Levels of myc, fos, Ha-ras, met and hepatocyte growth factor mRNA during regenerative cell proliferation in female mouse liver and male rat kidney after a cytotoxic dose of chloroform.

abstract：:Chemotherapeutic multidrug resistance (MDR) is a significant challenge to overcome in clinic practice. Several mechanisms contribute to MDR, one of which is the augmented drug efflux induced by the upregulation of ABCB1 in cancer cells. Regorafenib, a multikinase inhibitor targeting the RAS/RAF/MEK/ERK pathway, was ap...

journal_title：Cancer letters

authors： Wang YJ,Zhang YK,Zhang GN,Al Rihani SB,Wei MN,Gupta P,Zhang XY,Shukla S,Ambudkar SV,Kaddoumi A,Shi Z,Chen ZS

更新日期：2017-06-28 00:00:00

abstract：:Mice with hereditary intestinal polyposis have mutations of the APC gene which causes formation of multiple polyps. At least one other gene influences the susceptibility for development of polyps in mice, and the locus was named Mom1. The causative gene for the Mom1 locus has recently been cloned and was found to be i...

journal_title：Cancer letters

authors： Kawamata N,Seriu T,Bartram CR,Koeffler HP

更新日期：1997-01-01 00:00:00

abstract：:Continuous ethinyl estradiol treatment following ovariectomy at day 38 of BALB/cfC3H mice treated neonatally with estradiol resulted in a more organized vaginal epithelium than that seen in the absence of postnatal estrogen, 30 days after treatment was initiated. Although the epithelium became increasingly disorganize...

journal_title：Cancer letters

authors： Wong LM,Bern HA,Jones LA,Mills KT

更新日期：1982-11-01 00:00:00

abstract：:Precision medicine promises to better classify patients by individual clinical and biological biomarkers, which may provide an accurate assessment of disease risk, diagnosis, prognosis and treatment response. Cancer frequently displays substantial inter-tumor and intra-tumor heterogeneity and hence oncology is well su...

journal_title：Cancer letters

authors： Wu M,Zhang X,Han X,Pandey V,Lobie PE,Zhu T

更新日期：2021-03-31 00:00:00

abstract：:The mouse monoclonal anti-BAL antibody induced apoptosis in a pre-B acute lymphocytic leukemia cell line within 2 days of incubation, after being crosslinked by a secondary antibody. The antibody specifically recognized a 37 kDa membrane protein that was expressed on a wide spectrum of normal and malignant cells, but ...

journal_title：Cancer letters

authors： Wallén-Ohman M,Lönnbro P,Schön A,Borrebaeck CA

更新日期：1993-12-10 00:00:00

abstract：:Preventive intervention of colorectal cancer has become essential as a major portion of the population may develop the disease at some points during their lives. Diet and nutrition play an important role during this multistep colon carcinogenic process. Inhibitory activity of aqueous suspensions of garlic and tomato, ...

journal_title：Cancer letters

authors： Sengupta A,Ghosh S,Das S

更新日期：2004-05-28 00:00:00

abstract：:The variation of the E6 region of human papillomavirus type 16 (HPV16) is associated with a high risk for cervical carcinogenesis. To see whether the same is the case with HPV33, 52 and 58, known to have high homology with HPV16, we analyzed the E6 sequence variation of these HPVs in 107 Japanese women with cervical i...

journal_title：Cancer letters

authors： Xin CY,Matsumoto K,Yoshikawa H,Yasugi T,Onda T,Nakagawa S,Yamada M,Nozawa S,Sekiya S,Hirai Y,Shiromizu K,Fujii T,Taketani Y

更新日期：2001-09-10 00:00:00

abstract：:Somatic mutations and chromosome instability are hallmarks of genomic aberrations in cancer cells. Aneuploidies represent common manifestations of chromosome instability, which is frequently observed in human embryos and malignant solid tumors. Activation of human endogenous retroviruses (HERV)-derived loci is documen...

journal_title：Cancer letters

authors： Glinsky GV

更新日期：2016-10-10 00:00:00

abstract：:The porphyrin content of cells labelled with hematoporhyrin derivative (Hpd) and tumours of mice injected with Hpd was analysed by means of high pressure liquid chromatography (HPLC). The components of Hpd may be classified in 3 groups: (A) Components with a high fluorescence quantum yield and with sharp peaks in the ...

journal_title：Cancer letters

authors： Moan J,Sommer S

更新日期：1983-12-01 00:00:00

abstract：:FOY-305 is a synthetic serine protease inhibitor and ONO-3403 and FO-349 are its derivatives. The effects of these compounds on the proliferation of 13 human neuroblastoma cell lines were investigated in vitro by MTT colorimetric assay. The half maximum inhibition concentrations of ONO-3403 varied between 22 and 90 mi...

journal_title：Cancer letters

authors： Hiwasa T,Kondo K,Nakagawara A,Ohkoshi M

更新日期：1998-04-24 00:00:00

abstract：:Peroxiredoxin 2 (Prdx2) has been shown to act as an antioxidant whose main function is to reduce hydrogen peroxide (H2O2) in cells, and Prdx2 is abnormally elevated in colorectal cancer (CRC). However, the functional significance of this up-regulation and the detailed molecular mechanism behind the regulatory effect o...

journal_title：Cancer letters

authors： Lu W,Fu Z,Wang H,Feng J,Wei J,Guo J

更新日期：2014-02-28 00:00:00

abstract：:In our joint project in the search for anti-tumor promoters from natural plant sources, we carried out a primary screening of 12 phenylpropanoids isolated from Boronia pinnata Sm. (Rutaceae) by examining their possible inhibitory effects on Epstein-Barr virus early antigen (EBV-EA) activation induced by 12-O-tetradeca...

journal_title：Cancer letters

authors： Ito C,Itoigawa M,Furukawa H,Ichiishi E,Mukainaka T,Okuda M,Ogata M,Tokuda H,Nishino H

更新日期：1999-07-19 00:00:00

abstract：:Despite the improved 5-year survival rate of breast cancer, triple-negative breast cancer (TNBC) remains a challenge due to lack of effective targeted therapy and higher recurrence and metastasis than other subtypes. To identify novel druggable targets and to understand its unique biology, we tried to implement 24 pat...

journal_title：Cancer letters

authors： Jung J,Jang K,Ju JM,Lee E,Lee JW,Kim HJ,Kim J,Lee SB,Ko BS,Son BH,Lee HJ,Gong G,Ahn SY,Choi JK,Singh SR,Chang S

更新日期：2018-08-01 00:00:00

abstract：:We studied chromosome 1p loss of heterozygosity (1p-LOH) in 53 neuroblastomas (NBs) using 15 (CA)n repeat loci, which covered a region of 90 cM. We also assessed chromosome 1p36 deletion by fluorescence in situ hybridization (FISH) on interphase nuclei. 1p-LOH was found in 19 (36%, 95% confidence interval (CI) 23-50%)...

journal_title：Cancer letters

authors： Iolascon A,Lo Cunsolo C,Giordani L,Cusano R,Mazzocco K,Boumgartner M,Ghisellini P,Faienza MF,Boni L,De Bernardi B,Conte M,Romeo G,Tonini GP

更新日期：1998-08-14 00:00:00

abstract：:Incubation of mouse epidermal cells (HEL-37) with phospholipase C (Clostridium perfringens) caused about a 50% decrease in the specific binding of [20-3H]phorbol-12,13-dibutyrate. Phospholipase C caused a decrease in the apparent number of binding sites from 2.86 X 10(5) to 1.21 X 10(5) per cell with little effect on ...

journal_title：Cancer letters

authors： Jones MJ,Murray AW

更新日期：1983-05-01 00:00:00

abstract：:Cancerous breast hyperthermia is seemingly associated with non-neurological vasodilation modulated by nitric oxide (NO). NO, associated with enhanced immune response, is produced autocatalytically involving ferritin as the supplier of Fe2+, which catalyses the formation of NO. NO, in turn, releases Fe2+ from ferritin....

journal_title：Cancer letters

authors： Anbar M

更新日期：1994-08-29 00:00:00

abstract：:Oxaliplatin (trans-l-1,2-diaminocyclohexane oxalato Pt(II); 1R,2R-dach, l-OHP), its trans-d isomer (1S,2S-dach) and cis-dach (1R,2S-dach) isomers were compared in in vitro testing against human ovarian carcinoma cell lines A2780, A2780/CP (cisplatin resistant), A2780/l-OHP (oxaliplatin resistant), colon carcinoma cell...

journal_title：Cancer letters

authors： Pendyala L,Kidani Y,Perez R,Wilkes J,Bernacki RJ,Creaven PJ

更新日期：1995-11-06 00:00:00

abstract：:Epstein-Barr virus (EBV) is known to be linear in viral particles but EBV circularizes into an episomal form after infection. Recently, the presence of integrated EBV DNA has been reported. We investigated EBV integration into the human genome in EBV-associated disease using Southern blotting. One hundred four cases i...

journal_title：Cancer letters

authors： Ohshima K,Suzumiya J,Kanda M,Kato A,Kikuchi M

更新日期：1998-01-09 00:00:00

abstract：:Normal tissue injury may lead to severe, life threatening, late side effects after therapeutic use of irradiation. Neurological complications caused by radiation of the spinal cord are ascribed to progressive, irreversible damage to the vasculature. Hyperbaric oxygen (HBO) is known to induce angiogenesis in irradiated...

journal_title：Cancer letters

authors： Sminia P,van der Kleij AJ,Carl UM,Feldmeier JJ,Hartmann KA

更新日期：2003-02-28 00:00:00

abstract：:The important goal of cancer drug discovery is to develop therapeutic agents that are effective, safe, and affordable. In the present study, we demonstrated that alantolactone, which is a sesquiterpene lactone, has potential activity against triple-negative breast cancer MDA-MB-231 cells by suppressing the signal tran...

journal_title：Cancer letters

authors： Chun J,Li RJ,Cheng MS,Kim YS

更新日期：2015-02-01 00:00:00

abstract：:uPA system plays an important role in cancer invasion and metastasis. The binding of uPA to its receptor, uPAR, is necessary for the activation of uPA system. We studied by immunohistochemistry the distribution pattern of uPAR on 173 paraffin-embedded samples of invasive breast carcinomas in relation to clinicopatholo...

journal_title：Cancer letters

authors： Giannopoulou I,Mylona E,Kapranou A,Mavrommatis J,Markaki S,Zoumbouli Ch,Keramopoulos A,Nakopoulou L

更新日期：2007-02-08 00:00:00

abstract：:We have developed a monoclonal antibody (designated 1D7) which recognizes an M(r) 7-kDa plasma membrane protein overexpressed in ovarian MDR cancer cells. The expression of the M(r) 7-kDa protein in various human multidrug-resistant and drug-sensitive cell lines was analysed by Western blot and flow cytometry methods....

journal_title：Cancer letters

authors： Yang X,Pagé M

更新日期：1995-01-27 00:00:00

abstract：:Neuroblastoma (NB) is a common neuroectodermal tumor of childhood with low response to conventional therapy in patients with advanced stage disease. Among novel strategies, immumotherapy has attracted much interest. However, scanty information is available about the immunogenicity of human NB. Here, we review our data...

journal_title：Cancer letters

authors： Raffaghello L,Prigione I,Airoldi I,Camoriano M,Morandi F,Bocca P,Gambini C,Ferrone S,Pistoia V

更新日期：2005-10-18 00:00:00

abstract：:Pancreatic expression of the p53 tumor suppressor gene was studied in pancreatic adenocarcinomas and chronic pancreatitis. By immunohistochemistry, 16 of 34 (47%) cancers and none of the 24 chronic pancreatitis samples revealed nuclear staining. Sequence analysis indicated that 8 of 24 (33%) cancers were mutated for t...

journal_title：Cancer letters

authors： Casey G,Yamanaka Y,Friess H,Kobrin MS,Lopez ME,Buchler M,Beger HG,Korc M

更新日期：1993-05-14 00:00:00

abstract：:The DR5/TRAIL receptor 2 gene is a novel TNF receptor family member and induces apoptosis by overexpression of its product. DR5 is located on chromosome 8p21, where allelic deletions are often observed in advanced colorectal cancers. This evidence led us to examine whether or not mutations of the DR5 gene exist in the...

journal_title：Cancer letters

authors： Arai T,Akiyama Y,Okabe S,Saito K,Iwai T,Yuasa Y

更新日期：1998-11-27 00:00:00

abstract：:Endothelin-1 (ET-1) is a potent vasoconstrictor that has been shown to significantly impact many benign and malignant tissues by signaling through its two cognate receptors: ET(A) and ET(B). As ET-1 has a role in both normal and diseased kidney, we initiated studies to investigate endothelin axis expression and functi...

journal_title：Cancer letters

authors： Pflug BR,Zheng H,Udan MS,D'Antonio JM,Marshall FF,Brooks JD,Nelson JB

更新日期：2007-02-08 00:00:00

abstract：:Mouse mammary tumor viruses (MMTV) replicate in the mammary gland, appear as infectious particles in mother's milk and invade the sucking pups from the intestinal tract. The immune system is essential for MMTV in the gut to reach the mammary gland. These properties make the life cycle of MMTV unique. We review the onc...

journal_title：Cancer letters

authors： Matsuzawa A,Nakano H,Yoshimoto T,Sayama K

更新日期：1995-03-23 00:00:00

abstract：:Primary cultures of mouse embryo cells are more efficient in excising DNA-carcinogen adducts resulting from exposure to either 7-bromomethylbenz-[alpha]anthracene or the more carcinogen 7-bromomethyl-12-methylbenz[alpha]anthracene than are mouse L 929 cell suspension cultures. However, within each of these systems, th...

journal_title：Cancer letters

authors： Dipple A,Schultz E

更新日期：1979-07-01 00:00:00

abstract：:Inadequate immunity that occurs in a tumor environment is in part due to the presence of M2-type tumor-associated macrophages (TAMs). TGF-β has a multi-functional role in tumor development including modulating the biological activity of both the tumor and TAMs. In this study, using an in vitro TAM/tumor cell co-cultur...

journal_title：Cancer letters

authors： Peng J,Tsang JY,Li D,Niu N,Ho DH,Lau KF,Lui VC,Lamb JR,Chen Y,Tam PK

更新日期：2013-05-01 00:00:00

abstract：:Transforming growth factors (TGFs) are implicated in malignancy, therefore qualitative and quantitative differences of these growth factors in chronic myelogenous leukemia (CML) in chronic phase has been investigated in this report. Induction of anchorage independent growth of BALB/c 3T3 and NRK-49F fibroblasts was us...

journal_title：Cancer letters

authors： Kothari V,Advani SH,Rao SG

更新日期：1986-09-01 00:00:00