Telomerase as tumor marker.

abstract：:RNA interference (RNAi) is an evolutionary conserved mechanism for specific gene silencing. There are currently numerous cancer therapy clinical trials based on RNAi technology. Using an adenoviral system as a delivery mediator of RNAi, we investigated the therapeutic effects of targeting three genes simultaneously in...

journal_title：Cancer letters

authors： Han JB,Tao ZZ,Chen SM,Kong YG,Xiao BK

更新日期：2011-10-28 00:00:00

abstract：:Gene amplification has been found to be biologically important in cancer. We report a complementary DNA sequence obtained using a subtractive hybridization approach which is frequently and highly amplified in human gliomas. 39/45 (87%) glial tumor specimens (of pathologically low and high grade) revealed increases in ...

journal_title：Cancer letters

authors： Liang BC,Hays L

更新日期：1996-08-02 00:00:00

abstract：BACKGROUND:This study characterizes the second hit spectrum in BRCA1 and BRCA2-associated breast and ovarian cancers at both gene loci to investigate if second hit mechanisms are mutually exclusive or able to coincide within the same tumor. METHODS:Loss of heterozygosity, somatic point mutations and copy number altera...

journal_title：Cancer letters

authors： Van Heetvelde M,Van Bockstal M,Poppe B,Lambein K,Rosseel T,Atanesyan L,Deforce D,Van Den Berghe I,De Leeneer K,Van Dorpe J,Vral A,Claes KBM

更新日期：2018-07-01 00:00:00

abstract：:The effect of ligation of the left ureter on the development of lesions in the urinary bladder were investigated in male F344 rats treated with 0.05% N-butyl-N-(4-hydroxybutyl)-nitrosamine (BBN) for 2 weeks followed by 0.002% N-ethyl-N-(4-hydroxybutyl)nitrosamine (EHBN) for 10 or 22 weeks. The lesions of the urinary b...

journal_title：Cancer letters

authors： Miyata Y,Fukushima S,Imaida K,Ito N

更新日期：1984-07-01 00:00:00

abstract：:Tumor necrosis factor-alpha (TNF-alpha) is a macrophage-derived multifunctional cytokine that acts as a cytostatic or cytotoxic agent in many tumor cells. However, the molecular mechanisms by which tumor cells become sensitive to the cytotoxic action of TNF-alpha are not clear. In this study we demonstrated that the c...

journal_title：Cancer letters

authors： Park IC,Park MJ,Lee SH,Choe TB,Jang JJ,Hong SI

更新日期：1998-03-13 00:00:00

abstract：:Serum alpha-N-acetylgalactosaminidase (NaGalase) is responsible for the deglycosylation of vitamin D(3)-binding protein (Gc protein). The deglycosylated Gc protein cannot be converted into major macrophage-activating factor (MAF), leading to immunosuppression. NaGalase is universally detected in a variety of cancer pa...

journal_title：Cancer letters

authors： Reddi AL,Sankaranarayanan K,Arulraj HS,Devaraj N,Devaraj H

更新日期：2000-09-29 00:00:00

abstract：:The growth of primary subcutaneous fibrosarcomas and their pulmonary metastases was studied in normal and athymic Swiss mice. The metastases tended to develop more rapidly than did the primary tumors. However, when growth rates of tumors of small volumes (up to 1 cm3) were compared, the tumor and metastases exhibited ...

journal_title：Cancer letters

authors： Plesnicar S,Kuszynski C,Patil KD

更新日期：1982-03-01 00:00:00

abstract：:Lactoferrin, an iron-binding glycoprotein, exhibits suppressive effects on development of azoxymethane (AOM)-induced tumors in the rat colon, but the mechanisms are largely unknown. In this study, we investigated the effect of lactoferrin on the gene expression of 10 apoptosis-related molecules in colon mucosa of AOM-...

journal_title：Cancer letters

authors： Fujita K,Matsuda E,Sekine K,Iigo M,Tsuda H

更新日期：2004-09-15 00:00:00

abstract：:The objective of this work was to investigate the expression of glutathione S-transferase placental form (GST-P) in 9,10-dimethyl-1,2-benzanthracene (DMBA)-induced hamster buccal pouch carcinogenesis. Lesions were classified histopathologically into four categories, simple hyperplasia, papillary and nodular (PN) hyper...

journal_title：Cancer letters

authors： Iida K,Yamamoto M,Kato M,Yoshida K,Kurita K,Tatematsu M

更新日期：1999-01-29 00:00:00

abstract：:Glucosinolates constitute a well-defined group of secondary plant metabolites in cruciferous plants. They occur especially in brassica vegetables, which represent a major part of the human diet. Glucosinolates undergo hydrolysis, catalysed by an endogenous plant enzyme, known as myrosinase, into a range of biological ...

journal_title：Cancer letters

authors： Verkerk R,van der Gaag MS,Dekker M,Jongen WM

更新日期：1997-03-19 00:00:00

abstract：:Effect of CF(3)-STLC, a potent kinesin spindle protein (KSP) inhibitor, on K562 human CML cell line was investigated. Treatment with CF(3)-STLC induced mitotic arrest of the cell cycle with the appearance of characteristic monoastral spindles, subsequent apoptotic cell death and cleavage of PARP-1, caspase-3, and 4E-B...

journal_title：Cancer letters

authors： Shimizu M,Ishii H,Ogo N,Unno Y,Matsuno K,Sawada J,Akiyama Y,Asai A

更新日期：2010-12-01 00:00:00

abstract：:Many members of BCL2 (Bcl-2) apoptosis-related genes were found to be differentially expressed in various malignancies and were proposed as prognostic cancer biomarkers. Recently, a new member of the BCL2 gene family, BCL2L12, was cloned and was found to be expressed in mammary gland. In the present study, 55 specimen...

journal_title：Cancer letters

authors： Thomadaki H,Talieri M,Scorilas A

更新日期：2007-03-08 00:00:00

abstract：:Caveolins, essential scaffold proteins of caveolae, have emerged as versatile molecules that can influence numerous signaling pathways and disease processes. This brief review is focused on the role of caveolins in the physiology and pathology of musculoskeletal system and will discuss the key features of caveolins as...

journal_title：Cancer letters

authors： Serra M,Scotlandi K

更新日期：2009-11-01 00:00:00

abstract：:Gastroesophageal reflux disease (GERD) is the main risk factor for Barrett's tumorigenesis. In this study, we investigated the role of NRF2 in response to exposure to acidic bile salts (ABS), in conditions that mimic GERD, using Barrett's esophagus cell models. We detected an increase in NRF2 protein levels, following...

journal_title：Cancer letters

authors： Peng D,Lu H,Zhu S,Zhou Z,Hu T,Chen Z,Zaika A,El-Rifai W

更新日期：2019-08-28 00:00:00

abstract：:Many clinical studies have shown that circulating RNA rises in cancer patients, but little is known about the origins of abnormally elevated extracellular RNA (exRNA). We designed four different culture conditions: serum-deprived, hypoxia, low temperature and exposure to an anticancer drug to investigate the origins i...

journal_title：Cancer letters

authors： Zhou H,Xu W,Qian H,Yin Q,Zhu W,Yan Y

更新日期：2008-01-18 00:00:00

abstract：:This study investigated the role of miR-206 in estrogen receptor-α (ERα)-positive endometrial endometrioid adenocarcinoma (EEC). We profiled miR-206 expression in 30 EEC clinical samples using qRT-PCR, and explored its relationship with ERα and clinical parameters. A luciferase reporter assay assessed the ERα targetin...

journal_title：Cancer letters

authors： Chen X,Yan Q,Li S,Zhou L,Yang H,Yang Y,Liu X,Wan X

更新日期：2012-01-01 00:00:00

abstract：:The expression of DNA-topoisomerase II was analysed at the protein level in newly diagnosed cases of acute lymphoblastic leukemia (ALL) in children. Blast cells obtained from 81 children with untreated ALL were determined by means of immunocytochemistry. Of the ALL, 49 (60%) were positive for topoisomerase II and 32 (...

journal_title：Cancer letters

authors： Stammler G,Sauerbrey A,Volm M

更新日期：1994-09-15 00:00:00

abstract：:An apoptosis-inducing protein with molecular weight of 60 kDa has been purified from fetal bovine serum. The N-terminal amino acid sequence of this protein (e.g. I-P-L-D-P-V-A-G-Y-K) reveals that it is bovine fetuin, a fetal protein functioning to control embryogenesis. The apoptosis-inducing activity of fetuin is tot...

journal_title：Cancer letters

authors： Yu CL,Tsai MH

更新日期：2001-05-26 00:00:00

abstract：:The ability of tumor cells to adapt to changes in oxygen tension is essential for tumor development. Low oxygen concentration influences cellular metabolism and, thus, affects proliferation, migration, and invasion. A focal point of the cell's adaptation to hypoxia is the transcription factor HIF1α (hypoxia-inducible ...

journal_title：Cancer letters

authors： Paredes F,Williams HC,San Martin A

更新日期：2021-01-11 00:00:00

abstract：:Heat shock protein 90 (HSP90) is a highly conserved molecular chaperone that facilitates the maturation of a wide range of proteins, and it has been recognized as a crucial facilitator of oncogene addiction and cancer cell survival. Although HSP90 function is regulated by a variety of post-translational modifications,...

journal_title：Cancer letters

authors： Hamamoto R,Toyokawa G,Nakakido M,Ueda K,Nakamura Y

更新日期：2014-08-28 00:00:00

abstract：:Despite the improved 5-year survival rate of breast cancer, triple-negative breast cancer (TNBC) remains a challenge due to lack of effective targeted therapy and higher recurrence and metastasis than other subtypes. To identify novel druggable targets and to understand its unique biology, we tried to implement 24 pat...

journal_title：Cancer letters

authors： Jung J,Jang K,Ju JM,Lee E,Lee JW,Kim HJ,Kim J,Lee SB,Ko BS,Son BH,Lee HJ,Gong G,Ahn SY,Choi JK,Singh SR,Chang S

更新日期：2018-08-01 00:00:00

abstract：:We investigated the relationship between ErbB-2 and HLA in order to clarify the clinical and genetic factors related to Japanese patients with lung cancer. Thirty-nine of the 73 lung cancer patients (53.4%) had elevated levels of ErbB-2. Only seven of 23 (30. 4%) patients with small cell carcinoma had elevated ErbB-2 ...

journal_title：Cancer letters

authors： Yoshimura C,Nomura S,Yamaoka M,Ohtani T,Matsuzakiz T,Yamaguchi K,Fukuharal S

更新日期：2000-04-28 00:00:00

abstract：:The polymorphism in the ALDH2 gene plays a central role in Asian alcohol hypersensitivity and has been associated with the risk for esophageal cancer. In the present study, we attempted to examine associations between the ADH2 and ALDH2 polymorphisms, alcohol drinking and hepatocellular carcinoma (HCC) development in ...

journal_title：Cancer letters

authors： Takeshita T,Yang X,Inoue Y,Sato S,Morimoto K

更新日期：2000-02-28 00:00:00

abstract：:We previously identified Hop as over expressed in invasive pancreatic cancer cell lines and malignant tissues of pancreatic cancer patients, suggesting an important role for Hop in the biology of invasive pancreatic cancer. Hop is a co-chaperone protein that binds to both Hsp70/Hsp90. We hypothesised that by targeting...

journal_title：Cancer letters

authors： Walsh N,Larkin A,Swan N,Conlon K,Dowling P,McDermott R,Clynes M

更新日期：2011-07-28 00:00:00

abstract：:The mdm2 oncogene is amplified and overexpressed in a variety of human tumours and the oncogenic potential of MDM2 is partly due to its ability to inactivate tumour suppressor p53 function. In the present communication we describe the cloning, sequence analysis and expression of the complete wildtype canine and equine...

journal_title：Cancer letters

authors： Nasir L,Burr PD,McFarlane ST,Gault E,Thompson H,Argyle DJ

更新日期：2000-04-28 00:00:00

abstract：:Two human prostate tumor cell lines which exhibit a 2.4-fold difference in sensitivity to cis-platinum (cis-Pt) were found to possess slightly different sulphydryl contents, and the presence of a metallothionein-like zinc-binding protein was demonstrated in the line exhibiting relative resistance to cis-Pt. Although t...

journal_title：Cancer letters

authors： Metcalfe SA,Cain K,Hill BT

更新日期：1986-05-01 00:00:00

abstract：:Cancer stem cells (CSC) are critical for initiation, metastasis, and relapse of cancers, however, the underlying mechanism governing stemness of CSC remains unknown. Herein, we have investigated the roles of phosphodiesterase 5 (PDE5) in stemness of prostate cancer cells. Both PDE5 and WW domain-containing transcripti...

journal_title：Cancer letters

authors： Liu N,Mei L,Fan X,Tang C,Ji X,Hu X,Shi W,Qian Y,Hussain M,Wu J,Wang C,Lin S,Wu X

更新日期：2016-08-01 00:00:00

abstract：:Cancer stem-like cells (CSLCs) are potential targets for treatment of glioblastoma multiforme (GBM) due to their role in tumorigenesis and recurrence. In this study, we investigated the inhibitory effect of arsenic trioxide (As(2)O(3)) on CSLCs of GBM in human glioma cell lines (U87MG, U251MG and U373MG) in vivo and i...

journal_title：Cancer letters

authors： Zhen Y,Zhao S,Li Q,Li Y,Kawamoto K

更新日期：2010-06-01 00:00:00

abstract：:Well differentiated thyroid carcinomas provide a unique model of human, epithelial cell carcinogenesis. Their molecular characterization has allowed to associate specific genetic alterations to the two papillary and follicular histotypes which, despite their common origin, display different biological and clinical beh...

journal_title：Cancer letters

authors： Pierotti MA

更新日期：2001-05-10 00:00:00

abstract：:The treatment of HeLa cells with different concentrations of adriamycin (0, 5, 10, 25, 50 and 100 microg/ml) resulted in a significant and dose-dependent decline in the cell survival. Conversely, the frequency of micronuclei increased in a concentration-dependent manner. The micronuclei-induction and cell survival wer...

journal_title：Cancer letters

authors： Jagetia GC,Nayak V

更新日期：1996-12-20 00:00:00