The influence of asbestos dust on the oncogenic transformation of C3H10T 1/2 cells.

Abstract:

:The cell transforming ability of asbestos dust was investigated using C3H10T 1/2 murine fibroblasts. In a series of experiments both crocidolite and amosite caused no increase in the number of transformed foci over that seen in cultures from untreated cells. The dusts, were, however, capable of augmenting the oncogenic effect of benzo[a]pyrene (BP). This putative synergistic effect was evident when fibres and chemicals were added to cultures as simple mixtures and when BP was adsorbed to the surface of the fibres.

journal_name

Cancer Lett

journal_title

Cancer letters

authors

Brown RC,Poole A,Fleming GT

doi

10.1016/0304-3835(83)90071-x

subject

Has Abstract

pub_date

1983-03-01 00:00:00

pages

221-7

issue

2

eissn

0304-3835

issn

1872-7980

pii

0304-3835(83)90071-X

journal_volume

18

pub_type

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