Abstract:
:A cell line partially resistant to dimethylsulfoxide (DMSO) was derived from the HL-60 cell line. Cycloleucine, theophylline, sodium butyrate and elevated levels of DMSO were found to induce myeloid differentiation in this cell line while TPA induced monocytic differentiation. The levels of myc RNA and the genomic structure of the c-myc proto-oncogene were found to be the same in HL-60 and the resistant cell line. Differentiation of the DMSO resistant line was accompanied by a reduction in myc RNA levels.
journal_name
Cancer Lettjournal_title
Cancer lettersauthors
Grosso LE,Pitot HCdoi
10.1016/0304-3835(84)90043-0subject
Has Abstractpub_date
1984-02-01 00:00:00pages
55-63issue
1eissn
0304-3835issn
1872-7980pii
0304-3835(84)90043-0journal_volume
22pub_type
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