Abstract:
:Aberrant expression of many long non-coding RNAs has been observed in various types of cancer, implicating their crucial roles in tumorigenesis and cancer progression. Emerging knowledge with regard to the critical physiological and pathological roles of long non-coding RNAs in cancers makes them potential targets in cancer treatments. In this review, we present a summary of the relatively well studied long non-coding RNAs that are involved in oncogenesis and outline their functions and functional mechanisms. Recent findings that may be utilized in therapeutic intervention are also highlighted. With the fast development in nucleic acid-based therapeutic reagents that can target disease associated RNAs, lncRNAs should be explored as potential targets in cancer treatments.
journal_name
Cancer Lettjournal_title
Cancer lettersauthors
Chen L,Dzakah EE,Shan Gdoi
10.1016/j.canlet.2018.01.042subject
Has Abstractpub_date
2018-04-01 00:00:00pages
119-124eissn
0304-3835issn
1872-7980pii
S0304-3835(18)30064-8journal_volume
418pub_type
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