Abstract:
:Thyroid hormone receptor interactor 4 (TRIP4), a subunit of the tetrameric nuclear activating signal co-integrator 1 (ASC-1) complex, exerts pro-tumorigenic effects. The role for TRIP4 in the regulation of cervical cancer growth and radiation resistance is presently unknown. In this study, TRIP4 was found to be highly expressed in cervical cancer cells and tumor tissues. Knockdown of TRIP4 significantly suppressed cervical cancer cell proliferation and epithelial-mesenchymal transition (EMT), accompanied by inactivation of PI3K/AKT and MAPK/ERK signaling. TRIP4 was also found to target hTERT signaling by regulating its binding to the hTERT promoter. Moreover, the knockdown of TRIP4 increased cell sensitivity to radiation, concomitant with downregulation of Rad51 and p-H2AX. We also demonstrated in an in vivo study that the knockdown of TRIP4 effectively suppressed cervical cancer growth and progression in a xenograft tumor model, and these effects were concomitant with the downregulation of p-AKT, p-ERK, p-MEK1/2, MMP-9 and hTERT expression. Immunohistochemical analysis of tumor tissue microarrays showed that TRIP4 overexpression predicted poor prognosis in patients with cervical cancer. Collectively, these results show that TRIP4 plays an essential role in cervical cancer growth and survival.
journal_name
Cancer Lettjournal_title
Cancer lettersauthors
Che Y,Li Y,Zheng F,Zou K,Li Z,Chen M,Hu S,Tian C,Yu W,Guo W,Luo M,Deng W,Zou Ldoi
10.1016/j.canlet.2019.03.017subject
Has Abstractpub_date
2019-06-28 00:00:00pages
1-13eissn
0304-3835issn
1872-7980pii
S0304-3835(19)30173-9journal_volume
452pub_type
杂志文章相关文献
CANCER LETTERS文献大全abstract::To clarify the detailed molecular mechanism underlying cellular responses to nonthermal low-intensity pulsed ultrasound (LIPUS), gene expression patterns and genetic networks in human lymphoma U937 cells were examined using global-scale microarrays and computational gene expression analysis tools. Six hours after LIPU...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2008.05.018
更新日期:2008-11-08 00:00:00
abstract::Pancreatic ductal adenocarcinoma (PDAC) is highly aggressive disease and current treatment regimens fail to effectively cure PDAC. Development of resistance to current therapy is one of the key reasons for this outcome. Nimbolide (NL), a triterpenoid obtained from Azadirachta indica, exhibits anticancer properties in ...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2017.10.029
更新日期:2018-01-28 00:00:00
abstract::Smoking women are probably at a higher risk to develop lung cancer than men. Different explanations exist for these findings, a gender-specific impairment of tobacco carcinogen metabolism being one of them. In this study, we examined the inhibition of NNK reduction to NNAL, the first and most important detoxication st...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2017.07.016
更新日期:2017-10-01 00:00:00
abstract:OBJECTIVE:The bad prognosis of primary carcinoma of the Fallopian tube is ascribed to early lymphogenous metastasis. Due to the rarity of cases, there exist only few and divergent results on the importance of lymph node metastasis in the relevant literature. Thus, our study aimed at detecting the incidence of lymph nod...
journal_title:Cancer letters
pub_type: 杂志文章,多中心研究
doi:10.1016/s0304-3835(99)00273-6
更新日期:1999-12-01 00:00:00
abstract::Though many investigators have reported relationships between the CCND1 polymorphism and susceptibility to various carcinomas, to our knowledge, no report has been issued concerning its relationship with uterine cervical cancer. Thus, we undertook this study to investigate the association between CCND1 polymorphisms a...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2004.12.024
更新日期:2005-06-08 00:00:00
abstract::The mechanism underlying the chemopreventive effects of the non-steroidal anti-inflammatory drug sulindac remains unclear. Its active metabolite, sulindac sulfide, induces cell cycle arrest as well as apoptosis in mammalian cell lines. We now show that in murine thymocytes, sulindac sulfide-induced cell death is p53, ...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2004.06.015
更新日期:2005-02-28 00:00:00
abstract::Estrogens are important for the development and growth of estrogen receptor (ER)-positive breast cancer, for which anti-estrogen therapy is one of the most effective treatments. However, its efficacy can be limited by either de novo or acquired resistance. Aromatase is a key enzyme for the biosynthesis of estrogens, a...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2014.05.003
更新日期:2014-08-28 00:00:00
abstract::The synthetic compound 1,2-dimethylhydrazine is employed in carcinogenesis studies because of its reliable and specific ability to produce colon tumors in rodents. Male Fischer rats were treated at 7 weeks of age with a single oral dose of 1,2-dimethylhydrazine (35 mg/kg) and examined at autopsy 1.5 years later when t...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(81)90008-2
更新日期:1981-10-01 00:00:00
abstract::Diol-epoxide derivatives of polycyclic aromatic hydrocarbons are the ultimate carcinogenic forms of these compounds encountered in vivo. Using a novel electro-fluorescence apparatus, we report that, like the (+/-)-anti-diol-epoxide of benzo[a]pyrene (BP), the similar diol-epoxides of benzo[a]anthracene (BA) and 3-meth...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(84)90049-1
更新日期:1984-02-01 00:00:00
abstract::A polymorphism in the signal sequence (Ala-9Val) of the gene encoding the free radical-quenching manganese superoxide dismutase (MnSOD) has been reported to alter the risk for breast cancer. We evaluated this relationship in a population-based case-control study (476 breast cancer cases and 502 controls). Overall, rel...
journal_title:Cancer letters
pub_type: 杂志文章,多中心研究
doi:10.1016/s0304-3835(03)00349-5
更新日期:2003-09-10 00:00:00
abstract::The hepatitis B virus (HBV) is a major cause of hepatocellular carcinoma (HCC), partly driven by viral integration and specific oncogenic HBV variants. However, the biological significance of HBV genomes within lymphoid cells (i.e., peripheral blood mononuclear cells, PBMCs) is unclear. Here, we collected available pl...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2020.03.022
更新日期:2020-06-28 00:00:00
abstract::Urethane-induced lung tumors and their genetic changes were investigated in transgenic (Tg) mice carrying a human prototype c-Ha-ras gene (rasH2 mice). Male and female rasH2 mice and non-transgenic (non-Tg) littermates were injected intraperitoneally with 1000 mg/kg of urethane once or three times at 2-day intervals. ...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/s0304-3835(00)00372-4
更新日期:2000-05-29 00:00:00
abstract::Survivin, a novel antiapoptosis gene, was identified as a member of the inhibitor of apoptosis protein (IAP) family. Unique among IAP, survivin has been found to be abundantly expressed in a wide variety of human malignancies, whereas it is undetectable in normal adult tissues. Recently, three splicing variants of sur...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2003.12.020
更新日期:2004-12-28 00:00:00
abstract::To estimate the contents of flavonoids in the Danish diet, we have used a high performance liquid chromatographic method for the analysis of fruits, vegetables and beverages. The flavonoid contents were quantified, and the observations were verified by mass spectrometry. The investigation is not completed, but we are ...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/s0304-3835(97)04651-x
更新日期:1997-03-19 00:00:00
abstract::Herein we report a method for studying slow acting pharmaceutical COX-2 inhibitors in the MCF-7 breast cancer cell line where cells are grown in a three-dimensional format within an agarose matrix. The cancer cells are suspended in agarose and plated in a cell culture dish, where they will form small multicellular 'tu...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2003.10.030
更新日期:2004-03-08 00:00:00
abstract::In a series of invasive ductal breast carcinoma, we investigated the status of chromosomal and intrachromosomal instability by fluorescence in situ hybridisation and determined the level of mRNA expression for two genes involved in the mitotic spindle checkpoint pathway, BUB1B and MAD2L1. All breast cancers demonstrat...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2007.03.021
更新日期:2007-09-08 00:00:00
abstract::Artesunate (ART), a semi-synthetic derivative of artemisinin extracted from the Chinese herb Artemisia annua, is a safe and effective antimalarial drug. ART has now been analyzed for its anti-angiogenic activity in vivo and in vitro. The anti-angiogenic effect in vivo was evaluated on chicken chorioallantoic membrane ...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2004.03.014
更新日期:2004-08-10 00:00:00
abstract::Recent efforts have revealed that numerous natural antisense lncRNAs play a crucial role in the regulation of cancer biology. Here, based on our previous study, we further identified that the lncRNA FOXC2-AS1 and its antisense transcript FOXC2 are positively up-regulated in doxorubicin-resistant osteosarcoma cell line...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2017.03.018
更新日期:2017-06-28 00:00:00
abstract::Increased intramedullary apoptotic death of hematopoietic cells is thought to contribute to the ineffective hematopoiesis in myelodysplastic syndromes (MDS). Furthermore, high amounts of tumor necrosis factor alpha (TNF alpha) have previously been correlated with apoptosis in MDS marrows. The present studies were unde...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/s0304-3835(99)00072-5
更新日期:1999-06-01 00:00:00
abstract::Ditercalinium (7-H-pyridocarbazole dimer), a prospective antitumor drug, is a bis-intercalator characterized by a very high affinity towards nucleic acids. Specificity of binding of this drug has been studied using spectroscopy and flow cytometry. The competition experiments between the drug and 4',6-diamidino-2-pheny...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(88)90303-5
更新日期:1988-11-01 00:00:00
abstract::Peroxiredoxin I (Prx I) is newly discovered oxidative stress inducible protein, having a thioredoxin peroxidase activity. The Prx I expression level in 107 samples out of 60 thyroid lesions, including normal thyroid, tumors and thyroiditis including Graves' disease were examined using immunoblotting. Prx I expression ...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/s0304-3835(99)00243-8
更新日期:1999-10-18 00:00:00
abstract::Hypoxia induces survival signals in hepatocellular carcinoma (HCC). We attempted to find a hypoxia-induced signal that could be used for modulating HCC cell death. Cellular retinoic acid binding protein-II (CRABP-II) expression was significantly increased in hypoxic HCC cells. Treatment with retinoic acid (RA), a liga...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2010.03.005
更新日期:2010-09-28 00:00:00
abstract::The p53 tumor suppressor gene is often mutated in various human cancers. Recently, the p53 codon 72 polymorphism has been extensively studied to determine the risk factors responsible for cancer formation. We investigated the genotype distribution of the p53 codon 72 polymorphism in 112 male urothelial cancer cases an...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/s0304-3835(02)00518-9
更新日期:2003-01-10 00:00:00
abstract::Glioblastoma multiforme (GBM) is a brain tumor with a high mortality rate. Surgical resection combined with radiotherapy and chemotherapy is the standard treatment for GBM patients, but the 5-year survival rate of patients despite this treatment is low. Immunotherapy has attracted increasing attention in recent years....
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2020.09.028
更新日期:2021-01-01 00:00:00
abstract::Various dose levels of benzo[a]pyrene (BP) were tested on short-term cultured foetal hamster lung cells for transforming effects in vitro in 6 similar experiments. The statistical evaluation of the results indicated a weak reproducibility (P = 0.09). Factors which inherently influence such reproducibility were conside...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(79)90023-5
更新日期:1979-11-01 00:00:00
abstract::Cancer-associated fibroblasts (CAFs) are the predominant cell type in tumor microenvironment (TM) and featured with the distinct energy metabolism reprogramming (EMR) phenotype caused by many factors such as hypoxia and growth factors. The EMR of CAFs plays a key role in biological behaviors of cancer cells including ...
journal_title:Cancer letters
pub_type: 杂志文章,评审
doi:10.1016/j.canlet.2014.07.028
更新日期:2014-10-28 00:00:00
abstract::A cell line partially resistant to dimethylsulfoxide (DMSO) was derived from the HL-60 cell line. Cycloleucine, theophylline, sodium butyrate and elevated levels of DMSO were found to induce myeloid differentiation in this cell line while TPA induced monocytic differentiation. The levels of myc RNA and the genomic str...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(84)90043-0
更新日期:1984-02-01 00:00:00
abstract::Breast cancer cells in their virulent undifferentiated state are characterized by lack of functional estrogen receptors (ER) and/or progesterone receptors (PR) as well as relatively low levels of other normal differentiation markers such as milk proteins and lipid droplets. To date, no method for in situ elevation of ...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/s0304-3835(03)00146-0
更新日期:2003-05-08 00:00:00
abstract::Cancer results from genetic alterations in intracellular signaling pathways, which normally orchestrate the execution of developmental programs and the organismic response to extrinsic factors. Mutations in upstream activators and components of the cytoplasmic (Ras-Raf MEK-ERK) cascade frequently occur in tumors. In v...
journal_title:Cancer letters
pub_type: 杂志文章,评审
doi:10.1016/j.canlet.2004.08.003
更新日期:2005-01-10 00:00:00
abstract::Pretreatment of EMT-6 murine tumor cells for 24 h with 10(-4) M 8-methoxypsoralen (8-MOP) increased the photocytotoxicity of Photofrin II (P2) after cell exposure to low doses (1-1.5 J/cm2) of UVA by two- to three-fold. 8-MOP alone had no cytotoxic action under these experimental conditions and did not significantly c...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/s0304-3835(98)00069-x
更新日期:1998-06-19 00:00:00