Abstract:
:Diol-epoxide derivatives of polycyclic aromatic hydrocarbons are the ultimate carcinogenic forms of these compounds encountered in vivo. Using a novel electro-fluorescence apparatus, we report that, like the (+/-)-anti-diol-epoxide of benzo[a]pyrene (BP), the similar diol-epoxides of benzo[a]anthracene (BA) and 3-methylcholanthrene (3MC) also bind to the DNA helix at an inclination of approximately 50 degrees. This compares with the essentially perpendicular, intercalative-type binding generally found with saturated aromatic compounds, such as the native hydrocarbons, and may indicate a systematic behavior in the molecular associations precursive to carcinogenesis.
journal_name
Cancer Lettjournal_title
Cancer lettersauthors
Ridler P,Jennings Bdoi
10.1016/0304-3835(84)90049-1subject
Has Abstractpub_date
1984-02-01 00:00:00pages
95-8issue
1eissn
0304-3835issn
1872-7980pii
0304-3835(84)90049-1journal_volume
22pub_type
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