Deregulated c-myc expression is insufficient for emergence of the tumorigenic phenotype in malignancy-suppressed intratypic T-cell lymphoma hybrids: an in vitro model for multistep lymphomagenesis.


:The T-cell lymphoma cell line YACUT was fused with the Mls-1a antigen-responsive non-tumorigenic T-cell line G4 to construct growth-arrested hybrids which could be induced to proliferate in the presence of Mls-1a antigen. Prolonged growth of the hybrids by repeated antigenic stimulation resulted in the emergence of cells with transformed phenotype, which was accompanied by a reversion of c-myc expression to the levels of the YACUT lymphoma parent and an increase in the number of YACUT-derived chromosome 15 carrying the rearranged pvt-1 gene. Despite these two changes, early passage transformed hybrids as well as proliferation-suppressed hybrids were non-tumorigenic in vivo. The fact that only late passage transformed hybrids produced tumors in vivo indicated that additional genetic and/or epigenetic alterations are required for the emergence of hybrid lines with tumorigenic phenotype. Thus, this experimental system offers tangible possibilities for delineation of the three distinct phenotypes which could be exploited for the investigation of the multistep process of lymphomagenesis.


Cancer Lett


Cancer letters


Kubota K,Tamauchi H,Nakazato K




Has Abstract


1996-03-29 00:00:00














  • Anti-angiogenesis therapy in cancer: current challenges and future perspectives.

    abstract::It has been nearly 9years since the FDA (Food and Drug Administration) approved the first anti-angiogenic drug (bevacizumab) for treatment of metastatic colorectal cancer. Other angiogenic inhibitors have since been approved or are in different stages of clinical trials. However, continued clinical and preclinical inv...

    journal_title:Cancer letters

    pub_type: 杂志文章,评审


    authors: Shojaei F

    更新日期:2012-07-28 00:00:00

  • Caffeine-derived N-nitroso compounds. IV: Kinetics of mononitrosocaffeidine demethylation by rat liver microsomes.

    abstract::The study describes the kinetics of demethylation of mononitrosocaffeidine (MNC), a new asymmetric N-nitrosamine derived from caffeine. The demethylation of its precursor compound caffeidine was also studied. The results presented here suggest (a) that liver microsomes from fasted rats preferentially demethylate the N...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Razdan R,Frei E,Spiegelhalder B,Siddiqi M

    更新日期:1994-04-29 00:00:00

  • The dual role of mast cells in tumor fate.

    abstract::The exact role of mast cells in tumor growth is not clear and multifaceted. In some cases, mast cells stimulate while in others inhibit this process. This dual role may be explained to some extent by the huge number of bioactive molecules stored in mast cell granules, as well as differences between tumor microenvironm...

    journal_title:Cancer letters

    pub_type: 杂志文章,评审


    authors: Ribatti D,Tamma R,Crivellato E

    更新日期:2018-10-01 00:00:00

  • Suppression of the GTPase-activating protein RGS10 increases Rheb-GTP and mTOR signaling in ovarian cancer cells.

    abstract::The regulator of G protein signaling 10 (RGS10) protein is a GTPase activating protein that accelerates the hydrolysis of GTP and therefore canonically inactivates G proteins, ultimately terminating signaling. Rheb is a small GTPase protein that shuttles between its GDP- and GTP-bound forms to activate mTOR. Since RGS...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Altman MK,Alshamrani AA,Jia W,Nguyen HT,Fambrough JM,Tran SK,Patel MB,Hoseinzadeh P,Beedle AM,Murph MM

    更新日期:2015-12-01 00:00:00

  • Histone deacetylase inhibition induces apoptosis and autophagy in human neuroblastoma cells.

    abstract::Neuroblastoma (NB) is the most common solid extracranial tumor in children. Here we showed that trichostatin A, a histone deacetylase inhibitor (HDACi), decreases cell viability in three NB cell lines of different phenotypes. The treatment leads to G2/M-phase arrest, apoptosis and autophagy. Autophagy induction accomp...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Francisco R,Pérez-Perarnau A,Cortés C,Gil J,Tauler A,Ambrosio S

    更新日期:2012-05-01 00:00:00

  • Epigenetic biomarkers in skin cancer.

    abstract::Epigenetic aberrations have been associated with cutaneous melanoma tumorigenesis and progression including dysregulated DNA gene promoter region methylation, histone modification, and microRNA. Several of these major epigenetic aberrations have been developed into biomarkers. Epigenetic biomarkers can be detected in ...

    journal_title:Cancer letters

    pub_type: 杂志文章,评审


    authors: Greenberg ES,Chong KK,Huynh KT,Tanaka R,Hoon DS

    更新日期:2014-01-28 00:00:00

  • Synergistic cytotoxic effect of human recombinant tumor necrosis factor alpha combined with dihydroambazone.

    abstract::Dihydroambazone (DHA) is a water-soluble derivative of the experimental anticancer drug ambazone. In vitro, a combination of DHA and human recombinant tumor necrosis factor alpha (TNF) exerted a strong synergism of cytotoxicity against both mouse melanoma B16K cells and the TNF-sensitive mouse fibroblast line L-M (S)....

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Baumgart J,Gase K,Schulze W,Suehnel J,Gutsche W,Behnke D

    更新日期:1990-11-05 00:00:00

  • Tumor microenvironment and cancer therapy resistance.

    abstract::Innate resistance to various therapeutic interventions is a hallmark of cancer. In recent years, however, acquired resistance has emerged as a daunting challenge to anticancer treatments including chemotherapy, radiation and targeted therapy, which abolishes the efficacy of otherwise successful regimens. Cancer cells ...

    journal_title:Cancer letters

    pub_type: 杂志文章,评审


    authors: Sun Y

    更新日期:2016-09-28 00:00:00

  • The hypoxic tumour microenvironment: A safe haven for immunosuppressive cells and a therapeutic barrier to overcome.

    abstract::Dating back to the seminal work of Paul Ehrlich, the idea of harnessing our immune system to eliminate cancerous cells is now over a century old. In the presence of a functional immune system that so efficiently guards the host against developing neoplasms, tumour cells must evolve sophisticated strategies to escape i...

    journal_title:Cancer letters

    pub_type: 杂志文章,评审


    authors: Chang WH,Lai AG

    更新日期:2020-09-01 00:00:00

  • AK-1, a specific SIRT2 inhibitor, induces cell cycle arrest by downregulating Snail in HCT116 human colon carcinoma cells.

    abstract::SIRT2, a member of the sirtuin family, is involved in the regulation of a variety of physiological functions. In addition, SIRT2 has been studied in the context of pathological conditions including neurodegenerative diseases, metabolic syndrome, and cancer. The effect of SIRT2 on cancer cell growth depends on cancer t...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Cheon MG,Kim W,Choi M,Kim JE

    更新日期:2015-01-28 00:00:00

  • Establishment and characterization of a rat lung adenocarcinoma cell line with low malignant potential.

    abstract::To investigate characteristic of lung adenocarcinoma growth behavior, we have established a cell line (rat lung cancer in Nara (RLCNR)) from a tumor induced by N-nitrosobis(2-hydroxypropyl)amine (BHP) in a rat. This clone shows an epithelial cell morphology and grows as sheets in culture with an approximate doubling t...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Tsujiuchi T,Mori T,Amanuma T,Tanaka N,Tsutsumi M

    更新日期:2005-01-10 00:00:00

  • Potent growth-suppressive activity of a serine protease inhibitor, ONO-3403, toward malignant human neuroblastoma cell lines.

    abstract::FOY-305 is a synthetic serine protease inhibitor and ONO-3403 and FO-349 are its derivatives. The effects of these compounds on the proliferation of 13 human neuroblastoma cell lines were investigated in vitro by MTT colorimetric assay. The half maximum inhibition concentrations of ONO-3403 varied between 22 and 90 mi...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Hiwasa T,Kondo K,Nakagawara A,Ohkoshi M

    更新日期:1998-04-24 00:00:00

  • The metabolic landscape of urological cancers: New therapeutic perspectives.

    abstract::Deregulation of cell metabolism is an established cancer hallmark that contributes to tumor initiation and progression, as well as tumor heterogeneity. In solid tumors, alterations in different metabolic pathways, including glycolysis, pentose phosphate pathway, glutaminolysis and fatty acid metabolism, support the hi...

    journal_title:Cancer letters

    pub_type: 杂志文章,评审


    authors: Miranda-Gonçalves V,Lameirinhas A,Henrique R,Baltazar F,Jerónimo C

    更新日期:2020-05-01 00:00:00

  • The role of aberrant crypt foci induced by the two heterocyclic amines 2-amino-3-methyl-imidazo[4,5-f]quinoline (IQ) and 2-amino-1-methyl-6-phenyl-imidazo[4,5-b]pyridine (PhIP) in the development of colon cancer in mice.

    abstract::Aberrant crypt foci (ACF) have recently been identified as early putative preneoplastic lesions which appear in the colons of experimental animals treated with colon carcinogens. In a recent study the two heterocyclic amines, 2-amino-3-methyl-imidazo[4,5-f]quinoline (IQ) and 2-amino-1-methyl-6-phenyl-imidazo[4,5-b]pyr...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Kristiansen E

    更新日期:1996-12-20 00:00:00

  • Characteristics of proliferative lesions in the nasal cavities of mice following chronic inhalation of 1,2-dibromoethane.

    abstract::Groups of 50 male and 50 female B6C3F1 mice inhaled 10 or 40 ppm 1,2-dibromoethane 6 h/day, 5 days/week, for 103 (10 ppm) or 90 (40 ppm) weeks. Focal epithelial hyperplasia was found in 1 (low dose group) and 10 (high dose group) males and 3 (low dose group) and 11 (high dose group) females. Squamous papillomas or ade...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Stinson SF,Reznik G,Ward JM

    更新日期:1981-03-01 00:00:00

  • Ultrasound-induced apoptosis in the presence of Sonazoid and associated alterations in gene expression levels: a possible therapeutic application.

    abstract::Ultrasound (US) has been shown to induce apoptosis and cell lysis in cancer cells. In this study, we report on the potential of using Sonazoid, a new echo-contrast agent, that is chemically more stable and US-resistant in combination with US in cancer therapy. The biological effects and their mechanisms in the presenc...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Furusawa Y,Zhao QL,Hassan MA,Tabuchi Y,Takasaki I,Wada S,Kondo T

    更新日期:2010-02-01 00:00:00

  • The field bean protease inhibitor has the potential to suppress B16F10 melanoma cell lung metastasis in mice.

    abstract::Metastasis is a characteristic and fatal feature of human malignancies. Its regulation is therefore of the utmost significance to clinicians. The present study was undertaken to determine whether a legume-derived protease inhibitor (PI) of trypsin/chymotrypsin, the field bean PI (FBPI), also has plasmin inhibitory act...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Banerji A,Fernandes A,Bane S,Ahire S

    更新日期:1998-07-03 00:00:00

  • A novel antitumor activity of deguelin targeting the insulin-like growth factor (IGF) receptor pathway via up-regulation of IGF-binding protein-3 expression in breast cancer.

    abstract::In this study, we investigated the antitumor effects of deguelin in several human breast cancer cells in vitro and in vivo. Deguelin inhibited cell viability and the anchorage-dependent and anchorage-independent colony formation of triple-negative (MDA-MB-231 and MDA-MB-468) and triple-positive (MCF-7) breast cancer c...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Suh YA,Kim JH,Sung MA,Boo HJ,Yun HJ,Lee SH,Lee HJ,Min HY,Suh YG,Kim KW,Lee HY

    更新日期:2013-05-10 00:00:00

  • Reduction in NaCl-enhanced gastric carcinogenesis in rats fed a high-protein diet.

    abstract::The effect of a purified, high protein diet on enhanced gastric carcinogenesis induced by oral administration of NaCl was investigated in Wistar rats. Rats were fed on a purified diet with an equalized caloric content, containing 8% NaCl and 25% casein (normal protein diet), or 50% casein (high protein diet) after ora...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Tatsuta M,Iishi H,Baba M,Uehara H,Nakaizumi A,Iseki K

    更新日期:1997-06-24 00:00:00

  • Carcinogenic effect of di-isopropanolnitrosamine on the rat thyroid gland.

    abstract::Up to a 50% rate of thyroid gland tumours was induced in Sprague-Dawley rats after s.c. administration of di-isopropanolnitrosamine (DIPN). The neoplasms occurred both unilaterally and bilaterally, and were identified histologically as adenomas and adenocarcinomas of follicular epithelium origin. In a few instances, a...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Reznik G,Mohr U

    更新日期:1977-03-01 00:00:00

  • Low-level shear stress promotes migration of liver cancer stem cells via the FAK-ERK1/2 signalling pathway.

    abstract::Cancer stem cells (CSCs) are a small subpopulation of tumour cells that have been proposed to be responsible for cancer initiation, chemotherapy resistance and cancer recurrence. Shear stress activated cellular signalling is involved in cellular migration, proliferation and differentiation. However, little is known ab...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Sun J,Luo Q,Liu L,Song G

    更新日期:2018-07-28 00:00:00

  • The influence of chemical carcinogens on natural killer cell function in rats. A comparison of 2-acetylaminofluorene with 4-acetylaminofluorene.

    abstract::The influence of the carcinogen 2-acetylaminofluorene (2AAF) administration on splenic natural killer (NK) cell function in two strains of rats has been examined and compared with that of the non-carcinogenic analogue 4-acetylaminofluorene (4AAF). In both strains it was observed that daily exposure to 25 mg kg-1 2AAF ...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Kimber I,Griffin AC,Jones K

    更新日期:1986-01-01 00:00:00

  • Rapid induction of mammary cancer by repeated subcutaneous injection of the trans-3,4-dihydrodiol of 7,12-dimethylbenz[a]anthracene in the female Sprague-Dawley rat.

    abstract::The oral administration of a single 20mg dose of 7,12-dimethylbenz[a]anthracene regularly and rapidly induces mammary cancer in 50 day-old Sprague-Dawley female rats [Experimental Leukemia and Mammary Cancer, 1979, p. 74]. Several mechanisms by which 7,12-dimethylbenz[a]anthracene induces mammary cancer have been prop...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Horn J,Lehner AF,Flesher JW

    更新日期:2005-04-08 00:00:00

  • Epigenetic silencing of chemokine CCL2 represses macrophage infiltration to potentiate tumor development in small cell lung cancer.

    abstract::Highly invasive and rapidly fatal, small-cell lung cancer (SCLC) has been an insurmountable gulf since discovery. Innate immunity plays a vital role in anti-tumor response, among which macrophages contribute to an indispensable character. Here, we found that macrophage infiltration in SCLC reduced significantly in a s...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Zheng Y,Wang Z,Wei S,Liu Z,Chen G

    更新日期:2021-02-28 00:00:00

  • SMYD2-dependent HSP90 methylation promotes cancer cell proliferation by regulating the chaperone complex formation.

    abstract::Heat shock protein 90 (HSP90) is a highly conserved molecular chaperone that facilitates the maturation of a wide range of proteins, and it has been recognized as a crucial facilitator of oncogene addiction and cancer cell survival. Although HSP90 function is regulated by a variety of post-translational modifications,...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Hamamoto R,Toyokawa G,Nakakido M,Ueda K,Nakamura Y

    更新日期:2014-08-28 00:00:00

  • The predictive power of CD3+ T cell infiltration of oral squamous cell tumors is limited to non-diabetic patients.

    abstract::Diabetes mellitus type II (DM) and immune cell infiltration determine patient outcome in many tumor entities. Here we studied a possible link between the metabolic and immune cell status of OSCC patients. Glucose transporter (GLUT) 1 mRNA expression was elevated in all tumor samples, whereas other glycolytic markers s...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Spanier G,Ugele I,Nieberle F,Symeou L,Schmidhofer S,Brand A,Meier J,Spoerl S,Krupar R,Rümmele P,Siska P,Renner K,Peter K,Gerken M,Beckhove P,Reichert TE,Kreutz M,Singer K

    更新日期:2021-02-28 00:00:00

  • Resistance factors in colon cancer tissue and the adjacent normal colon tissue: glutathione S-transferases alpha and pi, glutathione and aldehyde dehydrogenase.

    abstract::Glutathione S-transferases (GST) alpha and pi, glutathione (GSH) and aldehyde dehydrogenase (ADH) were determined in colorectal cancer tissue specimens and in the adjacent normal colon tissue. The median contents in normal and cancer tissue were 8.1 (2.3-30.3) (5-95% quantiles) and 15.1 (5.3-50.3) microg/mg protein fo...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Hengstler JG,Böttger T,Tanner B,Dietrich B,Henrich M,Knapstein PG,Junginger T,Oesch F

    更新日期:1998-06-05 00:00:00

  • Accumulation of cytoplasmic CDC25A in cutaneous squamous cell carcinoma leads to a dependency on CDC25A for cancer cell survival and tumor growth.

    abstract::Despite its documented role in cell cycle regulation, over-expression of the cyclin-dependent kinase activator CDC25A does not consistently correlate with worse cancer patient outcomes or predict successful clinical response to CDC25A inhibition. The current study was undertaken to investigate CDC25A in skin cancer an...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Al-Matouq J,Holmes T,Hammiller B,Tran N,Holmes M,Freeman SC,Hansen LA

    更新日期:2017-12-01 00:00:00

  • Synergistic antitumor effect of adenovirus-mediated hING4 gene therapy and (125)I radiation therapy on pancreatic cancer.

    abstract::Pancreatic cancer has a poor prognosis, even with surgery. ING4 is a member of the inhibitor of growth (ING) tumor suppressor family that has potent inhibitory effects on a variety of tumors; meanwhile, radiotherapy is a common adjunctive therapy for pancreatic cancer. Prior to this study, the effectiveness of a combi...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Zhao Y,Su C,Zhai H,Tian Y,Sheng W,Miao J,Yang J

    更新日期:2012-03-28 00:00:00

  • Reactive oxygen species-independent G1 arrest induced by evening primrose extract in Ehrlich ascites tumor cells.

    abstract::We previously demonstrated that evening primrose extract (EPE) induced apoptosis in Ehrlich ascites tumor cells (EATC), and this effect was specific on tumor cells. Furthermore, our results demonstrated that EPE exposure elicited a rapid increase in the activity of superoxide dismutase and intracellular peroxides leve...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Arimura T,Kojima-Yuasa A,Kennedy DO,Matsui-Yuasa I

    更新日期:2004-04-15 00:00:00