Abstract：
:The anticarcinogenic action of the garlic constituent diallyl sulfide (DAS), was examined in the hamster buccal pouch and forestomach. Groups of hamsters were topically treated, for up to 14 weeks, with a 0.5% solution of the buccal pouch and forestomach carcinogen 7,12-dimethylbenz[a]anthracene (DMBA). Prior to, during and after DMBA treatment, groups of hamsters were also treated, on alternate days, with a 1% solution of DAS. In addition to tumor formation, the induction of gamma-glutamyl transpeptidase (gamma GT) buccal pouch epithelial lesions served as an additional presumptive index of in vivo carcinogenesis/anticarcinogenesis. DAS resulted in a significant reduction in buccal pouch tumor frequency, buccal pouch tumor burden, buccal pouch gamma GT lesion frequency and forestomach tumor frequency. In a separate experiment, DAS also reduced the level of autoradiographically quantified unscheduled DNA repair synthesis (UDS) in pieces of hamster buccal pouch concurrently exposed in vitro to the potent buccal pouch carcinogen N-methyl-N-benzylnitrosamine (MBN). This study demonstrates that DAS is an effective anticarcinogenic agent in squamous mucosa of the hamster and suggests novel cost-effective strategies for the rapid identification of tissue-specific anticarcinogens and a quantitative assessment of their efficacy.
journal_name
Cancer Lettjournal_title
Cancer lettersauthors
Nagabhushan M,Line D,Polverini PJ,Solt DBdoi
10.1016/0304-3835(92)90249-ukeywords:
subject
Has Abstractpub_date
1992-10-21 00:00:00pages
207-16issue
3eissn
0304-3835issn
1872-7980pii
0304-3835(92)90249-Ujournal_volume
66pub_type
杂志文章相关文献
CANCER LETTERS文献大全abstract：:Multidrug resistance (MDR) is a serious obstacle for cancer chemotherapy. The aim of this study was to reverse MDR of breast carcinoma cells specifically by degrading mdr1 mRNA with anti-mdr1 ribozyme. Our strategy was to limit the expression of ribozyme to only breast-derived cells, but not other type of cells. The r...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2007.06.005
更新日期：2007-10-18 00:00:00
abstract：:To understand the role of cyclooxygenase-2 (COX-2) in gastric cancer, we examined the abundance of COX-2, vascular endothelial growth factor-A (VEGF-A), and CD34 in 45 surgically resected human gastric cancers and paired normal gastric mucosa by immunohistochemical analysis. In addition, the message RNA (mRNA) express...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/s0304-3835(03)00153-8
更新日期：2003-05-30 00:00:00
abstract：:Despite recent improvements in chemotherapy and surgery, the problem of non-response osteosarcoma to chemotherapy remains, and is a parameter that is critical for prognosis. The present work investigated the therapeutic value of NVP-BEZ235, a dual class I PI3K/mTOR inhibitor. NVP-BEZ235 inhibited osteosarcoma cell pro...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2013.11.017
更新日期：2014-03-28 00:00:00
abstract：:A high-pressure liquid chromatographic (HPLC) method using a micro-particulate silica column and gradient elution was developed that separated 12-O-tetradecanoylphorbol-13-acetate (TPA) from 20-oxo-TPA; 12-O-tetradecanoylphorbol (TP); 13-O-acetylphorbol (PA), and from the diterpene alcohol, phorbol (P). A series of ot...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/s0304-3835(77)94943-6
更新日期：1977-09-01 00:00:00
abstract：:We investigated whether the level of bone marrow-derived progenitor cells and mature endothelial cells could be used as predictors of clinical outcome in patients receiving taxotere-based chemotherapy for advanced gastric cancer. Peripheral blood mononuclear cells were obtained from 49 gastric cancer patients who rece...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2008.05.011
更新日期：2008-11-08 00:00:00
abstract：:Aristolochic acid (AA), a component of some Chinese herbal medicines, may cause Chinese Herbs Nephropathy (CHN) and multi-systemic tumors by the formation of AA-DNA adducts. In this study, we established an animal model to further characterize the mechanisms of AA-induced diseases. Our results indicated that AA signif...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2005.02.021
更新日期：2006-02-08 00:00:00
abstract：:Oesophageal cancer is associated with high morbidity and mortality rates because it is highly invasive and prone to recurrence and metastasis, with a five-year survival rate of <20%. Therefore, there is an urgent need for new methods aimed at improving therapeutic intervention. Several studies have shown that targeted...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2020.10.005
更新日期：2021-01-01 00:00:00
abstract：:Glycyrrhetic acid is an anti-inflammatory agent isolated from licorice root that inhibits 12-O-tetradecanoylphorbol-13-acetate (TPA)-mediated tumor promotion in mouse skin. Although it has been established that glycyrrhetic acid inhibits a number of events induced by the phorbol ester tumor promoter TPA in cultured ce...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/0304-3835(90)90132-h
更新日期：1990-01-01 00:00:00
abstract：:Changes in reduced folates upon exposure of Krebs ascites cells and L1210 murine leukemia cells to methotrexate (MTX) have been measured by stoichiometric entrapment of tissue methylenetetrahydrofolate into a stable ternary complex with thymidylate synthase and tritiated 5-fluoro-2'-deoxy-uridine-5'-monophosphate. Tet...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/0304-3835(86)90132-1
更新日期：1986-01-01 00:00:00
abstract：:Pancreatic ductal adenocarcinoma (PDAC) remains one of the most lethal types of cancer with poor prognosis. Despite extensive efforts, the current treatment methods have limited success. Therefore, novel therapeutic approaches are required. The pancreatic tumor microenvironment is rich in growth factors and inflammato...
journal_title：Cancer letters
pub_type： 杂志文章,评审
doi：10.1016/j.canlet.2013.07.014
更新日期：2014-04-10 00:00:00
abstract：:A newly found human retrovirus, adult T-cell leukemia virus (ATLV) was shown by means of membrane immunofluorescence to bind to various hematopoietic cells including T-, B- and non-T, non-B-cell lines. Partially purified viral gp46 from culture fluids of ATL virus producer lines also bound efficiently to an ATLV-negat...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/0304-3835(84)90004-1
更新日期：1984-01-01 00:00:00
abstract：:The three mistletoe (Viscum album L.) lectins. ML I, ML II and ML III, were tested on their ability to enhance the secretion of the cytokines tumor necrosis factor (TNF)alpha, interleukin (IL)-1 alpha, IL-1 beta and IL-6 by human monocytes obtained from healthy donors. At lectin concentrations from 0.02 to 20/pg ml (1...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/s0304-3835(96)04401-1
更新日期：1996-12-03 00:00:00
abstract：:The heat shock protein 40kDa (HSP40/DNAJ) co-chaperones constitute the largest and most diverse sub-group of the heat shock protein (HSP) family. DNAJ are widely accepted as regulators of HSP70 function, but also have roles as co-chaperones for the HSP90 chaperone machine, and a growing number of biological functions ...
journal_title：Cancer letters
pub_type： 杂志文章,评审
doi：10.1016/j.canlet.2011.08.019
更新日期：2011-12-22 00:00:00
abstract：:Epidemiologic studies and meta-analyses have suggested that patients with type 2 diabetes mellitus (T2DM) have a higher incidence of malignancies, including myeloma. Metformin is a widely prescribed antidiabetic drug. Recently, researchers have shown that metformin has direct anticancer activity against many tumor cel...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2014.09.050
更新日期：2015-01-28 00:00:00
abstract：:Free hematoporphyrin administered intravenously to healthy rabbits (1-28 mg/kg body weight) is bound by the 3 major lipoprotein components of plasma (VLDL, LDL and HDL) with different efficiency. In vitro-prepared complexes of hematoporphyrin (Hp) with lipoprotein fractions isolated from mouse serum have been injected...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/0304-3835(86)90112-6
更新日期：1986-08-01 00:00:00
abstract：:Aberrant expression of many long non-coding RNAs has been observed in various types of cancer, implicating their crucial roles in tumorigenesis and cancer progression. Emerging knowledge with regard to the critical physiological and pathological roles of long non-coding RNAs in cancers makes them potential targets in ...
journal_title：Cancer letters
pub_type： 杂志文章,评审
doi：10.1016/j.canlet.2018.01.042
更新日期：2018-04-01 00:00:00
abstract：:Incubation of mouse epidermal cells (HEL-37) with phospholipase C (Clostridium perfringens) caused about a 50% decrease in the specific binding of [20-3H]phorbol-12,13-dibutyrate. Phospholipase C caused a decrease in the apparent number of binding sites from 2.86 X 10(5) to 1.21 X 10(5) per cell with little effect on ...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/0304-3835(83)90141-6
更新日期：1983-05-01 00:00:00
abstract：:Recently developed quantitative and high-throughput technologies that allow automated and rapid screening of the whole genome, transcriptome and proteome have revolutionized the field of cancer genetics. At the same time, new challenges are met, e.g. the need for improved data analysis and standardization of tumor sam...
journal_title：Cancer letters
pub_type： 杂志文章,评审
doi：10.1016/s0304-3835(03)00084-3
更新日期：2003-07-18 00:00:00
abstract：:Glioblastoma multiforme (GBM) is one of the most aggressive human tumors with poor prognosis. Current standard treatment includes chemotherapy using DNA alkylating agent temozolomide (TMZ) concomitant with surgical resection and/or irradiation. However, GBM patients exhibit various levels of the elevated expression of...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2012.12.005
更新日期：2013-04-30 00:00:00
abstract：:Despite being the subject of extensive research and clinical trials, neuroblastoma remains a major therapeutic challenge in pediatric oncology. The p53 protein is a central safeguard that protects cells against genome instability and malignant transformation. Mutated TP53 (the gene encoding p53) is implicated in many ...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2020.09.023
更新日期：2021-01-01 00:00:00
abstract：:A derivative of coumarin, 8-nitro-7-hydroxycoumarin (8-NO2-7-OHC), was synthesised, purified and characterised. The cytostatic and cytotoxic nature of this compound was determined using both human and animal cell lines grown in vitro for 96 h in the presence of drug (0-500 microM, equivalent to 0-104 microg/ml). 8-NO2...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/s0304-3835(97)00331-5
更新日期：1997-10-14 00:00:00
abstract：:The newly identified protein BLAP75/RMI1 associates with the helicase BLM and is critical for the function of the homologous recombination complex. Mutations altering BLM function are associated with highly elevated cancer susceptibility (Bloom's syndrome). We have analyzed the common polymorphism Ser455Asn in RMI1 an...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2007.08.005
更新日期：2007-12-08 00:00:00
abstract：:Multidrug-resistant MCF-7 breast adenocarcinoma cells (originally named MCF-7/AdrR cells and later re-designated NCI/ADR-RES) have served as an important and widely used research tool during the last two decades. However, the real identity of these cells has been in doubt since 1998 and has since been debated. The ori...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2006.01.013
更新日期：2007-01-08 00:00:00
abstract：:The vast majority of cancer deaths are caused by the formation of metastases rather than the primary tumor itself. Despite this clinical importance, the molecular and cellular events that support the dissemination of cancer cells are not yet fully unraveled. We have previously shown that CDX2, a homeotic transcription...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2016.10.040
更新日期：2017-02-01 00:00:00
abstract：:Peroxiredoxin 2 (Prdx2) has been shown to act as an antioxidant whose main function is to reduce hydrogen peroxide (H2O2) in cells, and Prdx2 is abnormally elevated in colorectal cancer (CRC). However, the functional significance of this up-regulation and the detailed molecular mechanism behind the regulatory effect o...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2013.10.002
更新日期：2014-02-28 00:00:00
abstract：:Cancer cachexia patients experience significant muscle wasting, which impairs the quality of life and treatment efficacy for patients. Skeletal muscle protein turnover is imparted by increased expression of ubiquitin-proteasome pathway components. Mitogen-activated protein kinases p38 and ERK have been shown to augmen...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2020.07.025
更新日期：2020-10-28 00:00:00
abstract：:Exosomes are biological nanovesicles that are involved in cell-cell communication via the functionally-active cargo (such as miRNA, mRNA, DNA and proteins). Because of their nanosize, exosomes are explored as nanodevices for the development of new therapeutic applications. However, bulk, safe and cost-effective produc...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2015.10.020
更新日期：2016-02-01 00:00:00
abstract：:The di-methyl-, di-ethyl-, di-propyl-, di-normal butyl-, and di-iso-butyl-ethers of hematoporphyrin were synthesized and shown to possess chromatographic properties similar to those of the tumorlocalizing components of hematoporphyrin derivative (Hpd). The cellular uptake of these ethers, as well as their retention in...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/0304-3835(87)90178-9
更新日期：1987-03-01 00:00:00
abstract：:Integrins emerge nowadays as crucial actors of tumor aggressiveness and resistance to therapies. Integrin α5β1, the fibronectin receptor, determines malignant properties of colon carcinoma which is one of the most important causes of cancer-related deaths in the world. Here we show that inhibition of α5 integrin subun...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2013.03.018
更新日期：2013-08-19 00:00:00
abstract：AIM:To estimate the incidence and latency of Vaginal Intraepithelial Neoplasia (VAIN) in women previously hysterectomized for benign/malign pathology and to evaluate the role of high risk HPVs in the prediction of persistent or recurrent disease. SUBJECTS AND METHODS:830 women with prior hysterectomy for benign/malign...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2006.09.003
更新日期：2007-05-08 00:00:00
