Abstract：
:Extracellular vesicles (EVs) have garnered much attention as key mediators of intercellular communication within the tumor microenvironment (TME) as well as at distinct metastatic sites. Nucleic acid molecules are the important components of the EV cargo. Characterizing EVs and strategies for modulating the nucleic acid content to promote anti-tumoral functions has led to the emerging role of EVs as potential novel targets for cancer therapy. Recent approaches of engineering the EVs to reach targeted sites have bought this to the forefront for nucleic acid delivery. In this article, we discuss EV biology with recent methods to analyze their nucleic acid contents. We emphasize the role of EV-mediated nucleic acid transfer in the TME assisting in tumor progression and metastasis and further review the strategies for modulating the nucleic acid content in EV for suppressing tumor growth and immune activation. The article further discusses the recent developments in generating EV mimics as nucleic acid delivery systems.
journal_name
Cancer Lettjournal_title
Cancer lettersauthors
Parayath NN,Padmakumar S,Amiji MMdoi
10.1016/j.canlet.2020.04.009subject
Has Abstractpub_date
2020-07-10 00:00:00pages
33-43eissn
0304-3835issn
1872-7980pii
S0304-3835(20)30186-5journal_volume
482pub_type
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