Abstract:
:The variation of the E6 region of human papillomavirus type 16 (HPV16) is associated with a high risk for cervical carcinogenesis. To see whether the same is the case with HPV33, 52 and 58, known to have high homology with HPV16, we analyzed the E6 sequence variation of these HPVs in 107 Japanese women with cervical intraepithelial neoplasia (CIN) or invasive cervical cancer (ICC): 20 HPV33-positive, 46 HPV52-positive and 41 HPV58-positive cases. HPV33 variants were more frequently observed in CINs I/II than in CIN III/ICCs (71% (5/7) versus 15% (2/13), P=0.02). In HPV52-positive cases, a single E6 variant was detected in 98% of the cases, whereas the prototype accounted for 98% of HPV58-positive cases. In summary, the distribution of E6 variants is different among HPV types tested, suggesting a link between E6 variation and oncogenic potential being type-specific.
journal_name
Cancer Lettjournal_title
Cancer lettersauthors
Xin CY,Matsumoto K,Yoshikawa H,Yasugi T,Onda T,Nakagawa S,Yamada M,Nozawa S,Sekiya S,Hirai Y,Shiromizu K,Fujii T,Taketani Ydoi
10.1016/s0304-3835(01)00570-5keywords:
subject
Has Abstractpub_date
2001-09-10 00:00:00pages
19-24issue
1eissn
0304-3835issn
1872-7980pii
S0304383501005705journal_volume
170pub_type
杂志文章相关文献
CANCER LETTERS文献大全abstract::It has been nearly 9years since the FDA (Food and Drug Administration) approved the first anti-angiogenic drug (bevacizumab) for treatment of metastatic colorectal cancer. Other angiogenic inhibitors have since been approved or are in different stages of clinical trials. However, continued clinical and preclinical inv...
journal_title:Cancer letters
pub_type: 杂志文章,评审
doi:10.1016/j.canlet.2012.03.008
更新日期:2012-07-28 00:00:00
abstract::The plant sterol guggulsterone has recently been shown to have anti-tumorigenic potential. This study was designed to investigate the anti-tumor efficacy of guggulsterone and to elucidate its molecular mechanisms in colon cancer. Guggulsterone significantly increased apoptosis in HT-29 cells by activating caspases-3 a...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2009.01.026
更新日期:2009-06-28 00:00:00
abstract::Tamoxifen (TAM)-induced DNA adduct formation in mouse skin was determined by a nuclease P1-enhanced 32P-postlabelling technique. Topical application of TAM significantly induced a number of DNA-adducts in mouse skin in a dose- and time-dependent manner. When SENCAR mice were topically treated with different doses of T...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(95)03802-4
更新日期:1995-06-08 00:00:00
abstract::NLRC5, the largest member of nucleotide-binding and oligomerization domain (NOD)-like receptor (NLR) family, has been reported to regulate immune responses and is associated with chronic inflammatory diseases. However, the biological function of NLRC5 in hepatocellular carcinoma (HCC) has not yet been well demonstrate...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2016.03.006
更新日期:2016-06-28 00:00:00
abstract::The immunomodulatory and antimetastatic/antitumor activity of thymosin alpha(1) (Talpha(1)) was evaluated in BALB/c-mice. Daily subcutaneous application (7 consecutive days, 0.01-10 microg of Talpha(1)/injection per mouse) upregulated the number of thymocytes and peripheral blood cells in tumor bearing mice. To check ...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/s0304-3835(00)00510-3
更新日期:2000-10-16 00:00:00
abstract::Dietary retinyl palmitate was administered for 22-30 weeks in CD-1 mice which had been initiated with 0.15 mumol of 7,12-dimethylbenz[a]anthracene (DMBA) and promoted with 8 nmol of 12-O-tetradecanoylphorbol-13-acetate (TPA) twice weekly thereafter. This treatment resulted in a dose response in both the tumoricidal ca...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(87)90089-9
更新日期:1987-08-01 00:00:00
abstract::The effects of the ornithine decarboxylase suicide substrate, difluoromethylornithine (DFMO), and of cyclophosphamide, individually and in combination, on the growth of the R3327MAT-Lu prostate derived tumor were determined. DFMO decreased the growth rate and resulted in a 75% reduction in DNA content compared to the ...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(82)90093-3
更新日期:1982-05-01 00:00:00
abstract::The cell transforming ability of asbestos dust was investigated using C3H10T 1/2 murine fibroblasts. In a series of experiments both crocidolite and amosite caused no increase in the number of transformed foci over that seen in cultures from untreated cells. The dusts, were, however, capable of augmenting the oncogeni...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(83)90071-x
更新日期:1983-03-01 00:00:00
abstract::Fibronectin concentration was determined in plasma from 97 patients with benign or malignant breast disease and from 62 controls. Median plasma fibronectin concentration (microgram FN/ml plasma) appeared to be significantly higher in patients with non-metastatic or metastatic breast cancer as compared to age-matched c...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(86)90071-6
更新日期:1986-12-01 00:00:00
abstract::Oxidative stress is implicated in the etiology of cancer, hence compounds that alleviate oxidative stress by inducing enzymes that defend against free radical damage might be useful as cancer chemopreventives. Glutathione S-transferase (GST) has been suggested to be a candidate for a critical enzyme in protecting cell...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/s0304-3835(00)00368-2
更新日期:2000-08-11 00:00:00
abstract::The aim of this study was to investigate the interaction of tamoxifen (TAM) with the so-called Type II estrogen binding sites (Type II EBS) in both the cytosolic and the nuclear fraction of the ER-negative A 2780 human ovarian cancer cell line and in an ER-negative ovarian cancer tissue. Although cytosolic and nuclear...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(95)03922-j
更新日期:1995-09-04 00:00:00
abstract::Treatment of mouse lymphoma L5178Y cells with spermine in Fischer's medium containing bovine serum lead to formation of chromatid aberrations. The cause of this effect seems to be that bovine serum contains spermine oxidase which catalyzes oxidation of spermine to unstable aldehyde derivatives (oxidized spermine) and ...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(88)90044-4
更新日期:1988-02-01 00:00:00
abstract::The small 25 kDa peptide, neutrophil gelatinase-associated lipocalin (NGAL), first known as an antibacterial factor of natural immunity, and an acute phase protein, is currently one of the most interesting and enigmatic proteins involved in the process of tumor development. The aim of the present review is to point ou...
journal_title:Cancer letters
pub_type: 杂志文章,评审
doi:10.1016/j.canlet.2009.05.027
更新日期:2010-02-01 00:00:00
abstract::Glioblastoma multiforme (GBM) is the most common malignant brain tumor, which remains incurable. Plant extracts are a potential source of potent anticancer medicines. In this study, we investigated the effect of isolinderalactone from Lindera aggregata on tumor growth using U-87 human glioblastoma cells. Treatment wit...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2018.11.027
更新日期:2019-02-28 00:00:00
abstract::Interstitial fluid pressure was measured by the wick-in-needle technique in DMBA-induced rat mammary tumours during resting conditions and during noradrenaline infusion. The rate of infusion was chosen to increase the systemic blood pressure by 30-40 mmHg, known to result in a markedly increased vascular resistance of...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(85)90181-8
更新日期:1985-07-01 00:00:00
abstract::Dioxane, perchloroethylene, and trichloroethylene were investigated as rat liver altered foci promoters in an initiation/promotion protocol. Animals were initiated with diethylnitrosamine, 30 mg/kg, injected i.p. 24 h after 2/3 partial hepatectomy. The chemical under study was administered by gavage once a day, 5 time...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(87)90099-1
更新日期:1987-07-01 00:00:00
abstract::Lumican is a small leucine-rich proteoglycan (SLRP) of the extracellular matrix (ECM) with anti-tumor activity. We recently demonstrated that lumican inhibits the migration of melanoma cells and identified beta1 integrin as mediator of this effect [M.F. D'Onofrio, S. Brézillon, T. Baranek, C. Perreau, P.J. Roughley, F...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2009.03.032
更新日期:2009-09-28 00:00:00
abstract::Here in, we investigated the mechanism underlying overexpression of miR-135b in the human head and neck squamous cell carcinoma (HNSCC) cell lines and in the HNSCC mouse model. Exogenous expression of miR-135b in these cell lines increased cell proliferation, migration, and colony formation. Gene silencing analysis re...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2013.01.003
更新日期:2013-05-01 00:00:00
abstract::In esophageal squamous cell carcinoma (SCC), we used immunohistochemical analysis to further elucidate the correlation of p53 protein expression with clinicopathological factors, as well as with risk factors, such as tobacco smoking, alcohol consumption and a family history of cancer, using odds ratios (ORs). The expr...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/s0304-3835(01)00461-x
更新日期:2001-06-10 00:00:00
abstract::Human mitogen-stimulated lymphocytes, cultured in the presence of amosite asbestos (AS), demonstrated a slight increase in aryl hydrocarbon hydroxylase (AHH) activity compared with non-induced (control) cultures (P = 0.005). A much greater increase in enzyme activity occurred following addition of the inducers benzant...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/s0304-3835(79)80113-5
更新日期:1979-07-01 00:00:00
abstract::Retinoic acid and retinol induced functional and morphological differentiation of human promyelocytic leukemia cells (HL-60) into mature granulocytes, but did not induce functional or morphological differentiation of mouse myeloid leukemia cells (M1). Cellular retinoic acid-binding protein, but not retinol-binding pr...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(81)90079-3
更新日期:1981-06-01 00:00:00
abstract::The chemokine CXCL12 (SDF-1) and its receptor, CXCR4, have been implicated in organ-specific metastases of several malignancies. Head and neck squamous cell carcinoma (HNSCC) predominantly metastasizes to lymph nodes, and recent evidence has shown that CXCL12 stimulates HNSCC migration. We explored the potential role ...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2004.04.035
更新日期:2004-10-28 00:00:00
abstract::TGF-β signaling plays an important role in breast cancer progression and metastasis. Epithelial-mesenchymal transition (EMT) is an important step in the progression of solid tumors to metastatic disease. We previously reported that IN-1130, a novel transforming growth factor-β type I receptor kinase (ALK5) inhibitor, ...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2014.05.006
更新日期:2014-08-28 00:00:00
abstract::The highly conserved RNA-binding protein, Lin28, is involved in many biological processes, including development, reprogramming, pluripotency, and metabolism. Importantly, Lin28 functions as an oncogene, promoting tumor progression and metastasis in various human cancers. Lin28 can regulate gene expression either by d...
journal_title:Cancer letters
pub_type: 杂志文章,评审
doi:10.1016/j.canlet.2016.02.050
更新日期:2016-05-28 00:00:00
abstract::Aurora-A (Aur-A) is a centrosome-associated serine/threonine kinase that is overexpressed in various cancers and potentially correlated with chemoresistance. In the Ara-C-sensitive leukemia cell lines, silencing of Aur-A by small interfering RNA transfection led to a significant increase in the Ara-C-induced cell deat...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2010.05.009
更新日期:2010-11-28 00:00:00
abstract::Digalloylresveratrol (DIG) is a new synthetic ester of the naturally occurring polyhydroxyphenolic substances gallic acid and resveratrol which both exert anti-cancer activity in a number of tumor cell lines. The aim of the study was to identify the biochemical effects of DIG in HT-29 human colon cancer cells. DIG ind...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2008.09.020
更新日期:2009-02-18 00:00:00
abstract::The p53 tumor suppressor gene is often mutated in various human cancers. Recently, the p53 codon 72 polymorphism has been extensively studied to determine the risk factors responsible for cancer formation. We investigated the genotype distribution of the p53 codon 72 polymorphism in 112 male urothelial cancer cases an...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/s0304-3835(02)00518-9
更新日期:2003-01-10 00:00:00
abstract::Macrophages that infiltrate tumor tissues, or tumor-associated macrophages (TAMs), affect the malignant behaviors of tumor cells. In this study, we attempted to induce monocytes to differentiate into TAM-like cells producing matrix metalloproteinases (MMPs) by co-culture with tumor cells. When human monocytes were co-...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2011.09.029
更新日期:2012-02-28 00:00:00
abstract::Carcinogenic and modification potential of 6-mercaptopurine (6-MP) was studied in a medium-term bioassay system for rat liver carcinogenesis. F344 male rats were initiated with a single dose (200 mg/kg body wt.) of diethylnitrosamine (DEN) i.p. and fed diets containing either 0.005% or 0.02% 6-MP with or without 0.05%...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(92)90069-8
更新日期:1992-06-15 00:00:00
abstract::The expression of the WAF1/CIP1 gene product, p21, in enzyme-altered foci (EAF) induced by diethylnitrosamine (DEN) and phenobarbital (PB) was examined. p21 expression in the nucleus of hepatocytes in EAF was decreased compared to surrounding tissue. Fifty-eight percent of all GST-P-positive EAF induced by DEN and 79%...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(96)04218-8
更新日期:1996-06-24 00:00:00