Electro-sensitisation of mammalian cells and tissues to ultrasound: a novel tumour treatment modality.

abstract：:In the course of screening for a novel inhibitor of cyclin-dependent kinase (CDK), HY52 (C17H30O2N2; molecular weight 294) was isolated from the leaves of Pata de Vaca (Bauhinia forficata). The growth of HeLa cells was inhibited in a dose-dependent manner when treated with 0.07 to 0.41 mM of HY52 for 24 h (IC50:0.11 m...

journal_title：Cancer letters

authors： Lim H,Kim MK,Lim Y,Cho YH,Lee CH

更新日期：2006-02-20 00:00:00

abstract：:Carcinogenic studies were performed on the skin of inbred male Lister rats using 7,12-dimethylbenz[alpha]anthracene (DMBA) in low doses (2.5 mg and 5.0 mg), followed by promotion with croton oil (CO) in one half of the animals. The clinically observed tumour rate did not differ after the two carcinogen doses and was p...

journal_title：Cancer letters

authors： Spaun E,Arffmann E

更新日期：1992-08-14 00:00:00

abstract：:Non-steroidal anti-inflammatory drugs (NSAIDs) are used extensively for analgesic and antipyretic treatments. In addition, NSAIDs reduce the risk and mortality to several cancers. Their mechanisms in anti-tumorigenesis are not fully understood, but both cyclooxygenase (COX)-dependent and -independent pathways play a r...

journal_title：Cancer letters

authors： Liggett JL,Zhang X,Eling TE,Baek SJ

更新日期：2014-05-01 00:00:00

abstract：:Brain metastasis is an important cause of morbidity and mortality in cancer-patients. Breast tumor cells frequently metastasize to brain and initiate severe therapeutic complications. In the present study, we evaluated the anti-metastatic effects of 2'-hydroxyflavanone (2HF) alone and in combination with RLIP targeted...

journal_title：Cancer letters

authors： Singhal J,Singhal P,Horne D,Salgia R,Awasthi S,Singhal SS

更新日期：2018-12-01 00:00:00

abstract：:The anticarcinogenic action of the garlic constituent diallyl sulfide (DAS), was examined in the hamster buccal pouch and forestomach. Groups of hamsters were topically treated, for up to 14 weeks, with a 0.5% solution of the buccal pouch and forestomach carcinogen 7,12-dimethylbenz[a]anthracene (DMBA). Prior to, duri...

journal_title：Cancer letters

authors： Nagabhushan M,Line D,Polverini PJ,Solt DB

更新日期：1992-10-21 00:00:00

abstract：:The effect of Pseudomonas aeruginosa colonizing in the gut on the development of gastrointestinal tumors was studied in rats treated orally with N-methyl-N'-nitro-N-nitrosoguanidine (MNNG). The animals were inoculated with or accidentally colonized by P. aeruginosa after MNNG treatment. In 3 serial experiments, P. aer...

journal_title：Cancer letters

authors： Morishita Y,Shimizu T

更新日期：1983-01-01 00:00:00

abstract：:The regulation of MYC-regulated long non-coding RNAs has been reported to contribute to certain types of cancers. However, the role of MYC-induced long non-coding RNA (MINCR) in the tumorigenesis of gallbladder cancer (GBC) is still largely unknown. In this study, we discovered that MINCR was markedly upregulated in G...

journal_title：Cancer letters

authors： Wang SH,Yang Y,Wu XC,Zhang MD,Weng MZ,Zhou D,Wang JD,Quan ZW

更新日期：2016-09-28 00:00:00

abstract：:The selectivity of photodynamic therapy (PDT) derived from the tailored accumulation of photosensitizing drug (photosensitizer; PS) in the tumor microenvironment (TME), and from local irradiation, turns it into a "magic bullet" for the treatment of resistant tumors without sparing the healthy tissue and possible adver...

journal_title：Cancer letters

authors： Pucelik B,Sułek A,Barzowska A,Dąbrowski JM

更新日期：2020-11-01 00:00:00

abstract：:Glutathione S-transferases (GST) alpha and pi, glutathione (GSH) and aldehyde dehydrogenase (ADH) were determined in colorectal cancer tissue specimens and in the adjacent normal colon tissue. The median contents in normal and cancer tissue were 8.1 (2.3-30.3) (5-95% quantiles) and 15.1 (5.3-50.3) microg/mg protein fo...

journal_title：Cancer letters

authors： Hengstler JG,Böttger T,Tanner B,Dietrich B,Henrich M,Knapstein PG,Junginger T,Oesch F

更新日期：1998-06-05 00:00:00

abstract：:Our previous studies demonstrated that dietary garlic powder supplementation inhibits N-nitrosamine induced DNA alkylation in liver and mammary tissue. The present studies compared the impact of dietary supplementation with garlic powder or two garlic constituents, water-soluble S-allyl cysteine (SAC) and oil-soluble ...

journal_title：Cancer letters

authors： Schaffer EM,Liu JZ,Green J,Dangler CA,Milner JA

更新日期：1996-04-19 00:00:00

abstract：:Ovarian cancer represents the leading cause of death among patients with gynecological cancer. The genetic changes underlying the initiation and progression of ovarian cancer have not been well defined. However, non-random structural chromosomal changes have been identified with common chromosomal breakpoints. We have...

journal_title：Cancer letters

authors： Panani AD,Roussos C

更新日期：2006-04-08 00:00:00

abstract：:Peroxiredoxin I (Prx I) is newly discovered oxidative stress inducible protein, having a thioredoxin peroxidase activity. The Prx I expression level in 107 samples out of 60 thyroid lesions, including normal thyroid, tumors and thyroiditis including Graves' disease were examined using immunoblotting. Prx I expression ...

journal_title：Cancer letters

authors： Yanagawa T,Ishikawa T,Ishii T,Tabuchi K,Iwasa S,Bannai S,Omura K,Suzuki H,Yoshida H

更新日期：1999-10-18 00:00:00

abstract：:Fludarabine phosphate is a synthetic analog of beta-arabinofuranosyl adenine (beta-ara-A), an anti-viral agent. Since beta-ara-A has been shown to be an effective inhibitor of potentially lethal damage (PLD) repair in cell culture system but ineffective in in vivo tumors, we carried out experiments to determine whethe...

journal_title：Cancer letters

authors： Kim JH,Alfieri AA,Kim SH,Fuks Z

更新日期：1986-04-01 00:00:00

abstract：:The epidermis of the skin is a multilayered stratified epithelium whose primary function is to provide a barrier against our external environment. As a result, cells in the epidermis are subject to constant assault from environmental pathogens, many of which can cause deleterious mutations. However, most of these muta...

journal_title：Cancer letters

authors： Thieu K,Ruiz ME,Owens DM

更新日期：2013-09-10 00:00:00

abstract：:To shed light on the association of intestinal microflora with the development of colon cancer, we studied the modifying effects of intestinal microflora on the occurrence of 1,2-dimethylhydrazine (DMH)-induced colonic aberrant crypt foci (ACF) in germfree (GF), gnotobiotic (GB) and conventionalized (Cvd) rats. In the...

journal_title：Cancer letters

authors： Onoue M,Kado S,Sakaitani Y,Uchida K,Morotomi M

更新日期：1997-02-26 00:00:00

abstract：:It has been shown that acquisition of epithelial-mesenchymal transition (EMT) and induction of cancer stem cell (CSC)-like properties contribute to metastasis of cancers in many studies; however, the molecular mechanisms underlying EMT and CSC phenotypes in liver cancer cells remain to be elucidated. MiR-155 is an imp...

journal_title：Cancer letters

authors： Liu F,Kong X,Lv L,Gao J

更新日期：2015-04-10 00:00:00

abstract：:We have previously shown that oligonucleotides designed to bind in triplex fashion to a specific p53 binding site homology inhibit the proliferation of colon cancer cells in vitro. The present study was designed to extend these observations in an in vivo model. HCT 116 human colon carcinoma cells were injected subcuta...

journal_title：Cancer letters

authors： Re RN,Cook JL,Giardina JF

更新日期：2004-06-08 00:00:00

abstract：:V600E being the most common mutation in BRAF, leads to constitutive activation of the MAPK signaling pathway. The majority of V600E BRAF positive melanoma patients treated with the BRAF inhibitor vemurafenib showed initial good clinical responses but relapsed due to acquired resistance to the drug. The aim of the pres...

journal_title：Cancer letters

authors： Zubrilov I,Sagi-Assif O,Izraely S,Meshel T,Ben-Menahem S,Ginat R,Pasmanik-Chor M,Nahmias C,Couraud PO,Hoon DS,Witz IP

更新日期：2015-05-28 00:00:00

abstract：:Metastatic colonization involves paracrine/juxtacrine interactions with the microenvironment inducing an adaptive response through transcriptional regulation. However, the identities of transcription factors (TFs) induced by the metastatic microenvironment in ovarian cancer (OC) and their mechanism of action is poorly...

journal_title：Cancer letters

authors： Tomar S,Plotnik JP,Haley J,Scantland J,Dasari S,Sheikh Z,Emerson R,Lenz D,Hollenhorst PC,Mitra AK

更新日期：2018-02-01 00:00:00

abstract：:Expression of the cytoplasmic soluble form of p53 protein in the different rat colon cancer cell lines transfected and non-transfected with Rous sarcoma virus-33 was studied. Concentrations of the p53 protein were detected by commonly used immunochemical methods after its isolation by affinity chromatography columns w...

journal_title：Cancer letters

authors： Sandler B,Grofova M,Smirnoff P,Zusman R,Zusman I

更新日期：1997-12-23 00:00:00

abstract：:Diabetes mellitus type II (DM) and immune cell infiltration determine patient outcome in many tumor entities. Here we studied a possible link between the metabolic and immune cell status of OSCC patients. Glucose transporter (GLUT) 1 mRNA expression was elevated in all tumor samples, whereas other glycolytic markers s...

journal_title：Cancer letters

authors： Spanier G,Ugele I,Nieberle F,Symeou L,Schmidhofer S,Brand A,Meier J,Spoerl S,Krupar R,Rümmele P,Siska P,Renner K,Peter K,Gerken M,Beckhove P,Reichert TE,Kreutz M,Singer K

更新日期：2021-02-28 00:00:00

abstract：:Trypsin inhibitors have been shown to promote pancreatic growth as well as the development of pancreatic tumours in rats. The present study was carried out to examine the effects of the synthetic trypsin inhibitor camostate on the growth of the pancreas and on the development of pancreatic preneoplastic and neoplastic...

journal_title：Cancer letters

authors： Meijers M,van Garderen-Hoetmer A,Lamers CB,Rovati LC,Jansen JB,Woutersen RA

更新日期：1991-12-01 00:00:00

abstract：:Cell kinetics (cell proliferation and cell death) and the expression of progesterone receptor (PgR) during growth and regression of pregnancy-dependent mammary tumors (PDMT) of female GRS/A mice were investigated on the histologic level. Cell proliferation was determined using monoclonal anti-proliferating cell nuclea...

journal_title：Cancer letters

authors： Yang J,Senzaki H,Nambu H,Tsubura A

更新日期：1996-08-23 00:00:00

abstract：:Highly active antiretroviral therapy (HAART) changed the natural history of pediatric HIV infection. This review focuses on trends of HIV-associated cancers in childhood in the HAART era and analyses potential pathogenetic mechanisms. HAART reduced AIDS-defined-malignancies (ADM), but incidence of several non-ADM is i...

journal_title：Cancer letters

authors： Chiappini E,Berti E,Gianesin K,Petrara MR,Galli L,Giaquinto C,de Martino M,De Rossi A

更新日期：2014-05-28 00:00:00

abstract：:The in vitro induction of sister chromatid exchanges (SCEs) in Chinese hamster ovary (CHO) cells by the polycyclic hydrocarbons, 7,12-dimethylbena[a]anthracene and 3-methylcholanthrene and some of the related dihydrodiols was investigated. Increased numbers of SCEs were seen in the chromosomes of cells exposed to non-...

journal_title：Cancer letters

authors： Pal K,Grover PL,Sims P

更新日期：1979-06-01 00:00:00

abstract：:Serum beta-glucuronidase activity is shown to differ quantitatively in the following strains of mice, listed in order of increasing activity: C3H, C57BL/6 less than BALB/c, DBA/2, ICR less than SENCAR, A/He. The level of the enzyme in the murine strains is shown to correlate with the urinary excretion of 17-ketosteroi...

journal_title：Cancer letters

authors： Walaszek Z,Hanausek-Walaszek M,Webb TE

更新日期：1986-10-01 00:00:00

abstract：:Vesnarinone (OPC-8212; 3,4-dihydro-6-[4-(3,4-dimethoxybenzoyl)-1-piperazinyl]-2(1H)-quinolinone ) is a synthetic oral cardiotonic agent that has been used for the treatment of patients with congestive heart failure. Six days of treatment with 30 microg/ml of vesnarinone induced 20-80% growth inhibitions in five out of...

journal_title：Cancer letters

authors： Yokozaki H,Ito R,Ono S,Hayashi K,Tahara E

更新日期：1999-06-01 00:00:00

abstract：:We have characterized the changes in composition of the nuclear matrix-intermediate filament complex (NM-IF) isolated from prostate cancer (PCa), compared with benign prostatic hyperplasia (BPH). We prepared the NM-IF from ten patients undergoing radical retropubic prostectomy; the benign hyperplastic tissue was obtai...

journal_title：Cancer letters

authors： Alberti I,Parodi S,Barboro P,Sanna P,Nicolò G,Allera C,Patrone E,Galli S,Balbi C

更新日期：1996-12-03 00:00:00

abstract：:In vitro cultured r/mHM-SFME-1 cells were injected into the hind foot pads of Balb/c mice. Metastasis was detected in the lungs of tumor-bearing mice by means of both PCR and histological methods. Primers for the PCR were set to amplify a 128 bp exon-1 sequence of the human c-Ha-ras1 gene which had been introduced int...

journal_title：Cancer letters

authors： Matano S,Ryoyama K,Nakamura S,Okada G,Nomura T

更新日期：1995-05-04 00:00:00

abstract：:Artesunate (ART), a semi-synthetic derivative of artemisinin extracted from the Chinese herb Artemisia annua, is a safe and effective antimalarial drug. ART has now been analyzed for its anti-angiogenic activity in vivo and in vitro. The anti-angiogenic effect in vivo was evaluated on chicken chorioallantoic membrane ...

journal_title：Cancer letters

authors： Huan-huan C,Li-Li Y,Shang-Bin L

更新日期：2004-08-10 00:00:00