Abstract:
:The binding of [14C] azaserine or its metabolites to DNA and protein in the organs of rats and hamsters was determined at various time after treatment with [14C] azaserine. The specific activity of 14C labelling of DNA and protein was determined. Rat liver DNA and protein were most extensively labelled at 90 min post-injection, but by 24 h the specific activity decreased to the levels found in pancreas and kidney. Thymus contained negligible amounts of radioactivity at all time-points. DNA and protein from hamster pancreas contained more label than did DNA and protein from rat pancreas. The results suggest that factors other than DNA binding play a role in determining the species and organ specificity of azaserine.
journal_name
Cancer Lettjournal_title
Cancer lettersauthors
Zurlo J,Coon CI,Longnecker DS,Curphey TJdoi
10.1016/0304-3835(82)90092-1subject
Has Abstractpub_date
1982-05-01 00:00:00pages
65-70issue
1eissn
0304-3835issn
1872-7980pii
0304-3835(82)90092-1journal_volume
16pub_type
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