Levels of myc, fos, Ha-ras, met and hepatocyte growth factor mRNA during regenerative cell proliferation in female mouse liver and male rat kidney after a cytotoxic dose of chloroform.


:Chloroform is a liver carcinogen in mice and a kidney carcinogen in rats. It is thought to act through a non-genotoxic-cytotoxic mode of action. Changes in expression of growth control genes accompanying chloroform-induced cytolethality and regeneration may play a part in the development of chloroform-induced tumors. In this experiment, we examined the levels of the myc, fos, Ha-ras, met and hepatocyte growth factor mRNA in livers of female B6C3F(1) mice and kidneys of male F-344 rats to detect changes in gene expression following a single, cytotoxic gavage dose of chloroform in corn oil. Poly A+ RNA was purified from homogenates of livers of mice treated with 350mg/kg chloroform and kidneys of rats treated with 180 mg/kg chloroform and used for Northern blot analysis. Livers of female mice showed large transient increases in levels of myc and fos mRNA while levels of Ha-ras, met and the hepatocyte growth factor gene mRNA remained near control levels. In the male rat kidney, levels of myc mRNA increased after treatement, while levels of mRNA of all other genes examined remained near control levels. This pattern of gene expression is consistent with that induced by other cytotoxic carcinogens and suggest that alteration of the myc and fos genes could be involved in the regenerative cell proliferation that ultimately could play a role in chloroform-induced tumors.


Cancer Lett


Cancer letters


Sprankle CS,Larson JL,Goldsworthy SM,Butterworth BE




Has Abstract


1996-03-19 00:00:00














  • Regorafenib overcomes chemotherapeutic multidrug resistance mediated by ABCB1 transporter in colorectal cancer: In vitro and in vivo study.

    abstract::Chemotherapeutic multidrug resistance (MDR) is a significant challenge to overcome in clinic practice. Several mechanisms contribute to MDR, one of which is the augmented drug efflux induced by the upregulation of ABCB1 in cancer cells. Regorafenib, a multikinase inhibitor targeting the RAS/RAF/MEK/ERK pathway, was ap...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Wang YJ,Zhang YK,Zhang GN,Al Rihani SB,Wei MN,Gupta P,Zhang XY,Shukla S,Ambudkar SV,Kaddoumi A,Shi Z,Chen ZS

    更新日期:2017-06-28 00:00:00

  • Molecular analysis of the secretory phospholipase A2 gene, a candidate of Mom1 gene, in neuroblastomas.

    abstract::Mice with hereditary intestinal polyposis have mutations of the APC gene which causes formation of multiple polyps. At least one other gene influences the susceptibility for development of polyps in mice, and the locus was named Mom1. The causative gene for the Mom1 locus has recently been cloned and was found to be i...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Kawamata N,Seriu T,Bartram CR,Koeffler HP

    更新日期:1997-01-01 00:00:00

  • Effect of later treatment with estrogen on reproductive tract lesions in neonatally estrogenized female mice.

    abstract::Continuous ethinyl estradiol treatment following ovariectomy at day 38 of BALB/cfC3H mice treated neonatally with estradiol resulted in a more organized vaginal epithelium than that seen in the absence of postnatal estrogen, 30 days after treatment was initiated. Although the epithelium became increasingly disorganize...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Wong LM,Bern HA,Jones LA,Mills KT

    更新日期:1982-11-01 00:00:00

  • The potential of long noncoding RNAs for precision medicine in human cancer.

    abstract::Precision medicine promises to better classify patients by individual clinical and biological biomarkers, which may provide an accurate assessment of disease risk, diagnosis, prognosis and treatment response. Cancer frequently displays substantial inter-tumor and intra-tumor heterogeneity and hence oncology is well su...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Wu M,Zhang X,Han X,Pandey V,Lobie PE,Zhu T

    更新日期:2021-03-31 00:00:00

  • Antibody-induced apoptosis in a human leukemia cell line is energy dependent: thermochemical analysis of cellular metabolism.

    abstract::The mouse monoclonal anti-BAL antibody induced apoptosis in a pre-B acute lymphocytic leukemia cell line within 2 days of incubation, after being crosslinked by a secondary antibody. The antibody specifically recognized a 37 kDa membrane protein that was expressed on a wide spectrum of normal and malignant cells, but ...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Wallén-Ohman M,Lönnbro P,Schön A,Borrebaeck CA

    更新日期:1993-12-10 00:00:00

  • Modulatory influence of garlic and tomato on cyclooxygenase-2 activity, cell proliferation and apoptosis during azoxymethane induced colon carcinogenesis in rat.

    abstract::Preventive intervention of colorectal cancer has become essential as a major portion of the population may develop the disease at some points during their lives. Diet and nutrition play an important role during this multistep colon carcinogenic process. Inhibitory activity of aqueous suspensions of garlic and tomato, ...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Sengupta A,Ghosh S,Das S

    更新日期:2004-05-28 00:00:00

  • Analysis of E6 variants of human papillomavirus type 33, 52 and 58 in Japanese women with cervical intraepithelial neoplasia/cervical cancer in relation to their oncogenic potential.

    abstract::The variation of the E6 region of human papillomavirus type 16 (HPV16) is associated with a high risk for cervical carcinogenesis. To see whether the same is the case with HPV33, 52 and 58, known to have high homology with HPV16, we analyzed the E6 sequence variation of these HPVs in 107 Japanese women with cervical i...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Xin CY,Matsumoto K,Yoshikawa H,Yasugi T,Onda T,Nakagawa S,Yamada M,Nozawa S,Sekiya S,Hirai Y,Shiromizu K,Fujii T,Taketani Y

    更新日期:2001-09-10 00:00:00

  • Single cell genomics reveals activation signatures of endogenous SCAR's networks in aneuploid human embryos and clinically intractable malignant tumors.

    abstract::Somatic mutations and chromosome instability are hallmarks of genomic aberrations in cancer cells. Aneuploidies represent common manifestations of chromosome instability, which is frequently observed in human embryos and malignant solid tumors. Activation of human endogenous retroviruses (HERV)-derived loci is documen...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Glinsky GV

    更新日期:2016-10-10 00:00:00

  • Uptake of the components of hematoporphyrin derivative by cells and tumours.

    abstract::The porphyrin content of cells labelled with hematoporhyrin derivative (Hpd) and tumours of mice injected with Hpd was analysed by means of high pressure liquid chromatography (HPLC). The components of Hpd may be classified in 3 groups: (A) Components with a high fluorescence quantum yield and with sharp peaks in the ...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Moan J,Sommer S

    更新日期:1983-12-01 00:00:00

  • Potent growth-suppressive activity of a serine protease inhibitor, ONO-3403, toward malignant human neuroblastoma cell lines.

    abstract::FOY-305 is a synthetic serine protease inhibitor and ONO-3403 and FO-349 are its derivatives. The effects of these compounds on the proliferation of 13 human neuroblastoma cell lines were investigated in vitro by MTT colorimetric assay. The half maximum inhibition concentrations of ONO-3403 varied between 22 and 90 mi...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Hiwasa T,Kondo K,Nakagawara A,Ohkoshi M

    更新日期:1998-04-24 00:00:00

  • Peroxiredoxin 2 knockdown by RNA interference inhibits the growth of colorectal cancer cells by downregulating Wnt/β-catenin signaling.

    abstract::Peroxiredoxin 2 (Prdx2) has been shown to act as an antioxidant whose main function is to reduce hydrogen peroxide (H2O2) in cells, and Prdx2 is abnormally elevated in colorectal cancer (CRC). However, the functional significance of this up-regulation and the detailed molecular mechanism behind the regulatory effect o...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Lu W,Fu Z,Wang H,Feng J,Wei J,Guo J

    更新日期:2014-02-28 00:00:00

  • Anti-tumor-promoting effects of phenylpropanoids on Epstein-Barr virus activation and two-stage mouse skin carcinogenesis.

    abstract::In our joint project in the search for anti-tumor promoters from natural plant sources, we carried out a primary screening of 12 phenylpropanoids isolated from Boronia pinnata Sm. (Rutaceae) by examining their possible inhibitory effects on Epstein-Barr virus early antigen (EBV-EA) activation induced by 12-O-tetradeca...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Ito C,Itoigawa M,Furukawa H,Ichiishi E,Mukainaka T,Okuda M,Ogata M,Tokuda H,Nishino H

    更新日期:1999-07-19 00:00:00

  • Novel cancer gene variants and gene fusions of triple-negative breast cancers (TNBCs) reveal their molecular diversity conserved in the patient-derived xenograft (PDX) model.

    abstract::Despite the improved 5-year survival rate of breast cancer, triple-negative breast cancer (TNBC) remains a challenge due to lack of effective targeted therapy and higher recurrence and metastasis than other subtypes. To identify novel druggable targets and to understand its unique biology, we tried to implement 24 pat...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Jung J,Jang K,Ju JM,Lee E,Lee JW,Kim HJ,Kim J,Lee SB,Ko BS,Son BH,Lee HJ,Gong G,Ahn SY,Choi JK,Singh SR,Chang S

    更新日期:2018-08-01 00:00:00

  • Interstitial and large chromosome 1p deletion occurs in localized and disseminated neuroblastomas and predicts an unfavourable outcome.

    abstract::We studied chromosome 1p loss of heterozygosity (1p-LOH) in 53 neuroblastomas (NBs) using 15 (CA)n repeat loci, which covered a region of 90 cM. We also assessed chromosome 1p36 deletion by fluorescence in situ hybridization (FISH) on interphase nuclei. 1p-LOH was found in 19 (36%, 95% confidence interval (CI) 23-50%)...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Iolascon A,Lo Cunsolo C,Giordani L,Cusano R,Mazzocco K,Boumgartner M,Ghisellini P,Faienza MF,Boni L,De Bernardi B,Conte M,Romeo G,Tonini GP

    更新日期:1998-08-14 00:00:00

  • Decreased [20-3H]phorbol-12,13-dibutyrate binding to phospholipase C pretreated epidermal cells.

    abstract::Incubation of mouse epidermal cells (HEL-37) with phospholipase C (Clostridium perfringens) caused about a 50% decrease in the specific binding of [20-3H]phorbol-12,13-dibutyrate. Phospholipase C caused a decrease in the apparent number of binding sites from 2.86 X 10(5) to 1.21 X 10(5) per cell with little effect on ...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Jones MJ,Murray AW

    更新日期:1983-05-01 00:00:00

  • Hyperthermia of the cancerous breast: analysis of mechanism.

    abstract::Cancerous breast hyperthermia is seemingly associated with non-neurological vasodilation modulated by nitric oxide (NO). NO, associated with enhanced immune response, is produced autocatalytically involving ferritin as the supplier of Fe2+, which catalyses the formation of NO. NO, in turn, releases Fe2+ from ferritin....

    journal_title:Cancer letters

    pub_type: 杂志文章,评审


    authors: Anbar M

    更新日期:1994-08-29 00:00:00

  • Cytotoxicity, cellular accumulation and DNA binding of oxaliplatin isomers.

    abstract::Oxaliplatin (trans-l-1,2-diaminocyclohexane oxalato Pt(II); 1R,2R-dach, l-OHP), its trans-d isomer (1S,2S-dach) and cis-dach (1R,2S-dach) isomers were compared in in vitro testing against human ovarian carcinoma cell lines A2780, A2780/CP (cisplatin resistant), A2780/l-OHP (oxaliplatin resistant), colon carcinoma cell...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Pendyala L,Kidani Y,Perez R,Wilkes J,Bernacki RJ,Creaven PJ

    更新日期:1995-11-06 00:00:00

  • Integrated and episomal forms of Epstein-Barr virus (EBV) in EBV associated disease.

    abstract::Epstein-Barr virus (EBV) is known to be linear in viral particles but EBV circularizes into an episomal form after infection. Recently, the presence of integrated EBV DNA has been reported. We investigated EBV integration into the human genome in EBV-associated disease using Southern blotting. One hundred four cases i...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Ohshima K,Suzumiya J,Kanda M,Kato A,Kikuchi M

    更新日期:1998-01-09 00:00:00

  • Prophylactic hyperbaric oxygen treatment and rat spinal cord re-irradiation.

    abstract::Normal tissue injury may lead to severe, life threatening, late side effects after therapeutic use of irradiation. Neurological complications caused by radiation of the spinal cord are ascribed to progressive, irreversible damage to the vasculature. Hyperbaric oxygen (HBO) is known to induce angiogenesis in irradiated...

    journal_title:Cancer letters

    pub_type: 杂志文章,评审


    authors: Sminia P,van der Kleij AJ,Carl UM,Feldmeier JJ,Hartmann KA

    更新日期:2003-02-28 00:00:00

  • Alantolactone selectively suppresses STAT3 activation and exhibits potent anticancer activity in MDA-MB-231 cells.

    abstract::The important goal of cancer drug discovery is to develop therapeutic agents that are effective, safe, and affordable. In the present study, we demonstrated that alantolactone, which is a sesquiterpene lactone, has potential activity against triple-negative breast cancer MDA-MB-231 cells by suppressing the signal tran...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Chun J,Li RJ,Cheng MS,Kim YS

    更新日期:2015-02-01 00:00:00

  • The prognostic value of the topographic distribution of uPAR expression in invasive breast carcinomas.

    abstract::uPA system plays an important role in cancer invasion and metastasis. The binding of uPA to its receptor, uPAR, is necessary for the activation of uPA system. We studied by immunohistochemistry the distribution pattern of uPAR on 173 paraffin-embedded samples of invasive breast carcinomas in relation to clinicopatholo...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Giannopoulou I,Mylona E,Kapranou A,Mavrommatis J,Markaki S,Zoumbouli Ch,Keramopoulos A,Nakopoulou L

    更新日期:2007-02-08 00:00:00

  • An M(r) 7-kDa membrane protein overexpressed in human multidrug-resistant ovarian cancer cells.

    abstract::We have developed a monoclonal antibody (designated 1D7) which recognizes an M(r) 7-kDa plasma membrane protein overexpressed in ovarian MDR cancer cells. The expression of the M(r) 7-kDa protein in various human multidrug-resistant and drug-sensitive cell lines was analysed by Western blot and flow cytometry methods....

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Yang X,Pagé M

    更新日期:1995-01-27 00:00:00

  • Mechanisms of immune evasion of human neuroblastoma.

    abstract::Neuroblastoma (NB) is a common neuroectodermal tumor of childhood with low response to conventional therapy in patients with advanced stage disease. Among novel strategies, immumotherapy has attracted much interest. However, scanty information is available about the immunogenicity of human NB. Here, we review our data...

    journal_title:Cancer letters

    pub_type: 杂志文章,评审


    authors: Raffaghello L,Prigione I,Airoldi I,Camoriano M,Morandi F,Bocca P,Gambini C,Ferrone S,Pistoia V

    更新日期:2005-10-18 00:00:00

  • p53 mutations are common in pancreatic cancer and are absent in chronic pancreatitis.

    abstract::Pancreatic expression of the p53 tumor suppressor gene was studied in pancreatic adenocarcinomas and chronic pancreatitis. By immunohistochemistry, 16 of 34 (47%) cancers and none of the 24 chronic pancreatitis samples revealed nuclear staining. Sequence analysis indicated that 8 of 24 (33%) cancers were mutated for t...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Casey G,Yamanaka Y,Friess H,Kobrin MS,Lopez ME,Buchler M,Beger HG,Korc M

    更新日期:1993-05-14 00:00:00

  • Genomic organization and mutation analyses of the DR5/TRAIL receptor 2 gene in colorectal carcinomas.

    abstract::The DR5/TRAIL receptor 2 gene is a novel TNF receptor family member and induces apoptosis by overexpression of its product. DR5 is located on chromosome 8p21, where allelic deletions are often observed in advanced colorectal cancers. This evidence led us to examine whether or not mutations of the DR5 gene exist in the...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Arai T,Akiyama Y,Okabe S,Saito K,Iwai T,Yuasa Y

    更新日期:1998-11-27 00:00:00

  • Endothelin-1 promotes cell survival in renal cell carcinoma through the ET(A) receptor.

    abstract::Endothelin-1 (ET-1) is a potent vasoconstrictor that has been shown to significantly impact many benign and malignant tissues by signaling through its two cognate receptors: ET(A) and ET(B). As ET-1 has a role in both normal and diseased kidney, we initiated studies to investigate endothelin axis expression and functi...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Pflug BR,Zheng H,Udan MS,D'Antonio JM,Marshall FF,Brooks JD,Nelson JB

    更新日期:2007-02-08 00:00:00

  • Biology of mouse mammary tumor virus (MMTV).

    abstract::Mouse mammary tumor viruses (MMTV) replicate in the mammary gland, appear as infectious particles in mother's milk and invade the sucking pups from the intestinal tract. The immune system is essential for MMTV in the gut to reach the mammary gland. These properties make the life cycle of MMTV unique. We review the onc...

    journal_title:Cancer letters

    pub_type: 杂志文章,评审


    authors: Matsuzawa A,Nakano H,Yoshimoto T,Sayama K

    更新日期:1995-03-23 00:00:00

  • Excision of DNA damage arising from chemicals of different carcinogenic potencies.

    abstract::Primary cultures of mouse embryo cells are more efficient in excising DNA-carcinogen adducts resulting from exposure to either 7-bromomethylbenz-[alpha]anthracene or the more carcinogen 7-bromomethyl-12-methylbenz[alpha]anthracene than are mouse L 929 cell suspension cultures. However, within each of these systems, th...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Dipple A,Schultz E

    更新日期:1979-07-01 00:00:00

  • Inhibition of TGF-β signaling in combination with TLR7 ligation re-programs a tumoricidal phenotype in tumor-associated macrophages.

    abstract::Inadequate immunity that occurs in a tumor environment is in part due to the presence of M2-type tumor-associated macrophages (TAMs). TGF-β has a multi-functional role in tumor development including modulating the biological activity of both the tumor and TAMs. In this study, using an in vitro TAM/tumor cell co-cultur...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Peng J,Tsang JY,Li D,Niu N,Ho DH,Lau KF,Lui VC,Lamb JR,Chen Y,Tam PK

    更新日期:2013-05-01 00:00:00

  • Growth factors in chronic myelogenous leukemia.

    abstract::Transforming growth factors (TGFs) are implicated in malignancy, therefore qualitative and quantitative differences of these growth factors in chronic myelogenous leukemia (CML) in chronic phase has been investigated in this report. Induction of anchorage independent growth of BALB/c 3T3 and NRK-49F fibroblasts was us...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Kothari V,Advani SH,Rao SG

    更新日期:1986-09-01 00:00:00