Lansoprazole induces sensitivity to suboptimal doses of paclitaxel in human melanoma.

abstract：:In the present study, the question of whether the ubiquitous environmental pollutant, 1-nitropyrene (1-NP), can induce gamma-glutamyltranspeptidase (GGT)-positive foci, an early lesion occurring during hepatocarcinogenesis, when given orally to F344 rats was examined. Significant induction of GGT-positive foci was obs...

journal_title：Cancer letters

authors： Denda A,Tsutsumi M,Tsujiuchi T,Eimoto H,Konishi Y,Sato S

更新日期：1989-04-01 00:00:00

abstract：:Ibrutinib, an inhibitor of Bruton tyrosine kinase (BTK), has shown promising pharmacologic effects in acute myeloid leukemia (AML). In this study, we report that abivertinib or AC0010, a novel BTK inhibitor, inhibits cell proliferation, reduces colony-forming capacity, and induces apoptosis and cell cycle arrest in AM...

journal_title：Cancer letters

authors： Huang S,Pan J,Jin J,Li C,Li X,Huang J,Huang X,Yan X,Li F,Yu M,Hu C,Jin J,Xu Y,Ling Q,Ye W,Wang Y,Jin J

更新日期：2019-10-01 00:00:00

abstract：:Estrogens are important for the development and growth of estrogen receptor (ER)-positive breast cancer, for which anti-estrogen therapy is one of the most effective treatments. However, its efficacy can be limited by either de novo or acquired resistance. Aromatase is a key enzyme for the biosynthesis of estrogens, a...

journal_title：Cancer letters

authors： Phuong NT,Lim SC,Kim YM,Kang KW

更新日期：2014-08-28 00:00:00

abstract：:MUTYH-associated polyposis (MAP) is an autosomal recessive condition predisposing to colorectal cancer, caused by constitutional biallelic mutations in the base excision repair (BER) gene MUTYH. Colorectal tumours from MAP patients display an excess of somatic G>T mutations in the APC and KRAS genes due to defective B...

journal_title：Cancer letters

authors： Tricarico R,Bet P,Ciambotti B,Di Gregorio C,Gatteschi B,Gismondi V,Toschi B,Tonelli F,Varesco L,Genuardi M

更新日期：2009-02-18 00:00:00

abstract：:We evaluated the changes in CTC count and CTC-associated miRNAs during the course of chemotherapy in patients with metastatic colorectal cancer. Blood samples were collected from 9 metastatic colorectal cancer patients prior to chemotherapy and at every other chemotherapy session during the course of treatment. CTCs w...

journal_title：Cancer letters

authors： Tan K,Leong SM,Kee Z,Caramat PV,Teo J,Blanco MVM,Koay ESC,Cheong WK,Soh TI,Yong WP,Pang A

更新日期：2018-06-01 00:00:00

abstract：:MDM2 is a phosphoprotein that interacts with P53 and inhibits its activity. Recently, a T/G substitution (SNP309) in the promoter of MDM2 was identified and has been demonstrated to be associated with an increased MDM2 expression and a significantly earlier age of onset of several tumors, including breast cancer. To t...

journal_title：Cancer letters

authors： Ma H,Hu Z,Zhai X,Wang S,Wang X,Qin J,Jin G,Liu J,Wang X,Wei Q,Shen H

更新日期：2006-08-28 00:00:00

abstract：:Apoptosis plays a role in the elimination of DNA-damaged cells thus protecting the host from cancer development. Some data indicate that normal variations within the sequence of apoptotic genes may lead to suboptimal apoptotic capacity and therefore increased cancer risk. We tested 19 coding apoptotic gene SNPs in 2-s...

journal_title：Cancer letters

authors： Ulybina YM,Kuligina ES,Mitiushkina NV,Rozanov ME,Ivantsov AO,Ponomariova DN,Togo AV,Levchenko EV,Shutkin VA,Brenister SI,Devilee P,Zhivotovsky B,Hirvonen A,Imyanitov EN

更新日期：2009-06-18 00:00:00

abstract：:Xanthine oxidase reduction of adriamycin (Am) and daunorubicin (Dm) to their respective 7-deoxy aglycones is inhibited by allopurinol. Administered to DBA/2 mice with L1210 leukemia, allopurinol (60 mg/kg per day X 3) enhances the antitumor activity of adriamycin. ...

journal_title：Cancer letters

authors： Schwartz HS

更新日期：1983-08-01 00:00:00

abstract：:Tumor-derived exosomes (TEXs) contain enriched miRNAs that act as novel non-invasive biomarkers for cancer diagnosis and play a role in cancer progression. We investigated the exosomal miRNAs that affect cancer progression in non-small cell lung cancer (NSCLC) and identified the specific molecules involved. We identif...

journal_title：Cancer letters

authors： Kim DH,Park S,Kim H,Choi YJ,Kim SY,Sung KJ,Sung YH,Choi CM,Yun M,Yi YS,Lee CW,Kim SY,Lee JC,Rho JK

更新日期：2020-04-10 00:00:00

abstract：:Bone metastasis is a major cause of prostate cancer (PCa) mortality. Although docetaxel chemotherapy initially extends patients' survival, in most cases PCa becomes chemoresistant and eventually progresses without a cure. In this study, we developed a novel small-molecule compound BKM1972, which exhibited potent in vi...

journal_title：Cancer letters

authors： Chen Y,Gera L,Zhang S,Li X,Yang Y,Mamouni K,Wu AY,Liu H,Kucuk O,Wu D

更新日期：2019-04-01 00:00:00

abstract：:Curcumin, a major component of the Curcuma species, is known to have antioxidant, anti-inflammatory properties and induce apoptosis of cancer cells, however, the precise molecular mechanisms of apoptosis in vitro are unclear. In this study, we showed that curcumin, a plant product containing the phenolic phytochemical...

journal_title：Cancer letters

authors： Lin SS,Huang HP,Yang JS,Wu JY,Hsia TC,Lin CC,Lin CW,Kuo CL,Gibson Wood W,Chung JG

更新日期：2008-12-08 00:00:00

abstract：:This study demonstrates that mammalian cell targets (erythrocytes and tumour cells) may be sensitised to ultrasound using electric pulses and this combination treatment results in destruction of those cells in vitro. It further demonstrates that when a tumour mass is treated in vivo using combined electric field and u...

journal_title：Cancer letters

authors： Rollan Haro AM,Smyth A,Hughes P,Reid CN,McHale AP

更新日期：2005-05-10 00:00:00

abstract：:Peroxiredoxin I (Prx I) is newly discovered oxidative stress inducible protein, having a thioredoxin peroxidase activity. The Prx I expression level in 107 samples out of 60 thyroid lesions, including normal thyroid, tumors and thyroiditis including Graves' disease were examined using immunoblotting. Prx I expression ...

journal_title：Cancer letters

authors： Yanagawa T,Ishikawa T,Ishii T,Tabuchi K,Iwasa S,Bannai S,Omura K,Suzuki H,Yoshida H

更新日期：1999-10-18 00:00:00

abstract：:To determine the genotoxic risk associated with therapeutic exposure to 131I, we studied the presence of micronuclei (MN) in binucleated peripheral blood lymphocytes of a group of 22 women, patients of thyroid cancer, who received 131I sodium iodide orally as an adjuvant after total thyroidectomy. The cytogenetic stud...

journal_title：Cancer letters

authors： Gutiérrez S,Carbonell E,Galofréa P,Xamena N,Creus A,Marcos R

更新日期：1995-05-08 00:00:00

abstract：:The widespread consumption of tea as beverage throughout the world has stimulated interest in the possibility of its use in chemoprevention of cancer. The present set of investigation was carried out to evaluate the anticarcinogenic activity of black tea using lung tumorigenesis model in Swiss albino mice. Diethylnitr...

journal_title：Cancer letters

authors： Shukla Y,Taneja P

更新日期：2002-02-25 00:00:00

abstract：:Chronic elevated free fatty (FFA) levels are linked to metabolic disorders and tumorigenesis. However, the molecular mechanism by which FFAs induce cancer remains poorly understood. Here, we show that the tumor suppressor PTEN protein levels were decreased in high fat diet (HFD) fed mice. As palmitic acid (PA, C16:0) ...

journal_title：Cancer letters

authors： Bai D,Wu Y,Deol P,Nobumori Y,Zhou Q,Sladek FM,Liu X

更新日期：2021-01-01 00:00:00

abstract：:The vectors PAI2, C595 and Herceptin target the membrane-bound uPA, MUC1 and HER2 antigens expressed by cancer cells, respectively. The expression of these receptors was tested in the ovarian cancer cell line OVCAR-3; MUC-1 was strongly expressed (3+), uPA moderately expressed (2+), but HER2 was negative (-). The alph...

journal_title：Cancer letters

authors： Song YJ,Qu CF,Rizvi SM,Li Y,Robertson G,Raja C,Morgenstern A,Apostolidis C,Perkins AC,Allen BJ

更新日期：2006-03-28 00:00:00

abstract：:Although Apc(Min/+) mice are widely used for an animal model of human familial adenomatous polyposis (FAP), a majority of intestinal polyps locate in the small intestine. We recently reported that numerous beta-catenin-accumulated crypts (BCAC), which are reliable precursor lesions for colonic adenocarcinoma, develop ...

journal_title：Cancer letters

authors： Hata K,Tanaka T,Kohno H,Suzuki R,Qiang SH,Yamada Y,Oyama T,Kuno T,Hirose Y,Hara A,Mori H

更新日期：2006-07-28 00:00:00

abstract：:Tumor angiogenesis is a critical step for the growth and metastasis of solid tumors. Vascular endothelial growth factor (VEGF) is the most important angiogenic molecule associated with tumor-induced neovascularization. VEGF exerts its activity through binding to its receptor tyrosine kinase, KDR/Flk-1, expressed on th...

journal_title：Cancer letters

authors： Lee SJ,Lee HM,Ji ST,Lee SR,Mar W,Gho YS

更新日期：2004-05-10 00:00:00

abstract：:The acquisition and persistence of fetal microchimerism, small numbers of genetically disparate cells from the fetus in the mother, is now a well-recognized consequence of normal pregnancy. Fetal microchimerism has been associated with several classical autoimmune diseases, but its role in normal health remains undefi...

journal_title：Cancer letters

authors： Gadi VK

更新日期：2009-04-08 00:00:00

abstract：:The newly identified protein BLAP75/RMI1 associates with the helicase BLM and is critical for the function of the homologous recombination complex. Mutations altering BLM function are associated with highly elevated cancer susceptibility (Bloom's syndrome). We have analyzed the common polymorphism Ser455Asn in RMI1 an...

journal_title：Cancer letters

authors： Broberg K,Höglund M,Gustafsson C,Björk J,Ingvar C,Albin M,Olsson H

更新日期：2007-12-08 00:00:00

abstract：:Certain polyunsaturated fatty acids can selectively kill tumor cell lines while causing little to no harm to normal cell lines. However, the mechanism of this cytotoxicity is only partially understood. Antioxidants such as vitamin E have been shown to be capable of completely blocking the cytotoxic response when admin...

journal_title：Cancer letters

authors： Ells GW,Chisholm KA,Simmons VA,Horrobin DF

更新日期：1996-01-02 00:00:00

abstract：:The fruiting body of Antrodia camphorata is well known in Taiwan as a traditional medicine for treating cancer and inflammation. The purpose of this study was to evaluate the apoptotic effects of ethylacetate extract from A. camphorata (EAC) fruiting bodies in two human liver cancer cell lines, Hep G2 and PLC/PRF/5. T...

journal_title：Cancer letters

authors： Hsu YL,Kuo YC,Kuo PL,Ng LT,Kuo YH,Lin CC

更新日期：2005-04-18 00:00:00

abstract：:Breast cancer, especially triple-negative breast cancer (TNBC), has limited treatment options. We repurposed the FDA-approved drug bazedoxifene as a novel inhibitor of interleukin 6/glycoprotein 130 signaling. In this study, we investigated the inhibitory effects of bazedoxifene alone or in combination with paclitaxel...

journal_title：Cancer letters

authors： Fu S,Chen X,Lo HW,Lin J

更新日期：2019-04-28 00:00:00

abstract：:Inherent DNA damage in the form of single strand breaks and alkali labile sites is generated by essential intracellular processes, such as DNA replication and repair. Utilizing the in situ DNA unwinding assay and the comet assay (single cell gel), we have observed high levels of alkali induced DNA strand breaks in cel...

journal_title：Cancer letters

authors： Fairbairn DW,Reyes WA,O'Neill KL

更新日期：1994-06-15 00:00:00

abstract：:Ellagic acid (EA) and 13-cis-retinoic acid (CRA), both alone and in combination, were tested for their ability to inhibit N-nitrosobenzylmethylamine-induced tumors in the rat esophagus. Groups of male rats were fed AIN-76A diet containing EA (4 g/kg), CRA (240 mg/kg), or a combination of EA and CRA (4 g/kg and 240 mg/...

journal_title：Cancer letters

authors： Daniel EM,Stoner GD

更新日期：1991-02-01 00:00:00

abstract：:DDX1, a gene mapping to the 2p24 region, has been observed to be co-amplified with MYCN in neuroblastoma. Co-amplification of the DDX1 gene is a consequence of the short physical distance between the two genes. Recently, it has been found that neuroblastoma cells can show a low increase in MYCN gene copy number, defin...

journal_title：Cancer letters

authors： Defferrari R,Tonini GP,Conte M,Papio F,Sementa AR,Valent A,Schena F,Perri P,Mazzocco K

更新日期：2007-10-18 00:00:00

abstract：:In the present work we investigated the in vivo regulation of the mucin gene MUC2, which is overexpressed in all mucinous colorectal carcinomas. The inhibition of methylation by 5-azadeoxycytidine induces de novo expression of MUC2 in the colon carcinoma cell line COLO 205. The expression is retained in xenograft tiss...

journal_title：Cancer letters

authors： Gratchev A,Siedow A,Bumke-Vogt C,Hummel M,Foss HD,Hanski ML,Kobalz U,Mann B,Lammert H,Mansmann U,Stein H,Riecken EO,Hanski C

更新日期：2001-07-10 00:00:00

abstract：:Glioblastoma multiforme (GBM), a malignant brain tumor, is the deadliest form of human cancer with low survival rates because of its highly invasive nature. In recent years, there has been a growing appreciation for the role that glioblastoma stem cells (GSCs) play during tumorigenesis and tumor recurrence of GBM. GSC...

journal_title：Cancer letters

authors： Nakod PS,Kim Y,Rao SS

更新日期：2018-08-10 00:00:00

abstract：:Both PTEN (encoding phosphate and tensin homologue) and p53 are known as cancer suppressor genes, and they are assumed that their gene mutations and loss of heterozygosity (LOH) occur frequently in various types of carcinoma. In the present study, we investigated both the p53 mutation and LOH of PTEN in 113 gastric ca...

journal_title：Cancer letters

authors： Oki E,Tokunaga E,Nakamura T,Ueda N,Futatsugi M,Mashino K,Yamamoto M,Watanabe M,Ikebe M,Kakeji Y,Baba H,Maehara Y

更新日期：2005-09-08 00:00:00