2.86 X 10(5) to 1.21 X 10(5) per cell with little effect on ...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/0304-3835(83)90141-6
更新日期：1983-05-01 00:00:00
abstract：:Ellagic acid (EA) is a polyphenol found in several plants and fruits. The objectives of this study were to examine the molecular mechanisms by which EA inhibits pancreatic cancer growth in Balb C nude mice. PANC-1 cells were injected subcutaneously into Balb c nude mice, and tumor-bearing mice were treated with EA. Th...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2013.05.009
更新日期：2013-09-01 00:00:00
abstract：:Conventional chemotherapies have some limitations, including the lack of selectivity, high toxicity to normal tissues, multidrug resistance, and tumor relapse. Recently, great progress was made in immunotherapies for anticancer research, with bacteria-mediated cancer therapy one of the most promising approaches among ...
journal_title：Cancer letters
pub_type： 杂志文章,评审
doi：10.1016/j.canlet.2019.10.033
更新日期：2020-01-28 00:00:00
abstract：:The implementation of novel therapeutic interventions has improved the survival rates of melanoma patients with metastatic disease. Nonetheless, only 33% of treated cases exhibit long term responses. Circulating tumor cell (CTC) measurements are currently of clinical value in breast, prostate and colorectal cancers. H...
journal_title：Cancer letters
pub_type： 杂志文章,评审
doi：10.1016/j.canlet.2018.03.013
更新日期：2018-06-28 00:00:00
abstract：:Vascular recovery or re-angiogenesis after radiotherapy plays a significant role in tumor recurrence, whereas molecular mechanisms of this process remain elusive. In this work, we found that dying glioma cells promoted post-irradiation angiogenesis through a caspase 3 dependent mechanism. Evidence in vitro and in vivo...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2016.10.042
更新日期：2017-01-28 00:00:00
abstract：:The preparation of chlorophyllin copper complex (CCC), shown to be a tumor promoter in an animal model (Nelson, R.L. (1992) Chlorophyllin, an antimutagen, acts as a tumor promoter in the rat-dimethylhydrazine colon carcinogenesis model. Anticancer Res., 12, 737-740), also inhibits the activities of direct- and indirec...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/s0304-3835(97)00304-2
更新日期：1997-12-09 00:00:00
abstract：:Polo-like kinase 1 (PLK1) is required for multiple stages of mitosis and has been found to be overexpressed in many human malignancies. Previous studies by our group have revealed PLK1 overexpression as an independent prognostic factor for hepatocellular carcinoma (HCC). However, the underlying mechanisms of the tumor...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2011.01.007
更新日期：2011-04-28 00:00:00
abstract：:Tobacco-specific N-nitrosamines (TSNA) are the most abundant carcinogens identified in tobacco and its smoke. Reducing their levels in tobacco products and especially in cigarette smoke is, therefore, a primary goal towards minimizing the carcinogenic burden of the tobacco consumer. This study delineates the mechanism...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/0304-3835(83)90173-8
更新日期：1983-01-01 00:00:00
abstract：:A rabbit gamma delta killer T-cell line against Shope carcinoma cells was established from peripheral blood lymphocytes (PBL) of a human T-lymphotropic virus type I (HTLV-I)-infected rabbit bearing Shope papilloma and carcinoma. Southern hybridization analysis of this cell line with an HTLV-I probe showed that the cel...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/0304-3835(95)90155-8
更新日期：1995-02-10 00:00:00
abstract：:Despite the significance of tumor angiogenesis and the extensive knowledge on the molecular basis of blood vessel formation in carcinoma of colorectum, no data exist in hyperplastic polyp. This prompted us to examine angiogenesis in hyperplastic polyp. Eleven small hyperplastic polyps, 13 large hyperplastic polyps and...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/S0304-3835(03)00183-6
更新日期：2005-02-10 00:00:00
abstract：BACKGROUND AND AIMS:Understanding the molecular pathogenesis of hepatocellular carcinoma (HCC) is essential to identify therapeutic targets. A hepatitis B virus (HBV) related double transgenic murine model was developed. METHODS:Liver specific expression of HBV X protein (HBx) and insulin receptor substrate 1 (IRS1) w...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2015.09.016
更新日期：2016-01-01 00:00:00
abstract：:Isothiocyanates are found in cruciferous vegetables such as broccoli, Brussels sprouts, cauliflower, and cabbage. Epidemiologic studies suggest that cruciferous vegetable intake may lower overall cancer risk, including colon and prostate cancer. Sulforaphane (SFN) is an isothiocyanate found in cruciferous vegetables a...
journal_title：Cancer letters
pub_type： 杂志文章,评审
doi：10.1016/j.canlet.2008.04.018
更新日期：2008-10-08 00:00:00
abstract：:Piwi-interacting RNAs (piRNAs), new non-coding small RNAs, are association with chromatin organization, messenger RNA stability and genome structure. However, the roles of piRNA in carcinogenesis are not clearly defined. By using real-time reverse transcription-polymerase chain reaction technology, we found that the e...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2011.10.004
更新日期：2012-02-01 00:00:00
abstract：:EglN prolyl hydroxylases, a family of oxygen-sensing enzymes, hydroxylate distinct proteins to modulate diverse physiopathological signals. Aberrant regulations of EglNs result in multiple human diseases, including cancer. Different from EglN1 which function largely depends on the role of hypoxia-induce factor alpha (...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2017.01.003
更新日期：2017-04-01 00:00:00
abstract：:The genomic aberration profile of chromosome 20q in distal CIN colon carcinomas was analysed using allelotyping and CGH arrays. Allelotyping revealed carcinomas with allelic imbalance along the full long arm, and carcinomas with fully non-aberrant 20q. Oligonucleotide-based CGH showed that among the carcinomas without...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2009.03.012
更新日期：2009-09-18 00:00:00
abstract：:Cancer results from genetic alterations in intracellular signaling pathways, which normally orchestrate the execution of developmental programs and the organismic response to extrinsic factors. Mutations in upstream activators and components of the cytoplasmic (Ras-Raf MEK-ERK) cascade frequently occur in tumors. In v...
journal_title：Cancer letters
pub_type： 杂志文章,评审
doi：10.1016/j.canlet.2004.08.003
更新日期：2005-01-10 00:00:00
abstract：:Cancer cachexia patients experience significant muscle wasting, which impairs the quality of life and treatment efficacy for patients. Skeletal muscle protein turnover is imparted by increased expression of ubiquitin-proteasome pathway components. Mitogen-activated protein kinases p38 and ERK have been shown to augmen...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2020.07.025
更新日期：2020-10-28 00:00:00
abstract：:Because lipoperoxides seem able to modulate tumor growth, we have examined the concomitant effects of dietary antioxidant (vitamin E) and of a high amount of polyunsaturated fatty acids (PUFA) in a model of chemically-induced mammary carcinogenesis. Two groups of rats received a high fat diet with or without added vit...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/s0304-3835(97)04671-5
更新日期：1997-03-19 00:00:00
abstract：:Previous studies point to protein kinase C (PKC) isozyme eta as a resistance factor in cancer cells. Therefore, we investigated whether down-regulation of PKCeta with second generation antisense oligonucleotides (ODNs) would sensitise A549 human lung carcinoma cells to cytostatics. The effects were compared to the out...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2004.02.001
更新日期：2004-06-25 00:00:00
abstract：:Post-transplant lymphoproliferative disorders (PTLDs) represent the most severe complication of both solid organ and hematopoietic stem cell transplantation. The Epstein-Barr Virus (EBV) is the main driver of PTLD, particularly those occurring early after transplantation. EBV-driven malignancies are associated with se...
journal_title：Cancer letters
pub_type： 杂志文章,评审
doi：10.1016/j.canlet.2015.08.007
更新日期：2015-12-01 00:00:00
abstract：:Increased abundance of the mRNA-binding protein human antigen R (HuR) is a characteristic feature of many cancers and frequently associated with a high grade malignancy and therapy resistance. HuR elicits a broad cell survival program mainly by stabilizing or increasing the translation of mRNAs coding for anti-apoptot...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2017.02.010
更新日期：2017-05-01 00:00:00
abstract：:Inactivation of antineoplastics is a serious problem in cancer therapy, and prevention of the inactivation is a surpassing strategy for enhancement of their therapeutic effects. BOF-A2, which contains both EM-FU, a masked form of 5-fluorouracil (5-FU), and CNDP, an inhibitor of 5-FU degradation, was developed with thi...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/s0304-3835(98)00330-9
更新日期：1999-03-22 00:00:00
abstract：:The involvement by tumour of intervertebral foramina and the consequent invasion of the spinal space, accompanied or not by neurological symptoms, represent a well-recognised pattern of presentation of neuroblastoma. The main peculiarity of this condition stands in the fact that, in case of its late detection or inade...
journal_title：Cancer letters
pub_type： 杂志文章,评审
doi：10.1016/j.canlet.2005.01.053
更新日期：2005-10-18 00:00:00
