Fibronectin concentration in the plasma of patients with malignant and benign breast disease.

abstract：:Thyroid hormone receptor interactor 4 (TRIP4), a subunit of the tetrameric nuclear activating signal co-integrator 1 (ASC-1) complex, exerts pro-tumorigenic effects. The role for TRIP4 in the regulation of cervical cancer growth and radiation resistance is presently unknown. In this study, TRIP4 was found to be highly...

journal_title：Cancer letters

authors： Che Y,Li Y,Zheng F,Zou K,Li Z,Chen M,Hu S,Tian C,Yu W,Guo W,Luo M,Deng W,Zou L

更新日期：2019-06-28 00:00:00

abstract：:Smoking women are probably at a higher risk to develop lung cancer than men. Different explanations exist for these findings, a gender-specific impairment of tobacco carcinogen metabolism being one of them. In this study, we examined the inhibition of NNK reduction to NNAL, the first and most important detoxication st...

journal_title：Cancer letters

authors： Stapelfeld C,Neumann KT,Maser E

更新日期：2017-10-01 00:00:00

abstract：:Amplification and overexpression of PPM1D (protein phosphatase magnesium-dependent 1 delta) has been observed in various cancer cell lines and primary tumors and has also been associated with cancers of poor prognosis. In addition to the negative feedback regulation of p38-p53 signaling, PPM1D inhibits other tumor sup...

journal_title：Cancer letters

authors： Pärssinen J,Alarmo EL,Khan S,Karhu R,Vihinen M,Kallioniemi A

更新日期：2008-01-18 00:00:00

abstract：:Fifteen samples from 11 patients suffering from chronic lymphocytic leukaemia (CLL; 5 untreated, 6 chemotherapeutically treated) were analysed for their individual gene expression of the multidrug resistance (MDR) associated genes encoding mdr1/P-glycoprotein, mrp, and topoisomerase II alpha/beta-isoenzymes by a compl...

journal_title：Cancer letters

authors： Beck J,Niethammer D,Gekeler V

更新日期：1994-10-28 00:00:00

abstract：:The T-cell lymphoma cell line YACUT was fused with the Mls-1a antigen-responsive non-tumorigenic T-cell line G4 to construct growth-arrested hybrids which could be induced to proliferate in the presence of Mls-1a antigen. Prolonged growth of the hybrids by repeated antigenic stimulation resulted in the emergence of ce...

journal_title：Cancer letters

authors： Kubota K,Tamauchi H,Nakazato K

更新日期：1996-03-29 00:00:00

abstract：:Cap-mediated translation is the default mechanism for the synthesis of proteins in eukaryotic cells. Increasingly, malignant cells have been found to have deregulation of this process. Return of normal translational control is associated with loss of tumorigenic potential in pre-clinical models. Currently, a variety o...

journal_title：Cancer letters

authors： Thumma SC,Kratzke RA

更新日期：2007-12-08 00:00:00

abstract：:Although end-binding protein 1 (EB1) is well known to regulate microtubule dynamics, the role of EB1 in apoptosis of non-small cell lung cancer (NSCLC) is poorly understood. Here, we investigated the molecular mechanism by which EB1 regulates apoptosis in H460, A549, and H1299 cells. Depletion of EB1 in A549 and H1299...

journal_title：Cancer letters

authors： Kim MJ,Yun HS,Hong EH,Lee SJ,Baek JH,Lee CW,Yim JH,Kim JS,Park JK,Um HD,Hwang SG

更新日期：2013-10-01 00:00:00

abstract：:Repeated application of the tumor promoter 12-O-tetradecanoyl phorbol-13-acetate (TPA) to the skin of mice previously treated with an initiating dose of the carcinogen 7,12-dimethylbenz[a] anthracene has been shown to lead to an increased incidence of papilloma. The studies presented here describe a modified murine tw...

journal_title：Cancer letters

authors： Devens BH,Lundak RL,Byus CV

更新日期：1984-01-01 00:00:00

abstract：:Tumor promotion potential of diacylglycerol (DAG)-rich edible oil was examined using a two-stage mouse skin carcinogenesis model initiated with 7,12-dimethylbenz[a]anthracene (DMBA). Topical treatment with 75 mg DAG oil once a day for 5 days/week for 35 weeks caused papillomas in 4 of 23 (17%) DMBA-treated female ICR ...

journal_title：Cancer letters

authors： Takasuka N,Takahashi M,Hori Y,Kitahashi T,Iigo M,Imai T,Yoshimi N,Sugimura T,Wakabayashi K

更新日期：2009-03-08 00:00:00

abstract：:Overexpression of Myristoylated Alanine-Rich C Kinase Substrate (MARCKS) is implicated in drug resistance and progression of multiple myeloma (MM). The basis for MARCKS induction and impact on MM are not known. Here we show that microRNA-34a (miR-34a), regulates MARCKS translation and is under-expressed in drug-resist...

journal_title：Cancer letters

authors： Zhang L,Rastgoo N,Wu J,Zhang M,Pourabdollah M,Zacksenhaus E,Chen Y,Chang H

更新日期：2020-06-28 00:00:00

abstract：:We have previously demonstrated that O-phospho-L-tyrosine (P-Tyr), a substrate for a wide range of PTPases, inhibits the growth of human renal cell carcinoma and human breast cancer cell lines and suppresses EGF-mediated EGFR tyrosine phosphorylation. We now show that P-Tyr inhibited the growth of the human hepatoma c...

journal_title：Cancer letters

authors： Mishra S,Hamburger AW

更新日期：1996-04-19 00:00:00

abstract：:NF-kappaB is activated in many types of cancer. Phosphorylation of p65 at serine 276 is required for the expression of a subset of NF-kappaB regulated genes, including vascular cell adhesion molecule-1 (VCAM-1) and interleukin-8 (IL-8). Thus, inhibition of serine 276 phosphorylation may prevent metastasis and angiogen...

journal_title：Cancer letters

authors： Law M,Corsino P,Parker NT,Law BK

更新日期：2010-05-28 00:00:00

abstract：:Bombesin (BBS) has been shown to promote pancreatic growth as well as the development of pancreatic (pre)neoplasia in rats. The present study was carried out to determine the effects of bombesin on pancreatic growth and on the development of pancreatic (pre)neoplastic lesions in hamsters treated with N-nitrosobis(2-ox...

journal_title：Cancer letters

authors： Meijers M,van Garderen-Hoetmer A,Lamers CB,Rovati LC,Jansen JB,Woutersen RA

更新日期：1991-07-26 00:00:00

abstract：:To understand the role of cyclooxygenase-2 (COX-2) in gastric cancer, we examined the abundance of COX-2, vascular endothelial growth factor-A (VEGF-A), and CD34 in 45 surgically resected human gastric cancers and paired normal gastric mucosa by immunohistochemical analysis. In addition, the message RNA (mRNA) express...

journal_title：Cancer letters

authors： Yu HG,Li JY,Yang YN,Luo HS,Yu JP,Meier JJ,Schrader H,Bastian A,Schmidt WE,Schmitz F

更新日期：2003-05-30 00:00:00

abstract：:We have evaluated the frequency of HLA class I and II antigens in 205 Italian patients with hepatocellular carcinoma (HCC) and 749 blood donors (controls). Moreover, we have looked for correlations between HLA antigen frequencies and HBV and/or HCV infections in HCC patients. We found great differences in HLA antigen ...

journal_title：Cancer letters

authors： Ricci G,Colombo C,Ghiazza B,Porta C,Moroni M,Illeni MT

更新日期：1995-11-27 00:00:00

abstract：:Lectins are suitable tools for investigating the glycoconjugate characteristics of metastatic cells. In the present study, we investigated whether there were differences between high metastatic T3 cells and a low metastatic isolate in their reactivities to several lectins specific for galactosyl and sialyl groups. Ana...

journal_title：Cancer letters

authors： Mannori G,Mugnai G,Ruggieri S

更新日期：1991-08-01 00:00:00

abstract：:Methylation of liver and nasal mucosal DNA at the O6 position of guanine (O6-MeG) was measured in intact and castrated male rats after a dose of N-nitrosobis(2-oxopropyl)amine (BOP) (20 mg/kg; i.p.). There were no differences in O6-MeG persistence in liver DNA from either group. In the nasal mucosa more O6-MeG was det...

journal_title：Cancer letters

authors： Lawson TA

更新日期：1990-08-01 00:00:00

abstract：:BEC, a standard mixture of solasodine glycosides is effective in vivo against murine sarcoma 180 (S180), whereas the aglycone solasodine at equimolar concentrations is ineffective. The efficacy of BEC against S180 in vivo can be inhibited by rhamnose. Mice which are in their terminal stage with S180 can tolerate and b...

journal_title：Cancer letters

authors： Cham BE,Daunter B

更新日期：1990-12-17 00:00:00

abstract：:Extracellular vesicles (EVs) have garnered much attention as key mediators of intercellular communication within the tumor microenvironment (TME) as well as at distinct metastatic sites. Nucleic acid molecules are the important components of the EV cargo. Characterizing EVs and strategies for modulating the nucleic ac...

journal_title：Cancer letters

authors： Parayath NN,Padmakumar S,Amiji MM

更新日期：2020-07-10 00:00:00

abstract：:Monitoring angiogenesis is potentially an effective strategy for the early detection of cancer. In this study, early detection was achieved by evaluating blood vessel density in the liver using a three-dimensional contrast-enhanced high-frequency ultrasound (CE-HFUS) system and Sonazoid microbubbles. Three-dimensional...

journal_title：Cancer letters

authors： Horie S,Chen R,Li L,Mori S,Kodama T

更新日期：2013-10-10 00:00:00

abstract：:Human kinome/phosphatome screen identified CAMK2N1 genes suppressing the development of human hepatocellular carcinoma (HCC). CAMK2N1 downregulation was found in 47% HCCs and associated with poor prognosis. The downregulation was mainly attributed to its genome deletion (28.4%) and DNA hypermethylation of its promoter...

journal_title：Cancer letters

authors： Peng JM,Tseng RH,Shih TC,Hsieh SY

更新日期：2021-01-28 00:00:00

abstract：:A direct relationship exists between aging and increasing incidences of chronic diseases. In fact, with most age-associated diseases individuals manifest an underlying chronic inflammatory state as evidenced by local infiltration of inflammatory cells, such as macrophages, and higher circulatory levels of pro-inflamma...

journal_title：Cancer letters

authors： Sarkar D,Fisher PB

更新日期：2006-05-08 00:00:00

abstract：:Cancer stem cells are known for their inherent resistance to therapy. Here we investigated whether normal stem cells with acquired resistance to stress can be used to identify novel markers of cancer stem cells. For this, we generated a human embryonic stem cell line resistant to Trichostatin A and analyzed changes in...

journal_title：Cancer letters

authors： Mousa SA,Sudha T,Dyskin E,Dier U,Gallati C,Hanko C,Chittur SV,Rebbaa A

更新日期：2010-03-28 00:00:00

abstract：:Although overall mortality rate of prostate cancer (PCa) declines in recent years, castration-resistant prostate cancer (CRPC) remains incurable. Clinical evidence indicates that CRPC recurred from hormonal therapy exhibits neuroendocrine differentiated (NED) phenotypes, which could contribute to therapeutic resistanc...

journal_title：Cancer letters

authors： Lin LC,Gao AC,Lai CH,Hsieh JT,Lin H

更新日期：2017-04-10 00:00:00

abstract：:Trastuzumab (or Herceptin), as the first erbB2-targeted therapy, has been successfully used to treat breast cancer patients with erbB2-overexpressing tumors. However, resistances to trastuzumab frequently occur, and novel strategies/agents are urgently needed to abrogate the resistant phenotype. Our current study expl...

journal_title：Cancer letters

authors： Huang X,Wang S,Lee CK,Yang X,Liu B

更新日期：2011-08-01 00:00:00

abstract：:Glioblastoma multiforme (GBM) is the most malignant form of central nervous system tumor, and current therapies are largely ineffective at treating the cancer. Developing a more complete understanding of the mechanisms controlling the tumor is important in order to explore new possible treatment options. It is specula...

journal_title：Cancer letters

authors： Haley EM,Kim Y

更新日期：2014-04-28 00:00:00

abstract：:Human mitogen-stimulated lymphocytes, cultured in the presence of amosite asbestos (AS), demonstrated a slight increase in aryl hydrocarbon hydroxylase (AHH) activity compared with non-induced (control) cultures (P = 0.005). A much greater increase in enzyme activity occurred following addition of the inducers benzant...

journal_title：Cancer letters

authors： McLemore TL,Jenkins WT,Arnott MS,Wray NP

更新日期：1979-07-01 00:00:00

abstract：:The sex-determining region Y-box 7 (Sox7) is a member of high mobility group (HMG) transcription factor family, essential for embryonic development and endoderm differentiation. Deregulation of Wnt signaling pathway is a hallmark of colorectal cancer. Our results showed that the expression level of SOX7 was frequently...

journal_title：Cancer letters

authors： Zhang Y,Huang S,Dong W,Li L,Feng Y,Pan L,Han Z,Wang X,Ren G,Su D,Huang B,Lu J

更新日期：2009-05-08 00:00:00

abstract：:Indomethacin is a non-steroidal anti-inflammatory agent that inhibits prostaglandin synthesis. Administration of indomethacin, in doses which were non-toxic to normal BALB/c mice, to mice bearing the BCL1 leukemia resulted in increased mortality of these animals. This effect was only observed if the indomethacin was a...

journal_title：Cancer letters

authors： Hart DA

更新日期：1984-06-01 00:00:00

abstract：:The genomic aberration profile of chromosome 20q in distal CIN colon carcinomas was analysed using allelotyping and CGH arrays. Allelotyping revealed carcinomas with allelic imbalance along the full long arm, and carcinomas with fully non-aberrant 20q. Oligonucleotide-based CGH showed that among the carcinomas without...

journal_title：Cancer letters

authors： Nicolet C,Guérin E,Neuville A,Kerckaert JP,Wicker N,Bergmann E,Brigand C,Kedinger M,Gaub MP,Guenot D

更新日期：2009-09-18 00:00:00