Abstract:
:The activity of 4 enzymes involved in the formation and interconversion of folate coenzymes has been examined in liver and kidney of healthy and Ehrlich ascites carcinoma-bearing mice. In the liver, a 50% increase of methylenetetrahydrofolate reductase activity was shown soon after tumour cell inoculation, while the activity of formyltetrahydrofolate synthetase and methylenetetrahydrofolate dehydrogenase decrease by 20% at an advanced stage of tumour development. In kidneys of the host mouse the only change observed was a decrease of dihydrofolate reductase activity. The levels of activity of all assayed enzymes found in host organs were similar to that in Ehrlich carcinoma cells.
journal_name
Cancer Lettjournal_title
Cancer lettersauthors
Chmurzyńska W,Manteuffel-Cymborowska M,Sikora E,Grzelakowska-Sztabert Bdoi
10.1016/s0304-3835(84)80048-8subject
Has Abstractpub_date
1984-12-01 00:00:00pages
217-24issue
2eissn
0304-3835issn
1872-7980pii
S0304-3835(84)80048-8journal_volume
25pub_type
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