Abstract:
:Boesenbergia pandurata (Zingiberaceae), Languas galanga (Zingiberaceae) and Citrus hystrix (Rutaceae) are edible plants that are commonly used as flavors or condiments in various Thai food dishes. They are known to exert strong anti-promoting activity in a test of tumor promoter-induced Epstein-Barr virus (EBV) activation. In the present study their effects on hepatocarcinogenesis were investigated in a medium-term bioassay using F344 male rats. C. hystrix significantly enhanced 2-amino-3,8-dimethylimidazo(4, 5-f)quinoxaline-associated preneoplastic liver cell focus development while B. pandurata and L. galanga had borderline effects. The results suggest that C. hystrix as well as B. pandurata and L. galanga may contain agents augmenting the hepatocarcinogenicity of 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline.
journal_name
Cancer Lettjournal_title
Cancer lettersauthors
Tiwawech D,Hirose M,Futakuchi M,Lin C,Thamavit W,Ito N,Shirai Tdoi
10.1016/s0304-3835(00)00530-9keywords:
subject
Has Abstractpub_date
2000-10-01 00:00:00pages
195-201issue
2eissn
0304-3835issn
1872-7980pii
S0304383500005309journal_volume
158pub_type
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