Prognostic significance of tumor angiogenesis in epithelial ovarian cancer.

abstract：:Cucurbitacin B is a natural anti-cancer compound found in Cucurbitaceae. Although the anti-cancer activity of cucurbitacin B in human leukemia cells has been reported, the underlining mechanism is still unclear. To clarify its anti-cancer activity and the mechanism of action, five different leukemia cell lines (CCRF-C...

journal_title：Cancer letters

authors： Chan KT,Li K,Liu SL,Chu KH,Toh M,Xie WD

更新日期：2010-03-01 00:00:00

abstract：:Pancreatic ductal adenocarcinoma (PDAC) remains one of the most lethal types of cancer with poor prognosis. Despite extensive efforts, the current treatment methods have limited success. Therefore, novel therapeutic approaches are required. The pancreatic tumor microenvironment is rich in growth factors and inflammato...

journal_title：Cancer letters

authors： Roshani R,McCarthy F,Hagemann T

更新日期：2014-04-10 00:00:00

abstract：:Lysophosphatidic acid (LPA) receptors including LPA(1), LPA(2), and LPA(3) mediate lysophosphatidic acid signals. We analyzed the expression of LPA receptors, vascular endothelial growth factor (VEGF), and interleukin-8 in 97 patients from normal ovary to ovarian cancer, using reverse transcription polymerase chain re...

journal_title：Cancer letters

authors： Fujita T,Miyamoto S,Onoyama I,Sonoda K,Mekada E,Nakano H

更新日期：2003-03-31 00:00:00

abstract：:Myosin light-chain kinase (MLCK) plays a crucial role in the cell migration and tumor metastasis. Herein, we investigated the signaling pathways involved in MLCK using ML-7, a specific inhibitor of MLCK, in breast cancer cell proliferation and migration. Our data showed that reduction of MLCK in breast cancer cells me...

journal_title：Cancer letters

authors： Zhou X,Liu Y,You J,Zhang H,Zhang X,Ye L

更新日期：2008-11-08 00:00:00

abstract：:A newly found human retrovirus, adult T-cell leukemia virus (ATLV) was shown by means of membrane immunofluorescence to bind to various hematopoietic cells including T-, B- and non-T, non-B-cell lines. Partially purified viral gp46 from culture fluids of ATL virus producer lines also bound efficiently to an ATLV-negat...

journal_title：Cancer letters

authors： Yamamoto N,Chosa T,Koyanagi Y,Tochikura T,Schneider J,Hinuma Y

更新日期：1984-01-01 00:00:00

abstract：:To address the possible involvement of hyperinsulinemia in breast cancer development, we have examined the susceptibility of lean and obese Zucker rats to N-methyl-N-nitrosourea (MNU)-induced mammary cancer. Fifty-day-old female lean or obese Zucker rats received intraperitoneal (i.p.) injections of 37.5 or 20 mg/kg M...

journal_title：Cancer letters

authors： Lee WM,Lu S,Medline A,Archer MC

更新日期：2001-01-26 00:00:00

abstract：:Staurosporine and its derivative 7-hydroxystaurosporine are protein kinase inhibitors that are being considered for treatments of cancers. Several recent studies have shown that cells with defective pRB protein are resistant to the G(1) cell cycle-inhibiting effects of staurosporine compounds. In this study, we examin...

journal_title：Cancer letters

authors： Zhou W,Lin Y,Wersto R,Chrest J,Gabrielson E

更新日期：2002-09-08 00:00:00

abstract：:Ellagic acid (EA) is a polyphenol found in several plants and fruits. The objectives of this study were to examine the molecular mechanisms by which EA inhibits pancreatic cancer growth in Balb C nude mice. PANC-1 cells were injected subcutaneously into Balb c nude mice, and tumor-bearing mice were treated with EA. Th...

journal_title：Cancer letters

authors： Zhao M,Tang SN,Marsh JL,Shankar S,Srivastava RK

更新日期：2013-09-01 00:00:00

abstract：:Previously, we had reviewed 43 cases of invasive cancers, adenosquamous cell carcinoma and adenocarcinoma for HPV type infections. With the same cases we extended the investigation to cytomegalovirus (CMV) and herpes simplex virus (HSV) infections. Results show that the prevalence of CMV and HSV infections from these ...

journal_title：Cancer letters

authors： Han CP,Tsao YP,Sun CA,Ng HT,Chen SL

更新日期：1997-12-09 00:00:00

abstract：:The activity of 4 enzymes involved in the formation and interconversion of folate coenzymes has been examined in liver and kidney of healthy and Ehrlich ascites carcinoma-bearing mice. In the liver, a 50% increase of methylenetetrahydrofolate reductase activity was shown soon after tumour cell inoculation, while the a...

journal_title：Cancer letters

authors： Chmurzyńska W,Manteuffel-Cymborowska M,Sikora E,Grzelakowska-Sztabert B

更新日期：1984-12-01 00:00:00

abstract：:The effect of vitamin A (retinyl acetate) on lung tumor development in strain A mice exposed to radiation was assessed. Four groups of 75 mice were utilized. Two groups were fed a low vitamin A diet (less than 100 IU/100 g diet) and the other 2 were fed a high vitamin A diet (800 IU/100 g diet). After 2 weeks one grou...

journal_title：Cancer letters

authors： Mian TA,Theiss JC,Gesell TF

更新日期：1984-02-01 00:00:00

abstract：:Glioblastoma (GBM) is the most aggressive, deadliest, and most common brain malignancy in adults. Despite the advances made in surgical techniques, radiotherapy and chemotherapy, the median survival for GBM patients has remained at a mere 14 months. GBM poses several unique challenges to currently available treatments...

journal_title：Cancer letters

authors： Paw I,Carpenter RC,Watabe K,Debinski W,Lo HW

更新日期：2015-06-28 00:00:00

abstract：:Multiple therapeutic strategies have been developed to treat pancreatic cancer. However, the outcomes of these approaches are disappointing. Due to deeper understandings of the pivotal roles of the immune system in pancreatic cancer tumorigenesis and progression, novel therapeutic strategies based on immune cells and ...

journal_title：Cancer letters

authors： Xu JW,Wang L,Cheng YG,Zhang GY,Hu SY,Zhou B,Zhan HX

更新日期：2018-07-01 00:00:00

abstract：:Enormous efforts have been made to explore small molecules that interfere with the TGF-β signaling pathway, so as to inhibit EMT and the cancer metastasis, but few agents have been identified. In this study, we demonstrated that Nutlin-3 could abolish the down-regulation of E-cadherin induced by TGF-β1 in p53-deficien...

journal_title：Cancer letters

authors： Wu Y,Fu Y,Zheng L,Lin G,Ma J,Lou J,Zhu H,He Q,Yang B

更新日期：2014-01-01 00:00:00

abstract：:Tumor acidity is now considered an important determinant of drug-resistance and tumor progression, and anti-acidic approaches, such as Proton Pump inhibitors (PPIs), have demonstrated promising antitumor and chemo-sensitizing efficacy. The main purpose of the present study was to evaluate the possible PPI-induced sens...

journal_title：Cancer letters

authors： Azzarito T,Venturi G,Cesolini A,Fais S

更新日期：2015-01-28 00:00:00

abstract：:Exposure of HeLa cells to 0, 5, 10, 25, 50 and 100 microg/ml of guduchi extracts (methanol, aqueous and methylene chloride) resulted in a dose-dependent but significant increase in cell killing, when compared to non-drug-treated controls. The effects of methanol and aqueous extracts were almost identical. However, met...

journal_title：Cancer letters

authors： Jagetia GC,Nayak V,Vidyasagar MS

更新日期：1998-05-15 00:00:00

abstract：:The oral administration of a single 20mg dose of 7,12-dimethylbenz[a]anthracene regularly and rapidly induces mammary cancer in 50 day-old Sprague-Dawley female rats [Experimental Leukemia and Mammary Cancer, 1979, p. 74]. Several mechanisms by which 7,12-dimethylbenz[a]anthracene induces mammary cancer have been prop...

journal_title：Cancer letters

authors： Horn J,Lehner AF,Flesher JW

更新日期：2005-04-08 00:00:00

abstract：:Monocrotaline is a representative naturally occurring genotoxic pyrrolizidine alkaloid. Metabolism of monocrotaline by liver microsomes of F344 female rats generated (+/-)6,7-dihydro-7-hydroxy-1-hydroxymethyl-5H-pyrrolizine (DHP) and monocrotaline-N-oxide as major metabolites. Metabolism in the presence of triacetylea...

journal_title：Cancer letters

authors： Wang YP,Yan J,Beger RD,Fu PP,Chou MW

更新日期：2005-08-08 00:00:00

abstract：:Innate resistance to various therapeutic interventions is a hallmark of cancer. In recent years, however, acquired resistance has emerged as a daunting challenge to anticancer treatments including chemotherapy, radiation and targeted therapy, which abolishes the efficacy of otherwise successful regimens. Cancer cells ...

journal_title：Cancer letters

authors： Sun Y

更新日期：2016-09-28 00:00:00

abstract：:To minimize adverse side effects of chemotherapy, we have developed a micellar drug carrier that retains hydrophobic drugs, and then releases the drug by ultrasonic stimulation. This study investigated the DNA damage induced by doxorubicin (DOX) delivered to human leukemia (HL-60) cells from pluronic P-105 micelles wi...

journal_title：Cancer letters

authors： Husseini GA,El-Fayoumi RI,O'Neill KL,Rapoport NY,Pitt WG

更新日期：2000-06-30 00:00:00

abstract：:The effect of magnesium hydroxide on the epithelial proliferation of the large bowel was examined using rats given methylazoxymethanol (MAM) acetate. Dietary administration of magnesium hydroxide at 250, 500, 1000 or 2000 ppm. for 1, 3 or 5 weeks did not influence the cell cycle of the cryptal cells of the large bowel...

journal_title：Cancer letters

authors： Mori H,Morishita Y,Mori Y,Yoshimi N,Sugie S,Tanaka T

更新日期：1992-02-14 00:00:00

abstract：:Prolonged exposure to elevated levels of estrogen is a risk factor for breast cancer. Though increased cell growth and loss of DNA repair capacity is one of the proposed mechanisms for estrogen-induced cancers, the mechanism through which estrogen induces cell growth and decreases DNA repair capacity is not clear. DNA...

journal_title：Cancer letters

authors： Singh KP,Treas J,Tyagi T,Gao W

更新日期：2012-03-01 00:00:00

abstract：:Over the last decade the linkage between hyperthermia, heat shock proteins and fever with the body's immune system has been well investigated. The immunomodulatory function of hyperthermia has been found to be quite sensitively regulated by temperature, as different levels of heating can bring different modulatory eff...

journal_title：Cancer letters

authors： Zhang HG,Mehta K,Cohen P,Guha C

更新日期：2008-11-28 00:00:00

abstract：:Lumican is a small leucine-rich proteoglycan (SLRP) of the extracellular matrix (ECM) with anti-tumor activity. We recently demonstrated that lumican inhibits the migration of melanoma cells and identified beta1 integrin as mediator of this effect [M.F. D'Onofrio, S. Brézillon, T. Baranek, C. Perreau, P.J. Roughley, F...

journal_title：Cancer letters

authors： Brézillon S,Radwanska A,Zeltz C,Malkowski A,Ploton D,Bobichon H,Perreau C,Malicka-Blaszkiewicz M,Maquart FX,Wegrowski Y

更新日期：2009-09-28 00:00:00

abstract：:To further investigate the possibility for retroviral involvement in the etiology of human breast cancer we processed peripheral blood monocytes and malignant breast tissue biopsies from 10 patients with breast cancer (infiltrating ductal carcinoma or infiltrating lobular carcinoma; ages 40-80 years) and 20 normal hea...

journal_title：Cancer letters

authors： Hughes G,McKerr G,Allen J,Barnett Y

更新日期：1996-06-05 00:00:00

abstract：:The variation of the E6 region of human papillomavirus type 16 (HPV16) is associated with a high risk for cervical carcinogenesis. To see whether the same is the case with HPV33, 52 and 58, known to have high homology with HPV16, we analyzed the E6 sequence variation of these HPVs in 107 Japanese women with cervical i...

journal_title：Cancer letters

authors： Xin CY,Matsumoto K,Yoshikawa H,Yasugi T,Onda T,Nakagawa S,Yamada M,Nozawa S,Sekiya S,Hirai Y,Shiromizu K,Fujii T,Taketani Y

更新日期：2001-09-10 00:00:00

abstract：:Treatment resistance in acute lymphoblastic leukemia (ALL) is often caused by defects in programmed cell death, e.g. by overexpression of Inhibitor of Apoptosis (IAP) proteins. Here, we report that small-molecule Smac mimetics (i.e. BV6, LCL161, birinapant) that neutralize x-linked IAP (XIAP), cellular IAP (cIAP)1 and...

journal_title：Cancer letters

authors： Gerges S,Rohde K,Fulda S

更新日期：2016-05-28 00:00:00

abstract：:Orlistat is an anti-obesity agent that increases the fecal fat excretion, which promotes colon carcinogenesis. Therefore, the present study was designed to verify the effects of Orlistat on the formation of rat colonic aberrant crypt foci (ACF) and cell proliferation evaluated by the PCNA method. Male Wistar rats rece...

journal_title：Cancer letters

authors： Garcia SB,Barros LT,Turatti A,Martinello F,Modiano P,Ribeiro-Silva A,Vespúcio MV,Uyemura SA

更新日期：2006-08-28 00:00:00

abstract：:Cancers of the gastrointestinal (GI) tract continue to represent a major health problem, despite progress in therapy. Gut microbiota is a key element related to the genesis of GI cancers, countless papers addressing this burning issue across the world. We provide an updated knowledge of the involvement of gut microbio...

journal_title：Cancer letters

authors： Serban DE

更新日期：2014-04-10 00:00:00

abstract：:The transcription factor NPAS2 is one of nine human core circadian genes that influence a variety of biological processes by regulating the 24-h circadian rhythm. Recently, it has been shown that NPAS2 is a risk biomarker in human cancers and plays a role in tumorigenesis by affecting cancer-related gene expression, a...

journal_title：Cancer letters

authors： Yi CH,Zheng T,Leaderer D,Hoffman A,Zhu Y

更新日期：2009-11-01 00:00:00