Abstract：
:Digalloylresveratrol (DIG) is a new synthetic ester of the naturally occurring polyhydroxyphenolic substances gallic acid and resveratrol which both exert anti-cancer activity in a number of tumor cell lines. The aim of the study was to identify the biochemical effects of DIG in HT-29 human colon cancer cells. DIG induced dose-dependently apoptosis after treatment for 72 h (40 microM DIG caused apoptosis in 45% of cells). DIG led to a substantial imbalance of deoxyribonucleoside triphosphates (dNTPs), the products of the enzyme ribonucleotide reductase (RR) and directly inhibited RR as it significantly reduced the incorporation of (14)C-labeled cytidine into the DNA of tumor cells. Furthermore, DIG affected the cell division and inhibited the transition from S to G2/M phase of the cell cycle. In contrast to resveratrol or gallic acid, DIG did not inhibit cyclooxygenases I and II. When HT-29 cells were simultaneously treated with DIG and 5-FU, the standard chemotherapeutic substance for colon cancer, additive growth inhibitory effects could be observed. With respect to the various biochemical and anti-proliferative effects of DIG in HT-29 cells, we regard DIG as a potential candidate for future treatment options of colon cancer and conclude that further preclinical and in vivo studies are warranted.
journal_name
Cancer Lettjournal_title
Cancer lettersauthors
Bernhaus A,Fritzer-Szekeres M,Grusch M,Saiko P,Krupitza G,Venkateswarlu S,Trimurtulu G,Jaeger W,Szekeres Tdoi
10.1016/j.canlet.2008.09.020subject
Has Abstractpub_date
2009-02-18 00:00:00pages
299-304issue
2eissn
0304-3835issn
1872-7980pii
S0304-3835(08)00786-6journal_volume
274pub_type
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