Primary brain tumor incidence in mice exposed to split-dose ionizing radiation and circularly polarized 60 Hz magnetic fields.

abstract：:We planned to determine the relationship between angiogenesis and p53 mutational status in advanced-stage epithelial ovarian cancer. Using 190 tumor samples from patients with stage III and IV ovarian cancer we performed p53 sequencing, immunohistochemistry, and CD31 microvessel density (MVD) determination. MVD was el...

journal_title：Cancer letters

authors： Nadkarni NJ,Geest KD,Neff T,Young BD,Bender DP,Ahmed A,Smith BJ,Button A,Goodheart MJ

更新日期：2013-04-30 00:00:00

abstract：:Nitrosamine formation from the reaction of nitroprusside with morpholine was found to be a light-dependent reaction. Maximum nitrosation occurred when the reactants were exposed to UV light (lambda = 275-300 nm). However, considerable nitrosation also occurred with light in the visible spectrum up to 500 nm. No signif...

journal_title：Cancer letters

authors： Cooney RV,Ramseyer J,Ross PD

更新日期：1988-06-15 00:00:00

abstract：:Two hepatoma cell lines were incubated for 72 h with ATRA and its analog 13cisRA and according to MTT assay, Hep3B cells were highly susceptible whereas HepG2 cells were more resistant to the treatment. At the high concentration of 166 microM, retinoids were able to induce apoptosis in both cell lines and the highest ...

journal_title：Cancer letters

authors： Arce F,Gätjens-Boniche O,Vargas E,Valverde B,Díaz C

更新日期：2005-11-18 00:00:00

abstract：:Enhanced expression of the nucleotide excision repair gene XPA is associated with resistance to cisplatin treatment in human ovarian cancer. Understanding the cause of enhanced XPA expression will provide new molecular targets for therapy directed at overcoming chemoresistance. Enhanced gene expression in cancer cells...

journal_title：Cancer letters

authors： States JC,Reed E

更新日期：1996-11-29 00:00:00

abstract：:Transforming growth factors (TGFs) are implicated in malignancy, therefore qualitative and quantitative differences of these growth factors in chronic myelogenous leukemia (CML) in chronic phase has been investigated in this report. Induction of anchorage independent growth of BALB/c 3T3 and NRK-49F fibroblasts was us...

journal_title：Cancer letters

authors： Kothari V,Advani SH,Rao SG

更新日期：1986-09-01 00:00:00

abstract：:Bombesin-like peptides (BLP) and their receptors are widely distributed throughout the intestine and are potential mitogens for gastrointestinal cancers. In this study we characterized the proliferation induced by BLP in the human adenocarcinoma cell line HT-29. The number of HT-29 cells, partially serum deprived (1% ...

journal_title：Cancer letters

authors： Cassano G,Resta N,Gasparre G,Lippe C,Guanti G

更新日期：2001-10-30 00:00:00

abstract：:Photodynamic action has been advocated as an alternative treatment of tumors but the most common used dyes, hematoporphyrin derivatives, are substrate for P-glycoprotein. This study investigated the MDR-reverting properties of methylene blue (MB) and compared the sensitivity to its photodynamic action (PDA) in five ce...

journal_title：Cancer letters

authors： Trindade GS,Farias SL,Rumjanek VM,Capella MA

更新日期：2000-04-14 00:00:00

abstract：:Cellular phosphoprotein profiles from normal mouse embryonic fibroblast AKR-2B cells were compared to those of their permanently, chemically transformed malignant counterparts AKR-MCA cells, and AKR-2B cells reversibly transformed by transforming growth factor (AKR-TGF). Similar 32P-phosphorylation profiles were obser...

journal_title：Cancer letters

authors： Chakrabarty S,Brattain MG

更新日期：1985-11-01 00:00:00

abstract：:Vascular mimicry (VM) describes the phenomenon that tumor cells but not endothelial cells form vascular-like channels, which provide blood perfusion for tumor tissues. VM is associated with tumor growth, metastasis and worse survival of different cancers. The mechanisms of VM formation remain largely unknown. We showe...

journal_title：Cancer letters

authors： Yang J,Lu Y,Lin YY,Zheng ZY,Fang JH,He S,Zhuang SM

更新日期：2016-12-01 00:00:00

abstract：:The tumor microenvironment (TME) of lung cancer has been documented to play an important role in participating in tumor disease progression. As the precursor of most stroma in TME, mesenchymal stem cells (MSCs) draw great attention since evidence has suggested that MSCs derived from lung cancer patients present a diff...

journal_title：Cancer letters

authors： Liu R,Wei S,Chen J,Xu S

更新日期：2014-10-28 00:00:00

abstract：:Two hair dye components, carcinogenic 4-nitro-2-aminophenol and 5-nitro-2-aminophenol, induced Cu(II)-dependent DNA cleavage frequently at thymine and guanine residues in DNA fragments obtained from the c-Ha-ras-1 protooncogene. When the p53 tumor suppressor gene was used, 4-nitro-2-aminophenol caused Cu(II)-dependent...

journal_title：Cancer letters

authors： Chen F,Oikawa S,Hiraku Y,Murata M,Yamashita N,Kawanishi S

更新日期：1998-04-10 00:00:00

abstract：:The over-expression of N-myc down-regulated gene 1 (NDRG1) in hepatocellular carcinoma (HCC) was previously reported to correlate with vascular invasion and patient survival. Our current study aims to elucidate its functions in HCC. We found that it lacked the tumorigenic ability to promote soft agar colony formation ...

journal_title：Cancer letters

authors： Yan X,Chua MS,Sun H,So S

更新日期：2008-04-08 00:00:00

abstract：:The current standard approach for assessing carcinogenic potential is to conduct a near lifetime rodent pathology study with the high dose set to the maximum tolerated dose (MTD) of the test chemical. The linearized multistage model is then used as the default approach to estimate the potential human cancer risk at en...

journal_title：Cancer letters

authors： Butterworth BE,Conolly RB,Morgan KT

更新日期：1995-06-29 00:00:00

abstract：:The role of reactive oxygen species (ROS) and p38 mitogen-activated protein kinases (MAPK) in tanshinones-induced apoptosis was investigated in HepG2 cells in this study. The major tanshinones (cryptotanshinone, dihydrotanshinone, tanshinone I, tanshinone IIA), isolated from Salvia miltiorrhiza, inhibit cell growth an...

journal_title：Cancer letters

authors： Lee WY,Liu KW,Yeung JH

更新日期：2009-11-18 00:00:00

abstract：:Previously, we showed that hypoxia-inducible factor (HIF)-1alpha, HIF-2alpha, carbonic anhydrase IX (CA IX), and vascular endothelial growth factor (VEGF) were frequently coexpressed in tumor biopsies from patients of nasopharyngeal carcinoma (NPC) and were associated with poor outcome after radiotherapy. Here, we fur...

journal_title：Cancer letters

authors： Sung FL,Hui EP,Tao Q,Li H,Tsui NB,Lo YM,Ma BB,To KF,Harris AL,Chan AT

更新日期：2007-08-08 00:00:00

abstract：:Mouse mammary tumor viruses (MMTV) replicate in the mammary gland, appear as infectious particles in mother's milk and invade the sucking pups from the intestinal tract. The immune system is essential for MMTV in the gut to reach the mammary gland. These properties make the life cycle of MMTV unique. We review the onc...

journal_title：Cancer letters

authors： Matsuzawa A,Nakano H,Yoshimoto T,Sayama K

更新日期：1995-03-23 00:00:00

abstract：:Increasing evidence points to a fundamental role for cancer stem cells (CSC) in the initiation and propagation of many tumors. As such, in the context of glioblastoma multiforme (GBM), the development of treatment strategies specifically targeted towards CSC-like populations may hold significant therapeutic promise. T...

journal_title：Cancer letters

authors： Ehtesham M,Mapara KY,Stevenson CB,Thompson RC

更新日期：2009-02-18 00:00:00

abstract：:Amplification and overexpression of PPM1D (protein phosphatase magnesium-dependent 1 delta) has been observed in various cancer cell lines and primary tumors and has also been associated with cancers of poor prognosis. In addition to the negative feedback regulation of p38-p53 signaling, PPM1D inhibits other tumor sup...

journal_title：Cancer letters

authors： Pärssinen J,Alarmo EL,Khan S,Karhu R,Vihinen M,Kallioniemi A

更新日期：2008-01-18 00:00:00

abstract：:Non-small cell lung cancer (NSCLC) remains one of the most metastasizing tumors, and directional cell migration is critical for targeting tumor metastasis. GIT2 has been known to bind to Paxillin to control cell polarization and directional migration. However, the molecular mechanisms underlying roles of GIT2 in contr...

journal_title：Cancer letters

authors： Duan B,Cui J,Sun S,Zheng J,Zhang Y,Ye B,Chen Y,Deng W,Du J,Zhu Y,Chen Y,Gu L

更新日期：2016-08-28 00:00:00

abstract：:An apoptosis-inducing protein with molecular weight of 60 kDa has been purified from fetal bovine serum. The N-terminal amino acid sequence of this protein (e.g. I-P-L-D-P-V-A-G-Y-K) reveals that it is bovine fetuin, a fetal protein functioning to control embryogenesis. The apoptosis-inducing activity of fetuin is tot...

journal_title：Cancer letters

authors： Yu CL,Tsai MH

更新日期：2001-05-26 00:00:00

abstract：:Both insulin-like growth factor II (IGF2) and H19 gene are located on chromosome 11p15.5 in close vicinity to each other, and are imprinted on different parental alleles. Although the exact mechanism remains unclear, loss of imprinting (LOI) leading to the biallelic expression of IGF2 and H19 genes has recently been r...

journal_title：Cancer letters

authors： Wu MS,Wang HP,Lin CC,Sheu JC,Shun CT,Lee WJ,Lin JT

更新日期：1997-11-25 00:00:00

abstract：:Previous studies have demonstrated that fibroblast growth factor 8b (FGF8b) is up-regulated in a large proportion of prostate cancer patients and that it plays a key role in prostate carcinogenesis. In this study, we designed and synthesized a gN helix domain derived short peptide (termed 8b-13) based on the analysis ...

journal_title：Cancer letters

authors： Li T,Luo W,He D,Wang R,Huang Y,Zeng X,Wang W,Chen X,Gao S,Yu Y,Li X,Wu X

更新日期：2013-10-10 00:00:00

abstract：:Fludarabine phosphate is a synthetic analog of beta-arabinofuranosyl adenine (beta-ara-A), an anti-viral agent. Since beta-ara-A has been shown to be an effective inhibitor of potentially lethal damage (PLD) repair in cell culture system but ineffective in in vivo tumors, we carried out experiments to determine whethe...

journal_title：Cancer letters

authors： Kim JH,Alfieri AA,Kim SH,Fuks Z

更新日期：1986-04-01 00:00:00

abstract：:Preventive intervention of colorectal cancer has become essential as a major portion of the population may develop the disease at some points during their lives. Diet and nutrition play an important role during this multistep colon carcinogenic process. Inhibitory activity of aqueous suspensions of garlic and tomato, ...

journal_title：Cancer letters

authors： Sengupta A,Ghosh S,Das S

更新日期：2004-05-28 00:00:00

abstract：:Head and neck cancers are commonly treated with the DNA-damaging agent cisplatin. While many tumors respond well to cisplatin treatment, some do not. The mechanism for this differential sensitivity of head and neck tumors to cisplatin is not understood in detail. In this study, we explored whether the functional statu...

journal_title：Cancer letters

authors： Burkitt K,Ljungman M

更新日期：2007-08-08 00:00:00

abstract：:Dibenzoylmethane (DBM), a minor beta-diketone constituent of licorice and sunscreens, has been shown to exhibit anti-neoplastic effects in chemically induced skin and mammary cancers in several animal models. To date, no mechanism for the growth inhibitory effects of DBM on prostate cancer cells has been proposed. In ...

journal_title：Cancer letters

authors： Jackson KM,DeLeon M,Verret CR,Harris WB

更新日期：2002-04-25 00:00:00

abstract：:The transcription factor Forkhead Box P3 (Foxp3) has been shown to play important roles in the occurring of regulatory T cells (Tregs). Limited evidence indicated that it was also expressed in tissues other than thymus and spleen, while, very recently, it was identified as a suppressor gene in breast cancer. However, ...

journal_title：Cancer letters

authors： Zhang HY,Sun H

更新日期：2010-01-01 00:00:00

abstract：:Earlier studies performed both by us and by others have demonstrated that some n-3 and n-6 fatty acids can inhibit the growth of tumour cells in vitro. Though studies done with various types of oils rich in n-3 and n-6 fatty acids did show that the tumour incidence and growth can be modified, there were relatively few...

journal_title：Cancer letters

authors： Ramesh G,Das UN

更新日期：1998-01-30 00:00:00

abstract：:Spectroscopic techniques have demonstrated that in the microscopically normal mucosa, there is an increase in mucosal micro-circulation in patients harboring neoplasia elsewhere in the colon (i.e. marker of field carcinogenesis). However, the physiological and molecular basis of this early increase in blood supply (EI...

journal_title：Cancer letters

authors： Tiwari AK,Crawford SE,Radosevich A,Wali RK,Stypula Y,Kunte DP,Mutyal N,Ruderman S,Gomes A,Cornwell ML,De La Cruz M,Brasky J,Gibson TP,Backman V,Roy HK

更新日期：2011-07-28 00:00:00

abstract：:During the late period of pregnancy (on the 50th and 53rd days post coitum) 2 dogs were injected intraperitoneally with 100 mg/kg (a single administration) of nitrosoethylurea. Nine puppies were born. During the 9 year period of observation no tumours were detected in mother-dogs. Three of 9 offspring developed the fo...

journal_title：Cancer letters

authors： Napalkov NP,Alexandrov VA,Anisimov VN

更新日期：1981-03-01 00:00:00