Abstract:
:We planned to determine the relationship between angiogenesis and p53 mutational status in advanced-stage epithelial ovarian cancer. Using 190 tumor samples from patients with stage III and IV ovarian cancer we performed p53 sequencing, immunohistochemistry, and CD31 microvessel density (MVD) determination. MVD was elevated in tumors with p53 null mutations compared to p53 missense mutation or no mutation. Disease recurrence was increased with higher MVD in both unadjusted and adjusted analyses. In adjusted analysis, p53 null mutation was associated with increased recurrence and worse overall survival. Worse overall survival and increased recurrence risk were also associated with the combination of CD31 MVD values >25 vessels/HPF and any p53 mutation. P53 mutation status and MVD may have prognostic significance in patients with advanced-stage ovarian cancer. Tumors with p53 null mutations are likely to be more vascular, contributing to decreased survival and increased recurrence probability.
journal_name
Cancer Lettjournal_title
Cancer lettersauthors
Nadkarni NJ,Geest KD,Neff T,Young BD,Bender DP,Ahmed A,Smith BJ,Button A,Goodheart MJdoi
10.1016/j.canlet.2012.12.016subject
Has Abstractpub_date
2013-04-30 00:00:00pages
99-104issue
1eissn
0304-3835issn
1872-7980pii
S0304-3835(12)00733-1journal_volume
331pub_type
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